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1. 发明申请

WO2008041190A3 METHODS AND SYSTEMS FOR DETECTION WITH FRONT IRRADIATION 审中-公开
标题翻译：用于检测前辐照的方法和系统
公开(公告)号：WO2008041190A3
公开(公告)日：2008-07-03
申请号：PCT/IB2007054022
申请日：2007-10-03
申请人： KONINKL PHILIPS ELECTRONICS NV , JOHNSON MARK T , PONJEE MARC W G , BALISTRERI MARCELLO L M , VAN HERPEN MAARTEN M J W , KLUNDER DERK J W
发明人： JOHNSON MARK T , PONJEE MARC W G , BALISTRERI MARCELLO L M , VAN HERPEN MAARTEN M J W , KLUNDER DERK J W
IPC分类号： G01N21/64 , B01L3/00
CPC分类号： G01N21/6428 , B01L3/5027 , G01N21/6454
摘要： A radiation detection system (100) is described comprising a measurement region (104) in a measurement chamber adapted for receiving at least one sample (108) to be examined and adapted for receiving excitation radiation for impingement on the at least one sample (108) and for generating sample radiation. The radiation detection system (100) furthermore comprises at least one detector element (106) for detection of the generated sample radiation. The radiation detection system thereby is a front irradiation system, i.e. the excitation radiation is incident on a first side of the measurement region (104) in a measurement chamber and the at least one detector element (106) is positioned at a second side of the measurement region (104) in a measurement chamber, the second side being opposite to the first side with respect to the measurement region (104) in a measurement chamber, such that detection occurs at the side facing the first side. The detection system (100) also comprises optical means (112) adapted for guiding said excitation radiation aside the at least one detector element (106).
摘要翻译：描述了包括测量室中的测量区域（104）的辐射检测系统（100），所述测量室适于接收待检查的至少一个样本（108）并且适于接收用于撞击所述至少一个样本（108）的激发辐射，并用于产生样品辐射。辐射探测系统（100）还包括用于探测所产生的样本辐射的至少一个探测器元件（106）。由此辐射检测系统是前照射系统，即激发辐射入射到测量室中的测量区域（104）的第一侧上，并且至少一个检测器元件（106）定位在测量室的第二侧测量室中的测量区域（104），第二侧相对于测量室中的测量区域（104）与第一侧相对，使得检测发生在面向第一侧的一侧。检测系统（100）还包括适于将所述激发辐射引导到所述至少一个检测器元件（106）旁边的光学装置（112）。

2. 发明申请

WO2009060360A3 MICROELECTRONIC OPIACAL EVANESCENT FIELD SENSOR 审中-公开
标题翻译：微电子光学现场传感器
公开(公告)号：WO2009060360A3
公开(公告)日：2009-07-16
申请号：PCT/IB2008054522
申请日：2008-10-30
申请人： KONINKL PHILIPS ELECTRONICS NV , KLUNDER DERK J W , DE WITZ CHRISTIANNE R M , PENTERMAN ROEL , DE BOER RUTH W I , VAN DIJK ERIK M H P
发明人： KLUNDER DERK J W , DE WITZ CHRISTIANNE R M , PENTERMAN ROEL , DE BOER RUTH W I , VAN DIJK ERIK M H P
IPC分类号： G01N21/55 , G01N21/64 , G01N21/77 , G01N33/551
CPC分类号： G01N21/648 , B82Y15/00 , G01N21/552 , G01N21/554 , G01N21/6452 , G01N21/7703 , G01N33/54373 , G01N2021/6432 , G01N2021/7786 , G02B6/0229 , G02B2006/12138
摘要： There is provided a microelectronic sensor device (100) for the detection of target components (10) near a binding surface (12), comprising a source (21) for emitting a beam (101) of radiation having a wavelength incident at the binding surface (12); an optical structure (11) near the binding surface (12), for providing evanescent radiation, in response to the radiation incident at the binding surface (12), in a detection volume (4) bound by the binding surface (12) and extending over a decaylength away from the binding surface (12) into a sample chamber (2); and a detector (31) for detecting radiation (102) from the target component (10)1 present in the detection volume (4), in response to the emitted incident radiation (101) from the source (21) wherein the binding surface (12) is provided with upstanding walls of a dielectric material (3), for providing one or more detection volumes (4) bound to a maximum in plane detection volume dimension (Wl) smaller than a diffraction limit, the diffraction limit defined by the radiation wavelength and the medium (2) for containing the target components (10).
摘要翻译：提供了用于在绑定表面（12）附近检测目标部件（10）的微电子传感器装置（100），包括用于发射具有入射在结合表面处的波长的辐射束（101）的源（21）（12）; 在结合表面（12）附近的光学结构（11），用于响应于在结合表面（12）处入射的辐射，在由结合表面（12）限定的检测体积（4）中提供ev逝辐射，并延伸超过从结合表面（12）离开到样品室（2）的衰减长度; 以及检测器（31），用于响应于来自所述源（21）的所述发射入射辐射（101），检测来自所述检测体积（4）中的目标成分（10）1的辐射（102），其中所述结合表面 12）设置有介电材料（3）的直立壁，用于提供一个或多个检测体积（4），该检测体积（4）与小于衍射极限的平面检测体积尺寸（W1）最大限度地结合，由辐射限定的衍射极限波长和用于容纳目标成分（10）的介质（2）。

3. 发明申请

WO2007034395A3 LUMINESCENCE SENSOR COMPRISING AT LEAST TWO WIRE GRIDS 审中-公开
标题翻译：包含最少两根网格的发光体传感器
公开(公告)号：WO2007034395A3
公开(公告)日：2008-10-30
申请号：PCT/IB2006053336
申请日：2006-09-18
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN HERPEN MAARTEN M J W , VAN HOUTEN HENK , KLUNDER DERK J W
发明人： VAN HERPEN MAARTEN M J W , VAN HOUTEN HENK , KLUNDER DERK J W
IPC分类号： G01N21/64 , G02B5/30
CPC分类号： G01N21/6428 , G01N21/6445 , G01N21/648 , G02B5/3058
摘要： The present invention proposes a sub-wavelength luminescence sensor, such as e.g. a luminescence biosensor or a luminescence chemical sensor, comprising at least two wire grids (1, 2) positioned perpendicular with respect to each other. The luminescence sensor, in which the excitation radiation is efficiently used and the luminescence radiation is efficiently detected, has an improved signal-to-noise ratio and a separated excitation and luminescence radiation.
摘要翻译：本发明提出了一种亚波长发光传感器，例如，发光生物传感器或发光化学传感器，其包括相对于彼此垂直定位的至少两个线栅（1,2）。其中有效地利用激发辐射和有效地检测发光辐射的发光传感器具有改善的信噪比和分离的激发和发光辐射。

4. 发明申请

WO2007066255A3 SENSOR WITH IMPROVED SIGNAL-TO-NOISE RATIO AND IMPROVED ACCURACY 审中-公开
标题翻译：传感器具有改善的信噪比和提高的准确性
公开(公告)号：WO2007066255A3
公开(公告)日：2007-09-20
申请号：PCT/IB2006054476
申请日：2006-11-28
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN HERPEN MAARTEN M J W , BALISTRERI MARCELLO L M , KLUNDER DERK J W , LIEDENBAUM COEN T H F
发明人： VAN HERPEN MAARTEN M J W , BALISTRERI MARCELLO L M , KLUNDER DERK J W , LIEDENBAUM COEN T H F
IPC分类号： G01N21/64
CPC分类号： G01N21/6456
摘要： The present invention provides a sensor and a method for detecting an optically variable molecule (9) in a sample (3). The sensor comprises an excitation radiation source (1) for irradiating the sample (4) and exciting the optically variable molecule (9), thus generating a luminescence signal (7). The sensor furthermore comprises a modulation means (4) for modulating the excitation radiation beam (2) in a direction different from, preferably substantially perpendicular to, a scanning direction of the excitation radiation beam (2) over the sample (3). The method and sensor according to the invention lead to an improved signal- to-noise ratio by reducing and even minimising the background signal in the luminescence signal (7) and to an improved accuracy by minimising signals coming from false-positives.
摘要翻译：本发明提供了用于检测样品（3）中的光学可变分子（9）的传感器和方法。该传感器包括用于照射样品（4）并且激励光学可变分子（9）的激发辐射源（1），由此产生发光信号（7）。该传感器还包括调制装置（4），用于在与样品（3）上的激发辐射束（2）的扫描方向不同的方向上，优选基本上垂直于该方向上调制激发辐射束（2）。根据本发明的方法和传感器通过减少并甚至最小化发光信号（7）中的背景信号而导致改进的信噪比，并通过最小化来自假阳性的信号来提高准确度。

5. 发明申请

WO2006087681A3 FLUID OPTICAL WAVEGUIDE 审中-公开
标题翻译：流体光波导
公开(公告)号：WO2006087681A3
公开(公告)日：2006-11-09
申请号：PCT/IB2006050501
申请日：2006-02-15
申请人： KONINKL PHILIPS ELECTRONICS NV , KLUNDER DERK J W , HENDRIKS BERNARDUS H W , KUIPER STEIN
发明人： KLUNDER DERK J W , HENDRIKS BERNARDUS H W , KUIPER STEIN
IPC分类号： G02B6/35
CPC分类号： G02B6/3538 , G02B6/122 , G02B6/3594 , G02B6/3596 , G02B2006/0325
摘要： An optical waveguide comprises a body (13), the body including an entrance window (9) and an exit window (11) defining an optical path (13) through a cavity. The cavity contains a first fluid (A) and a second fluid (B), with an interface between the first fluid and the second fluid defined by a meniscus. The meniscus lies longitudinally along the optical path. Means for adjusting the meniscus are provided, for example a voltage source and at least two electrodes. Electrowetting can be used for influencing the fluids.
摘要翻译：光波导包括主体（13），主体包括通过空腔限定光路（13）的入口窗（9）和出口窗（11）。空腔包含第一流体（A）和第二流体（B），在第一流体和由弯月面限定的第二流体之间具有界面。弯液面沿光路纵向延伸。提供了用于调整弯液面的装置，例如电压源和至少两个电极。电润湿可用于影响流体。

6. 发明申请

WO2009063368A2 PLASMON GRATING BIOSENSOR 审中-公开
公开(公告)号：WO2009063368A2
公开(公告)日：2009-05-22
申请号：PCT/IB2008054645
申请日：2008-11-06
申请人： KONINKL PHILIPS ELECTRONICS NV , DE BOER RUTH W I , VAN DIJK ERIK M H P , GOMEZ RIVAS JAIME , KLUNDER DERK J W
发明人： DE BOER RUTH W I , VAN DIJK ERIK M H P , GOMEZ RIVAS JAIME , KLUNDER DERK J W
IPC分类号： G01N21/55
CPC分类号： G01N21/648 , G01N21/6458 , G01N21/658 , G01N21/7743 , G01N2021/6439
摘要： The present invention discloses a novel concept for real-time, high-sensitivity optical biosensing that is suitable for cheap and simple incorporation in existing standard microscopes, and other similar apparatuses. Moreover, the present invention proposes to use surface plasmon polaritons (SPPs) on gold structured surfaces to localize the excitation and/or detection volume in an optical biosensor to a range
摘要翻译：本发明公开了用于实时，高灵敏度光学生物传感的新颖概念，其适用于现有标准显微镜和其他类似装置中廉价和简单的结合。此外，本发明提出在金结构化表面上使用表面等离子体激元（SPP）以将光学生物传感器中的激发和/或检测体积定位在基板表面上方<500nm的范围内。根据一些实施例，在衬底侧执行激发和检测，并且金属膜的结构被设计为使得激发和发射光路几乎垂直于金属膜行进。

7. 发明申请

WO2008047272A3 DEVICE FOR AMPLIFICATION AND DETECTION OF NUCLEIC ACIDS 审中-公开
标题翻译：用于放大和检测核酸的装置
公开(公告)号：WO2008047272A3
公开(公告)日：2008-06-12
申请号：PCT/IB2007054141
申请日：2007-10-11
申请人： KONINKL PHILIPS ELECTRONICS NV , VOSSENAAR ERIK R , KLUNDER DERK J W
发明人： VOSSENAAR ERIK R , KLUNDER DERK J W
IPC分类号： B01L3/00 , C12Q1/68
CPC分类号： B01L3/50825 , B01L3/50853 , B01L7/52 , B01L2300/047 , B01L2300/0636 , B01L2300/0832 , G01N2035/00158
摘要： A device is provided which is suitable for use in the amplification and detection of nucleic acids. The device comprises a sample tube comprising a compartment (3) that is preferably open at the top such that its content flows out when the tubed) is turned upside down. The tube further comprises a cap (2) which comprises a microarray of nucleic acids to which amplified sample DNA may hybridize.
摘要翻译：提供了适用于核酸扩增和检测的装置。该装置包括样品管，该样品管包括隔间（3），隔室（3）优选地在顶部开口，使得其内容物在管状物被翻转时被翻转）。该管进一步包括盖（2），其包含核酸的微阵列，扩增的样品DNA可与之杂交。

8. 发明申请

WO2008053442A2 BIOSENSOR USING WIRE-GRIDS FOR INCREASING CAVITY ENERGY 审中-公开
标题翻译：生物传感器使用线网增加腔体能量
公开(公告)号：WO2008053442A2
公开(公告)日：2008-05-08
申请号：PCT/IB2007054425
申请日：2007-10-31
申请人： KONINKL PHILIPS ELECTRONICS NV , KLUNDER DERK J W , HERPEN MAARTEN M J W
发明人： KLUNDER DERK J W , HERPEN MAARTEN M J W
IPC分类号： G01N21/64 , G01J3/44 , G02B5/30
CPC分类号： G01N21/648 , G01J3/26 , G01J3/4406 , G01N21/6428 , G01N2021/6469 , G02B5/204 , G02B5/284 , G02B5/3058
摘要： The invention discloses a luminescence sensor (101) for bio-sensing having an input reflector (253) and an output reflector (254). The gap (S) between the input and output reflectors constitutes an optical cavity. One or both of the input and output reflectors can be a wire-grid (270) having apertures (211,212), where at least one dimension of the apertures is below the diffraction limit. When input radiation (221) impinges the input reflector a fraction of the input radiation is transmitted into the cavity. The energy of the radiation inside the cavity is increased due to the resonance properties of the cavity. Due to the increase of the cavity excitation energy, the luminescent radiation emitted from the luminescent particles inside the cavity can be detected outside the cavity. Since the input and output reflectors have high reflection coefficients the input radiation is effectively prohibited from being transmitted through the luminescence detector. In addition, luminescence generated in the cavity is significantly higher than luminescence generated outside the cavity.
摘要翻译：本发明公开了一种用于生物感测的发光传感器（101），其具有输入反射器（253）和输出反射器（254）。输入和输出反射器之间的间隙（S）构成光学腔。输入和输出反射器中的一个或两个可以是具有孔（211,212）的线栅（270），其中孔的至少一个维度低于衍射极限。当输入辐射（221）撞击输入反射器时，一部分输入辐射被传输到空腔中。由于谐振腔的谐振特性，谐振腔内辐射的能量增加。由于腔激发能量的增加，腔内发光颗粒发出的发光辐射可以在腔外被探测到。由于输入和输出反射器具有高反射系数，输入辐射被有效地禁止透射通过发光检测器。另外，空腔中产生的发光显着高于空腔外部产生的发光。

9. 发明申请

WO2007010428A3 LUMINESCENCE SENSOR USING MULTI-LAYER SUBSTRATE STRUCTURE 审中-公开
标题翻译：使用多层基板结构的发光传感器
公开(公告)号：WO2007010428A3
公开(公告)日：2007-04-05
申请号：PCT/IB2006052300
申请日：2006-07-07
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN HERPEN MAARTEN M J W , KLUNDER DERK J W
发明人： VAN HERPEN MAARTEN M J W , KLUNDER DERK J W
IPC分类号： G01J1/58 , G01N21/76 , G01N33/58
CPC分类号： G01N21/76 , G01N21/648 , G01N33/54306 , G01N33/582
摘要： The present invention provides a luminescence sensor (2), such as e.g. a luminescence biosensor, comprising a multi-layer structure. The multi-layer structure comprises at least a first layer (2a) formed of a first material and a second layer (2b) formed of a second material. The first material has a first binding capacity towards luminophores and the second material has a second binding capacity towards luminophores, the first the first binding capacity being different from the second binding capacity. The luminescence sensor (2) according to the present invention shows a high sensitivity because it provides preferred binding sites for luminophores at locations where the combined excitation and detection efficiency is the highest.
摘要翻译：本发明提供一种发光传感器（2），例如，发光生物传感器，包括多层结构。多层结构至少包括由第一材料形成的第一层（2a）和由第二材料形成的第二层（2b）。第一材料具有朝向发光体的第一结合能力，第二材料具有朝向发光体的第二结合能力，第一材料具有与第二结合能力不同的第一结合能力。根据本发明的发光传感器（2）显示出高灵敏度，因为它在组合的激发和检测效率最高的位置处为发光体提供优选的结合位点。

10. 发明专利

BRPI0717634A2 未知
公开(公告)号：BRPI0717634A2
公开(公告)日：2013-10-29
申请号：BRPI0717634
申请日：2007-10-11
申请人： KONINKL PHILIPS ELECTRONICS NV
发明人： VOSSENAAR ERIK R , KLUNDER DERK J W
IPC分类号： B01L3/00 , C12Q1/68

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