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1. 发明公开

EP2647391A4 MRI CONTRAST AGENT CONTAINING COMPOSITE PARTICLES 有权
标题翻译： MRI造影剂复合粒子
公开(公告)号：EP2647391A4
公开(公告)日：2016-07-06
申请号：EP11845744
申请日：2011-09-29
申请人： KANEKA CORP
发明人： TAGO YOSHIYUKI , YOSHIDA SHINICHI , OHNO KOHJI , TSUJII YOSHINOBU , TABATA YASUHIKO
IPC分类号： A61K49/00 , A61K49/18
CPC分类号： A61K49/12 , A61K49/1854 , A61K49/186
摘要： Intended is to provide an MRI contrast agent that tends not to be phagocytized by reticuloendothelial cells and that has improved dispersion stability. The present invention is an MRI contrast agent containing composite particles, wherein the composite particles are those with polymer graft chains bound to surfaces of microparticles at a very high density sufficient to allow steric repulsion to occur between the graft chains, the microparticles are inorganic microparticles that exhibit superparamagnetism, and the polymer graft chains have a number average molecular weight (Mn) of at least 30,000. Preferably, the MRI contrast agent is for tumor diagnosis.

2. 发明公开

EP2728001A4 ENZYME FUNCTION MODIFICATION METHOD AND ENZYME VARIANT THEREOF 审中-公开
标题翻译：方法的修饰酶特性和酶的变体的
公开(公告)号：EP2728001A4
公开(公告)日：2015-05-27
申请号：EP12803805
申请日：2012-06-27
申请人： KANEKA CORP
发明人： YOSHIDA SHINICHI , TAIRA SHUNICHI , NISHIHACHIJYO MASAKATSU , NOJIRI MASUTOSHI , KAWANO SHIGERU
IPC分类号： C12N15/09 , C07H21/02 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/04 , C12P19/32
CPC分类号： C12N9/0006 , C07H19/207 , C12P19/36 , Y02P20/52

3. 发明公开

EP2557157A4 PROTEIN CAPABLE OF BINDING SPECIFICALLY TO IMMUNOGLOBULIN, AND IMMUNOGLOBULIN-BINDING AFFINITY LIGAND 有权转让
标题翻译：蛋白质的特异性结合免疫球蛋白及免疫球蛋白结合亲和力配
公开(公告)号：EP2557157A4
公开(公告)日：2013-09-04
申请号：EP11759504
申请日：2011-03-24
申请人： KANEKA CORP
发明人： YOSHIDA SHINICHI , MURATA DAI , TAIRA SHUNICHI , TAKANO MASAYUKI , IGUCHI KEITA , NAKANO YOSHIYUKI
IPC分类号： C12N15/09 , C07K1/22 , C07K14/31 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02
CPC分类号： C07K14/195 , C07K1/22 , C07K14/31 , C07K16/065 , C07K16/32 , C07K2317/24 , C07K2317/55 , C07K2317/92

4. 发明公开

EP2690108A4 NOVEL IMMUNOGLOBULIN-BINDING POLYPEPTIDE 有权
标题翻译：免疫抑制剂多糖
公开(公告)号：EP2690108A4
公开(公告)日：2014-12-31
申请号：EP12765583
申请日：2012-03-26
申请人： KANEKA CORP
发明人： YOSHIDA SHINICHI , MURATA DAI , TAIRA SHUNICHI
IPC分类号： C07K14/00 , C12N15/09
CPC分类号： C07K14/00 , C07K14/31 , C07K14/47
摘要： An object of the present invention is to provide novel polypeptides that are capable of binding to an immunoglobulin and have high stability against alkali. The present invention relates to proteins having the amino acid sequence of SEQ ID No:1 or 2.
摘要翻译：本发明的目的是提供能够结合免疫球蛋白并且对碱具有高稳定性的新型多肽。本发明涉及具有SEQ ID No：1或2的氨基酸序列的蛋白质。

5. 发明公开

EP2412809A4 PROTEIN HAVING AFFINITY FOR IMMUNOGLOBULIN, AND IMMUNOGLOBULIN-BINDING AFFINITY LIGAND 有权
标题翻译：免疫球蛋白亲和蛋白与配体的亲和力免疫球蛋白结合
公开(公告)号：EP2412809A4
公开(公告)日：2013-05-29
申请号：EP10756084
申请日：2010-03-24
申请人： KANEKA CORP
发明人： YOSHIDA SHINICHI , MURATA DAI , TAKANO MASAYUKI , AKAGI JUNYA , IGUCHI KEITA , NAKANO YOSHIYUKI
IPC分类号： C12N15/09 , B01J20/281 , C07K1/22 , C07K14/31 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02
CPC分类号： C07K14/47 , B01D15/3809 , B01J20/286 , B01J20/3244 , B01J20/3274 , C07K14/31

6. 发明公开

EP2899271A4 PROTEIN LIGAND FOR AFFINITY ISOLATION MATRIX 有权
标题翻译： PROTEINLIGANDFÜREINEAFFINITÄTSISOLIERUNGSMATRIX
公开(公告)号：EP2899271A4
公开(公告)日：2016-06-29
申请号：EP13838208
申请日：2013-09-24
申请人： KANEKA CORP
发明人： YOSHIDA SHINICHI , MURATA DAI , KONOIKE FUMINORI , IGUCHI KEITA , NAKAISHI TOMOYUKI , HAYASHI MASAHIRO
IPC分类号： C12N15/09 , C07K1/22 , C07K14/31 , C07K17/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02
CPC分类号： C07K14/31 , B01D15/3809 , B01J2220/4856 , C07K1/22 , C07K16/00 , C07K16/065 , C07K16/1271 , C07K17/00 , C07K17/12 , C07K2317/21 , C07K2317/52 , C07K2317/92
摘要： An object of the present invention is to develop techniques to create novel engineered protein ligands that maximize the binding capacity and binding efficiency to a target molecule of affinity separation matrices on which the protein ligands are immobilized. The present invention provides protein ligands (variants) that can be immobilized on carriers in a manner shown in schematic Figs. 1(4)-(15) , as well as antibody affinity separation matrices obtained by immobilizing such a protein ligand on a water-insoluble carrier. The affinity separation matrices are characterized by their excellent binding capacity and binding efficiency to a target molecule.
摘要翻译：本发明的一个目的是开发技术以产生最大限度地将蛋白质配体固定在其上的亲和分离基质的靶分子的结合能力和结合效率最大化的新型工程蛋白质配体。本发明提供了蛋白质配体（变体），其可以如图所示的方式固定在载体上。 1（4） - （15），以及通过将这种蛋白质配体固定在水不溶性载体上获得的抗体亲和分离基质。亲和力分离基质的特征在于其与目标分子的优异的结合能力和结合效率。

7. 发明公开

EP2690173A4 PROTEIN FOR AFFINITY-SEPARATION MATRIX 有权
标题翻译：用于蛋白质亲和分离矩阵
公开(公告)号：EP2690173A4
公开(公告)日：2015-01-14
申请号：EP12764978
申请日：2012-03-26
申请人： KANEKA CORP
发明人： YOSHIDA SHINICHI , MURATA DAI , TAIRA SHUNICHI
IPC分类号： C12N15/09 , C07K1/22 , C07K14/31 , C07K17/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02
CPC分类号： C07K14/31 , C07K1/22
摘要： An object of the present invention is to provide a technique to create novel engineered protein ligands that, when immobilized through a lysine residue (its side chain µ-amino group) which allows for efficient immobilization to a carrier, show the optimum binding capacity and binding efficiency to a target molecule. The present invention provides an engineered protein having a sequence obtained by replacing all the lysine residues in Protein A, which is the most typical protein ligand, with other amino acids, and adding lysine at a terminal; and an affinity separation matrix in which such an engineered protein is immobilized on a water-insoluble carrier by reductive amination or the like. This affinity separation matrix is characterized by its high binding capacity to a target molecule even when the immobilized amount of the ligand is small.

8. 发明公开

EP2527436A4 NADH OXIDASE MUTANT HAVING IMPROVED STABILITY AND USE THEREOF 有权
标题翻译：稳定性提高NADH氧化酶突变体及其用途
公开(公告)号：EP2527436A4
公开(公告)日：2013-09-18
申请号：EP11734660
申请日：2011-01-19
申请人： KANEKA CORP
发明人： YOSHIDA SHINICHI , IWASAKI AKIRA , WASHIDA MOTOHISA , NISHIYAMA TOZO , MORIYAMA DAISUKE , TAOKA NAOAKI
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/04
CPC分类号： C12N9/0036 , C12N9/0065 , C12P7/02 , C12P7/18 , C12P7/42 , C12P13/04 , C12P19/36 , C12Y106/03 , C12Y106/03001 , C12Y111/01001

9. 发明公开

EP3040344A4 Fab REGION-BINDING PEPTIDE 有权
标题翻译： FAB-REGIONBINDENDES PEPTID
公开(公告)号：EP3040344A4
公开(公告)日：2017-07-12
申请号：EP14841163
申请日：2014-08-28
申请人： KANEKA CORP
发明人： YOSHIDA SHINICHI , MURATA DAI
IPC分类号： C07K14/315 , C07K1/22 , C07K16/12
CPC分类号： C07K16/1275 , C07K1/22 , C07K14/315 , C07K2317/55 , C12N2510/02
摘要： An object of the present invention is to provide a Fab region-binding peptide having an excellent ability for binding to a Fab region of IgG, an affinity separation matrix having the peptide as a ligand, and a method for producing a Fab region-containing protein, the method using the affinity separation matrix. Further, another object of the present invention is to provide a DNA encoding for the peptide, a vector containing the DNA, and a transformant which has been transformed by the vector. The Fab region-binding peptide according to the present invention is characterized in having a mutation at a specific site in comparison with wild-type SpG-²1.
摘要翻译：本发明的目的在于提供具有优异的与IgG的Fab区域结合能力的Fab区域结合性肽，以该肽为配体的亲和分离基质，以及含有Fab区域的蛋白质的制造方法，该方法使用亲和分离矩阵。此外，本发明的另一个目的是提供编码该肽的DNA，含有该DNA的载体和已经被该载体转化的转化体。与野生型SpG-1相比，本发明的Fab区域结合性肽的特征在于在特定部位具有突变。

10. 发明专利

SG11201502238PA PROTEIN LIGAND FOR AFFINITY ISOLATION MATRIX 未知
公开(公告)号：SG11201502238PA
公开(公告)日：2015-05-28
申请号：SG11201502238P
申请日：2013-09-24
申请人： KANEKA CORP
发明人： YOSHIDA SHINICHI , MURATA DAI , KONOIKE FUMINORI , IGUCHI KEITA , NAKAISHI TOMOYUKI , HAYASHI MASAHIRO
IPC分类号： C12N15/09 , C07K1/22 , C07K14/31 , C07K17/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02

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