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1. 发明申请

WO2014145002A2 LOW MOLECULAR WEIGHT SILK COMPOSITIONS AND STABILIZING SILK COMPOSITIONS 审中-公开
标题翻译：低分子量丝绸组合物和稳定的丝素组合物
公开(公告)号：WO2014145002A2
公开(公告)日：2014-09-18
申请号：PCT/US2014029636
申请日：2014-03-14
申请人： KLUGE JONATHAN A , OMENETTO FIORENZO G , KAPLAN DAVID L
发明人： KLUGE JONATHAN A , OMENETTO FIORENZO G , KAPLAN DAVID L
CPC分类号： A61K47/42 , A61K9/08 , A61K9/19 , A61K38/1825 , A61L27/3604 , B01J20/24 , C07H21/02 , C07K14/43518 , C07K14/43586 , C07K14/503 , C07K2319/00
摘要： The present disclosure provides certain silk-fibroin compositions with particular characteristics and/or properties. In some embodiments, the disclosure provides low molecular weight compositions. In some embodiments, the disclosure provides silk fibroin compositions that comprise an active (e.g., a biological) agent or component. In some embodiments, the disclosure provides low molecular weight silk fibroin compositions that comprise an active (e.g., a biological) agent or component. In some embodiments, an active agent is stabilized in a silk composition, e.g., for a period of time and/or against certain conditions or events. In some embodiments, a component present in a silk fibroin composition may be subject to analysis and/or characterization. In some embodiments, a component present in a silk fibroin composition may be recovered from the composition.
摘要翻译：本公开内容提供某些具有特征和/或性质的丝素蛋白组合物。在一些实施方案中，本公开提供了低分子量组合物。在一些实施方案中，本公开提供了包含活性（例如，生物）试剂或组分的丝素蛋白组合物。在一些实施方案中，本公开提供了包含活性（例如，生物）试剂或组分的低分子量丝素蛋白组合物。在一些实施方案中，活性剂在丝组合物中稳定，例如一段时间和/或某些条件或事件。在一些实施方案中，存在于丝素蛋白组合物中的组分可以进行分析和/或表征。在一些实施方案中，存在于丝素蛋白组合物中的组分可以从组合物中回收。

2. 发明申请

WO2012054582A3 SILK FIBROIN-BASED MICRONEEDLES AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：基于蚕丝蛋白的微针及其制备方法
公开(公告)号：WO2012054582A3
公开(公告)日：2012-07-12
申请号：PCT/US2011056856
申请日：2011-10-19
申请人： TUFTS COLLEGE , KAPLAN DAVID L , TSIORIS KONSTANTINOS , OMENETTO FIORENZO G , PRITCHARD ELEANOR M
发明人： KAPLAN DAVID L , TSIORIS KONSTANTINOS , OMENETTO FIORENZO G , PRITCHARD ELEANOR M
IPC分类号： A61M37/00 , A61L27/58 , A61M5/158
CPC分类号： A61L31/125 , A61B17/205 , A61K9/0021 , A61L31/047 , A61L31/16 , A61M5/158 , A61M37/0015 , A61M2037/0046 , A61M2037/0053
摘要： A microneedle or microneedle device includes a microneedle body extending from a base to a penetrating tip formed from a silk fibroin based material, which is easy to fabricate and highly biocompatible. The microneedle device can include one or more microneedles mounted to a substrate. The silk fibroin can include active agents to be transported into or across biological barriers such as skin, tissue and cell membranes. The silk fibroin microneedles can be fully or partially biodegradable and/or bioerodible. The silk fibroin is highly stable, affords room temperature storage and is implantable. The silk fibroin structure can be modulated to control the rate of active agent delivery.
摘要翻译：微针或微针装置包括从基部延伸到由基于丝素蛋白的材料形成的穿刺尖端的微针体，其易于制造且具有高生物相容性。微针装置可以包括安装到基底上的一个或多个微针。丝素蛋白可以包含要被运输进入或穿过生物屏障例如皮肤，组织和细胞膜的活性剂。丝素蛋白微针可以是完全或部分生物可降解的和/或生物可蚀解的。丝素蛋白非常稳定，可提供室温储存并可植入。可以调节丝素蛋白结构以控制活性剂递送的速率。

4. 发明申请

WO2011109691A3 SILK-BASED IONOMERIC COMPOSITIONS 审中-公开
标题翻译：基于SILK的离子组合物
公开(公告)号：WO2011109691A3
公开(公告)日：2012-02-09
申请号：PCT/US2011027153
申请日：2011-03-04
申请人： TUFTS COLLEGE , KAPLAN DAVID L , SERBAN MONICA A
发明人： KAPLAN DAVID L , SERBAN MONICA A
IPC分类号： C08L89/00 , C07K19/00 , C08H1/00 , C08L101/12
CPC分类号： A61L27/52 , A61K9/5063 , A61L15/26 , A61L15/32 , A61L15/42 , A61L27/18 , A61L27/227 , A61L27/26 , A61L27/50 , A61L27/54 , A61L2300/00 , Y10T428/2982 , C08L77/04
摘要： Disclosed herein are pH-dependent silk fibroin-based ionomeric compositions and colloids, and methods of making the same. The state of the silk fibroin ionomeric compositions is reversible and can transform from a gel-like colloid to a more fluid-like solution, or vice versa, upon an environmental stimulus, e.g., pH. Thus, the silk-based ionomeric compositions and colloids can be applied in various industries, ranging from electronic applications to biomedical applications, such as sensors, gel diodes, absorbent materials, drug delivery systems, tissue implants and contrast agents.
摘要翻译：本文公开了基于pH的丝心蛋白基离聚物组合物和胶体及其制备方法。丝素蛋白离聚物组合物的状态是可逆的，并且可以在诸如pH的环境刺激下从凝胶状胶体转化为更流体状的溶液，或反之亦然。因此，基于丝的离聚物组合物和胶体可以应用于各种行业，从电子应用到生物医学应用，例如传感器，凝胶二极管，吸收材料，药物递送系统，组织植入物和造影剂。

5. 发明申请

WO2011008842A2 ELECTROSPUN SILK MATERIAL SYSTEMS FOR WOUND HEALING 审中-公开
标题翻译： ELECTROSPUN丝绸材料系统用于创伤治疗
公开(公告)号：WO2011008842A2
公开(公告)日：2011-01-20
申请号：PCT/US2010041953
申请日：2010-07-14
申请人： TUFTS COLLEGE , UNIV MASSACHUSETTS FOUNDATION INC , ZHANG XIAOHUI , KAPLAN DAVID L , WHARRAM SCOTT E , MCCARTHY STEPHEN
发明人： ZHANG XIAOHUI , KAPLAN DAVID L , WHARRAM SCOTT E , MCCARTHY STEPHEN
IPC分类号： A61L15/22 , A61L15/32 , A61L15/36 , A61L15/44 , D01D5/00
CPC分类号： A61L15/40 , A61L15/225 , A61L15/44 , A61L2300/406 , A61L2300/62 , A61L2300/64 , D01D5/003 , D01F4/02 , D04H1/09 , D04H1/4266 , D04H1/728 , C08L71/02
摘要： The present invention relates to the processes of preparing silkfibroin/polyethylene oxide blended materials, and the resulting materials thereof, which are suitable for biomedical applications such as wound healing. In particular, the electrospun silk fibroin/PEO mats with a silk:PEO blend ratio of 2:1 to 4:1, treated with controlled evaporation, constraint-drying techniques, and/or alcohol treatment, and/or PEO extraction, demonstrate suitable physical and biofunctional properties, such as fiber structure, topography, absorption, water vapor transmission rates, oxygen permeation, and biodegradability, relevant to biomaterial systems with utility for wound dressings.
摘要翻译：本发明涉及制备丝纤蛋白/聚环氧乙烷共混材料的方法及其所得材料，其适用于生物医学应用如伤口愈合。特别地，具有丝绸：PEO混合比为2:1至4:1的电纺丝丝素/ PEO垫，用受控蒸发，约束干燥技术和/或醇处理和/或PEO提取处理，显示出合适的与用于伤口敷料的生物材料系统相关的物理和生物功能性质，例如纤维结构，形貌，吸收，水蒸汽透过率，氧渗透和生物降解性。

6. 发明申请

WO2009052448A3 ELECTRIC RESOURCE POWER METER IN A POWER AGGREGATION SYSTEM FOR DISTRIBUTED ELECTRIC RESOURCES 审中-公开
标题翻译：分布式电源电力集中系统中的电力电量表
公开(公告)号：WO2009052448A3
公开(公告)日：2009-07-16
申请号：PCT/US2008080392
申请日：2008-10-17
申请人： V2GREEN INC , BRIDGES SETH W , POLLACK SETH B , KAPLAN DAVID L
发明人： BRIDGES SETH W , POLLACK SETH B , KAPLAN DAVID L
IPC分类号： G06Q50/00
CPC分类号： G01D4/004 , G01R21/133 , Y02B90/242 , Y04S20/322
摘要： Systems and methods are described for a power aggregation system. In one implementation, an apparatus includes a meter operable to measure bidirectional energy transfer between an electric resource and a power grid during fixed or variable intervals of time, and an interface coupled to the meter and operable to send the measurements to a service that aggregates power of distributed electric resources as a function of the measurements.
摘要翻译：系统和方法描述了一个电源聚合系统。在一个实施方式中，一种设备包括可操作以在固定或可变时间间隔期间测量电力资源与电力网之间的双向能量转移的仪表，以及耦合至仪表并且可操作以将测量结果发送至聚集功率的服务的接口作为测量的函数的分布式电力资源。

7. 发明申请

WO2009052447A3 USER INTERFACE AND USER CONTROL IN A POWER AGGREGATION SYSTEM FOR DISTRIBUTED ELECTRIC RESOURCES 审中-公开
标题翻译：用于分布式电力资源的电力分配系统中的用户界面和用户控制
公开(公告)号：WO2009052447A3
公开(公告)日：2009-06-18
申请号：PCT/US2008080390
申请日：2008-10-17
申请人： V2GREEN INC , BRIDGES SETH W , POLLACK SETH B , KAPLAN DAVID L
发明人： BRIDGES SETH W , POLLACK SETH B , KAPLAN DAVID L
IPC分类号： G06Q50/00
CPC分类号： B60L11/1811 , B60L3/12 , B60L11/1816 , B60L11/184 , B60L11/1842 , B60L11/1846 , B60L11/1848 , B60L2230/16 , B60L2230/34 , B60L2240/72 , B60L2240/80 , B60L2250/10 , B60L2250/16 , B60L2260/52 , B60L2260/54 , B60L2260/58 , B60L2270/32 , G06Q30/0283 , H02J13/0079 , H02J13/0086 , Y02E60/721 , Y02T10/7005 , Y02T10/7088 , Y02T10/7291 , Y02T90/121 , Y02T90/127 , Y02T90/128 , Y02T90/14 , Y02T90/163 , Y02T90/169 , Y04S10/126 , Y04S30/14 , Y04S50/00 , Y04S50/14
摘要： Systems and methods are described for a power aggregation system. In one implementation, an electric charging station connected to a power grid includes a power connection operable to connect an electric resource to the electric charging station. Additionally, the electric charging station includes a user interface operable to provide a user access to information associated with the electric resource and the power grid.
摘要翻译：为功率聚合系统描述了系统和方法。在一个实施方式中，连接到电网的充电站包括可操作以将电力资源连接到充电站的电力连接。此外，充电站包括用户界面，其可操作以向用户提供对与电力资源和电网相关联的信息的访问。

8. 发明申请

WO2008073474A3 USER INTERFACE AND USER CONTROL IN A POWER AGGREGATION SYSTEM FOR DISTRIBUTED ELECTRIC RESOURCES 审中-公开
标题翻译：用于分布式电源的功率汇聚系统中的用户界面和用户控制
公开(公告)号：WO2008073474A3
公开(公告)日：2008-08-07
申请号：PCT/US2007025439
申请日：2007-12-11
申请人： V2GREEN INC , POLLACK SETH B , BRIDGES SETH W , KAPLAN DAVID L
发明人： POLLACK SETH B , BRIDGES SETH W , KAPLAN DAVID L
IPC分类号： H02J13/00
CPC分类号： B60L11/1848 , B60L3/12 , B60L11/1816 , B60L11/184 , B60L11/1842 , B60L11/1844 , B60L11/1846 , B60L2230/34 , B60L2240/70 , B60L2270/32 , H02J3/32 , H02J3/38 , H02J13/0079 , H02J13/0086 , H04L12/4625 , H04L67/12 , H04L67/125 , Y02B90/2669 , Y02E40/76 , Y02E60/721 , Y02E60/722 , Y02T10/7005 , Y02T10/7088 , Y02T10/7291 , Y02T90/121 , Y02T90/128 , Y02T90/14 , Y02T90/16 , Y02T90/163 , Y02T90/169 , Y04S10/126 , Y04S10/14 , Y04S10/545 , Y04S30/14 , Y04S40/128
摘要： Systems and methods are described for a power aggregation system. In one implementation, a service establishes individual Internet connections to numerous electric resources intermittently connected to the power grid, such as electric vehicles. The Internet connection may be made over the same wire that connects the resource to the power grid. The service optimizes power flows to suit the needs of each resource and each resource owner, while aggregating flows across numerous resources to suit the needs of the power grid. The service can bring vast numbers of electric vehicle batteries online as a new, dynamically aggregated power resource for the power grid. Electric vehicle owners can participate in an electricity trading economy regardless of where they plug into the power grid.
摘要翻译：系统和方法描述了一个电源聚合系统。在一个实施方式中，服务建立到间歇连接到电网的众多电力资源（例如电动车辆）的单独互联网连接。互联网连接可以通过将资源连接到电网的相同导线进行。该服务优化电力流量以适应每个资源和每个资源所有者的需求，同时汇集大量资源的流量以适应电网的需求。该服务可将大量电动车电池作为电网的新动态聚合电源。电动车主可以参与电力交易经济，而不管他们插入电网的位置。

9. 发明申请

WO2006028996A2 EMULSAN-ALGINATE MICROSPHERES AND METHODS OF USE THEREOF 审中-公开
标题翻译：微乳化微球及其使用方法
公开(公告)号：WO2006028996A2
公开(公告)日：2006-03-16
申请号：PCT/US2005031372
申请日：2005-09-02
申请人： TUFTS COLLEGE , KAPLAN DAVID L , CASTRO GUILLERMO R , PANILAITIS BRUCE
发明人： KAPLAN DAVID L , CASTRO GUILLERMO R , PANILAITIS BRUCE
IPC分类号： A61K9/50
CPC分类号： A61K9/167
摘要： The present invention relates generally to emulsan-alginate compositions and to methods of use. Methods are provided for use of emulsan-alginate compositions as drug delivery vehicles. In addition, methods are provided for use of emulsan-alginate compositions in applications requiring protein adsorption (e.g removal of protein toxins from food products or other products and solutions). The compositions of the invention avoid some of the problems seen in the art with alginate microspheres or particles.
摘要翻译：本发明一般涉及藻酸 - 海藻酸盐组合物和使用方法。提供了用作乳剂 - 藻酸盐组合物作为药物递送载体的方法。此外，提供了在需要蛋白质吸附的应用（例如从食品或其他产品和溶液中除去蛋白质毒素）的情况下使用乳藻 - 藻酸盐组合物的方法。本发明的组合物避免了藻酸盐微球或颗粒在本领域中看到的一些问题。

10. 发明申请

WO2011041395A3 SILK NANOSPHERES AND MICROSPHERES AND METHODS OF MAKING SAME 审中-公开
标题翻译：丝绸纳米球和微球及其制备方法
公开(公告)号：WO2011041395A3
公开(公告)日：2011-08-25
申请号：PCT/US2010050698
申请日：2010-09-29
申请人： TUFTS COLLEGE , WANG XIAOQIN , KAPLAN DAVID L
发明人： WANG XIAOQIN , KAPLAN DAVID L
IPC分类号： B82B3/00 , B82B1/00
CPC分类号： A61K9/5169 , A61K9/14 , A61K9/1605 , A61K9/1647 , A61K9/5052 , A61K9/5089 , A61K9/5192 , A61K31/352 , Y10T428/2982
摘要： The present invention provides for methods of preparing silk nanoparticles and microparticles, methods of encapsulating an active agent into the silk nano- and microparticles and compositions comprising these silk particles. In particular, the silk spheres are prepared from phase separation of silk and polyvinyl alcohol (PVA), without exposure to an organic solvent. The method employs a chemical, PVA, which is an FDA-approved ingredient in drug formulations. Different parameters can be adjusted to control the size and shape of the silk spheres during the fabrication process. The silk particle compositions of the present invention may also encapsulate active agents or chemicals. Such compositions allow the active agents to be controllably and sustainably released to the target organs or tissues. The silk composition entrapping active agents also provides for a long-term storage medium for the active agents so entrapped. The silk nano- and microparticles of the present invention are thus suitable for a variety of biomedical and pharmaceutical applications, such as drug delivery or tissue engineering.
摘要翻译：本发明提供制备丝纳米颗粒和微颗粒的方法，将活性剂包封到丝纳米颗粒和微颗粒中的方法以及包含这些丝颗粒的组合物。特别地，丝球由丝和聚乙烯醇（PVA）的相分离制备，而不暴露于有机溶剂。该方法使用化学药品PVA，它是药物制剂中FDA批准的成分。可以调整不同的参数来控制制造过程中丝球的尺寸和形状。本发明的丝粒组合物也可以包封活性剂或化学品。这样的组合物允许活性剂可控地并且可持续地释放到靶器官或组织。捕获活性剂的丝组合物也为这种包埋的活性剂提供了长期存储介质。因此，本发明的蚕丝纳米颗粒和微米颗粒适用于各种生物医学和药物应用，例如药物递送或组织工程。

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