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1. 发明申请

WO8503507A3 METALLICENIUM SALTS AND UTILIZATION THEREOF AS CYTOSTATIC AGENTS FOR COMBATTING CANCER 审中-公开
标题翻译：金属盐的销售和利用作为用于组合癌症的细胞毒素
公开(公告)号：WO8503507A3
公开(公告)日：1985-09-26
申请号：PCT/EP8500047
申请日：1985-02-08
申请人： KOEPF MAIER PETRA , KOEPF HARTMUT , NEUSE EBERHARD WILHELM
发明人： KOEPF-MAIER PETRA , KOEPF HARTMUT , NEUSE EBERHARD WILHELM
IPC分类号： C07F17/00 , A61K31/28 , A61K31/295 , A61P35/00 , C07F17/02
CPC分类号： C07F17/02 , C07F17/00
摘要： Metallicenium salts having the general formula (I), wherein M represents Fe, Co, Ni, Ru or Os; C5H5-xRx and C5H5-yR'y represent cyclopentadienyl cycles which may be independently unsubstituted (x, y = 0) or substituted between 1 and 5 times (x, y = 1, 2, 3, 4 or 5), R and R' representing independently from each other similar or different substituents, and alkyl, cycloalkyl, hydroxyalkyl, aminoalkyl, halogenoalkyl, alkenyl, aryl, aralkyl, ferrocenyl, ferrocenylium, ferrocenylalkyl, acyl, halogenyl, trialkylsilyl, tricycloalkylsilyl, triarylsilyl, triaralkylsilyl or carboxyl, ester, amide or hydrazide groups, R and R' forming together an alkylen bridge with 2 to 4 bridge atoms; a, b, m and n are integers, m being 1 or 2 and n being 1, 2 or 3, while a.m = b.n; A representing a complexing or high density anion, stabilizing the metallicenium cation; as well as the solvates of said salts to be used as drugs, particularly as cytostatic agents for combatting cancer.

2. 发明申请

WO8503507A2 METALLICENIUM SALTS AND UTILIZATION THEREOF AS CYTOSTATIC AGENTS FOR COMBATTING CANCER 审中-公开
标题翻译：金属盐的销售和利用作为用于组合癌症的细胞毒素
公开(公告)号：WO8503507A2
公开(公告)日：1985-08-15
申请号：PCT/EP8500047
申请日：1985-02-08
申请人： KOEPF MAIER PETRA , KOEPF HARTMUT , NEUSE EBERHARD WILHELM
发明人： KOEPF-MAIER PETRA , KOEPF HARTMUT , NEUSE EBERHARD WILHELM
IPC分类号： C07F17/00 , A61K31/28 , A61K31/295 , A61P35/00 , C07F17/02
CPC分类号： C07F17/02 , C07F17/00
摘要： Metallicenium salts having the general formula (I), wherein M represents Fe, Co, Ni, Ru or Os; C5H5-xRx and C5H5-yR'y represent cyclopentadienyl cycles which may be independently unsubstituted (x, y = 0) or substituted between 1 and 5 times (x, y = 1, 2, 3, 4 or 5), R and R' representing independently from each other similar or different substituents, and alkyl, cycloalkyl, hydroxyalkyl, aminoalkyl, halogenoalkyl, alkenyl, aryl, aralkyl, ferrocenyl, ferrocenylium, ferrocenylalkyl, acyl, halogenyl, trialkylsilyl, tricycloalkylsilyl, triarylsilyl, triaralkylsilyl or carboxyl, ester, amide or hydrazide groups, R and R' forming together an alkylen bridge with 2 to 4 bridge atoms; a, b, m and n are integers, m being 1 or 2 and n being 1, 2 or 3, while a.m = b.n; A representing a complexing or high density anion, stabilizing the metallicenium cation; as well as the solvates of said salts to be used as drugs, particularly as cytostatic agents for combatting cancer.
摘要翻译：具有通式（I）的金属盐，其中M表示Fe，Co，Ni，Ru或Os; C5H5-xRx和C5H5-yR'y代表环戊二烯基循环，其可以独立地是未取代的（x，y = 0）或取代1至5倍（x，y = 1,2,3,4或5），R和R 烷基，环烷基，羟基烷基，氨基烷基，卤代烷基，烯基，芳基，芳烷基，二茂铁基，二茂铁基，二茂铁基烷基，酰基，卤代，三烷基甲硅烷基，三环烷基甲硅烷基，三芳基甲硅烷基，三烷基甲硅烷基或羧基酯，酰胺或酰肼基团，R和R'一起形成具有2至4个桥原子的亚烷基桥; a，b，m和n为整数，m为1或2，n为1,2或3，而a.m = b.n; A代表络合或高密度阴离子，稳定金属鎓阳离子; 以及用作药物的所述盐的溶剂化物，特别是用作抗癌作用的细胞抑制剂。

3. 发明专利

DK237086A 未知
公开(公告)号：DK237086A
公开(公告)日：1986-11-23
申请号：DK237086
申请日：1986-05-21
申请人： KOEPF MAIER PETRA , KOEPF HARTMUT
发明人： KOEPF-MAIER PETRA , KOEPF HARTMUT
IPC分类号： C07F7/28 , A61K31/28 , A61P35/00 , C07F17/00 , C07F , A61K
摘要： 1. Titanocene complexes having the general formula I see diagramm : EP0202673,P17,F1 wherein A represents the group see diagramm : EP0202673,P17,F2 in which X is an oxygen atom or sulfur atom, R is hydrogen or a C1-4 -alkyl group, and Y is a halide ; or A represents the group -O-CO-R', in which R' is the group -CF3 , -CCI3 , -CBr3 , -CHCI2 , -CH2 CI, -CH=CH-COOH or -(CH2 )n COOH, and n has the value 0, 1, 2, 3 or 4, and B is a halide or is defined as the radical A ; for use as pharmaceuticals.

4. 发明专利

FI81358C FOERFARANDE FOER FRAMSTAELLNING AV FERRICENIUMTRIKLORACETAT-MONO(TRIKLORAETTIKSYRA). 未知
公开(公告)号：FI81358C
公开(公告)日：1990-10-10
申请号：FI853818
申请日：1985-10-02
申请人： KOEPF MAIER PETRA , KOEPF HARTMUT , NEUSE EBERHARD WILHELM
发明人： KOEPF-MAIER PETRA , KOEPF HARTMUT , NEUSE EBERHARD WILHELM
IPC分类号： C07F17/00 , A61K31/28 , A61K31/295 , A61P35/00 , C07F17/02

5. 发明专利

NO862006A 未知
公开(公告)号：NO862006A
公开(公告)日：1986-11-24
申请号：NO862006
申请日：1986-05-21
申请人： KOEPF MAIER PETRA , KOEPF HARTMUT
发明人： KOEPF-MAIER PETRA , KOEPF HARTMUT
IPC分类号： C07F7/28 , A61K31/28 , A61P35/00 , C07F17/00
CPC分类号： C07F17/00

6. 发明专利

FI862132A 未知
公开(公告)号：FI862132A
公开(公告)日：1986-11-23
申请号：FI862132
申请日：1986-05-21
申请人： KOEPF MAIER PETRA , KOEPF HARTMUT
发明人： KOEPF-MAIER PETRA , KOEPF HARTMUT
IPC分类号： C07F7/28 , A61K31/28 , A61P35/00 , C07F17/00 , C07F
摘要： 1. Titanocene complexes having the general formula I see diagramm : EP0202673,P17,F1 wherein A represents the group see diagramm : EP0202673,P17,F2 in which X is an oxygen atom or sulfur atom, R is hydrogen or a C1-4 -alkyl group, and Y is a halide ; or A represents the group -O-CO-R', in which R' is the group -CF3 , -CCI3 , -CBr3 , -CHCI2 , -CH2 CI, -CH=CH-COOH or -(CH2 )n COOH, and n has the value 0, 1, 2, 3 or 4, and B is a halide or is defined as the radical A ; for use as pharmaceuticals.

7. 发明专利

FI862132A0 未知
公开(公告)号：FI862132A0
公开(公告)日：1986-05-21
申请号：FI862132
申请日：1986-05-21
申请人： KOEPF MAIER PETRA , KOEPF HARTMUT
发明人： KOEPF-MAIER PETRA , KOEPF HARTMUT
IPC分类号： C07F7/28 , A61K31/28 , A61P35/00 , C07F17/00 , C07F
摘要： 1. Titanocene complexes having the general formula I see diagramm : EP0202673,P17,F1 wherein A represents the group see diagramm : EP0202673,P17,F2 in which X is an oxygen atom or sulfur atom, R is hydrogen or a C1-4 -alkyl group, and Y is a halide ; or A represents the group -O-CO-R', in which R' is the group -CF3 , -CCI3 , -CBr3 , -CHCI2 , -CH2 CI, -CH=CH-COOH or -(CH2 )n COOH, and n has the value 0, 1, 2, 3 or 4, and B is a halide or is defined as the radical A ; for use as pharmaceuticals.

8. 发明专利

DK237086D0 未知
公开(公告)号：DK237086D0
公开(公告)日：1986-05-21
申请号：DK237086
申请日：1986-05-21
申请人： KOEPF MAIER PETRA , KOEPF HARTMUT
发明人： KOEPF-MAIER PETRA , KOEPF HARTMUT
IPC分类号： C07F7/28 , A61K31/28 , A61P35/00 , C07F17/00 , C07F , A61K
摘要： 1. Titanocene complexes having the general formula I see diagramm : EP0202673,P17,F1 wherein A represents the group see diagramm : EP0202673,P17,F2 in which X is an oxygen atom or sulfur atom, R is hydrogen or a C1-4 -alkyl group, and Y is a halide ; or A represents the group -O-CO-R', in which R' is the group -CF3 , -CCI3 , -CBr3 , -CHCI2 , -CH2 CI, -CH=CH-COOH or -(CH2 )n COOH, and n has the value 0, 1, 2, 3 or 4, and B is a halide or is defined as the radical A ; for use as pharmaceuticals.

9. 发明专利

DK456585A 未知
公开(公告)号：DK456585A
公开(公告)日：1985-10-07
申请号：DK456585
申请日：1985-10-07
申请人： KOEPF MAIER PETRA , KOEPF HARTMUT , NEUSE EBERHARD WILHELM
发明人： KOEPF-MAIER PETRA , KOEPF HARTMUT , NEUSE EBERHARD WILHELM
IPC分类号： C07F17/00 , A61K31/28 , A61K31/295 , A61P35/00 , C07F17/02 , C07F , A61K
摘要： PCT No. PCT/EP85/00047 Sec. 371 Date Oct. 3, 1985 Sec. 102(e) Date Oct. 3, 1985 PCT Filed Feb. 8, 1985 PCT Pub. No. WO85/03507 PCT Pub. Date Aug. 15, 1985.Metallicenium salts of the general formula I [( eta 5-C5H-xRx)M( eta 5-C5H5-yR'y)]am+[A]bn-(I) in which M is Fe, Co, Ni, Ru or Os; C5H5-xRx and C5H5-yR'y denote cyclopendadienyl rings which, independently of one another, can be unsubstituted (x and y=0) or mono-, di-, tri-, tetra- or penta-substituted (x and y=1, 2, 3, 4 or 5), and in which R and R' independently of one another represent identical or different substituents and denote alkyl, cycloalkyl, hydroxyalkyl, aminoalkyl, halogenoalkyl, alkenyl, aryl, aralkyl, ferrocenyl, ferrocenylium, ferrocenylalkyl, acyl, halogenyl, trialkylsilyl, tricycloalkylsilyl, triarylsilyl, triaralkylsilyl or carboxyl, ester, amide or hydrazide groups, or R and R' together form an alkylene bridge with 2 to 4 bridge atoms; a, b, m and n are integers, and m has the value 1 or 2, n has the value 1, 2 or 3 and axm=bxn; and A is a complexating or very bulky anion which stabilizes the metallicenium cation; and solvates of these salts, for use as medicaments, in paticular as cytostatics in combating tumors susceptible thereto.

10. 发明专利

FI82941C FOERFARANDE FOER FRAMSTAELLNING AV TERAPEUTISKT ANVAENDBARA TITANOCENKOMPLEX. 未知
公开(公告)号：FI82941C
公开(公告)日：1991-05-10
申请号：FI862132
申请日：1986-05-21
申请人： KOEPF MAIER PETRA , KOEPF HARTMUT
发明人： KOEPF-MAIER PETRA , KOEPF HARTMUT
IPC分类号： C07F7/28 , A61K31/28 , A61P35/00 , C07F17/00

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