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1. 发明申请

WO03063876A2 METHODS OF TREATING PATIENTS SUFFERING FROM MOVEMENT DISORDERS 审中-公开
标题翻译：治疗运动障碍患者的方法
公开(公告)号：WO03063876A2
公开(公告)日：2003-08-07
申请号：PCT/US0302658
申请日：2003-01-28
申请人： KASE HIROSHI , MORI AKIHISA , WAKI YUTAKA , OHSAWA YUTAKA , KARASAWA AKIRA , KUWANA YOSHITOSHI
发明人： KASE HIROSHI , MORI AKIHISA , WAKI YUTAKA , OHSAWA YUTAKA , KARASAWA AKIRA , KUWANA YOSHITOSHI
IPC分类号： C07D473/06 , A61K31/522 , A61K45/00 , A61P25/14 , A61P25/16
CPC分类号： A61K31/522 , A61K9/0019 , A61K9/20 , A61K9/48 , A61K31/198 , A61K45/06
摘要： The present invention is directed to methods of treating movement disorders by administering an effective amount of one or more adenosine A2A receptor antagonist to a patient in need thereof. The present invention also provides methods of decreasing the adverse effects of L-DOPA in patients receiving L-DOPA therapy in the treatment of Parkinson's disease. The present invention further provides methods and compositions for treating Parkinson's disease patients with sub-clinically effective doses of L-DOPA by combining LDOPA treatment with an effective amount of one or more adenosine A2A receptor antagonists i.e., L-DOPA sparing effect. The present invention further provides methods of effective treatment of Parkinson's disease by co-administering at least one adenosine A2A receptor antagonist, L-DOPA and a dopamine agonist and/or a COMT inhibitor and/or a MAO inhibitor. The present invention further provides methods of prolonging effective treatment of Parkinson's disease by administering an adenosine A2A receptor antagonist singly or together with a dopamine agonist, and/or a COMT inhibitor, and/or a MAO inhibitor without prior or subsequent administration of L-DOPA, delaying or removing on-set of L-DOPA motor complication.
摘要翻译：本发明涉及通过向有需要的患者施用有效量的一种或多种腺苷A 2A受体拮抗剂来治疗运动障碍的方法。本发明还提供降低L-DOPA在接受L-DOPA治疗的帕金森病治疗中的不良反应的方法。本发明还提供了通过将LDOPA治疗与有效量的一种或多种腺苷A2A受体拮抗剂（即L-DOPA备用效应）组合来治疗帕金森病患者的亚临床有效剂量的L-DOPA的方法和组合物。本发明还提供了通过共同施用至少一种腺苷A 2A受体拮抗剂，L-DOPA和多巴胺激动剂和/或COMT抑制剂和/或MAO抑制剂来有效治疗帕金森病的方法。本发明还提供了延长帕金森病有效治疗的方法，通过单独或与多巴胺激动剂和/或COMT抑制剂和/或MAO抑制剂一起施用腺苷A2A受体拮抗剂，而无需先前或随后给予L-DOPA ，延迟或消除L-DOPA电机并发症。

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