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1. 发明申请

WO2011015958A2 ONCOLOGY THERAPIES EMPLOYING RADIOACTIVE SEEDS 审中-公开
标题翻译：使用放射性种子进行肿瘤治疗
公开(公告)号：WO2011015958A2
公开(公告)日：2011-02-10
申请号：PCT/IB2010053094
申请日：2010-07-06
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , RIBBING CAROLINA , OVERDICK MICHAEL
发明人： RIBBING CAROLINA , OVERDICK MICHAEL
IPC分类号： A61K51/12
CPC分类号： A61K51/1255 , A61N5/1015 , A61N5/1027 , A61N2005/1024
摘要： An oncology therapy method comprises implanting a radioactive seed (10, 20, 30, 40, 50) in an oncology subject (S). In some embodiments the radioactive seed comprises a radioactive material (12, 32, 33, 42) including at least one radioisotope disposed in a biodegradable host (14, 24, 25, 44) configured to biodegrade over a therapy time period when implanted in the oncology subject. In some embodiments the radioactive seed is implanted in soft tissue of an oncology subject (S), and the radioactive seed comprises a radioactive material (12, 32, 33, 42) including at least one radioisotope disposed in a host material (14, 24, 25, 44) having softness comparable with or softer than the soft tissue into which the radioactive seed is implanted.
摘要翻译：肿瘤治疗方法包括在肿瘤学科（S）中植入放射性种子（10,20,30,40,50）。在一些实施方案中，放射性种子包括放射性材料（12,32,33,42），其包括设置在可生物降解的宿主（14,24,25,44）中的至少一个放射性同位素，所述放射性同位素被配置为在植入在肿瘤科在一些实施方案中，将放射性种子植入到肿瘤学对象（S）的软组织中，并且放射性种子包括放射性物质（12,32,33,42），其包括放置在宿主材料（14,24）中的至少一种放射性同位素，25,44）具有与放射性种子植入的软组织相当或更软的柔软度。

2. 发明申请

WO2010136942A3 A METHOD AND DEVICE FOR SIDE-EFFECT PROGNOSIS AND MONITORING 审中-公开
标题翻译：一种用于侧面预处理和监测的方法和装置
公开(公告)号：WO2010136942A3
公开(公告)日：2011-04-07
申请号：PCT/IB2010052266
申请日：2010-05-21
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , RIBBING CAROLINA , WEIBRECHT MARTIN , BACHMANN PETER KLAUS , PERKUHN MICHAEL , LIERFELD MARCO DANIEL PASCAL , PINKAWA MICHAEL
发明人： RIBBING CAROLINA , WEIBRECHT MARTIN , BACHMANN PETER KLAUS , PERKUHN MICHAEL , LIERFELD MARCO DANIEL PASCAL , PINKAWA MICHAEL
IPC分类号： G06F19/00 , A61N5/10
CPC分类号： A61N5/103 , G06F19/3481
摘要： A method for radiotherapy monitoring is provided. The method comprises calculation of treatment-guiding indices of side-effects based on processing image derived descriptors and measurement values of selected disease specific biomarkers and optionally questionnaire data. A computer program product is also provided.
摘要翻译：提供放射治疗监测方法。该方法包括基于处理图像导出的描述符和所选疾病特异性生物标志物的测量值以及任选的问卷数据来计算副作用的治疗指导指数。还提供了计算机程序产品。

3. 发明申请

WO2010106449A3 FUNCTIONAL IMAGING 审中-公开
标题翻译：功能成像
公开(公告)号：WO2010106449A3
公开(公告)日：2010-12-29
申请号：PCT/IB2010050579
申请日：2010-02-09
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , SOLF TORSTEN , SCHWEIZER BERND , WEIBRECHT MARTIN , RIBBING CAROLINA
发明人： SOLF TORSTEN , SCHWEIZER BERND , WEIBRECHT MARTIN , RIBBING CAROLINA
IPC分类号： A61B6/00 , G06F19/00 , G06T11/00
CPC分类号： A61B6/00 , A61B5/055 , A61B5/743 , A61B6/037 , A61B6/463 , A61B6/545 , A61B8/463 , A61B8/481 , A61B8/585 , G06F19/321 , G16H15/00
摘要： A method includes obtaining an image of a region of interest of a subject, wherein the image is generated with image data produced by an imaging system used to scan the subject, obtaining a signal indicative of a physiological state of the subject before the scan, and displaying both the image and data indicative of the physiological state. In another aspect, a method includes correcting, via a processor, a tracer uptake value for a target region of interest based on a tracer uptake correction factor.
摘要翻译：一种方法包括获得对象感兴趣区域的图像，其中使用由用于扫描对象的成像系统产生的图像数据来生成图像，获得指示扫描之前对象的生理状态的信号，以及显示指示生理状态的图像和数据。在另一方面，一种方法包括：通过处理器，基于示踪剂摄取校正因子来校正目标感兴趣区域的示踪剂吸收值。

4. 发明申请

WO2011070461A3 DIAGNOSTIC TECHNIQUES FOR CONTINUOUS STORAGE AND JOINT ANALYSIS OF BOTH IMAGE AND NON-IMAGE MEDICAL DATA 审中-公开
标题翻译：用于连续存储和联合分析两个图像和非图像医学数据的诊断技术
公开(公告)号：WO2011070461A3
公开(公告)日：2011-12-08
申请号：PCT/IB2010055237
申请日：2010-11-17
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , RIBBING CAROLINA , WEIBRECHT MARTIN , BACHMANN PETER K
发明人： RIBBING CAROLINA , WEIBRECHT MARTIN , BACHMANN PETER K
IPC分类号： G06F19/00
CPC分类号： G06F19/321 , G16H50/20
摘要： An apparatus comprises: a database (30) storing medical data including image medical data and non-image medical data for a plurality of patients; a digital processor (40) configured to (i) generate a features vector (56) comprising features indicative of a patient derived from patient medical data stored in the database including both patient image medical data and patient non-image medical data and (ii) perform multivariate analysis (64) on a features vector generated for a patient of interest to determine a proposed diagnosis for the patient of interest; and a user interface (42) configured to output a human perceptible representation of the proposed diagnosis for the patient of interest.
摘要翻译：一种装置包括：数据库（30），存储包括用于多个患者的图像医疗数据和非图像医疗数据的医学数据; 数字处理器（40），被配置为（i）生成特征向量（56），其特征向量（56）包括表示从存储在数据库中的患者医疗数据导出的病人的特征，包括患者图像医疗数据和患者非图像医疗数据，以及（ii）对为感兴趣的患者生成的特征向量执行多变量分析（64）以确定对感兴趣的患者的建议诊断; 以及用户界面（42），其被配置为输出针对感兴趣的患者的所提出的诊断的人感知表示。

5. 发明申请

WO2009016546A3 NANOSTRUCTURES AND METHOD FOR MAKING THEM 审中-公开
标题翻译：纳米结构及其制造方法
公开(公告)号：WO2009016546A3
公开(公告)日：2009-10-15
申请号：PCT/IB2008052947
申请日：2008-07-23
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , BACHMANN PETER K , CHEN ZEXIANG , KOEHLER IRMGARD H , RIBBING CAROLINA , VILLARREAL LAURA
发明人： BACHMANN PETER K , CHEN ZEXIANG , KOEHLER IRMGARD H , RIBBING CAROLINA , VILLARREAL LAURA
IPC分类号： C01B31/02 , G01N27/00
CPC分类号： B82Y40/00 , B82Y30/00 , C01B32/05 , C01B32/162
摘要： The present invention relates to nanostructures comprising nanosized filamentary material based on carbon and to a method of fabricating it. The inventive method improves the adhesion of nanosized filamentary carbon-based materials, like carbon nanotubes, to substrates. It was found that the presence of at least one carbide- forming material can improve the adhesion of a nanosized filamentary carbon-based material to a substrate. Therefore, in another aspect, a method for firmly attaching a nanosized filamentary carbon-based material to a substrate is provided, wherein a layer is formed over the substrate, the layer comprising at least one carbide-forming material and at least one catalytically active material, and the nanosized filamentary carbon-based material is grown on the catalytically active material.
摘要翻译：本发明涉及包含基于碳的纳米尺寸丝状材料的纳米结构及其制造方法。本发明的方法改善了纳米尺寸的丝状碳基材料如碳纳米管对基材的附着力。发现至少一种碳化物形成材料的存在可以改善纳米尺寸丝状碳基材料与基材的粘附性。因此，另一方面，提供了一种将纳米级丝状碳基材料牢固地附着到基底上的方法，其中在基底上形成层，所述层包含至少一种碳化物形成材料和至少一种催化活性材料并且纳米尺寸丝状碳基材料在催化活性材料上生长。

6. 发明申请

WO2008062372A3 DEVICE FOR SEPARATION AND MALDI ANALYSIS OF AN ANALYTE IN A SAMPLE 审中-公开
标题翻译：分析仪器和样品中分析仪的MALDI分析
公开(公告)号：WO2008062372A3
公开(公告)日：2008-12-24
申请号：PCT/IB2007054736
申请日：2007-11-21
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , RIBBING CAROLINA , OEHMAN OVE
发明人： RIBBING CAROLINA , OEHMAN OVE
IPC分类号： H01J49/16
CPC分类号： H01J49/0418
摘要： The present invention relates to a device for separating at least one analyte in a liquid sample and further analyzing said analyte by laser desorption/ionization (LDI) mass spectrometry. The invention is further concerned with the use of devices for separating at least one analyte in a liquid sample and subsequent determination of the presence and/or amount of said at least one analyte by LDI mass spectrometry. The invention is also concerned with a method for separating at least one analyte in a liquid sample and subsequent determination of the presence and/or amount of said at least one analyte by LDI mass spectrometry.
摘要翻译：本发明涉及用于分离液体样品中的至少一种分析物并通过激光解吸/电离（LDI）质谱进一步分析所述分析物的装置。本发明还涉及用于分离液体样品中的至少一种分析物的装置的使用，并且随后通过LDI质谱法确定所述至少一种分析物的存在和/或量。本发明还涉及用于分离液体样品中的至少一种分析物并随后通过LDI质谱法测定所述至少一种分析物的存在和/或量的方法。

7. 发明申请

WO2007088492A2 IMPROVED RADIATION THERAPY PLANNING PROCEDURE 审中-公开
标题翻译：改进的辐射治疗方案
公开(公告)号：WO2007088492A2
公开(公告)日：2007-08-09
申请号：PCT/IB2007050204
申请日：2007-01-22
申请人： PHILIPS INTELLECTUAL PROPERTY , KONINKL PHILIPS ELECTRONICS NV , SPIES LOTHAR , HUMMEL HELGA , RIBBING CAROLINA , HOFFMANN RALF , BACHMANN PETER KLAUS
发明人： SPIES LOTHAR , HUMMEL HELGA , RIBBING CAROLINA , HOFFMANN RALF , BACHMANN PETER KLAUS
IPC分类号： A61N5/10
CPC分类号： A61N5/1031
摘要： An improved radiation therapy planning procedure is suggested. The procedure comprises the steps of specifying and determining the absolute grade of cell degeneracy by in- vitro tests, whereby marker(s) indicative for specific cell degeneracy are detected and quantified, establishing a biology-based segmentation of areas with similar grade of relative cell degeneracy and applying the absolute grade of cell degeneracy to the biology-based segmentation data, thereby establishing an improved radiation therapy planning procedure. Moreover, the present invention suggests a system for an improved radiation therapy planning procedure and its use in procedures of diagnosis and/or therapy management of cancer.
摘要翻译：建议采用改进的放射治疗计划程序。该方法包括以下步骤：通过体外测试来指定和确定细胞退化的绝对等级，由此检测和量化指示特异性细胞退化的标志物，建立具有相似等级相对细胞的区域的基于生物学的分割退化并将绝对等级的细胞退化应用于基于生物学的分割数据，从而建立改进的放射治疗计划程序。此外，本发明提出了一种改进的放射治疗计划程序及其在癌症诊断和/或治疗管理程序中的应用的系统。

8. 发明申请

WO2007149751A3 MULTI-SOURCE ENCODED X-RAY IMAGING 审中-公开
标题翻译：多源编码X射线成像
公开(公告)号：WO2007149751A3
公开(公告)日：2008-02-21
申请号：PCT/US2007071101
申请日：2007-06-13
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS CORP , RIBBING CAROLINA , VOGTMEIER GEREON , PROKSA ROLAND
发明人： RIBBING CAROLINA , VOGTMEIER GEREON , PROKSA ROLAND
IPC分类号： A61B6/03
CPC分类号： A61B6/5282 , A61B6/032 , A61B6/4014 , A61B6/483 , A61B6/508 , G01T1/2985
摘要： A tomographic apparatus (10) includes at least two x-ray sources (16) that are concurrently driven with different switching patterns to generate uniquely encoded radiation. The tomographic apparatus (10) further includes at least two detectors (20) that each detect primary radiation emitted by its corresponding one of the at least two x-ray sources (16) and cross scatter radiation from at least one of the other at least two x-ray sources (16). Each of the at least two detectors (20) produces an aggregate signal representative of the detected primary and cross scatter radiation. The tomographic apparatus (10) further includes a decoupler (30) which, based on the different switching patterns, identifies at least one signal corresponding to at least one of the at least two x-ray sources (16) within the aggregate signal and associates the identified signal with its corresponding x-ray source (16).
摘要翻译：断层摄影装置（10）包括至少两个x射线源（16），它们以不同的切换模式同时驱动以产生唯一编码的辐射。断层摄影装置（10）还包括至少两个检测器（20），每个检测器（20）检测由其至少两个X射线源（16）中的相应一个发射的主要辐射，并且至少另外至少另外两个X射线源两个x射线源（16）。所述至少两个检测器（20）中的每个检测器（20）产生代表检测到的主要和交叉散射辐射的聚集信号。断层摄影装置（10）还包括解耦器（30），其基于不同的切换模式，识别对应于聚合信号内的至少两个x射线源（16）中的至少一个的至少一个信号和关联所识别的信号与其相应的X射线源（16）。

9. 发明申请

WO2013001507A3 TREATMENT PLANNING BASED ON POLYPEPTIDE RADIOTOXICITY SERUM MARKERS 审中-公开
标题翻译：基于多肽放射性毒性标记的治疗计划
公开(公告)号：WO2013001507A3
公开(公告)日：2013-05-10
申请号：PCT/IB2012053323
申请日：2012-06-29
申请人： KONINKL PHILIPS ELECTRONICS NV , BITTER KATRIN , RIBBING CAROLINA
发明人： BITTER KATRIN , RIBBING CAROLINA
IPC分类号： A61N5/10 , G01N33/574 , G01N33/68
CPC分类号： A61N5/1038 , A61N5/1039 , G01N33/57434 , G01N33/6851 , G01N2800/50 , G01N2800/52 , G01N2800/60 , G06F19/18 , G06F19/3481
摘要： A method includes at least one of creating or adapting a treatment plan for a patient based on a set of serum polypeptides of the patient that are indicative of a radiotoxicity of the patient at least one of before or after at least one of a plurality of radiotherapy treatments of the treatment plan, wherein the radiotoxicity is induced by radiation exposure from the radiotherapy treatment. A system includes a treatment planning device (108) that facilitates at least one of creating or adapting a treatment plan for a patient based on amounts or concentrations of a set of serum polypeptides of the patient that indicate a high risk of or an early radiotoxicity of the patient to radiation from radiotherapy.
摘要翻译：一种方法包括以下步骤中的至少一种：基于一组患者的血清多肽来形成或适应患者的治疗计划，所述血清多肽指示患者的放射毒性，在多个放射治疗中的至少一个之前或之后的至少之一治疗计划的治疗，其中通过放射治疗的放射线暴露诱导放射毒性。一种系统包括治疗计划装置（108），该治疗计划装置（108）有助于基于患者的一组血清多肽的量或浓度来创建或调整患者的治疗计划中的至少一个，其指示患者的血清多肽的高风险或早期放射毒性患者放射线放射治疗。

10. 发明申请

WO2007066243A2 SYSTEMS AND METHODS FOR SCANNING AND DATA ACQUISITION IN COMPUTED TOMOGRAPHY (CT) APPLICATIONS 审中-公开
标题翻译：计算机断层扫描（CT）应用中扫描和数据采集的系统和方法
公开(公告)号：WO2007066243A2
公开(公告)日：2007-06-14
申请号：PCT/IB2006053331
申请日：2006-09-16
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS CORP , LEWALTER ASTRID , PIETIG RAINER , ZEITLER GUENTER , ECK KAI , HERRMANN CHRISTOPH , KIEWITT RAINER , LOEF CHRISTOPH , MUELHENS OLIVER , RIBBING CAROLINA , MATTHIAS SIMON , WISCHHUSEN OLAF , ROSE GEORG
发明人： LEWALTER ASTRID , PIETIG RAINER , ZEITLER GUENTER , ECK KAI , HERRMANN CHRISTOPH , KIEWITT RAINER , LOEF CHRISTOPH , MUELHENS OLIVER , RIBBING CAROLINA , MATTHIAS SIMON , WISCHHUSEN OLAF , ROSE GEORG
IPC分类号： A61B6/03 , H01J35/24
CPC分类号： A61B6/032 , A61B6/027 , A61B6/4021 , A61B6/503 , A61B6/504 , H01J2235/086 , H05G1/52
摘要： Systems and methods for data acquisition in computed tomography (CT) applications are provided. The systems and methods are particularly adapted for scanning and acquiring/processing data in connection with high-power cone-beam CT applications. The electron beam is moved/scanned along the anode surface to multiple focal positions. Data acquisition for a full projection at one focus position and one view angle is achieved by activating each focus position multiple times during the data acquisition for one angle of the gantry. The detector array and associated data processing system are adapted to rapidly switch between the different focus positions during the acquisitions for one view angle and to collect all data belonging to the same projection into the same data set. Adaptive electron optics are utilized to move/scan the electron beam along the anode surface to the various focus positions. Alternatively, a plurality of cathodes may be provided for respective focus positions and the system may support fast switching therebetween to achieve desirably short spot times. The disclosed CT system permits greater power densities without risk of heat damage to the anode and effectively increases the track velocity of the electron beam on the anode surface. The CT system and associated data acquisition methods have particular utility in CT applications requiring increased time resolution and/or spatial resolution, e.g., cardiac CT applications.
摘要翻译：提供了计算机断层摄影（CT）应用中数据采集的系统和方法。该系统和方法特别适用于扫描和获取/处理与大功率锥束CT应用有关的数据。电子束沿着阳极表面移动/扫描到多个焦点位置。通过在台架的一个角度的数据采集过程中激活每个聚焦位置多次来实现在一个聚焦位置和一个视角处的全投影的数据采集。检测器阵列和相关联的数据处理系统适于在一次视角的采集期间在不同焦点位置之间快速切换，并将属于相同投影的所有数据收集到同一数据集中。使用自适应电子光学器件将电子束沿着阳极表面移动/扫描到各种焦点位置。或者，可以为各个焦点位置设置多个阴极，并且系统可以支持它们之间的快速切换，以实现期望的短光斑时间。所公开的CT系统允许更大的功率密度，而不会对阳极造成热损害的风险，并且有效地增加阳极表面上的电子束的轨道速度。 CT系统和相关数据采集方法在需要增加时间分辨率和/或空间分辨率（例如心脏CT应用）的CT应用中具有特别的用途。

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