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1. 发明专利

AT390107T 未知
公开(公告)号：AT390107T
公开(公告)日：2008-04-15
申请号：AT98958109
申请日：1998-11-25
申请人： KERAPLAST TECH LTD
发明人： TIMMONS SCOTT , BLANCHARD CHERYL , SMITH ROBERT
IPC分类号： A61F13/00 , A61K9/70 , A61K35/36 , A61K38/00 , A61K38/17 , A61K38/39 , A61L15/00 , A61L15/32 , A61L26/00 , A61L27/22 , A61L27/34 , A61L27/60 , A61L31/04 , A61L31/10 , C07K14/47 , C08G63/48 , C08G63/91 , C08H1/06 , C08L89/00 , C12N5/00
摘要： Methods for producing thin keratin films, sheets, and bulk materials, and products formed using these methods. One method includes providing hair, reducing the hair such that the disulfide linkages are broken and free cysteine thiol groups formed, separating out a more soluble keratin fraction in solution, forming a thin layer from the more soluble fraction, and air drying the keratin fraction in the presence of oxygen, thereby forming new disulfide bonds imparting strength to the resulting thin keratin film. One method includes reducing hair by heating the hair under nitrogen in an ammonium hydroxide and ammonium thioglycolate solution followed by centrifuging and collecting the supernatant containing the more soluble keratin fraction. The more soluble keratin in this method is precipitated using HCl, removed, and resuspended in ammonium hydroxide. The keratin solution thus formed is poured onto a flat surface and allowed to air dry into a thin keratin film. The film may be used as a wound dressing, a tissue-engineering scaffold, a diffusion membrane, a coating for implantable devices, and as a cell encapsulant. In another method, the keratin solution thus formed is concentrated, poured into a mold, and allowed to air dry into a three dimensional keratin product. The resulting bulk product can be used as a cross-linked implantable biomaterial for soft and hard tissue replacement. In another method, a keratin solution is emulsified and freeze dried, forming a porous, open cell keratin material.

2. 发明专利

AT386571T 未知
公开(公告)号：AT386571T
公开(公告)日：2008-03-15
申请号：AT98958709
申请日：1998-11-25
申请人： KERAPLAST TECH LTD
发明人： BLANCHARD CHERYL , TIMMONS SCOTT , SMITH ROBERT
IPC分类号： A61Q5/00 , A61K38/00 , A61K38/17 , A61K38/39 , A61L26/00 , A61L27/22 , A61L27/34 , A61L27/52 , A61L27/60 , A61L31/04 , A61L31/10 , C07K1/00 , C07K14/00 , C07K14/47 , C07K16/00 , C08G63/48 , C08G63/91 , C08H1/06
摘要： A keratin hydrogel which can be used as a wound dressing and cell scaffolding. The keratin hydrogel is formed from clean, washed hair by partially oxidizing a significant percentage of disulfide linkages to form cysteic acid groups, while some disulfide linkages remain intact. The partially oxidized hair is treated with a reducing agent, thereby reducing most of the remaining disulfide linkages to cysteine-thioglycollate disulfide and cysteine groups. A soluble fraction of hair is collected and oxidized, such that the reduced sulfur groups are allowed to reform disulfide linkages, thereby binding the keratin together. The cysteic acid groups remain, providing hydrophilic sites within the hydrogel. A higher degree of partial oxidation results in a greater abundance of hydrophilic cysteic acid groups in the hydrogel.

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