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    • 5. 发明专利
      CA2209422C 4-AMINO-3-ACYLNAPHTHYRIDINE DERIVATIVES 未知
    • 4-AMINO-3-ACYLNAPHTHYRIDINE DERIVATIVES
    • CA2209422C
    • 2001-09-11
    • CA2209422
    • 1996-06-01
    • YUNGJIN PHARMACEUTICAL CO LTD
    • CHUNG KAE JONG , CHANG MAN SIK , YOO HAN YONG , KIM SUNG GYU , KANG BOG GOO , KIM YOUNG HUN , PAEK JANG HOON , SOHN SANG KWON , KIM YOUNG HEUI , SEO KWI HYON , CHOI WAHN SOO , KANG DAE PIL
    • A61K31/435 , A61K31/4375 , A61P1/04 , A61P35/00 , C07D471/04
    • A novel 4-amino-3-acylnaphthyridine derivatives represented by general formu la (I), wherein R1 is hydrogen atom, a C1-C6 lower alkyl group, a C1-C6 lower alkoxy group, a C1-C6 lower alkoxyalkyl group, a C3-C6 cycloalkyl group, a C 3- C6 cycloalkyl C1-C6 alkyl group, a substituted or unsubstituted phenyl, or a phenyl C1-C6 alkyl group of which phenyl group may be substituted; R2 is hydrogen atom, a C1-C6 lower alkyl group, a C1-C6 alkoxy group, a C1-C6 alkylthio group, or a group of a formula: NR6R7 wherein R6 and R7, identical to or different from each other, are independently hydrogen atom or a C1-C6 lower alkyl group, or R6 and R7 may form together 5-membered or 6-membered cycloalkyl group; R3 is hydrogen atom, a C1-C6 lower alkyl group, a C1-C6 alkoxy group, a C1-C6 alkylthio group, an amino group substituted with one o r two C1-C6 alkyl groups, a halogen atom, a cyano group, a C1-C6 alkanoyl grou p, or trifluoromethyl group; R4 is hydrogen atom or a substituted or unsubstituted C1-C6 alkyl group; R5 is hydrogen atom, a C1-C6 lower alkyl group, a C1-C6 alkoxy group, an amino group substituted with one or two C1-C 6 alkyl groups, a C1-C6 alkylthio group, a halogen atom, a cyano group, a hydroxycarbamoyl group, a carboxy group, a C1-C6 alkanoyl group, or trifluoromethyl group, or an alkyl group which forms together with R4 a 5- membered or 6-membered cycloalkyl group; m is an integer from 0 to 4, inclusive; and n is an integer from 1 to 3, inclusive; with proviso that all alkyl and alkoxy groups may be linear or branched, and said halogen atom mea ns fluorine, chlorine or bromine atom, or its pharmaceutically acceptable salts are disclosed. These compounds show excellent anti-ulcer activity.
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Espacenet 法律信息 同族专利 专利引用
    • 7. 发明专利
      CA2209422A1 4-AMINO-3-ACYLNAPHTHYRIDINE DERIVATIVES 未知
    • 4-AMINO-3-ACYLNAPHTHYRIDINE DERIVATIVES
    • CA2209422A1
    • 1997-01-30
    • CA2209422
    • 1996-06-01
    • YUNGJIN PHARMACEUTICAL CO LTD
    • YOO HAN YONG , SEO KWI HYON , KIM YOUNG HUN , CHUNG KAE JONG , CHOI WAHN SOO , KANG DAE PIL , KIM YOUNG HEUI , KANG BOG GOO , CHANG MAN SIK , SOHN SANG KWON , PAEK JANG HOON , KIM SUNG GYU
    • A61K31/435 , A61K31/4375 , A61P1/04 , A61P35/00 , C07D471/04
    • A novel 4-amino-3-acylnaphthyridine derivatives represented by general formu la (I), wherein R1 is hydrogen atom, a C1-C6 lower alkyl group, a C1-C6 lower alkoxy group, a C1-C6 lower alkoxyalkyl group, a C3-C6 cycloalkyl group, a C 3- C6 cycloalkyl C1-C6 alkyl group, a substituted or unsubstituted phenyl, or a phenyl C1-C6 alkyl group of which phenyl group may be substituted; R2 is hydrogen atom, a C1-C6 lower alkyl group, a C1-C6 alkoxy group, a C1-C6 alkylthio group, or a group of a formula: NR6R7 wherein R6 and R7, identical to or different from each other, are independently hydrogen atom or a C1-C6 lower alkyl group, or R6 and R7 may form together 5-membered or 6-membered cycloalkyl group; R3 is hydrogen atom, a C1-C6 lower alkyl group, a C1-C6 alkoxy group, a C1-C6 alkylthio group, an amino group substituted with one o r two C1-C6 alkyl groups, a halogen atom, a cyano group, a C1-C6 alkanoyl grou p, or trifluoromethyl group; R4 is hydrogen atom or a substituted or unsubstituted C1-C6 alkyl group; R5 is hydrogen atom, a C1-C6 lower alkyl group, a C1-C6 alkoxy group, an amino group substituted with one or two C1-C 6 alkyl groups, a C1-C6 alkylthio group, a halogen atom, a cyano group, a hydroxycarbamoyl group, a carboxy group, a C1-C6 alkanoyl group, or trifluoromethyl group, or an alkyl group which forms together with R4 a 5- membered or 6-membered cycloalkyl group; m is an integer from 0 to 4, inclusive; and n is an integer from 1 to 3, inclusive; with proviso that all alkyl and alkoxy groups may be linear or branched, and said halogen atom mea ns fluorine, chlorine or bromine atom, or its pharmaceutically acceptable salts are disclosed. These compounds show excellent anti-ulcer activity.
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Espacenet 法律信息 同族专利 专利引用
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