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1. 发明申请

WO2014144247A1 HANDLE MECHANISM AND FUNCTIONALITY FOR REPOSITIONING AND RETRIEVAL OF TRANSCATHETER HEART VALVES 审中-公开
标题翻译：手持式心脏瓣膜检查和检查的手柄机制与功能
公开(公告)号：WO2014144247A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/028576
申请日：2014-03-14
申请人： KHERADVAR, Arash , KELLEY, Gregory S. , GHARIB, Morteza
发明人： KHERADVAR, Arash , KELLEY, Gregory S. , GHARIB, Morteza
IPC分类号： A61F2/95 , A61F2/82 , A61M25/09
CPC分类号： A61F2/2439 , A61F2/2418 , A61F2002/9505 , A61F2002/9517 , A61F2220/0033 , A61F2250/0006
摘要： Improved catheter devices for delivery, repositioning and/or percutaneous retrieval of percutaneously implanted heart valves are described, including a medical device handle that provides an array of features helpful in conducting a percutaneous heart valve implantation procedure while variously enabling radial expansion or contraction and/or lateral positioning control over the heart valve during the medical procedure.
摘要翻译：描述了用于经皮植入的心脏瓣膜的输送，重新定位和/或经皮取回的改进的导管装置，包括提供有助于进行经皮心脏瓣膜植入程序的特征阵列的医疗装置手柄，同时使径向扩张或收缩和/或在医疗过程中对心脏瓣膜进行横向定位控制。

2. 发明申请

WO2013022798A1 PERCUTANEOUS HEART VALVE DELIVERY SYSTEMS 审中-公开
标题翻译： PERCUTANEOUS心脏瓣膜输送系统
公开(公告)号：WO2013022798A1
公开(公告)日：2013-02-14
申请号：PCT/US2012/049645
申请日：2012-08-03
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , KHERADVAR, Arash , KELLEY, Gregory, S. , GHARIB, Morteza
发明人： KHERADVAR, Arash , KELLEY, Gregory, S. , GHARIB, Morteza
IPC分类号： A61F2/06
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2439 , A61F2230/0054
摘要： Embodiments described herein address the need for improved catheter devices for delivery, repositioning and/or percutaneous retrieval of the percutaneously implanted heart valves. One embodiment employs a plurality of spring-loaded arms releasably engaged with a stent frame for controlling expansion for valve deployment. Another embodiment employs a plurality of filaments passing through a distal end of a pusher sleeve and apertures in a self- expandable stent frame to control its state deployment. Yet another embodiment includes plurality of outwardly biased arms held to complimentary stent frame features by overlying sheath segments. Variations on hardware and methods associated with the use of these embodiments are contemplated in addition to those shown and described.
摘要翻译：本文描述的实施例解决了对用于经皮植入的心脏瓣膜的输送，重新定位和/或经皮取出的改进的导管装置的需要。一个实施例采用可释放地与支架框架接合的多个弹簧加载臂，用于控制阀部署的膨胀。另一个实施例采用多个细丝穿过推进套筒的远端和自扩张支架框架中的孔，以控制其状态展开。又一个实施例包括多个向外偏置的臂，通过覆盖护套段保持到互补的支架框架特征。除了显示和描述的之外，还考虑了与使用这些实施例相关联的硬件和方法的变化。

3. 发明申请

WO2009009131A2 CARDIAC ASSIST SYSTEM USING HELICAL ARRANGEMENT OF CONTRACTILE BANDS AND HELICALLY-TWISTING CARDIAC ASSIST DEVICE 审中-公开
标题翻译： CARDIAC辅助系统使用合同安全套装和直升机辅助装置
公开(公告)号：WO2009009131A2
公开(公告)日：2009-01-15
申请号：PCT/US2008/008539
申请日：2008-07-11
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , GHARIB, Morteza , KHERADVAR, Arash , GROSBERG, Anna
发明人： GHARIB, Morteza , KHERADVAR, Arash , GROSBERG, Anna
IPC分类号： A61M1/10
CPC分类号： A61M1/1068 , A61F2/2478 , A61F2/2481 , A61F2/915 , A61M1/1003 , A61M1/1048 , A61M1/1049 , A61M1/1056 , A61M1/1058 , A61M1/12 , A61M1/122 , A61M1/127 , A61M1/36 , A61M2205/0283 , A61N1/36 , A61N1/3627 , A61N1/36514 , A61N1/36521
摘要： A cardiac assist system using a helical arrangement of contractile bands and a helically-twisting cardiac assist device are disclosed. One embodiment discloses a cardiac assist system comprising at least one contractile elastic band helically arrangement around a periphery of a patient's heart, where upon an actuation the band contracts helically, thereby squeezing the heart and assisting the pumping function of the heart. Another embodiment discloses a helically twisting cardiac-apex assist device comprising an open, inverted, substantially conical chamber with two rotatable ring portions of different diameters located at the base and apex of the chamber, with a plurality of substantially helical connecting elements positioned substantially flush with the chamber wall and connecting the two rotatable ring portions, whereby a relative twisting motion of the two rings causes a change in volume of the chamber thereby assisting the cardiac pumping function.
摘要翻译：公开了使用收缩带的螺旋排列和螺旋扭转心脏辅助装置的心脏辅助系统。一个实施方案公开了一种心脏辅助系统，其包括至少一个收缩弹性带，其围绕患者心脏的周边螺旋地布置，其中当致动带时，螺旋状地收缩，从而挤压心脏并辅助心脏的泵送功能。另一实施例公开了一种螺旋扭转心尖辅助装置，其包括开放的，倒置的基本上圆锥形的腔室，其具有位于腔室的基部和顶点处的不同直径的两个可旋转环部分，多个基本上螺旋的连接元件基本上与腔室壁并且连接两个可旋转的环部分，由此两个环的相对扭转运动导致腔室的体积变化，从而辅助心脏泵送功能。

4. 发明申请

WO2008091493A1 IN-SITU FORMATION OF A VALVE 审中-公开
标题翻译：现场形成阀门
公开(公告)号：WO2008091493A1
公开(公告)日：2008-07-31
申请号：PCT/US2008/000277
申请日：2008-01-08
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , GHARIB, Morteza , KHERADVAR, Arash
发明人： GHARIB, Morteza , KHERADVAR, Arash
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2/2439 , A61F2220/0016 , A61F2220/005 , A61F2220/0066 , A61F2230/0054
摘要： An in-situ forming valve (840), comprising: an expandable component (800) and a sheet (810) with a distal circumference and a proximal. circumference, the distal circumference of the sheet held in at least partial contact with the distal end of the expandable component and an at least one link (820) detachably attached to at least one point of the proximal end of the sheet, the link configured to evert the proximal end of the sheet component into the hollow portion of the expandable component thereby forming a functional valve in situ. The link may be a fiber or a pivotable prong (820).
摘要翻译：一种原位成形阀（840），包括：具有远端圆周和近端的可膨胀部件（800）和片材（810）。所述片材的远端圆周保持与所述可扩张部件的远端至少部分接触，以及至少一个可拆卸地连接到所述片材的近端的至少一个点上的连杆（820），所述连杆被配置成将片材组件的近端转移到可膨胀部件的中空部分中，从而在原位形成功能阀。该链接可以是光纤或可枢转叉（820）。

5. 发明申请

WO2011126572A9 AN EXPANDABLE STENT THAT COLLAPSES INTO A NON-CONVEX SHAPE AND EXPANDS INTO AN EXPANDED, CONVEX SHAPE 审中-公开
公开(公告)号：WO2011126572A9
公开(公告)日：2011-10-13
申请号：PCT/US2011/000636
申请日：2011-04-07
申请人： OFFICE OF TECHNOLOGY TRANSFER , KHERADVAR, Arash , GHARIB, Morteza
发明人： KHERADVAR, Arash , GHARIB, Morteza
IPC分类号： A61M29/02 , A61F2/82 , A61L27/58 , A61L27/04 , A61L27/28 , A61L27/54 , A61F2/84
摘要： An expandable stent that can transform between a collapsed state and an expanded state is described. The stent includes a first cross-sectional shape and a second cross-sectional shape. The first cross-sectional shape is a non-convex shape when the stent is in the collapsed state. Alternatively, the second cross-sectional shape is a convex shape when the stent is in an expanded state. The stent can be formed of super elastic Nitinol, which allows it to be shape set in the desired shape. Due to its shape setting properties and the non- convex cross-section, the stent is capable of dramatically reducing its cross-sectional radial profile which is beneficial in a variety of procedures.

6. 发明申请

WO2006110228A3 IMPLANTABLE SMALL PERCUTANEOUS VALVE AND METHODS OF DELIVERY 审中-公开
公开(公告)号：WO2006110228A3
公开(公告)日：2006-10-19
申请号：PCT/US2006/007022
申请日：2006-02-27
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , KHERADVAR, Arash , RAVICHANDRAN, Guruswami , GHARIB, Morteza
发明人： KHERADVAR, Arash , RAVICHANDRAN, Guruswami , GHARIB, Morteza
IPC分类号： A61F2/24
摘要： An implantable prosthetic valve that is transformable from a first helical pre-implantation configuration to a second valvular functional configuration, and methods of delivery.

7. 发明申请

WO2008100382A2 MONOLITHIC IN-SITU FORMING VALVE SYSTEM 审中-公开
标题翻译：单相成形阀系统
公开(公告)号：WO2008100382A2
公开(公告)日：2008-08-21
申请号：PCT/US2008/001321
申请日：2008-01-30
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , GHARIB, Morteza , KHERADVAR, Arash
发明人： GHARIB, Morteza , KHERADVAR, Arash
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2415 , A61F2/2475 , A61F2/88 , A61F2220/0066 , A61F2230/0054 , A61F2230/0091
摘要： Described is a monolithic in situ forming valve system. The valve system is delivered in an unformed, collapsed configuration that lacks any functional characteristics commonly associated with a valve before. However, once expanded, the system is transformed into a competent valve for use in a wide variety of applications. The valve system includes a superior expandable structure, an inferior expandable structure, and a helical pre-valve component. The helical pre-valve component comprises a first end attached with the superior expandable structure and a second end attached with the inferior expandable structure. The helical pre-valve component is formed such that expansion of the superior expandable structure and the inferior expandable structure causes the helical pre-valve structure to transform into a functional valve held between each of the expandable structures.
摘要翻译：描述了一种单片原位成型阀系统。阀系统以未成形的，倒塌的构造递送，其缺乏通常与阀之前相关联的功能特征。然而，一旦扩大，该系统将转变为适用于各种应用的主管阀门。阀系统包括优异的可膨胀结构，下部可膨胀结构和螺旋预阀部件。螺旋预阀部件包括附接有上可膨胀结构的第一端和附接有下可膨胀结构的第二端。螺旋预阀部件形成为使得上部可膨胀结构和下部可膨胀结构的膨胀导致螺旋形预阀结构转变成保持在每个可膨胀结构之间的功能阀。

9. 发明申请

WO2014018456A1 MULTI-LAYERED LIQUID-DIODE FABRIC AND PRODUCTS 审中-公开
标题翻译：多层液体二极体织物和产品
公开(公告)号：WO2014018456A1
公开(公告)日：2014-01-30
申请号：PCT/US2013/051518
申请日：2013-07-22
申请人： GHARIB, Morteza , GAT, Amir , VAHDANI, Aria
发明人： GHARIB, Morteza , GAT, Amir , VAHDANI, Aria
IPC分类号： D06M17/00 , A41D31/02 , A43B1/00
CPC分类号： B32B5/02 , A41B11/005 , A41D27/00 , A41D31/0016 , A41D2400/22 , A43B1/00 , A43B7/125 , A43B19/00 , A43B23/022 , F16K15/14 , Y10T137/7879 , Y10T428/249921 , Y10T428/249962 , Y10T428/2835
摘要： Multi-layer fabrics and products incorporating the same are described in which the fabrics are configured to provide asymmetric resistance to liquid flow from one side of the fabric to the other. In garments or other products worn by a user, the effect can be utilized to prevent penetration of liquids (e.g., rain droplets) and contact of liquids from the exterior with the user's skin while allowing for extraction of droplets (e.g., sweat) in contact with an inner layer of the fabric out of contact with the skin and accelerating their evaporation. Medical and industrial applications of the fabric are contemplated as well.
摘要翻译：描述了包含其的多层织物和产品，其中织物被配置为对从织物的一侧到另一侧的液体流提供不对称的阻力。在用户佩戴的服装或其他产品中，可以利用该效果来防止液体（例如，雨滴）的渗透和来自外部的液体与使用者的皮肤的接触，同时允许提取接触中的液滴（例如汗液）织物的内层与皮肤接触并加速它们的蒸发。也可以考虑织物的医疗和工业应用。

10. 发明申请

WO2011008986A2 A METHOD APPLYING HEMODYNAMIC FORCING AND KLF2 TO INITIATE THE GROWTH AND DEVELOPMENT OF CARDIAC VALVES 审中-公开
标题翻译：应用血液动力学和KLF2的方法来启动心脏瓣膜的生长和发育
公开(公告)号：WO2011008986A2
公开(公告)日：2011-01-20
申请号：PCT/US2010/042176
申请日：2010-07-15
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , GHARIB, Morteza , RINDERKNECHT, Derek , FOROUHAR, Arian , VERMOT, Julien , FRASER, Scott, E.
发明人： GHARIB, Morteza , RINDERKNECHT, Derek , FOROUHAR, Arian , VERMOT, Julien , FRASER, Scott, E.
IPC分类号： C12N5/071 , C12N5/02 , A61F2/06 , A61F2/24 , C12M3/00
CPC分类号： A61L27/3625 , A61F2/2415 , A61L27/3834 , A61L27/507 , A61L2430/20 , C12M21/08 , C12M25/14 , C12M29/12 , C12M35/04 , C12N5/0657 , C12N2501/15 , C12N2501/165 , C12N2521/00
摘要： A method for forming a cardiovascular structure in culture is provided. The method includes applying mechanical force to a cell population in culture such that a cardiovascular structure is formed. In some embodiments, the mechanical force is produced in culture medium by a pulsatile liquid flow with a retrograde component. The cell population can include stem cells or differentiated cells, or combinations of both. In particular embodiments, a cardiovascular valve is formed. Scaffolds for the support and growth of the cell population, and bioreactors including the scaffolds, are also provided.
摘要翻译：提供了一种在培养中形成心血管结构的方法。该方法包括对培养物中的细胞群体施加机械力，从而形成心血管结构。在一些实施方案中，通过具有逆行组分的脉动液体流在培养基中产生机械力。细胞群可包括干细胞或分化细胞，或两者的组合。在特定实施例中，形成心血管瓣膜。还提供了用于支持和生长细胞群体的支架，以及包括支架的生物反应器。

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