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1. 发明专利

AU2002351118A1 USE OF (R)-VERAPAMIL FOR THE TREATMENT OF ABNORMAL INCREASES IN GASTROINTESTINAL MOTILITY 未知
公开(公告)号：AU2002351118A1
公开(公告)日：2004-05-04
申请号：AU2002351118
申请日：2002-11-15
申请人： KELLY JOHN , DEVANE JOHN
发明人： KELLY JOHN , DEVANE JOHN
IPC分类号： A61K31/277 , A61P1/06
摘要： The present invention is directed to methods of treating, and/or managing abnormal increases in gastrointestinal motility, and intestinal conditions that cause the same. Such conditions include, but are not limited to, irritable bowel syndrome (IBS), infectious diseases of the small and large intestines, and symptoms of any of the foregoing. In particular, the present invention discloses methods of using enriched (R)-verapamil, as well as compositions and formulations containing the same.

2. 发明申请

WO2004014849A2 ISOSORBIDE MONONITRATE COMPOSITIONS AND METHODS OF THEIR USE 审中-公开
标题翻译：异硫氰酸酯单体化合物及其使用方法
公开(公告)号：WO2004014849A2
公开(公告)日：2004-02-19
申请号：PCT/IB0304245
申请日：2003-08-08
申请人： BIOVAIL LAB INC , DEVANE JOHN , STARK PAUL , KELLY JOHN , BUTLER JACKIE
发明人： DEVANE JOHN , STARK PAUL , KELLY JOHN , BUTLER JACKIE
IPC分类号： C07D493/04 , A61K9/20 , A61K9/22 , A61K9/28 , A61K9/32 , A61K9/50 , A61K9/58 , A61K31/34 , A61K47/12 , A61K47/20 , A61K47/32 , A61K47/34 , A61K47/38 , A61P9/04 , A61P9/10 , C07D
CPC分类号： A61K9/5078 , A61K9/2054 , A61K9/2846 , A61K9/5026 , A61K9/5047 , A61K31/34
摘要： The present invention relates to delayed onset, extended release formulations of isosorbide mononitrates (ISMNs), and methods of their use in treating, preventing, reducing, reversing, and/or managing nitrate tolerance and/or cardiovascular conditions. In particular, the present invention is directed to once-daily delayed onset, extended release formulations that (1) provide a subject with a therapeutically effective amount of ISMNs during the early morning hours prior to and after awakening, (2) continue to provide therapeutically effective amounts of ISMN throughout the waking hours of the day, and (3) provide a reduction, or washout, of ISMN plasma levels to treat, prevent, reduce, reverse, and/or manage nitrate tolerance.
摘要翻译：本发明涉及异山梨醇单硝酸盐（ISMN）的延迟开始，延长释放制剂及其用于治疗，预防，减少，逆转和/或控制硝酸盐耐受性和/或心血管疾病的方法。特别地，本发明涉及每日一次延迟发作的延长释放制剂，其（1）在醒来之前和之后的清晨时间向受试者提供治疗有效量的ISMNs，（2）继续提供治疗在一天的醒来时间内有效量的ISMN，以及（3）提供ISMN血浆水平的减少或清除以治疗，预防，减少，逆转和/或控制硝酸盐耐受性。

3. 发明申请

WO2009090453A2 COMPOSITIONS AND METHODS HAVING MT1 RECEPTOR ACTIVITY 审中-公开
标题翻译：具有MT1受体活性的组合物和方法
公开(公告)号：WO2009090453A2
公开(公告)日：2009-07-23
申请号：PCT/IB2008002678
申请日：2008-07-09
申请人： AGI THERAPEUTICS RES LTD , DEVANE JOHN , KELLY JOHN , MARTIN MARY
发明人： DEVANE JOHN , KELLY JOHN , MARTIN MARY
CPC分类号： A61K31/00 , A61K31/277 , A61K45/06
摘要： The present invention is directed to compositions and to methods comprising a composition comprising a therapeutically effective amount of a pharmaceutically active agent such as (R)-verapamil, a derivative thereof, or a pharmaceutically acceptable salt thereof, wherein the composition treats and/or manages at least one condition having MT1 receptor activity and releases the pharmaceutically active agent, a derivative thereof or a pharmaceutically acceptable salt thereof to exhibit a primary activity on the MT1 receptor such as, exhibiting at least five times more activity on the MT1 receptor compared with the MT2 receptor.
摘要翻译：本发明涉及组合物和方法，其包含包含治疗有效量的药物活性剂如（R） - 维拉帕米，其衍生物或其药学上可接受的盐的组合物，其中所述组合物治疗和/或管理至少一种具有MT1受体活性的条件，并释放其药物活性剂，其衍生物或其药学上可接受的盐，以在MT1受体上显示出主要活性，例如与MT1受体相比表现出至少五倍的活性 MT2受体。

4. 发明申请

WO2008029300A2 METHODS FOR TREATING AT LEAST ONE CONDITION HAVING MT1 RECEPTOR, 5HT2B RECEPTOR, AND L-TYPE CALCIUM CHANNEL ACTIVITY 审中-公开
标题翻译：用于处理具有MT1受体，5HT2B受体和L型钙通道活性的至少一种条件的方法
公开(公告)号：WO2008029300A2
公开(公告)日：2008-03-13
申请号：PCT/IB2007004185
申请日：2007-07-18
申请人： AGI THERAPEUTICS RES LTD , DEVANE JOHN , KELLY JOHN , MARTIN MARY
发明人： DEVANE JOHN , KELLY JOHN , MARTIN MARY
CPC分类号： A61K31/277
摘要： The present invention is directed to methods comprising administering a composition comprising a therapeutically effective amount of (R)-verapamil, a derivative thereof, or a pharmaceutically acceptable salt thereof, wherein the composition treats, prevents and/or manages at least one condition having MT1 receptor, 5-HT2B receptor and L-type calcium channel activity and releases the (R)-verapamil, a derivative thereof or a pharmaceutically acceptable salt thereof to exhibit a co-primary activity on the MT1 receptor, the 5-HT2B receptor, and the L- type calcium channel.
摘要翻译：本发明涉及包括施用包含治疗有效量的（R） - 维拉帕米，其衍生物或其药学上可接受的盐的组合物的组合物，其中所述组合物治疗，预防和/或控制至少一种具有MT1 受体，5-HT2B受体和L-型钙通道活性，并释放（R） - 维拉帕米，其衍生物或其药学上可接受的盐，以在MT1受体，5-HT2B受体和 L-型钙通道。

5. 发明申请

WO2011095435A3 STAIN BLOCKING COMPOSITIONS INCLUDING AN ALKYL AMIDE 审中-公开
标题翻译：含有亚胺酰胺的阻塞组合物
公开(公告)号：WO2011095435A3
公开(公告)日：2011-12-29
申请号：PCT/EP2011051198
申请日：2011-01-28
申请人： BASF SE , WILDESON JACOB , KELLY JOHN
发明人： WILDESON JACOB , KELLY JOHN
IPC分类号： C09D133/00 , C08K5/20 , C09D5/02
CPC分类号： C09D133/00 , C08K5/20 , C09D5/024 , C09D7/63
摘要： An aqueous coating composition for blocking stains and a method of using the coating composition are described. The coating composition includes an aqueous dispersion of a co- polymer that is derived from an emulsion polymerization of an ethylenically unsaturated non-ionic monomer, an ethylenically unsaturated monomer with a functional acid group having a pKa of 2 or greater or salt thereof, and an alkyl amide.
摘要翻译：描述了用于阻挡污渍的水性涂料组合物和使用该涂料组合物的方法。涂料组合物包括共聚物的水分散体，其衍生自烯键式不饱和非离子单体，具有pKa为2或更大的官能酸基的烯属不饱和单体或其盐，和烷基酰胺。

6. 发明申请

WO2005062772A3 APPARATUS AND METHOD FOR CONTROLLED COMBUSTION OF GASEOUS POLLUTANTS 审中-公开
标题翻译：控制燃烧气体污染物的装置和方法
公开(公告)号：WO2005062772A3
公开(公告)日：2007-01-18
申请号：PCT/US2004042334
申请日：2004-12-16
申请人： ADVANCED TECH MATERIALS , FERRON SHAWN , KELLY JOHN , VERMEULEN ROBBERT
发明人： FERRON SHAWN , KELLY JOHN , VERMEULEN ROBBERT
IPC分类号： B01D50/00 , B01D53/34 , F23D3/40 , F23G7/06 , F23L7/00 , F23M5/00
CPC分类号： B01D53/34 , F23G7/061 , F23L7/00 , F23L2900/07005 , F23L2900/07008 , F23M5/00 , F23M2900/05004 , Y02E20/344
摘要： The present invention relates to systems and methods for controlled combustion of gaseous pollutants while reducing and removing deposition of unwanted reaction products from within the treatment systems. The systems employ a two-stage thermal reactor (10) having an upper thermal reactor (12) including at least one inlet (16) for mixing a gaseous waste stream with oxidants and combustible fuels for thermal combustion within the upper thermal reactor (12). The upper thermal reactor (12) further includes a double wall structure having an outer exterior wall (20) and an interior porous wall (22) that defines an interior space (26) for holding a fluid and ejecting same, in a pulsating mode, through the interior porous wall (22) into the upper thermal reactor (12) to reduce deposition of the reaction products on the interior of the upper reactor chamber (12). The two-stage thermal reactor (10) further includes a lower reactor chamber (14) through a water vortex (33) that provides a water overflow along the interior of the lower reactor chamber thereby reducing deposition of unwanted products on the interior surface of the lower reactor (14).
摘要翻译：本发明涉及用于气态污染物的受控燃烧的系统和方法，同时减少和去除处理系统内不需要的反应产物的沉积。该系统采用具有上部热反应器（12）的两级热反应器（10），其包括用于将气态废物流与氧化剂混合的至少一个入口（16）和用于在上部热反应器（12）内热燃烧的可燃性燃料，。上部热反应器（12）还包括双壁结构，其具有外部外壁（20）和内部多孔壁（22），其限定用于保持流体并以脉动模式喷射流体的内部空间（26）通过内部多孔壁（22）进入上部热反应器（12）以减少反应产物在上部反应器室（12）内部的沉积。两级热反应器（10）还包括通过水涡流（33）的下反应器室（14），其沿着下反应器室的内部提供水溢流，从而减少不需要的产物在内反应器下反应器（14）。

7. 发明申请

WO2004053898A2 ENCAPSULATED CONDUCTIVE POLYMER DEVICE AND METHOD OF MANUFACTURING SAME 审中-公开
标题翻译：封装的导电聚合物装置及其制造方法
公开(公告)号：WO2004053898A2
公开(公告)日：2004-06-24
申请号：PCT/US0302339
申请日：2003-01-24
申请人： BOURNS INC , BURKE RAY , O'BRIEN MAURICE , AHEARNE BRIAN , KELLY JOHN , BOURNS GORDON L
发明人： BURKE RAY , O'BRIEN MAURICE , AHEARNE BRIAN , KELLY JOHN , BOURNS GORDON L
IPC分类号： H01C1/028 , H01C1/14 , H01C1/142 , H01C17/00 , H01C17/02 , H01C
CPC分类号： H01C1/14 , H01C1/028 , H01C1/1406 , H01C1/142 , H01C17/006 , H01C17/02 , H01C17/281
摘要： The present invention relates to encapsulated or insulated devices. In certain environments and applications, it is necessary to protect devices from external agents. The present invention achieves this by providing a device comprising a segment of insulating material having an aperture defined therein. An element of active, for example positive temperature coefficient (PTC), material is received within the defined aperture. The element is substantially covered by a first metal layer on one side and a second metal layer on the opposing side. A first layer of insulating material substantially covers the first metal layer and a second layer of insulating material substantially covers the second layer of metal. A first terminal provides an external electrical connection to the first metal layer and a second terminal provides an external electrical connection to the second metal layer. The first terminal is connected to the first metal layer by a conductive interconnect which passes through the first insulating layer and the second terminal is connected to the second metal layer by a conductive interconnect passes through the second insulating layer. Moreover, the invention provides a method for manufacturing devices in a matrix form using conventional PCB techniques to facilitate the mass production of encapsulated devices. Additionally, the resulting components may be used as either leaded or SMT components in either single device or multiple device configurations in both SIP and DIP packages.
摘要翻译：本发明涉及封装或绝缘装置。在某些环境和应用中，有必要保护设备免受外部代理的影响。本发明通过提供一种包括具有限定在其中的孔的绝缘材料的部分来实现这一点。活动的元件，例如正温度系数（PTC）的材料被接收在限定的孔内。元件基本上被一侧上的第一金属层和相对侧上的第二金属层覆盖。第一绝缘材料层基本上覆盖第一金属层，第二绝缘材料层基本上覆盖第二金属层。第一端子提供到第一金属层的外部电连接，而第二端子提供到第二金属层的外部电连接。第一端子通过导电布线连接到第一金属层，导电布线穿过第一绝缘层，第二端子通过导电布线连接到第二金属层，穿过第二绝缘层。此外，本发明提供了一种使用常规PCB技术制造矩阵形式的器件的方法，以便于大量生产封装器件。另外，所得到的组件可以用作单一设备中的含铅或SMT组件或SIP和DIP封装中的多个器件配置。

8. 发明专利

AU2011242125B2 Neuromodulation cryotherapeutic devices and associated systems and methods 未知
公开(公告)号：AU2011242125B2
公开(公告)日：2014-11-13
申请号：AU2011242125
申请日：2011-10-26
申请人： BUCKLEY NAOMI , CUMMINS MICHAEL , DONOVAN DANNY , GELFAND MARK , HUGHES LUKE , KELLY BRIAN , KELLY GARY , KELLY GRACE , KELLY JOHN , LEUNG MARK , MORIARTY MICHAEL , MULLINS BARRY , NAGA KARUN D , SWEENEY FIACHRA , TILOTTA VINCENZO , WOOD RONAN , WOOLLEY LANA , ZARINS DENISE
发明人： BUCKLEY NAOMI , CUMMINS MICHAEL , DONOVAN DANNY , GELFAND MARK , HUGHES LUKE , KELLY BRIAN , KELLY GRACE , KELLY GARY , KELLY JOHN , LEUNG MARK , MORIARTY MICHAEL , MULLINS BARRY , NAGA KARUN D , SWEENEY FIACHRA , TILOTTA VINCENZO , WOOD RONAN , WOOLLEY LANA , ZARINS DENISE
IPC分类号： A61B18/02
摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

9. 发明专利

AU2011239363B2 Neuromodulation cryotherapeutic devices and associated systems and methods 未知
公开(公告)号：AU2011239363B2
公开(公告)日：2014-11-06
申请号：AU2011239363
申请日：2011-10-26
申请人： BUCKLEY NAOMI , CLARK BENJAMIN , CUMMINS MICHAEL , DONOVAN DANNY , GELFAND MARK , HUGHES LUKE , KELLY BRIAN , KELLY GARY , KELLY GRACE , KELLY JOHN , LEUNG MARK , MCMULLIN GWENDA , MULLINS BARRY , NAGA KARUN D , NASH STEPHEN , RYBA ERIC , SWEENEY FIACHRA , TILOTTA VINCENZO , TUROVSKIY MICHAEL , TUROVSKIY ROMAN , WOOLLEY LANA , ZARINS DENISE
发明人： ZARINS DENISE , BUCKLEY NAOMI , RYBA ERIC , TUROVSKIY ROMAN , CLARK BENJAMIN , CUMMINS MICHAEL , DONOVAN DANNY , GELFAND MARK , HUGHES LUKE , KELLY BRIAN , KELLY GRACE , KELLY GARY , KELLY JOHN , LEUNG MARK , MCMULLIN GWENDA , MULLLINS BARRY , NAGA KARUN D , NASH STEPHEN , SWEENEY FIACHRA , TILOTTA VINCENZO , WOOLLEY LANA , TUROVSKIY MICHAEL
IPC分类号： A61B18/02
摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

10. 发明专利

AU2011242125A1 Neuromodulation cryotherapeutic devices and associated systems and methods 未知
公开(公告)号：AU2011242125A1
公开(公告)日：2012-05-10
申请号：AU2011242125
申请日：2011-10-26
申请人： KELLY GARY , DONOVAN DANNY , NAGA KARUN , WOOD RONAN , HUGHES LUKE , ZARINS DENISE , TILOTTA VINCENZO , BUCKLEY NAOMI , MULLINS BARRY , KELLY JOHN , GELFAND MARK , SWEENEY FIACHRA , KELLY GRACE , KELLY BRIAN , MORIARTY MICHAEL , WOOLLEY LANA , CUMMINS MICHAEL , LEUNG MARK
发明人： BUCKLEY NAOMI , CUMMINS MICHAEL , DONOVAN DANNY , GELFAND MARK , HUGHES LUKE , KELLY BRIAN , KELLY GRACE , KELLY GARY , KELLY JOHN , LEUNG MARK , MORIARTY MICHAEL , MULLINS BARRY , NAGA KARUN D , SWEENEY FIACHRA , TILOTTA VINCENZO , WOOD RONAN , WOOLLEY LANA , ZARINS DENISE
IPC分类号： A61B18/02
摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

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