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1. 发明申请

WO2009049268A1 INTEGRATED MICROFLUIDIC DEVICE AND METHODS 审中-公开
标题翻译：综合微流体装置及方法
公开(公告)号：WO2009049268A1
公开(公告)日：2009-04-16
申请号：PCT/US2008/079659
申请日：2008-10-10
申请人： KIONIX, INC. , ZHOU, Peng , YOUNG, Lincoln C. , ROSWECH, Todd , SPIZZ, Gwendolyn , CHEN, Zongyuan , THOMAS, Benjamin W. , LEE, Travis
发明人： ZHOU, Peng , YOUNG, Lincoln C. , ROSWECH, Todd , SPIZZ, Gwendolyn , CHEN, Zongyuan , THOMAS, Benjamin W. , LEE, Travis
IPC分类号： B01L3/00
CPC分类号： B01F13/0059 , B01F5/0683 , B01F5/0688 , B01F11/0074 , B01L3/50273 , B01L7/52 , B01L2200/027 , B01L2200/0621 , B01L2200/10 , B01L2300/0816 , B01L2300/1816 , B01L2300/1822 , B01L2300/1827 , B01L2300/1844 , B01L2300/185 , B01L2400/0487 , B01L2400/0638 , B01L2400/084
摘要： A microf luidic device for analyzing a sample of interest is provided. The tnicrof luidic device can comprise a microfluidic device body, wherein the microf luidic device body comprises a sample preparation area (101), a nucleic acid amplification area (102), a nucleic acid analysis area (103), and a network of fluid channels. Each of the sample preparation area (101), the nucleic acid amplification area (102) and the nucleic acid analysis area (103) are fluidly interconnected to at least one of the other two areas by at least one of the fluid channels. Using the microfluidic device, sample preparation can be combined with amplification of a biologically active molecule, and a suitable biological sample can be provided for analysis and/or detection of a molecule of interest. The small-scale apparatus and methods provided are easier, faster, less expensive, and equally efficacious compared to larger scale equipment for the preparation and analysisof a biological sample.
摘要翻译：提供了一种用于分析感兴趣样品的微流控装置。微流体装置可以包括微流体装置主体，其中微流体装置主体包括样品制备区域（101），核酸扩增区域（102），核酸分析区域（103）和流体通道网络。每个样品制备区域（101），核酸扩增区域（102）和核酸分析区域（103）通过至少一个流体通道流体地互连到另外两个区域中的至少一个区域。使用微流体装置，样品制备可以与生物活性分子的扩增相结合，并且可以提供合适的生物样品用于分析和/或检测目的分子。与用于生物样品的制备和分析的较大规模的设备相比，所提供的小型装置和方法更容易，更快，更便宜，并且同样有效。

2. 发明申请

WO2006043922A1 LAMINATED MICROFLUIDIC STRUCTURES AND METHOD FOR MAKING 审中-公开
标题翻译：层压微流体结构和制备方法
公开(公告)号：WO2006043922A1
公开(公告)日：2006-04-27
申请号：PCT/US2004/033791
申请日：2004-10-13
申请人： KIONIX, INC. , ZHOU, Peng , YOUNG, Lincoln, C.
发明人： ZHOU, Peng , YOUNG, Lincoln, C.
IPC分类号： C09J5/10
CPC分类号： B29C66/54 , B01L3/502707 , B01L2200/0689 , B01L2200/12 , B01L2300/0816 , B01L2300/0887 , B29C65/4815 , B29C65/483 , B29C65/4895 , B29C66/543 , B29C66/71 , B29L2031/756 , B29K2069/00 , B29K2033/08 , B29K2025/06
摘要： A method for making a polymeric microfluidic structure in which two or more components (layers) of the microfluidic structure are fixedly bonded or laminated with a weak solvent bonding agent, particularly acetonitrile or a mixture of acetonitrile and alcohol. In an aspect, acetonitrile can be used as a weak solvent bonding agent to enclose a microstructure fabricated in or on a non-elastomeric polymer such as polystyrene, polycarbonate, acrylic or other linear polymer to form a three-dimensional microfluidic network. The method involves the steps of wetting at least one of the opposing surfaces of the polymeric substrate components with the weak solvent bonding agent in a given, lower temperature range, adjacently contacting the opposing surfaces, and thermally activating the bonding agent at a higher temperature than the lower temperature range for a given period of time. The contacted polymeric substrates may also be aligned prior to thermal activation and compressed during thermal activation. A laminated, polymeric microfluidic structure is also disclosed.
摘要翻译：一种制备聚合物微流体结构的方法，其中微流体结构的两个或多个组分（层）用弱溶剂粘合剂，特别是乙腈或乙腈和醇的混合物固定粘合或层压。在一个方面，乙腈可以用作弱溶剂粘合剂以包围在非弹性聚合物如聚苯乙烯，聚碳酸酯，丙烯酸或其它线性聚合物中或其上制造的微结构，以形成三维微流体网络。该方法包括以下步骤：在给定的较低温度范围内用弱溶剂粘合剂润湿聚合物基材组分的至少一个相对表面，相邻地接触相对表面，并在比例在一定时间内较低的温度范围。接触的聚合物基材还可以在热活化之前对准，并在热活化期间被压缩。还公开了层压聚合物微流体结构。

3. 发明申请

WO2012115926A2 MICROFLUIDIC DEVICE-BASED NUCLEIC ACID PURIFICATION METHOD 审中-公开
标题翻译：基于微流体装置的核酸净化方法
公开(公告)号：WO2012115926A2
公开(公告)日：2012-08-30
申请号：PCT/US2012/025861
申请日：2012-02-21
申请人： RHEONIX, INC. , YOUNG, Lincoln C. , ZHOU, Peng , SPIZZ, Gwendolyn , YASMIN, Rubina
发明人： YOUNG, Lincoln C. , ZHOU, Peng , SPIZZ, Gwendolyn , YASMIN, Rubina
CPC分类号： C12N15/1013 , C12Q1/6806
摘要： A method is provided for purifying nucleic acid from a sample in a microfluidic device. The method can be used to purify nucleic acids from any source known in the art that comprises nucleic acids, such as prokaryotic or eukaryotic organisms, viruses, cell, tissues, organs, etc. In a specific example, the tissue is whole blood. The method for purifying nucleic acid may run fully automated in the microfluidic device.
摘要翻译：提供了一种用于从微流体装置中的样品中纯化核酸的方法。该方法可用于从本领域已知的任何来源纯化核酸，其包含核酸，例如原核或真核生物，病毒，细胞，组织，器官等。在具体实例中，组织是全血。纯化核酸的方法可以在微流体装置中完全自动化。

4. 发明申请

WO2011005495A2 DEVICES AND METHODS FOR DISPENSING A CRYOGENIC FLUID 审中-公开
标题翻译：用于分配低温流体的装置和方法
公开(公告)号：WO2011005495A2
公开(公告)日：2011-01-13
申请号：PCT/US2010/039423
申请日：2010-06-22
申请人： STC CONSULTING, LLC , NIEDBALA, R., Sam , YOUNG, Lincoln, C. , ZHOU, Peng
发明人： NIEDBALA, R., Sam , YOUNG, Lincoln, C. , ZHOU, Peng
IPC分类号： A61B18/02 , A61M11/00 , A61M35/00 , A61F7/12 , A61H39/06
CPC分类号： A61B18/0218 , A61B2018/0275
摘要： A dispensing head for dispensing a cryogenic fluid may compose a flow passage configured to be placed in flow communication with a reservoir containing a cryogenic fluid, the flow passage defining a flow passage inlet opening configured to receive the cryogenic fluid from the reservoir, and a flow passage outlet opening opposite the flow passage inlet opening. The dispensing head may further comprise a dispensing member configured to dispense the cryogenic fluid, the dispensing member defining a lumen having a lumen inlet opening and a lumen outlet opening, and at least one porous member disposed in the flow passage, the at least one porous member being configured as a primary flow regulation mechanism to limit a flow rate of the cryogenic fluid as it flows from the reservoir to the lumen outlet opening.
摘要翻译：用于分配低温流体的分配头可以构成流动通道，该流动通道构造成与包含低温流体的储存器流动连通，该流动通道限定流动通道入口开口，该流动通道入口开口构造成接收低温来自贮存器的流体以及与流动通道入口相对的流动通道出口开口。分配头还可包括配置成分配低温流体的分配构件，分配构件限定具有腔入口开口和腔出口开口的腔，以及设置在流动通道中的至少一个多孔构件，至少一个多孔构件构件被配置为主要流量调节机构以限制低温流体从贮存器流向内腔出口开口时的流速。

5. 发明申请

WO2007064404A3 MICROFLUIDIC MEMBRANE PUMP AND VALVE 审中-公开
公开(公告)号：WO2007064404A3
公开(公告)日：2007-06-07
申请号：PCT/US2006/039135
申请日：2006-10-03
申请人： KIONIX, INC. , YOUNG, Lincoln , ZHOU, Peng
发明人： YOUNG, Lincoln , ZHOU, Peng
IPC分类号： B01L3/00 , F04B43/04 , B32B27/00 , F04B53/10
摘要： Plastic microfluidic structures having a substantially rigid diaphragm that actuates between a relaxed state wherein the diaphragm sits against the surface of a substrate and an actuated state wherein the diaphragm is moved away from the substrate. As will be seen from the following description, the microfluidic structures formed with this diaphragm provide easy to manufacture and robust systems, as well readily made components such as valves and pumps.

6. 发明申请

WO2004103562A2 RECONFIGURABLE MODULAR MICROFLUIDIC SYSTEM AND METHOD OF FABRICATION 审中-公开
标题翻译：可重构的模块化微流体系统和制造方法
公开(公告)号：WO2004103562A2
公开(公告)日：2004-12-02
申请号：PCT/US2004/014811
申请日：2004-05-12
申请人： KIONIX, Inc. , ZHOU, Peng , YOUNG, Lincoln
发明人： ZHOU, Peng , YOUNG, Lincoln
IPC分类号： B01L
CPC分类号： B01L3/502715 , B01J2219/0081 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/028 , B01L2300/043 , B01L2300/0816 , B01L2300/0829 , B01L2300/0861 , B01L2300/0874 , G01N30/6082 , G01N30/6095 , Y10T29/49 , Y10T29/49002 , Y10T436/11 , Y10T436/117497 , Y10T436/118339 , G01N30/74 , G01N30/6047 , G01N2030/8881
摘要： A reconfigurable modular microfluidic system, providing a microfluidic breadboard platform for the formation of fluidic network and fluidic sealing upon a system assembly. Modular microfluidic elements or "chips" are arranged on a precisely machined alignment base to form a fluidic network, with fluid connections provided directly from chip-to-chip at overlapping corners. Fluidic access to external devices is possible at every fluid connection and through special ingress/egress chips. By maintaining a largely planar layout, optical access is provided for detecting or visualization for every chip. The assembly may be covered by a perforated cover plate.
摘要翻译：可重构模块化微流体系统，提供用于在系统组件上形成流体网络和流体密封的微流体面包板平台。模块化微流体元件或“芯片”被布置在精确加工的对准基底上以形成流体网络，其中在重叠的角落处直接从芯片到芯片提供流体连接。在每个流体连接和特殊的入口/出口芯片处都可以对外部设备进行流体访问。通过维持大体平面的布局，提供了光学访问，用于每个芯片的检测或可视化。组件可以被穿孔盖板覆盖。

7. 发明申请

WO2010132753A1 BATTERY PACK HEAT EXCHANGER, SYSTEMS, AND METHODS 审中-公开
标题翻译：电池组热交换器，系统和方法
公开(公告)号：WO2010132753A1
公开(公告)日：2010-11-18
申请号：PCT/US2010/034876
申请日：2010-05-14
申请人： SINOELECTRIC POWERTRAIN INC , ZHOU, Peng
发明人： ZHOU, Peng
IPC分类号： H01M10/50
CPC分类号： F28D15/02 , H01M2/105 , H01M2/1077 , H01M2/1083 , H01M10/0525 , H01M10/613 , H01M10/617 , H01M10/643 , H01M10/653 , H01M10/6554 , H01M10/6561 , H01M10/6567 , H01M10/6568 , H01M10/6569 , Y02T10/7011
摘要： A battery pack heat exchanger, system, and method comprises a plurality of battery modules comprising a heat exchanger having an outer shell and a plurality of cylinders extending within the outer shell. A plurality of battery cells are positioned within the plurality of cylinders and a coolant is poured into the shell via a fill port. As a result, the coolant is able to absorb and dissipate localized heat produced by the battery cells throughout the heat exchanger. Therefore, if one battery cell undergoes a thermal run-away, the heat will be distributed throughout the shell volume thereby greatly reducing the likelihood that battery cells directly adjacent the run-away cell absorb the brunt of the heat and undergo thermal run-away themselves.
摘要翻译：电池组热交换器，系统和方法包括多个电池模块，其包括具有外壳和在外壳内延伸的多个气缸的热交换器。多个电池单元位于多个气缸内，并且冷却剂经由一个填充口注入壳体。结果，冷却剂能够吸收并消散由整个热交换器中的电池单元产生的局部热。因此，如果一个电池单元遭受热损失，则热量将分布在整个壳体内，从而大大降低了直接邻近排空电池的电池单元吸收热量的首要因素并经受热自身脱落的可能性。

8. 发明申请

WO2010025595A1 PROTECTIVE DEVICE 审中-公开
标题翻译：保护装置
公开(公告)号：WO2010025595A1
公开(公告)日：2010-03-11
申请号：PCT/CN2008/072276
申请日：2008-09-05
申请人： ROBERT BOSCH GMBH , ZHOU, Peng , JIANG, Xianbin , WIKER, Juergen
发明人： ZHOU, Peng , JIANG, Xianbin , WIKER, Juergen
IPC分类号： B27G19/02 , B23D45/16 , B27B9/00 , B25D17/24
CPC分类号： B27B9/00 , B27G19/04
摘要： A protective device for a machine tool (12a), in particular a circular saw, includes a protective hood (14a-k) which can be moved between at least one working position and a protecting position and a return-momentum reducing unit (16a-k) which is provided for the purpose of at least partially reducing the rebound of the protective hood (14a-k) when the protecting position is reached. The prevent invention provides a better protection for an operator.
摘要翻译：用于机床（12a），特别是圆锯的保护装置包括可在至少一个工作位置和保护位置之间移动的保护罩（14a-k）和返回动量降低单元（16A- k），其用于当达到保护位置时至少部分地减少保护罩（14a-k）的回弹。防止发明为操作者提供更好的保护。

9. 发明申请

WO2003062756A3 APPARATUS FOR DISPENSING POWDER IN AN ARRAY 审中-公开
公开(公告)号：WO2003062756A3
公开(公告)日：2003-07-31
申请号：PCT/US2003/002396
申请日：2003-01-24
申请人： BRISTOL-MYERS SQUIBB COMPANY , ZHOU, Peng , KUSPIEL, Edward, Joseph , RUEDIGER, Waldemar , BERTOK, Alexander , TRPISOVSKY, Carl, J.
发明人： ZHOU, Peng , KUSPIEL, Edward, Joseph , RUEDIGER, Waldemar , BERTOK, Alexander , TRPISOVSKY, Carl, J.
IPC分类号： G01F11/20
摘要： A bifurcated bracket (12) carries two powder dispensing assemblies (B). Each assembly includes a powder reservoir (20) and a rotatable screw (64) received within a compliant silicone sleeve (74). The outer diameter of the screw is slightly larger than the inner diameter of the sleeve such that the screw blade maintains direct contact with the sleeve wall as the screw is rotated. The bracket is sequentially moved to align each assembly with containers in two arrays. Each array of containers is situated in a tray. The trays are manually positioned on independent scales which generate signals that are a function of the sensed weight of each array. To fill each container, the screw in the aligned assembly is rotated at a high rate for an initial period and then at a slower rate. The scales are operational only during the slower rate period. Assembly movement and screw rotation are computer controlled.

10. 发明申请

WO2011106315A1 SELF-CONTAINED BIOLOGICAL ASSAY APPARATUS, METHODS, AND APPLICATIONS 审中-公开
标题翻译：自包含生物测定装置，方法和应用
公开(公告)号：WO2011106315A1
公开(公告)日：2011-09-01
申请号：PCT/US2011/025712
申请日：2011-02-22
申请人： RHEONIX, INC. , ZHOU, Peng , YOUNG, Lincoln , THOMAS, Benjamin , CHEN, Zongyuan , MOUCHKA, Greg , ROSWECH, Todd , SPIZZ, Gwendolyn , YASMIN, Rubina
发明人： ZHOU, Peng , YOUNG, Lincoln , THOMAS, Benjamin , CHEN, Zongyuan , MOUCHKA, Greg , ROSWECH, Todd , SPIZZ, Gwendolyn , YASMIN, Rubina
IPC分类号： G01N35/10 , G01N33/50
CPC分类号： C12Q1/6806 , B01L3/022 , B01L3/5027 , B01L3/502753 , B01L7/52 , B01L2200/0647 , B01L2200/0689 , B01L2200/141 , B01L2200/142 , B01L2300/044 , B01L2300/0681 , B01L2300/0829 , B01L2300/0838 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2300/088 , B01L2300/0887 , B01L2400/043 , B01L2400/0481 , B01L2400/0666 , C12Q1/6846 , C12Q1/686 , C12Q1/6883 , C12Q1/708 , G01N35/1002 , C12Q2565/629
摘要： A self-contained, fully automated, biological assay-performing apparatus includes a housing; a dispensing platform including a controllably-movable reagent dispensing system, disposed in the housing; a reagent supply component disposed in the housing; a pneumatic manifold removably disposed in the housing in a space shared by the dispensing platform, removably coupled to a fluidic transport layer and a plurality of reservoirs, wherein the fluidic transport layer, the reservoirs, and a test sample to be introduced therein are disposed in the housing in the space separate from the dispensing platform; a pneumatic supply system removably coupled to the pneumatic manifold in the housing in a space separate from the dispensing platform; and a control system coupled to at least one of the dispensing platform and the pneumatic supply system, disposed in the housing.
摘要翻译：独立的，完全自动化的生物测定执行装置包括壳体; 包括设置在所述壳体中的可控制的试剂分配系统的分配平台; 设置在所述壳体中的试剂供应部件; 气动歧管，其可移除地设置在由分配平台共享的空间中的可拆卸地联接到流体输送层和多个储存器的壳体中，其中流体输送层，储存器和待引入其中的测试样品设置在空间中的壳体与分配平台分离; 气动供给系统，其可拆卸地联接到与分配平台分离的空间中的壳体中的气动歧管; 以及耦合到所述分配平台和所述气动供应系统中的至少一个的控制系统，设置在所述壳体中。

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