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1. 发明申请

WO2019177550A1 THERAPEUTIC NANOPARTICLES CONTAINING ARGONAUTE FOR MICRORNA DELIVERY AND COMPOSITIONS AND METHODS USING SAME 审中-公开
公开(公告)号：WO2019177550A1
公开(公告)日：2019-09-19
申请号：PCT/TR2018/050094
申请日：2018-03-10
申请人： KOC UNIVERSITESI , SABANCI UNIVERSITESI
发明人： ACAR, Havva Yagci , GOZUACIK, Devrim , KOSAR, Ali , UNAL, Ozlem , KOCAK, Muhammed , AKKOC, Yunus , ZUVIN, Merve
IPC分类号： A61K47/69 , A61K47/62 , A61K47/68 , A61K47/60 , A61K41/00 , A61P35/00 , C12N15/113
摘要： The present invention relates to oligonucleotide carriers for oligonucleotide delivery to a subject to provide gene therapy. More particularly, the present invention relates to therapeutic nanoparticles for microRNA (miRNA) delivery to a subject. More particularly, the present invention relates to therapeutic nanoparticles wherein miRNA is bindable to biocompatible nanoparticles using natural gene carrier Argonaute (AGO) protein or a variant thereof. Optionally, therapeutic nanoparticles of the present invention additionally contain targeting moieties for targeting said therapeutic nanoparticles to cancer cells and/or chemotherapeutic agents. Optionally, said biocompatible nanoparticles are trackable nanoparticles, such as superparamagnetic iron oxide nanoparticles (SPION), to provide multifunctional theranostics.

2. 发明申请

WO2011141775A1 AN APPARATUS FOR USING HYDRODYNAMIC CAVITATION IN MEDICAL TREATMENT 审中-公开
标题翻译：在医疗治疗中使用水动力储存的装置
公开(公告)号：WO2011141775A1
公开(公告)日：2011-11-17
申请号：PCT/IB2010/052146
申请日：2010-05-14
申请人： SABANCI UNIVERSITESI , KOSAR, Ali
发明人： KOSAR, Ali
IPC分类号： A61B17/3203
CPC分类号： A61B17/2251 , A61B17/3203 , A61B90/37 , A61B2017/32032 , Y10T83/0453
摘要： The present invention relates to an apparatus for using the hydrodynamic cavitation in medical treatment such as destroying kidney stones or killing infected cancer cells. This apparatus comprising a tank used as a container for a fluid,a compressor which is connected to the tank in order to maintain the input pressure of the fluid, a tubing in which the fluid flows,a probe in which the cavitation occurs,a valve, which is positioned inside the tubing, allowing the fluid to flow into the probe,a filter, which is positioned inside the tubing, preventing the predetermined size particles flow into the probe,a fitting connecting the probe to the tubing, a flowmeter measuring the volume flow rate of the fluid through the probe,an image capturing unit capturing the sequential images of bubble growing and collapsing of the bubbles after the bubbles exit from the probe,a positioning assembly which adjusts the distance between the probe and the target surface and a control and data acquisition unit.
摘要翻译：本发明涉及一种在医疗中使用水动力空化的装置，例如破坏肾结石或杀死感染的癌细胞。该装置包括用作流体容器的罐，连接到罐的压缩机，以便保持流体的输入压力，流体流动的管，发生气蚀的探针，阀，其位于管道内部，允许流体流入探针，过滤器，其位于管道内部，防止预定尺寸的颗粒流入探针，将探针连接到管道的配件，测量管道的流量计通过探针的流体的体积流量，捕获气泡生长的气泡生长和气泡在从探针出射之后塌陷的顺序图像的图像捕获单元，调整探针与目标表面之间的距离的定位组件和控制和数据采集单元。

3. 发明公开

EP2568893A1 AN APPARATUS FOR USING HYDRODYNAMIC CAVITATION IN MEDICAL TREATMENT 有权
标题翻译：设备技术水力空化在医学治疗中的应用
公开(公告)号：EP2568893A1
公开(公告)日：2013-03-20
申请号：EP10723792.7
申请日：2010-05-14
申请人： Sabanci Universitesi
发明人： KOSAR, Ali
IPC分类号： A61B17/3203
CPC分类号： A61B17/2251 , A61B17/3203 , A61B90/37 , A61B2017/32032 , Y10T83/0453
摘要： The present invention relates to an apparatus for using the hydrodynamic cavitation in medical treatment such as destroying kidney stones or killing infected cancer cells. This apparatus comprising a tank used as a container for a fluid,a compressor which is connected to the tank in order to maintain the input pressure of the fluid, a tubing in which the fluid flows,a probe in which the cavitation occurs,a valve, which is positioned inside the tubing, allowing the fluid to flow into the probe,a filter, which is positioned inside the tubing, preventing the predetermined size particles flow into the probe,a fitting connecting the probe to the tubing, a flowmeter measuring the volume flow rate of the fluid through the probe,an image capturing unit capturing the sequential images of bubble growing and collapsing of the bubbles after the bubbles exit from the probe,a positioning assembly which adjusts the distance between the probe and the target surface and a control and data acquisition unit.

5. 发明公开

EP3927425A1 ROTARY MAGNETIC ACTUATION SYSTEM 有权
公开(公告)号：EP3927425A1
公开(公告)日：2021-12-29
申请号：EP19726520.0
申请日：2019-02-20
申请人： Sabanci Üniversitesi , Sabanci Üniversitesi Nanoteknoloji Arastirma Ve Uygulama Merkezi Sunum , KOC Universitesi
发明人： AKGÖNÜL, Sarp , ZUVIN, Merve , SEVGEN, Mükerrem Ilker , KOSAR, Ali , GÖZÜACIK, Devrim , KUTLU, Özlem , YAGCI ACAR, Havva
IPC分类号： A61N2/00 , C12N13/00 , A61N2/02 , C12N15/87

6. 发明授权

EP2568893B1 AN APPARATUS FOR USING HYDRODYNAMIC CAVITATION IN MEDICAL TREATMENT 有权
标题翻译：设备技术水力空化在医学治疗中的应用
公开(公告)号：EP2568893B1
公开(公告)日：2015-06-24
申请号：EP10723792.7
申请日：2010-05-14
申请人： Sabanci Universitesi
发明人： KOSAR, Ali
IPC分类号： A61B17/3203 , A61B17/225 , A61B19/00
CPC分类号： A61B17/2251 , A61B17/3203 , A61B90/37 , A61B2017/32032 , Y10T83/0453

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