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1. 发明申请

WO2006061771A3 PATIENT IDENTIFICATION FOR POINT OF CARE DIAGNOSTICS 审中-公开
标题翻译：患者心脏诊断点患者识别
公开(公告)号：WO2006061771A3
公开(公告)日：2006-09-08
申请号：PCT/IB2005054057
申请日：2005-12-05
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS CORP , WENDT MATTHIAS , BOOS ANDREAS , SPEKOWIUS GERHARD , BACHMANN PETER K , NIKOL HANS , HUMMEL HELGA
发明人： WENDT MATTHIAS , BOOS ANDREAS , SPEKOWIUS GERHARD , BACHMANN PETER K , NIKOL HANS , HUMMEL HELGA
IPC分类号： A61B5/117 , A61B5/00 , A61B5/15 , A61B10/00 , G06F19/00 , G06F21/00
CPC分类号： G06F21/32 , A61B5/0002 , A61B5/117 , A61B5/1172 , A61B5/150022 , A61B5/150389 , A61B5/150503 , A61B5/150786 , A61B5/15105 , A61B5/15186 , A61B10/0045 , A61B10/007 , A61B90/90 , G16H10/20
摘要： A patient presses a finger concurrently against a needle (14) of a collection container (12) and a fingerprint surface (22, 52). In one embodiment, the patient's fingerprint is read electronically by a scanner (24) and correlated with a container serial number (16). In another embodiment, the patient's fingerprint is embossed in a foil layer (52). An analyzer assembly (40, 40' 40") analyzes the biological sample and reads either the container serial number or scans the fingerprint carrying layer (52) and sends the test results and either the fingerprint or container identification to a patient memory (30). Using the fingerprint information, a processor (32) correlates the test results with a record (60) of a corresponding patient. Alternately or additionally, the analyzer assembly includes a DNA analyzer (70) which measures preselected DNA characteristics (76) of the sample. The processor (32) compares the measured DNA subset characteristics with DNA subset characteristics (66) in the patient records to correlate or confirm the correlation of the analysis results with the proper patient.
摘要翻译：患者将手指同时按压在收集容器（12）的针头（14）和指纹表面（22,52）上。在一个实施例中，患者的指纹由扫描仪（24）电子读取并与容器序列号（16）相关联。在另一个实施例中，患者的指纹被压印在箔层（52）中。分析器组件（40,40'40“）分析生物样品并读取容器序列号或扫描指纹携带层（52），并将测试结果和指纹或容器标识发送到患者存储器（30）使用指纹信息，处理器（32）将测试结果与相应患者的记录（60）相关联，或者或另外，分析器组件包括测量预选的DNA特征（76）的DNA分析器（70）处理器（32）将测量的DNA子集特征与患者记录中的DNA亚类特征（66）进行比较，以将分析结果与适当患者的相关性相关联或确认。

2. 发明申请

WO2007072290A2 METHOD OF PERFORMING A MICROARRAY ASSAY 审中-公开
标题翻译：执行微观测定的方法
公开(公告)号：WO2007072290A2
公开(公告)日：2007-06-28
申请号：PCT/IB2006054737
申请日：2006-12-11
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , BACHER JOHANNES , BOOS ANDREAS , LUEDKE GERD
发明人： BACHER JOHANNES , BOOS ANDREAS , LUEDKE GERD
IPC分类号： C12Q1/68
CPC分类号： G01N33/54386 , C12Q1/6837 , G01N33/544 , C12Q2565/102 , C12Q2537/143
摘要： Disclosed is a method for performing a microarray assay on one or more sample fluid(s), sais fluids comprising target biological compounds. The method comprises the step of tagging said target biological compounds with labels. The following step comprises contacting said sample fluid(s) with a substrate and detecting the presence of said labels at the surface of said substrate. The method is suitable for the simultaneous analysis, in one microarray, of one or more types of target biological compounds, in one or more sample fluid(s). To this end each of said types of biological compounds is tagged with a different label so that target biological compounds belonging to different sample fluids have different labels. Said different labels are discriminable upon detection at the surface of said substrate. Also disclosed is the use of a polymer substrate in a method for performing a microarray assay.
摘要翻译：公开了一种对一种或多种样品流体进行微阵列测定的方法，其包含靶生物化合物。该方法包括用标记标记所述靶生物化合物的步骤。接下来的步骤包括使所述样品流体与基底接触，并在所述基底的表面检测所述标记物的存在。该方法适用于在一个或多个样品流体中在一个微阵列中同时分析一种或多种类型的靶生物化合物。为此，每种所述类型的生物化合物被标记有不同的标记，使得属于不同样品流体的目标生物化合物具有不同的标记。所述不同标签在所述基板的表面检测时是可辨别的。还公开了在进行微阵列测定的方法中使用聚合物底物。

3. 发明申请

WO2007129256A3 INTEGRATED TEMPERATURE SENSOR 审中-公开
标题翻译：集成温度传感器
公开(公告)号：WO2007129256A3
公开(公告)日：2008-01-24
申请号：PCT/IB2007051610
申请日：2007-05-01
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , DEN TOONDER JACOB M J , BOOS ANDREAS
发明人： DEN TOONDER JACOB M J , BOOS ANDREAS
IPC分类号： G01K5/48
CPC分类号： G01K5/486
摘要： A biochip has an integrated temperature sensor comprising a micro mechanical actuator (20) having a deformation dependent on temperature, and a detector (30) arranged to output a signal according to a deformation of the actuator. The actuator can be formed of LC material in an elastomeric network. The detector (30) can be optical, magnetic or capacitive. The actuator can be arranged as a layer and the deformation be a curling of the layer.
摘要翻译：生物芯片具有集成的温度传感器，其包括具有取决于温度的变形的微机械致动器（20），以及检测器（30），其布置成根据致动器的变形输出信号。致动器可以由弹性体网络中的LC材料形成。检测器（30）可以是光学的，磁性的或电容的。致动器可以被布置为层，并且变形是层的卷曲。

4. 发明申请

WO2006136990A3 CARTRIDGE, SYSTEM AND METHOD FOR AUTOMATED MEDICAL DIAGNOSTICS 审中-公开
标题翻译： CARTRIDGE，系统和自动化诊断方法
公开(公告)号：WO2006136990A3
公开(公告)日：2007-03-08
申请号：PCT/IB2006051941
申请日：2006-06-16
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN HAAG CHRIS , JONGERIUS MICHIEL J , SCHAEFER DANNY G A , VAN DEN BIJGAART ADRIANUS W D , DE GIER RONALD C , DE JONG MICHIEL , PROSS GERHARD , BACHER JOHANNES , BOOS ANDREAS , LUEDKE GERD , SEHER JENS-PETER
发明人： VAN HAAG CHRIS , JONGERIUS MICHIEL J , SCHAEFER DANNY G A , VAN DEN BIJGAART ADRIANUS W D , DE GIER RONALD C , DE JONG MICHIEL , PROSS GERHARD , BACHER JOHANNES , BOOS ANDREAS , LUEDKE GERD , SEHER JENS-PETER
IPC分类号： B01L3/00 , G01N1/28 , G01N21/76 , G01N33/487 , G01N35/00
CPC分类号： B01L7/52 , B01L3/502715 , B01L3/502738 , B01L3/545 , B01L2200/027 , B01L2200/028 , B01L2200/10 , B01L2300/02 , B01L2300/087 , B01L2300/1805 , G01N21/6428 , G01N35/00069 , G01N2035/00158
摘要： Disclosed is a cartridge for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a generic part and one or more separate application-specific parts, which are connectable to the generic part. Also disclosed is a system for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. This system comprising a reusable apparatus, wherein said apparatus is configured to receive a cartridge and to control a process for the detection of the presence, absence and/or amount of a target nucleotide sequence in the sample, being present in said cartridge.
摘要翻译：公开了用于检测包含一个或多个核酸序列的样品中靶核苷酸序列的存在，不存在和/或量的盒。墨盒包括通用部件和可以连接到通用部件的一个或多个单独的应用特定部件。还公开了用于检测包含一个或多个核酸序列的样品中靶核苷酸序列的存在，不存在和/或数量的系统。该系统包括可重复使用的装置，其中所述装置被配置为接收盒并且控制用于检测存在于所述盒中的样品中目标核苷酸序列的存在，不存在和/或量的过程。

5. 发明申请

WO2007072373A3 A SENSOR FOR BIOMOLECULES AND A METHOD OF ANALYSIS USING SAID SENSOR 审中-公开
标题翻译：生物分子传感器及其应用分析方法
公开(公告)号：WO2007072373A3
公开(公告)日：2007-10-18
申请号：PCT/IB2006054883
申请日：2006-12-15
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , BACHER JOHANNES , BOOS ANDREAS , LUEDKE GERD
发明人： BACHER JOHANNES , BOOS ANDREAS , LUEDKE GERD
IPC分类号： B01L3/00 , G01N33/53
CPC分类号： B01L3/502 , B01L2300/0636 , B01L2300/0681
摘要： Disclosed is a method of preparing a sensor for the analysis of a sample fluid, said sample fluid containing one or more target molecules. The method comprises the step of introducing said sample fluid into a chamber equipped with a porous substrate, one or more probe molecules being applied to said porous substrate and said probes being able to specifically bind to said one or more target molecules. The method further comprises the step of moving said substrate and said chamber relatively to each other in order to force said sample fluid through the pores of said porous substrate and to capture the one or more target molecules with the one or more probe molecules. Also disclosed is a sensor for the analysis of a sample fluid.
摘要翻译：公开了一种制备用于分析样品流体的传感器的方法，所述样品流体包含一种或多种目标分子。该方法包括将所述样品流体引入配备有多孔基底的室中的步骤，将一种或多种探针分子施加到所述多孔基底上，并且所述探针能够特异性结合所述一种或多种目标分子。该方法还包括将所述基底和所述腔室相对于彼此移动的步骤，以迫使所述样品流体通过所述多孔基底的孔并用一个或多个探针分子捕获一个或多个目标分子。还公开了一种用于分析样品流体的传感器。

6. 发明申请

WO2007072311A2 A SENSOR FOR BIOMOLECULES AND A METHOD FOR PREPARING AND USING THE SAME 审中-公开
标题翻译：生物分子传感器及其制备和使用方法
公开(公告)号：WO2007072311A2
公开(公告)日：2007-06-28
申请号：PCT/IB2006054792
申请日：2006-12-13
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS INTELLECTUAL PROPERTY , BACHER JOHANNES , BOOS ANDREAS , LUEDKE GERD
发明人： BACHER JOHANNES , BOOS ANDREAS , LUEDKE GERD
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： G01N33/54366
摘要： Disclosed is a method of preparing a sensor for the analysis of a sample fluid, said sample fluid containing one or more target molecules. The method comprises the steps of applying a non-activated porous organic polymer membrane with probes in the form of an array of probe locations, said probes being able to specifically bind to said one or more target molecules. Furthermore, the method comprises the steps of blocking areas remaining free of probes of said porous organic polymer membrane with one or more blocking substances and forcing the sample fluid repeatedly in one or two directions through the pores of said porous organic polymer membrane. Also disclosed is a sensor for the analysis of a sample fluid.
摘要翻译：公开了一种制备用于分析样品流体的传感器的方法，所述样品流体包含一种或多种靶分子。该方法包括以探针位置阵列的形式施加非活化多孔有机聚合物膜的步骤，所述探针能够特异性地结合所述一个或多个靶分子。此外，该方法包括以下步骤：用一种或多种封闭物质阻挡剩余的不含所述多孔有机聚合物膜的探针的区域，并通过所述多孔有机聚合物膜的孔在一个或两个方向上反复强制样品流体。还公开了用于分析样品流体的传感器。

7. 发明专利

DE60224846T2 未知
公开(公告)号：DE60224846T2
公开(公告)日：2009-01-22
申请号：DE60224846
申请日：2002-07-10
申请人： KONINKL PHILIPS ELECTRONICS NV
发明人： BOOS ANDREAS , BACHER JOHANNES , PROSS GERHARD , SEHER JENS-PETER
IPC分类号： A61B5/15 , G01N33/48 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/1468 , A61B5/157
摘要： The present invention relates to a system for point of care diagnosis and/or analysis of body fluids of a patient, comprising: a cartridge (2), a diagnosis and/or analysis apparatus (3), means (6) for measurement of the concentration of at least one specific component of a sample of the body fluids, connecting means (8, 13) providing communication for electrical and/or optical values between the cartridge (2) and the diagnosis and/or analysis apparatus (3), wherein said values correlate with at least one of the respective concentrations, diagnosing and/or analysing means (14) measuring the respective concentration value via the connecting means (8, 13), storage means (10) for storing cartridge specific data and/or information, reading means (15) for reading the data and/or information out of the storage means (10), wherein the diagnosing and/or analysing means (14) evaluate the respective concentration values in accordance to the cartridge specific data and/or information.

8. 发明专利

DE60224846D1 未知
公开(公告)号：DE60224846D1
公开(公告)日：2008-03-13
申请号：DE60224846
申请日：2002-07-10
申请人： KONINKL PHILIPS ELECTRONICS NV
发明人： BOOS ANDREAS , BACHER JOHANNES , PROSS GERHARD , SEHER JENS-PETER
IPC分类号： A61B5/15 , G01N33/48 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/1468 , A61B5/157
摘要： The present invention relates to a system for point of care diagnosis and/or analysis of body fluids of a patient, comprising: a cartridge (2), a diagnosis and/or analysis apparatus (3), means (6) for measurement of the concentration of at least one specific component of a sample of the body fluids, connecting means (8, 13) providing communication for electrical and/or optical values between the cartridge (2) and the diagnosis and/or analysis apparatus (3), wherein said values correlate with at least one of the respective concentrations, diagnosing and/or analysing means (14) measuring the respective concentration value via the connecting means (8, 13), storage means (10) for storing cartridge specific data and/or information, reading means (15) for reading the data and/or information out of the storage means (10), wherein the diagnosing and/or analysing means (14) evaluate the respective concentration values in accordance to the cartridge specific data and/or information.

9. 发明专利

BRPI0711286A2 未知
公开(公告)号：BRPI0711286A2
公开(公告)日：2011-10-04
申请号：BRPI0711286
申请日：2007-05-01
申请人： KONINKL PHILIPS ELECTRONICS NV
发明人： DEN TOONDER JACOB M J , BOOS ANDREAS
IPC分类号： G01K5/48
摘要： A biochip has an integrated temperature sensor comprising a micro mechanical actuator (20) having a deformation dependent on temperature, and a detector (30) arranged to output a signal according to a deformation of the actuator. The actuator (comprising a thermally actuable polymer) can be formed of LC Liquid Crystal material in an elastomeric network. The detector (30) can be optical, magnetic or capacitive. The actuator can be arranged as a layer and the deformation be a curling of the layer.

10. 发明专利

AT384476T 未知
公开(公告)号：AT384476T
公开(公告)日：2008-02-15
申请号：AT02755408
申请日：2002-07-10
申请人： KONINKL PHILIPS ELECTRONICS NV
发明人： BOOS ANDREAS , BACHER JOHANNES , PROSS GERHARD , SEHER JENS-PETER
IPC分类号： A61B5/15 , G01N33/48 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/1468 , A61B5/157
摘要： The present invention relates to a system for point of care diagnosis and/or analysis of body fluids of a patient, comprising: a cartridge (2), a diagnosis and/or analysis apparatus (3), means (6) for measurement of the concentration of at least one specific component of a sample of the body fluids, connecting means (8, 13) providing communication for electrical and/or optical values between the cartridge (2) and the diagnosis and/or analysis apparatus (3), wherein said values correlate with at least one of the respective concentrations, diagnosing and/or analysing means (14) measuring the respective concentration value via the connecting means (8, 13), storage means (10) for storing cartridge specific data and/or information, reading means (15) for reading the data and/or information out of the storage means (10), wherein the diagnosing and/or analysing means (14) evaluate the respective concentration values in accordance to the cartridge specific data and/or information.

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