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1. 发明专利

JPH08231391A DEMENTIA-IMPROVING MEDICINE 失效
公开(公告)号：JPH08231391A
公开(公告)日：1996-09-10
申请号：JP3636295
申请日：1995-02-24
申请人： KANAGAWA KAGAKU KENKYUSHO KK , SAGAMI CHEM RES , FUJI YAKUHIN KK
发明人： YAZAWA KAZUYOSHI , MIYANAGA KAZUO , MIYAGAWA TOMIO , MURAMATSU HIROSHI
IPC分类号： A61K31/20 , A61P25/28
摘要： PURPOSE: To obtain a medicine containing docosahexaenoic acid as an active ingredient, capable of improving the depression of volition due to the dementia, delirium, the aggravation of interpersonal relation, dromomania, the deficiency of composure, and the lowering of calculation ability, judgment ability and higher functions, etc., and having no side effect. CONSTITUTION: This improving medicine contains docosahexaenoic acid, and its salt, ester, glyceride, phospholipid, choline compound, ascorbic acid compound, and an amino acid compound usually in an amount of 10-100wt.% (preferably 50-100wt.%). An oil containing the docosahexaenoic acid includes a fish oil extracted from a blue back fish such as sardine, mackerel, horse mackerel, salmon or saucy pike, a fish oil originated from the orbital fatty oil of a large sea fish such as tuna or bonito, a fatty oil originated from a microorganism, a krill oil, a sea product-originated fatty oil extracted from the livers of cod or cuttlefish. The dementia symptom-improving medicine is usually administered at a dose of 100-2000mg per day in one to several proportions a day.

2. 发明专利

JPH0920658A IMPROVING AGENT FOR HYPER-REMNANT BLOOD DISEASE 失效
公开(公告)号：JPH0920658A
公开(公告)日：1997-01-21
申请号：JP17517295
申请日：1995-07-11
申请人： KANAGAWA KAGAKU KENKYUSHO KK , SAGAMI CHEM RES
发明人： YAZAWA KAZUYOSHI , KIKUCHI HIDEAKI , TSUJII TADASHI
IPC分类号： A61K35/60 , A61K31/20 , A61P1/16 , A61P3/04 , A61P3/06 , A61P3/08 , A61P9/08 , A61P9/10 , A61P13/02 , A61P15/00
摘要： PROBLEM TO BE SOLVED: To obtain an improving agent for hyper-remnant blood disease capable of remarkably inhibiting sthenia of the hyper-remnant blood disease but having improving activity and useful for preventing and curing arterial sclerosis by the participation of remnant-lipoprotein by bringing a specific highly unsaturated fatty acid as an effective ingredient. SOLUTION: This improving agent against hyper-remnant blood disease contains a highly unsaturated fatty acid of n-3 series, preferably eicosapentaenoic acid(EPA) and/or docosahexaenoic(DHA) acid as effective ingredients'. E.g. as an oil-containing fatty acid, an oil containing >=20% fatty acid based on the total fatty acid is preferable. Thus, it is preferable to use fish oil, etc., extracted from blueback fishes such as sardines, etc. It is preferable to administer about 100-5,000mg EPA or DHA per day.

3. 发明专利

JPH1059844A IMPROVING MEDICINE FOR PERCEPTION RESPONSE FUNCTION 失效
公开(公告)号：JPH1059844A
公开(公告)日：1998-03-03
申请号：JP21555096
申请日：1996-08-15
申请人： KANAGAWA KAGAKU KENKYUSHO KK , SAGAMI CHEM RES
发明人： YAZAWA KAZUYOSHI , ISHIKAWA CHIKAKO , MIYANAGA KAZUO
IPC分类号： A61K31/20 , A61K31/23 , A61P3/06 , A61P25/28
摘要： PROBLEM TO BE SOLVED: To obtain an improving medicine for perception responsive function applied to not only improvement of perception function lowered by senility, dementia, cerebropathy, etc., but also development of the perception function of healthy subject without side effects by using a specific unsaturated fatty acid as an active ingredient. SOLUTION: This improving medicine for perception responsive function is obtained by using docosahexaenoic acid as an active ingredient. The improving medicine for the perception responsive function is useful as a medicine for improving an auditory stimulation. The medicine is also useful as a medicine concerning dementia, especially a remedy or a preventive for the dementia. Not only a free acid but also its salt, ester, glyceride, phospholipid, choline compound, ascorbic acid compound, amino acid compound, etc., are used as the docosahexaenoic acid. The formulation amount of the docosahexaenoic acid based on the improving medicine for perception responsive function is 10-100wt.%, preferably 50-100wt.%.

4. 发明专利

JPH08143454A NERVE GROWTH FACTOR PRODUCTION ENHANCER 失效
公开(公告)号：JPH08143454A
公开(公告)日：1996-06-04
申请号：JP28308494
申请日：1994-11-17
申请人： KANAGAWA KAGAKU KENKYUSHO KK , SAGAMI CHEM RES
发明人： YAZAWA KAZUYOSHI , KANO MAYUMI , YAMAGUCHI KOJI , TSUJI TOMOKO
IPC分类号： A61K31/20 , A61K31/23 , A61P9/10 , A61P25/02 , A61P25/28 , A61P43/00 , C07C57/12 , C07C69/587
摘要： PURPOSE: To obtain a nerve growth factor production enhancer having excellent activity free from adverse effect. CONSTITUTION: This nerve growth factor production enhancer contains eicosapentaenoic acid and/or docosahexaenoic acid, a 20-22C n-3 based highly unsaturated fatty acid, its ester and a pharmaceutically permissible salt as an active ingredient. Since eicosapentaenoic acid and docosahexaenoic acid show strong NGF production activity, they are useful as a preventive and a therapeutic agent for neutral function disorder, especially dementia of Alzheimer and cerebral ischemic disease and as the nerve growth factor production enhancer for recovering peripheral nerve function and promoting neuranagenesis.

5. 发明专利

JPH10323182A CULTURE SOLUTION OF BACTERIUM HAVING PHOSPHOLIPASE A1 ACTIVITY, PREPARATION OF PHOSPHOLIPID HIGHLY CONTAINING DOCOSAHEXAENOIC ACID AND PRODUCTION OF 2-ACYLLYSOPHOSPHLIPID 失效
公开(公告)号：JPH10323182A
公开(公告)日：1998-12-08
申请号：JP2196298
申请日：1998-02-03
申请人： SAGAMI CHEM RES , FUJI YAKUHIN KK
发明人： YAZAWA KAZUYOSHI , WATABE KAZUO , KAMATA MASAZUMI , MURAMATSU HIROSHI
IPC分类号： C12P7/64 , C12N1/20 , C12P9/00 , C12R1/01 , C12R1/63
摘要： PROBLEM TO BE SOLVED: To obtain the subject bacterium culture solution capable of efficiently producing a highly docosahexaenoic acid (DHA)-containing phospholipid and 2- acyllysophospholipid in large amounts by inoculating a docosahexaenoic acid-producing bacterium in a culture medium and subsequently shaking and culturing the bacterium. SOLUTION: This bacterium culture solution having a phospholipase A1 activity and useful for lipid biochemical researches, phospholipid modification, such as the production of a highly DHA-containing phospholipid or acyllysophospholipid, is obtained by inoculating a docosahexaenoic acid-producing bacterium such as a bacterium belonging to the genus Shewanella [e.g. Shewanella benthica-analogue SCRC-21406 (FERM P-15693)], a bacterium belonging to the genus Pseudoalteromonas [e.g. Pseudoalteromonas SCRC-21416 (FERM P-15935)], a bacterium belonging to the genus Vibrio [e.g. Vibrio marinas (ATCC 15381)] in a culture medium containing peptone, a yeast extract, artificial seawater, etc., shaking and culturing the bacterium at 8 deg.C for about 48 hr, centrifugally removing the cells of the bacterium, and collecting the supernatant.

6. 发明专利

JPH10291955A 13C-LABELED DOCOSAHEXAENOIC ACID AND ITS PRODUCTION 失效
公开(公告)号：JPH10291955A
公开(公告)日：1998-11-04
申请号：JP10408397
申请日：1997-04-22
申请人： SAGAMI CHEM RES , FUJI YAKUHIN KK
发明人： YAZAWA KAZUYOSHI , WATABE KAZUO , MURAMATSU HIROSHI
IPC分类号： C12P31/00 , C07C57/12 , C11C3/00 , C12N1/38 , C12R1/01
摘要： PROBLEM TO BE SOLVED: To obtain the subject compound useful for elucidating physiological action of docosahexaenoic acid, having high labeling ratio, high safety, capable of measuring human metabolic experiment and metabolic ability, by culturing a docosahexaenoic acid-producing bacterium in the presence of a C labeled carbon source. SOLUTION: This compound is C labeled docosahexaenoic acid (A) or its ester. For example, the C labeled docosahexaenoic acid (A) is obtained by culturing a bacterium belonging to the genus Shewanella or Pseudoalteromonas, capable of producing docosahexaenoic acid in a medium containing a C labeled carbon source (e.g. sodium acetate, a saccharide, an amino acid or carbon dioxide) (to be concrete, a medium comprising 1% of peptone, 0.2% of yeast essence, 50% of artificial seawater and 0.05-1.0% of C labeled acetic acid).

7. 发明专利

JPH11318434A MICROORGANISM PRODUCING DOCOSAHEXAENOIC ACID AND PHOSPHOLIPASE A1, PRODUCTION OF DOCOSAHEXAENOIC ACID, CULTURE SOLUTION OF MICROORGANISM, PREPARATION OF PHOSPHOLIPID HIGHLY CONTAINING THE DOCOSAHEXAENOIC ACID AND PRODUCTION OF 2-ACYLLYSOPHOSPHOLIPID 失效
公开(公告)号：JPH11318434A
公开(公告)日：1999-11-24
申请号：JP13151598
申请日：1998-05-14
申请人： SAGAMI CHEM RES , FUJI YAKUHIN KK
发明人： YAZAWA KAZUYOSHI , WATABE KAZUO , KAMATA MASAZUMI , TOMITA YOSHIO , MURAMATSU HIROSHI
IPC分类号： C12N9/16 , C12N1/20 , C12N9/18 , C12P7/64 , C12P9/00 , C12R1/01
摘要： PROBLEM TO BE SOLVED: To provide a microorganism belonging to the genus Psychrobacter and producing docosahexaenoic acid, to provide the culture solution of the microorganism having a phospholipase A1 activity, to provide a method for preparing a highly docosahexaenoic acid-containing phospholipid by the use of the culture solution, and to provide a method for producing a 2-acyllysophospholipid by hydrolyzing the phospholipid with the culture solution. SOLUTION: This microorganism belonging to the genus Psychrobacter and producing docosahexaenoic acid can fermentatively efficiently produce the docosahexaenoic acid, and can give a docosahexaenoic acid-containing phospholipid, further the docosahexaenoic acid and other derivatives in large amounts in a short time. The culture solution having the phospholipase A1 activity can more efficiently prepare the highly docosahexaenoic acid-containing phospholipid than lipase and further efficiently produce a 2-acyllysophospholipid. The obtained docosahexaenoic acid and the obtained concentrated docosahexaenoic acid solution can be used as medicines, medicine carriers, food additives and health foods.

8. 发明专利

JPH08245378A TRANQUILIZER 失效
公开(公告)号：JPH08245378A
公开(公告)日：1996-09-24
申请号：JP4952195
申请日：1995-03-09
申请人： SAGAMI CHEM RES , FUJI YAKUHIN KK
发明人： YAZAWA KAZUYOSHI , HAMAZAKI TOMOHITO , SAWAZAKI SHIGEKI , NAGAO YOKO
IPC分类号： A61K31/20 , A61P25/20
摘要： PURPOSE: To obtain a tranquilizer, containing docosahexaenoic acid as an active ingredient, having no or extremely slight side effects and capable of manifesting remarkable tranquilizing effects especially in applying a stress. CONSTITUTION: This tranquilizer contains docosahexaenoic acid (salt) having preferably >=90% (especially >=95%) purity and its ester, glyceride, phospholipid, choline compound, ascorbic acid compound and amino acid compound as an active ingredient in an amount of 5-100wt.% (preferably 20-100wt.%) expressed in terms of a free acid. The daily dose thereof is about 100-500mg expressed in terms of the amount of the docosahexaenoic acid and orally or parenterally administered in one to several divided portions. Furthermore, fish oils extracted from a blueback fish such as a sardine, a mackerel, a horse mackerel, a salmon or a saury, fish oils derived from orbital fats of a large-sized marine fish such as a tuna or bonito, oils and fats derived from a microorganism or a seaweed, krill oils and oils and fats, etc., derived from a marine product extracted from a cod or a cuttlefish liver.

9. 发明专利

JPH10191993A MICROORGANISM PRODUCING DOCOSAHEXAENOIC ACID AND PRODUCTION OF DOCOSAHEXAENOIC ACID 失效
公开(公告)号：JPH10191993A
公开(公告)日：1998-07-28
申请号：JP17671097
申请日：1997-07-02
申请人： SAGAMI CHEM RES , FUJI YAKUHIN KK
发明人： YAZAWA KAZUYOSHI , WATABE KAZUO , ISHIKAWA CHIKAKO , TOMITA YOSHIO , MURAMATSU HIROSHI
IPC分类号： C12P7/64 , C12N1/20 , C12R1/01
摘要： PROBLEM TO BE SOLVED: To provide a novel subject microorganism that is in Shewanella, capable of producing docosahexaenoic acid and is used as a microorganism giving docosahexaenoic acid useful as a medicine, a medicinal carrier, a food additive and a health food. SOLUTION: This novel microorganism is in Shewanella and can produce docosahexaenoic acid, for example, Shewanella sp. SCRC-21406 (FERM P-15693) that can efficiently produce docosahexaenoic acid useful as a medicine, a medicinal carrier, a food additive, a health food and the like and phospholipids containing the same. This novel microorganism is obtained by collecting marine lives from sea and inoculating them to a sterilized agar flat plate medium that is diluted with half concentration of artificial marine water, and statically culturing them at a temperature lower than 8 deg.C and selecting the strain that markedly producing docosahexaenoic acid.

10. 发明专利

JPH06276989A 'MISO' CONTAINING DOCOSAHEXAENOIC ACID AND SPICY VEGETABLE INGREDIENT AND ITS PRODUCTION 失效
公开(公告)号：JPH06276989A
公开(公告)日：1994-10-04
申请号：JP9052393
申请日：1993-03-26
申请人： KANAGAWA KAGAKU KENKYUSHO KK , KUBOTA MISO SHOYU KK
发明人： YAZAWA KAZUYOSHI , NAKANO ISAMU
IPC分类号： A23L11/20 , A23L1/202
摘要： PURPOSE:To provide 'miso' (fermented soybean paste) from which docosahexaenoic acid(DHA) can easily be taken without impairing its flavor. CONSTITUTION:The 'miso' containing (A) 0.01-10wt.% of DHA, (B) 0.01-5wt.% of spicy vegetable ingredient(s) and (C) 0.001-5wt.% of liquid lecithin. The 'miso' can also contain whey mineral(s). This 'miso' is virtually free from fishy smell derived from DHA fish oil as a raw material, being good in taste, scent and palate feel. Besides, the dispersion stability of the DHA in the 'miso' is also good.

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