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1. 发明申请

WO2010080667A1 MANIFOLDS, SYSTEMS, AND METHODS FOR ADMINISTERING REDUCED PRESSURE TO A SUBCUTANEOUS TISSUE SITE 审中-公开
标题翻译：用于将降低压力管理至少量组织场的手段，系统和方法
公开(公告)号：WO2010080667A1
公开(公告)日：2010-07-15
申请号：PCT/US2009/069527
申请日：2009-12-24
申请人： KCI LICENSING, INC. , SANTORA, Carl, Joseph , MANWARING, Michael , CORNET, Douglas, A. , SWAIN, Larry , LONG, Justin, Alexander
发明人： SANTORA, Carl, Joseph , MANWARING, Michael , CORNET, Douglas, A. , SWAIN, Larry , LONG, Justin, Alexander
IPC分类号： A61M1/00 , A61M27/00 , A61F13/00 , A61F13/84 , A61B17/08
CPC分类号： A61M3/0283 , A61B17/1355 , A61B17/80 , A61B17/88 , A61F2/30767 , A61F2/36 , A61F2/3662 , A61F2002/30677 , A61F2002/30785 , A61F2002/30787 , A61F2002/30968 , A61F2002/3611 , A61F2002/3625 , A61F2002/368 , A61F2002/3694 , A61F2310/00395 , A61F2310/00592 , A61F2310/00928 , A61M1/0058 , A61M1/0084 , A61M3/0295 , A61M25/0009 , A61M25/003 , A61M25/0032 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M25/0071 , A61M25/0074 , A61M25/0082 , A61M27/00 , A61M2025/0003 , A61M2025/0034 , A61M2025/0036 , A61M2025/0076 , A61M2207/00
摘要： Systems, methods, and apparatuses are provided for delivering reduced pressure to a subcutaneous tissue site, such as a bone tissue site. In one instance, a manifold for providing reduced pressure to a subcutaneous tissue includes a longitudinal manifold body formed with at least one purging lumen and a reduced-pressure lumen. The manifold further includes a plurality of manifolding surface features or slits formed on the second, tissue-facing side of the longitudinal manifold body and a plurality of apertures formed in the longitudinal manifold body on the second, tissue-facing side. The plurality of apertures fluidly couple the reduced- pressure lumen and the manifolding surface features or slits. The manifold further includes an end cap fluidly coupling the reduced-pressure lumen and the at least one purging lumen. Other systems, apparatuses, and methods are presented.
摘要翻译：提供的系统，方法和装置用于将减压递送到皮下组织部位，例如骨组织部位。在一个实例中，用于向皮下组织提供减压的歧管包括形成有至少一个清洗腔和减压腔的纵向歧管体。歧管还包括形成在纵向歧管主体的第二面向组织侧的多个歧管表面特征或狭缝，以及形成在第二面向组织侧的纵向歧管体中的多个孔。多个孔流体地联接减压腔和歧管表面特征或狭缝。所述歧管还包括将所述减压腔和所述至少一个清洗腔流体连接的端盖。提出了其他系统，装置和方法。

2. 发明申请

WO2010078353A2 SYSTEMS FOR PROVIDING FLUID FLOW TO TISSUES 审中-公开
标题翻译：用于提供流体流向组织的系统
公开(公告)号：WO2010078353A2
公开(公告)日：2010-07-08
申请号：PCT/US2009/069722
申请日：2009-12-29
申请人： KCI LICENSING, INC. , SWAIN, Larry , MANWARING, Michael , LEUNG, Braden , CORNET, Douglas
发明人： SWAIN, Larry , MANWARING, Michael , LEUNG, Braden , CORNET, Douglas
IPC分类号： A61M37/00 , A61M31/00 , A61L27/14 , A61L27/54 , A61L27/58 , A61M1/00 , A61M27/00
CPC分类号： A61F13/00068 , A61B17/88 , A61F2/2846 , A61F13/00063 , A61F2002/2835 , A61F2002/30784 , A61F2002/368 , A61F2013/00357 , A61F2013/00927 , A61K38/18 , A61K38/19 , A61K38/22 , A61K49/223 , A61M1/0023 , A61M1/0088 , A61M27/00 , A61M37/00 , A61M37/0092 , A61N5/062
摘要： Provided is an apparatus that includes a scaffold with a gel or liquid composition deposed on at least a portion of a luminal surface, the gel or liquid composition adapted to include microbubbles. Also provided is a system that includes a source of reduced pressure, the above scaffold, a manifold adjacent the scaffold, and a conduit for providing fluid communication between the manifold and the source of reduced pressure. Additionally provided is a method that includes implanting the above scaffold at the tissue site and disrupting a substantial portion of the microbubbles to induce fluid flow to the scaffold. Further provided is an apparatus that includes a scaffold that comprises a slowly degradable material and a quickly degradable material. Additionally provided is a system for coupling nerve tissue and a microchip assembly.
摘要翻译：所提供的设备包括具有置于腔表面的至少一部分上的凝胶或液体组合物的支架，所述凝胶或液体组合物适于包含微泡。还提供了一种系统，该系统包括减压源，上述支架，邻近支架的歧管以及用于在歧管和减压源之间提供流体连通的导管。另外提供的方法包括将上述支架植入组织部位并破坏大部分微泡以诱导流体流向支架。还提供了一种包括支架的设备，该支架包含缓慢降解材料和快速降解材料。另外提供的是用于耦合神经组织和微芯片组件的系统。

3. 发明申请

WO2010078349A2 TISSUE ROLL SCAFFOLDS 审中-公开
标题翻译：组织滚动轴承
公开(公告)号：WO2010078349A2
公开(公告)日：2010-07-08
申请号：PCT/US2009/069718
申请日：2009-12-29
申请人： KCI LICENSING, INC. , SWAIN, Larry , CORNET, Douglas , MANWARING, Michael , LEUNG, Braden
发明人： SWAIN, Larry , CORNET, Douglas , MANWARING, Michael , LEUNG, Braden
IPC分类号： A61M1/00 , A61M27/00 , A61L27/58 , A61L27/54 , A61L27/24
CPC分类号： A61M1/0088 , A61B17/11 , A61B17/1128 , A61F13/00063 , A61F13/00068
摘要： An apparatus and system for treating a wound having a cavity is disclosed. The apparatus comprises a scaffold including a scaffold lamina and a tissue lamina wherein the scaffold lamina forms a laminate in fluid communication with the tissue lamina. The laminate is rolled into a generally cylindrical shape having two end surfaces. The apparatus further comprises a manifold having a port for coupling to a source of reduced pressure and that is positioned in fluid communication with the scaffold to provide reduced pressure to the scaffold lamina and the wound. The apparatus also comprises a drape formed of substantially impermeable material to cover the scaffold and the manifold within the wound. A method for treating a wound having a cavity is also disclosed and comprises positioning a scaffold lamina adjacent a tissue lamina to form a laminate in fluid communication with the tissue lamina, rolling the laminate into a generally cylindrical shape having two end surface, and positioning the scaffold within the cavity of the wound to provide reduced pressure to the wound. The method further comprises positioning a manifold in fluid communication with the scaffold to provide reduced pressure to the scaffold lamina and the wound.
摘要翻译：公开了一种用于治疗具有腔的伤口的装置和系统。该设备包括支架，该支架包括支架层和组织层，其中支架层形成与组织层流体连通的层压体。层压体卷成具有两个端面的大致圆柱形。该设备还包括歧管，歧管具有用于联接到减压源的端口并且定位成与支架流体连通以向支架薄层和伤口提供减压。该设备还包括由基本上不可渗透的材料形成的盖布以覆盖伤口内的支架和歧管。还公开了用于治疗具有腔的伤口的方法，并且包括将支架薄层定位在组织薄层附近以形成与组织薄层流体连通的层压体，将层压体卷成具有两个端面的大体圆柱形形状，在伤口空腔内的支架以向伤口提供减压。该方法还包括将歧管定位成与支架流体连通以向支架薄层和伤口提供减压。

4. 发明申请

WO2010078342A2 SYSTEM FOR PROVIDING FLUID FLOW TO NERVE TISSUES 审中-公开
标题翻译：用于提供流体流动以制造组织的系统
公开(公告)号：WO2010078342A2
公开(公告)日：2010-07-08
申请号：PCT/US2009/069710
申请日：2009-12-29
申请人： KCI LICENSING INC. , SWAIN, Larry , MANWARING, Michael , LEUNG, Braden , CORNET, Douglas
发明人： SWAIN, Larry , MANWARING, Michael , LEUNG, Braden , CORNET, Douglas
IPC分类号： A61M1/00 , A61M27/00 , A61M37/00 , A61M31/00 , A61L27/58 , A61L27/24 , A61L27/54 , A61L27/56
CPC分类号： A61M1/0088 , A61B17/11 , A61B17/1128 , A61F13/00063 , A61F13/00068
摘要： An apparatus and system for providing reduced pressure to a defect in a nerve is disclosed. The apparatus comprises a nerve conduit having a generally tubular shape that has walls including a luminal wall surrounding the tissue site to contain fluids within a luminal space between the tissue site to contain fluids within a luminal space between the tissue site and the luminal wall. The apparatus further comprises a manifold having a porous body and a connector for receiving reduced pressure, wherein the manifold is positioned within the luminal space adjacent the tissue site to distribute the reduced pressure to the defect. Additionally, a method for providing reduced pressure to a defect in a nerve is disclosed that includes implanting the nerve conduit and manifold at a site of damaged nerve tissue and applying a reduced pressure to the manifold thereby stimulating repair or regrowth of nerve tissue.
摘要翻译：公开了一种用于向神经缺陷提供减压的装置和系统。该装置包括具有大致管状形状的神经导管，该神经导管具有壁，该壁包括围绕组织部位的腔壁，以在组织部位之间的管腔空间内容纳流体，以在组织部位和腔壁之间的腔空间内容纳流体。该装置还包括具有多孔体的歧管和用于接收减压的连接器，其中歧管位于邻近组织部位的管腔内，以将减压分配到缺陷。此外，公开了一种用于向神经缺损提供减压的方法，其包括将神经导管和歧管植入损伤的神经组织的部位并将减压施加到歧管，从而刺激神经组织的修复或再生长。

5. 发明申请

WO2010078345A2 SYSTEM FOR PROVIDING FLUID FLOW TO NERVE TISSUES 审中-公开
标题翻译：用于提供流体流动以制造组织的系统
公开(公告)号：WO2010078345A2
公开(公告)日：2010-07-08
申请号：PCT/US2009/069713
申请日：2009-12-29
申请人： KCI LICENSING, INC. , SWAIN, Larry , MANWARING, Michael , LEUNG, Braden , CORNET, Douglas
发明人： SWAIN, Larry , MANWARING, Michael , LEUNG, Braden , CORNET, Douglas
IPC分类号： A61M1/00 , A61M27/00 , A61F13/00 , A61B17/08
CPC分类号： A61M1/0088 , A61B17/11 , A61B17/1128 , A61F13/00063 , A61F13/00068
摘要： Provided is an apparatus that includes a nerve conduit, a manifold and a support structure for providing a reduced pressure. Also provided is a system that includes a source of reduced pressure, a nerve conduit, a manifold, a support structure and a conduit for providing fluid communication between the manifold support and the source of reduced pressure. Additionally provided is a method that includes implanting the above nerve conduit, manifold and support structure at a site of damaged nerve tissue and applying a reduced pressure to the manifold thereby stimulating repair or regrowth of nerve tissue.
摘要翻译：提供了一种包括神经管道，歧管和用于提供减压的支撑结构的装置。还提供了一种包括减压源的系统，神经管道，歧管，支撑结构和用于在歧管支撑件和减压源之间提供流体连通的导管。另外提供了一种方法，其包括在损伤的神经组织的位置处植入上述神经导管，歧管和支撑结构，并将减压施加到歧管，从而刺激神经组织的修复或再生长。

6. 发明申请

WO2010078347A2 SYSTEM FOR PROVIDING FLUID FLOW TO NERVE TISSUES 审中-公开
标题翻译：用于向神经组织提供流体流动的系统
公开(公告)号：WO2010078347A2
公开(公告)日：2010-07-08
申请号：PCT/US2009/069715
申请日：2009-12-29
申请人： KCI LICENSING, INC. , SWAIN, Larry , MANWARING, Michael , LEUNG, Braden , CORNET, Douglas
发明人： SWAIN, Larry , MANWARING, Michael , LEUNG, Braden , CORNET, Douglas
IPC分类号： A61M37/00 , A61M31/00 , A61L27/54 , A61L27/58 , A61L27/24 , A61M1/00 , A61M27/00
CPC分类号： A61M1/0088 , A61B17/11 , A61B17/1128 , A61F13/00063 , A61F13/00068
摘要： Provided is an apparatus that includes a nerve conduit and a nested manifold for providing a reduced pressure. Also provided is a system that includes a source of reduced pressure, a nerve conduit and nested manifold, and a conduit for providing fluid communication between the manifold and the source of reduced pressure. Additionally provided is a method that includes implanting the above nerve conduit and manifold at a site of damaged nerve tissue and applying a reduced pressure to the manifold thereby stimulating repair or regrowth of nerve tissue.
摘要翻译：提供了一种包括神经导管和用于提供减压的嵌套歧管的装置。还提供了一种系统，其包括减压源，神经导管和嵌套歧管以及用于在歧管和减压源之间提供流体连通的导管。另外提供了一种方法，其包括将上述神经导管和歧管植入受损神经组织的部位并向歧管施加减压，从而刺激神经组织的修复或再生长。

7. 发明申请

WO2009158480A2 STIMULATION OF CARTILAGE FORMATION USING REDUCED PRESSURE TREATMENT 审中-公开
标题翻译：使用减少压力治疗刺激造血
公开(公告)号：WO2009158480A2
公开(公告)日：2009-12-30
申请号：PCT/US2009/048628
申请日：2009-06-25
申请人： KCI LICENSING, INC. , GIROUARD, Michael, Richard , STEVENSON, Eric , SWAIN, Larry , THOMPSON, Sean
发明人： GIROUARD, Michael, Richard , STEVENSON, Eric , SWAIN, Larry , THOMPSON, Sean
IPC分类号： A61M5/142 , A61P19/00 , A61L27/48 , A61K9/70 , A61K35/32 , A61K38/18 , A61K38/30
CPC分类号： A61L27/3817 , A61K35/32 , A61K38/18 , A61K38/30 , A61L27/3852 , A61L27/3895 , A61L2430/06 , A61K2300/00
摘要： Provided is a method of stimulating cartilage formation at a tissue site in a mammal. Also provided is a biocompatible scaffold. Additionally, a system for stimulating cartilage formation at a tissue site is provided. Further provided is the use of a manifold, a chondrocyte, and a reduced-pressure source to stimulate cartilage formation at a tissue site of a mammal.
摘要翻译：提供了刺激哺乳动物组织部位软骨形成的方法。还提供了生物相容性支架。另外，提供了用于刺激组织部位的软骨形成的系统。还提供了使用歧管，软骨细胞和减压源来刺激哺乳动物组织部位的软骨形成。

8. 发明申请

WO2010078358A2 SYSTEMS FOR INDUCING FLUID FLOW TO STIMULATE TISSUE GROWTH 审中-公开
标题翻译：用于诱导流体流动刺激组织生长的系统
公开(公告)号：WO2010078358A2
公开(公告)日：2010-07-08
申请号：PCT/US2009/069727
申请日：2009-12-29
申请人： KCL LICENSING, INC. , SWAIN, Larry , MANWARING, Michael , LEUNG, Braden , CORNET, Douglas
发明人： SWAIN, Larry , MANWARING, Michael , LEUNG, Braden , CORNET, Douglas
IPC分类号： A61M37/00 , A61M31/00 , A61M25/01 , A61M39/22 , A61L27/14 , A61L27/54 , A61L27/58 , A61M1/00 , A61M27/00
CPC分类号： A61F2/28 , A61F2002/2817 , A61F2002/4685 , A61L27/54 , A61M1/0031 , A61M1/0035 , A61M1/0088 , A61M5/16881 , A61M27/00 , A61M39/22 , A61M2205/3334
摘要： Provided are apparatuses, systems, and methods for treating tissue at a tissue site in a mammal that includes a scaffold adapted to be disposed adjacent to the tissue site and to be fluidly coupled to a blood vessel of the mammal for receiving blood therefrom. Additionally, a scaffold is provided that includes a charged surface comprising a streaming potential.
摘要翻译：提供了用于在哺乳动物的组织部位处理组织的装置，系统和方法，所述装置，系统和方法包括适于邻近所述组织部位设置并与所述哺乳动物的血管流体耦合以从其接收血液的支架。另外，提供了一种支架，其包括包含流动电位的带电表面。

9. 发明申请

WO2008045183A2 CHEMICAL DISTRIBUTION DEVICE 审中-公开
标题翻译：化学品分配装置
公开(公告)号：WO2008045183A2
公开(公告)日：2008-04-17
申请号：PCT/US2007/020090
申请日：2007-09-12
申请人： SWAIN, Larry
发明人： SWAIN, Larry
IPC分类号： B67D5/08
CPC分类号： A01M1/245
摘要： A device for delivering a chemical to an area includes a chemical supply tank and, optionally, a solvent supply line. The device includes a controller that delivers the chemicals, or a mixture of the chemicals and solvent, and actuates flow of the chemicals or chemical-solvent mixture from the controller. Optionally, the actuator includes a timer in combination with a pump and/or control valve. The chemicals or chemical-solvent mixture is delivered to a feed line, optionally through a filter and flow controller, to a dispenser.
摘要翻译：用于将化学品输送到区域的装置包括化学品供应罐和任选的溶剂供应管线。该装置包括一个控制器，用于输送化学物质或化学物质和溶剂的混合物，并促使化学物质或化学溶剂混合物从控制器流出。可选地，致动器包括与泵和/或控制阀组合的定时器。化学品或化学溶剂混合物通过过滤器和流量控制器输送到进料管线，然后输送到分配器。

10. 发明授权

EP2370119B1 TISSUE ROLL SCAFFOLDS 有权
标题翻译：轧辊机架
公开(公告)号：EP2370119B1
公开(公告)日：2014-12-17
申请号：EP09837122.2
申请日：2009-12-29
申请人： KCI Licensing, Inc.
发明人： SWAIN, Larry , CORNET, Douglas , MANWARING, Michael , LEUNG, Braden
IPC分类号： A61M1/00 , A61M27/00 , A61F13/00 , A61B17/08
CPC分类号： A61M1/0088 , A61B17/11 , A61B17/1128 , A61F13/00063 , A61F13/00068

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