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1. 发明申请

WO2008114199A3 AN ACTUATOR DEVICE AND A METHOD OF MANUFACTURING THE SAME 审中-公开
标题翻译：一种致动器装置及其制造方法
公开(公告)号：WO2008114199A3
公开(公告)日：2008-12-31
申请号：PCT/IB2008050992
申请日：2008-03-17
申请人： KONINKL PHILIPS ELECTRONICS NV , GILLIES MURRAY F , PONJEE MARC W G , CATTANEO STEFANO , JOHNSON MARK T , DEN TOONDER JACOB M J , DE GOEDE JUDITH M , BROER DIRK J , WILDERBEEK JOHANNES T A , MOL GRIETJE N , TALEN WIM
发明人： GILLIES MURRAY F , PONJEE MARC W G , CATTANEO STEFANO , JOHNSON MARK T , DEN TOONDER JACOB M J , DE GOEDE JUDITH M , BROER DIRK J , WILDERBEEK JOHANNES T A , MOL GRIETJE N , TALEN WIM
IPC分类号： B81B3/00
CPC分类号： B81B3/0021 , B81B2201/038 , B81B2201/058 , H02N1/004
摘要： An actuator device (100) comprising a substrate (102), an electrode structure (105) provided in and/or on the substrate (102), and an actuator unit (107) being movable relative to the substrate (102) upon application of an electrical signal to the electrode structure (105), wherein the actuator unit (107) is made of a dielectric material.
摘要翻译：一种致动器装置（100），包括衬底（102），设置在衬底（102）中和/或衬底上的电极结构（105），以及致动器单元（107），在施加向电极结构（105）提供电信号，其中致动器单元（107）由电介质材料制成。

2. 发明申请

WO2008035295A3 A MICRO-ACTUATOR DEVICE FOR THE USE IN A BIOCHIP OR BIOSYSTEM 审中-公开
标题翻译：用于生物化学或生物体系的微型致动器装置
公开(公告)号：WO2008035295A3
公开(公告)日：2009-02-05
申请号：PCT/IB2007053796
申请日：2007-09-19
申请人： KONINKL PHILIPS ELECTRONICS NV , GILLIES MURRAY F , DEN TOONDER JACOB M J , JOHNSON MARK T , PONJEE MARC W G
发明人： GILLIES MURRAY F , DEN TOONDER JACOB M J , JOHNSON MARK T , PONJEE MARC W G
IPC分类号： B81B3/00
CPC分类号： B81B3/0029 , B81B2201/036
摘要： The Invention concerns to a micro-actuator device for the use in biochip or bio-system. In order to achieve a micro-actuator device for the use as a micro pump in biosensors or bio-systems, or at least bio-chips, by which the actuation can be steered very precisely and effective, the solution is that the micro actuator consist of a photosensitive actuator element (1), which can be deformed from a reversal basic-form into an activated deformation form by photonic activation of a light source (3, 4, L1, L2) in order to generate with this controlled movement a defined flow in a gas or a liquid.
摘要翻译：本发明涉及用于生物芯片或生物系统的微致动器装置。为了实现微致动器装置，用作生物传感器或生物系统中的微泵，或至少可以非常精确和有效地转动致动的生物芯片，解决方案是微型致动器包括感光致动器元件（1），其可以通过光源（3,4，L1，L2）的光子激活而从反转基本形式变形为激活的变形形式，以便以该受控运动产生定义的在气体或液体中流动。

3. 发明申请

WO2008035293A3 A MICRO-FLUIDIC DEVICE FOR THE USE IN BIOCHIPS OR BIOSYSTEMS 审中-公开
标题翻译：用于生物化学或生物制品的微流体装置
公开(公告)号：WO2008035293A3
公开(公告)日：2011-07-14
申请号：PCT/IB2007053792
申请日：2007-09-19
申请人： KONINKL PHILIPS ELECTRONICS NV , PONJEE MARC W G , DEN TOONDER JACOB M J , GILLIES MURRAY F , JOHNSON MARK T
发明人： PONJEE MARC W G , DEN TOONDER JACOB M J , GILLIES MURRAY F , JOHNSON MARK T
IPC分类号： B01L3/00 , F04D33/00
CPC分类号： F04D33/00 , B01L3/50273 , B01L2300/0819 , B01L2300/1822 , B01L2400/0484 , Y10T29/494
摘要： The Invention concerns to a micro-fluidic device for the use in biochip or bio- system, wherein an 2 dimensional matrix array of temperature sensitive po Iy-MEM actuators (1) is arranged in a 2 dimensional thermal processing array, in which each single temperature control element (6) or thermal element can be steered independently from each other, in order to be able to activate each single poly-MEM actuator (1).
摘要翻译：本发明涉及用于生物芯片或生物系统的微流体装置，其中将温度敏感的pIy-MEM致动器（1）的二维矩阵阵列布置在二维热处理阵列中，其中每个单个温度控制元件（6）或热元件可以彼此独立地转向，以便能够激活每个单个多MEM执行元件（1）。

4. 发明申请

WO2008125927A3 MICROFLUIDIC SYSTEM WITH ACTUATORS 审中-公开
标题翻译：具有执行器的微流控系统
公开(公告)号：WO2008125927A3
公开(公告)日：2009-01-29
申请号：PCT/IB2007055104
申请日：2007-12-14
申请人： KONINKL PHILIPS ELECTRONICS NV , GILLIES MURRAY F , DEN TOONDER JACOB M J , PONJEE MARC W G , JOHNSON MARK T
发明人： GILLIES MURRAY F , DEN TOONDER JACOB M J , PONJEE MARC W G , JOHNSON MARK T
IPC分类号： F04B19/00 , B01L3/00
CPC分类号： B01F13/0059 , B01F13/0091 , B01L3/50273 , B01L3/502792 , B01L7/52 , B01L7/54 , B01L2300/0819 , B01L2300/089 , B01L2300/1822 , B01L2300/1827 , B01L2300/1872 , B01L2400/0484 , B01L2400/0633 , B01L2400/0688 , F04B19/006 , F04B19/24 , F04D33/00
摘要： The invention relates to microfluidic system (100), particularly a biosensor, for manipulating a sample in a sample chamber (1). The device comprises at least one actuator (10) that reversibly changes its spatial configuration if it is heated and/or cooled. The actuator (10) may particularly be arranged adjacent to an associated heating element (20) of a 5 heating array that is used to establish a predetermined spatial and/or temporal temperature profile in the sample chamber (1). The configuration change of the actuator (10) can be used to move the sample fluid or to control its passage through fluid channels. A plurality of actuators (10) may optionally be provided that undergo their configuration changes at different temperatures, particularly temperatures within a range that is passed during a 10 reaction like PCR.
摘要翻译：本发明涉及用于操纵样品室（1）中的样品的微流体系统（100），特别是生物传感器。该装置包括至少一个致动器（10），其如果被加热和/或冷却则可逆地改变其空间构造。致动器（10）可以特别地布置成与用于在样品室（1）中建立预定空间和/或时间温度分布的5个加热阵列的相关联的加热元件（20）相邻。致动器（10）的配置变化可用于移动样品流体或控制其通过流体通道。可以任选地提供多个致动器（10），其在不同温度，特别是在10反应期间通过的范围内的温度（如PCR）中进行其配置变化。

5. 发明申请

WO2008020374A3 AN ELECTRIC BASED MICRO-FLUIDIC DEVICE USING ACTIVE MATRIX PRINCIPLE 审中-公开
标题翻译：基于有源矩阵原理的电动微流体装置
公开(公告)号：WO2008020374A3
公开(公告)日：2008-04-24
申请号：PCT/IB2007053176
申请日：2007-08-10
申请人： KONINKL PHILIPS ELECTRONICS NV , JOHNSON MARK T , DEN TOONDER JACOB M J , GILLIES MURRAY F , FRENCH IAN , PONJEE MARC W G
发明人： JOHNSON MARK T , DEN TOONDER JACOB M J , GILLIES MURRAY F , FRENCH IAN , PONJEE MARC W G
IPC分类号： F04B19/00 , F04D33/00
CPC分类号： F04D33/00 , B01F13/0059 , B01F13/0091 , F04B19/006
摘要： The invention relates to an electric based micro-fluidic device using active matrix principle, for the use in medical and health and wellness products, in particular biochips or bio-systems. An electric based micro-fluidic device using active matrix principle, for the use in medical and health and wellness products, in particular biochips or bio-systems, wherein an 2-dimensional matrix array of poly MEMS actuators (PMA) (1) is arranged in a 2-dimenional system in which each single actuator is electrically/electronically steered independently from each other, in order to be able to generate a pattern of activation in the matrix.
摘要翻译：本发明涉及使用有源矩阵原理的电基微流体装置，用于医疗和健康以及健康产品，特别是生物芯片或生物系统。一种使用有源矩阵原理的基于电的微流体装置，用于医疗和健康以及健康产品，特别是生物芯片或生物系统，其中多MEMS致动器（PMA）（1）的二维矩阵阵列被布置在其中每个单个致动器彼此独立地电/电控制的二维系统中，以便能够在矩阵中产生激活模式。

6. 发明申请

WO2008120135A2 A MICRO-FLUIDIC DEVICE BASED UPON ACTIVE MATRIX PRINCIPLES 审中-公开
标题翻译：基于有源矩阵原理的微流体设备
公开(公告)号：WO2008120135A2
公开(公告)日：2008-10-09
申请号：PCT/IB2008051102
申请日：2008-03-25
申请人： KONINKL PHILIPS ELECTRONICS NV , GILLIES MURRAY F , PONJEE MARC W G , JOHNSON MARK T
发明人： GILLIES MURRAY F , PONJEE MARC W G , JOHNSON MARK T
IPC分类号： B01L3/00 , G01F1/684 , G01F1/696 , G01F1/708 , G01P5/10 , G01P5/18
CPC分类号： B01L3/502715 , B01L3/502792 , B01L7/52 , B01L7/525 , B01L2200/0673 , B01L2200/143 , B01L2200/147 , B01L2300/0819 , B01L2300/1827 , G01F1/6845 , G01F1/696 , G01F1/708 , G01P5/10 , G01P5/12 , G01P5/18
摘要： A micro-fluidic device (1) including a two-dimensional array of a plurality of components (2) for processing a fluid and/or for sensing properties of the fluid is suggested. Each component (2) is coupled to at least one control terminal (9,10) enabling an active matrix to change the state of each component individually. The components comprise at least one heater element (13). The active matrix includes a two-dimensional array of electronic components (12) realized in thin film technology. The active matrix provides a high versatility of the device. The thin film technology ensures a very cost efficient manufacturing also of large devices. In the micro-fluidic device the fluid flow can be detected.
摘要翻译：提出了包括用于处理流体和/或感测流体性质的多个组件（2）的二维阵列的微流体装置（1）。每个组件（2）耦合到至少一个控制终端（9,10），使得有源矩阵能够单独改变每个组件的状态。这些部件包括至少一个加热元件（13）。有源矩阵包括以薄膜技术实现的电子元件（12）的二维阵列。有源矩阵提供了高通用性的器件。薄膜技术确保了大型设备的高性价比制造。在微流体装置中，可以检测流体流动。

7. 发明申请

WO2009053870A3 DEVICE AND METHOD FOR THE MONITORING OF THE MOVEMENT OF CELLS 审中-公开
标题翻译：用于监测细胞运动的装置和方法
公开(公告)号：WO2009053870A3
公开(公告)日：2009-06-11
申请号：PCT/IB2008054195
申请日：2008-10-13
申请人： KONINKL PHILIPS ELECTRONICS NV , CATTANEO STEFANO , GILLIES MURRAY F , VULTO SIMONE I E , DE HOOG THOMAS J , MERKLE DENNIS , JOHNSON MARK T
发明人： CATTANEO STEFANO , GILLIES MURRAY F , VULTO SIMONE I E , DE HOOG THOMAS J , MERKLE DENNIS , JOHNSON MARK T
IPC分类号： C12M1/34 , G01N15/10 , G01N33/487 , G01N33/50
CPC分类号： B03C5/028 , G01N15/1031
摘要： The present invention relates to a device for the monitoring of very small movements of cells, in particular when undergoing chemotaxis. The invention makes use of various ways of electrical detection, like capacitance or impedance measurements. In this way the detection of the movement of cells can be done in situ, which accelerates the chemotaxis assay and increases the accuracy of the measurements. The device according to the present invention particularly comprises a stimulant gradient chamber (1) for providing a concentration gradient of a stimulant, said stimulant gradient chamber (1) having a cell inlet (12) for the inlet of cells (C), - an electrical sensor (2) placed in a measurement area for measuring an electrical parameter which changes in response to a movement of cells (C) in the surrounding of said sensor (2) and for generating a detection signal, and a signal evaluation unit (3) for evaluating said detection signal.
摘要翻译：本发明涉及用于监测细胞的非常小的运动的装置，特别是当经历趋化性时。本发明利用电检测的各种方式，如电容或阻抗测量。通过这种方式，细胞运动的检测可以在原位进行，这加速了趋化性测定并增加了测量的准确性。根据本发明的装置特别包括用于提供兴奋剂浓度梯度的兴奋剂梯度室（1），所述兴奋剂梯度室（1）具有用于细胞（C）入口的细胞入口（12）， - 电传感器（2），放置在测量区域中，用于测量响应于所述传感器（2）周围的单元（C）的移动而变化并且用于生成检测信号的电参数;以及信号评估单元（3 ）用于评估所述检测信号。

8. 发明申请

WO2008029372A3 DEVICE FOR THE CONTROLLED RELEASE OF A PREDEFINED QUANTITY OF A SUBSTANCE 审中-公开
标题翻译：控制释放物质预定量的装置
公开(公告)号：WO2008029372A3
公开(公告)日：2008-11-20
申请号：PCT/IB2007053596
申请日：2007-09-06
申请人： KONINKL PHILIPS ELECTRONICS NV , JOHNSON MARK T , FRENCH IAN , PONJEE MARC W G
发明人： JOHNSON MARK T , FRENCH IAN , PONJEE MARC W G
IPC分类号： A61M37/00 , A61K9/00
CPC分类号： A61M37/00 , A61K9/0009 , A61K9/0097
摘要： Device for the controlled release of a predefined quantity of a substance and method for the production of a device for the controlled release of a predefined quantity of a substance. To realize a controlled delivery of a substance based upon a multiplicity of individual compartments, the reservoirs are formed in plastic substrates that allow the substance delivery device to be flexible and conformal with both internal and external body parts. The fabrication technology for the plastic drug release reservoirs is compatible with active matrix array technology, allowing control of delivery to be based upon active matrix principles. Applications are for controlled external drug delivery (patches), implantable drug delivery and oral drug delivery (electronic pill).
摘要翻译：用于控制释放预定量物质的装置和用于生产用于控制释放预定量物质的装置的方法。为了实现基于多个单独隔室的物质的受控递送，储存器在塑料基底中形成，所述塑料基底允许物质递送装置是柔性的并与内部和外部身体部分共形。塑料药物释放容器的制造技术与有源矩阵阵列技术兼容，允许基于有源矩阵原理控制输送。应用程序用于控制外部药物递送（贴剂），植入式药物递送和口服药物递送（电子药丸）。

9. 发明申请

WO2007072382A3 ACTIVE MATRIX TEMPERATURE CONTROLLER ARRAY 审中-公开
标题翻译：主动矩阵温度控制器阵列
公开(公告)号：WO2007072382A3
公开(公告)日：2008-10-09
申请号：PCT/IB2006054893
申请日：2006-12-15
申请人： KONINKL PHILIPS ELECTRONICS NV , FISH DAVID A , PONJEE MARC W G , JOHNSON MARK T
发明人： FISH DAVID A , PONJEE MARC W G , JOHNSON MARK T
IPC分类号： G05D23/20
CPC分类号： G05D23/20 , G05D23/1934
摘要： In an array (ATC) for temperature controlled cells (TC) the cells are driven in an active matrix array. A temperature processing array may be employed in biochip, such as underneath a biosensor or underneath reaction chambers. Due to the active matrix complex driver circuitry (ADC, DDC) may be positioned outside the actual array of cells. Bach cell is provided with a switch (SE) for coupling the cell circuitry to the driver circuitry. When coupled to the driver circuitry, a memory element (ME) in the cell circuitry may be provided with a heating setting. Then, the cell circuitry is uncoupled from the driver circuitry and a heating element (HE) is controlled to heat the cell in accordance with the setting stored in the memory element.
摘要翻译：在温度控制单元（TC）的阵列（ATC）中，单元以有源矩阵阵列驱动。温度处理阵列可用于生物芯片，例如生物传感器下方或反应室下方。由于有源矩阵复合驱动器电路（ADC，DDC）可能位于实际阵列阵列之外。 Bach单元设置有用于将单元电路耦合到驱动器电路的开关（SE）。当耦合到驱动器电路时，单元电路中的存储元件（ME）可以设置有加热设置。然后，单元电路与驱动器电路分离，并且加热元件（HE）被控制以根据存储在存储元件中的设置加热单元。

10. 发明申请

WO2007063457A3 BIO CHIP DEVICE WITH A SAMPLE COMPARTMENT AND A LIGHT SENSITIVE ELEMENT, METHOD FOR THE DETECTION OF FLUORESCENT PARTICLES WITHIN AT LEAST ONE SAMPLE COMPARTMENT OF A BIO CHIP DEVICE 审中-公开
标题翻译：具有样品瓶的生物芯片装置和光敏元件，用于在最小的一个生物芯片装置的一个样品瓶中检测荧光颗粒的方法
公开(公告)号：WO2007063457A3
公开(公告)日：2007-11-01
申请号：PCT/IB2006054397
申请日：2006-11-23
申请人： KONINKL PHILIPS ELECTRONICS NV , PONJEE MARC W G , JOHNSON MARK T , BALISTRERI MARCELLO L M , VAN HERPEN MAARTEN M J W , KLUNDER DERK J W
发明人： PONJEE MARC W G , JOHNSON MARK T , BALISTRERI MARCELLO L M , VAN HERPEN MAARTEN M J W , KLUNDER DERK J W
IPC分类号： G01N21/64 , G01N21/25
CPC分类号： G01N21/6454
摘要： The invention provides a bio chip device comprising at least one sample compartment and at least one light sensitive element, the at least one sample compartment being provided on a first side of the at least one light sensitive element, wherein incident light is provided incident from a second side opposite of the first side of the at least one light sensitive element. Further, the invention provides a method for the detection of fluorescent particles within at least one sample compartment of a bio chip device.
摘要翻译：本发明提供一种包括至少一个样品室和至少一个光敏元件的生物芯片装置，所述至少一个样品室设置在所述至少一个光敏元件的第一侧上，其中入射光从第二侧与所述至少一个光敏元件的第一侧相对。此外，本发明提供了一种用于检测生物芯片器件的至少一个样品室内的荧光颗粒的方法。

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