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    • 2. 发明申请
    • GENOME-SCALE ANALYSIS OF ABERRANT DNA METHYLATION IN COLORECTAL CANCER
    • 染色体癌细胞DNA甲基化的基因分析
    • US20130065228A1
    • 2013-03-14
    • US13486988
    • 2012-06-01
    • TOSHINORI HINOUEHUI SHENDANIEL J. WEISENBERGERPETER W. LAIRD
    • TOSHINORI HINOUEHUI SHENDANIEL J. WEISENBERGERPETER W. LAIRD
    • C12Q1/68
    • C12Q1/6886C12Q2600/154C12Q2600/158
    • Particular aspects provide methods and compositions (e.g., gene marker panels) having substantial utility for at least one of diagnosis, identification and classification of colorectal cancer (CRC) (e.g., tumors) relating to distinctive DNA methylation-based subgroups of CRC including CpG island methylator phenotype (CIMP) groups (e.g., CIMP-H and CIMP-L) and non-CIMP groups. Exemplary marker panels include: B3GAT2, FOXL2, KCNK13, RAB31 and SLIT1 (CIMP marker panel); and FAM78A, FSTL1, KCNC1, MYOCD, and SLC6A4 (CIMP-H marker panel). Further aspects relate to genetic mutations, and other epigenetic markers relating to said CRC subgroups that can be used in combination with the gene marker panels for at least one of diagnosis, identification and classification of colorectal cancer (CRC) (e.g., tumors) relating to distinctive CIMP and non-CIMP groups.
    • 具体方面提供了方法和组合物(例如,基因标记物组),其具有与基于特异性DNA甲基化的CRC亚基(包括CpG岛)相关的结肠直肠癌(CRC)(例如肿瘤)的诊断,鉴定和分类中的至少一种的实质效用 甲基化表型(CIMP)组(如CIMP-H和CIMP-L)和非CIMP组。 示例性标记面板包括:B3GAT2,FOXL2,KCNK13,RAB31和SLIT1(CIMP标记物组); 和FAM78A,FSTL1,KCNC1,MYOCD和SLC6A4(CIMP-H标记物组)。 其它方面涉及遗传突变和与所述CRC亚组相关的其它表观遗传标记,其可以与基因标记物组合使用,用于诊断,鉴定和分类结肠直肠癌(CRC)(例如肿瘤)中的至少一种 独特的CIMP和非CIMP组。