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1. 发明申请

US20100048549A1 Peptidomimetics selective for the somatostatin receptor subtypes 1 and/or 4 审中-公开
标题翻译：选择性生长抑素受体亚型1和/或4的肽模拟物
公开(公告)号：US20100048549A1
公开(公告)日：2010-02-25
申请号：US11919968
申请日：2006-05-16
申请人： Jussi Tomperi , Harri Salo , Oili Kallatsa , Pia Knuuttila , Päivi Laakso , Iisa Höglund , Anna-Marja Hoffrén , Kurt Kokko , Pauli Saarenketo , Mia Engström , Siegfried Wurster
发明人： Jussi Tomperi , Harri Salo , Oili Kallatsa , Pia Knuuttila , Päivi Laakso , Iisa Höglund , Anna-Marja Hoffrén , Kurt Kokko , Pauli Saarenketo , Mia Engström , Siegfried Wurster
IPC分类号： A61K31/18 , A61K31/5375 , A61K31/472 , A61K31/445 , A61K31/40 , C07D295/13 , C07D217/02 , C07D211/28 , C07D207/09 , C07C311/13 , A61P29/00 , A61P25/00 , A61P25/24 , A61P35/00 , A61P9/00 , A61P17/02 , A61P27/02
CPC分类号： C07C323/49 , A61K31/18 , A61K31/38 , A61K31/40 , A61K31/415 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/535 , C07C311/13 , C07C311/18 , C07C311/19 , C07C323/58 , C07C323/60 , C07C2601/14 , C07C2602/10 , C07D207/09 , C07D217/02 , C07D233/32 , C07D233/48 , C07D233/64 , C07D295/13 , C07D295/185 , C07D333/62
摘要： The invention relates to (hetero)arylsulfonylamino based peptidomimetics of formula (I), wherein A, D, E, J, Q1 R1, R2, R3, p and j are defined as disclosed, or a pharmaceutically acceptable salt or ester thereof. Compounds of formula (I) possess high affinity and selectivity for the somatostatin receptor subtypes sst1 and/or sst4 and can be used for the treatment or diagnosis of diseases or conditions wherein sst1 and/or sst4 agonists or antagonists are indicated to be useful.
摘要翻译：本发明涉及式（I）的（杂）芳基磺酰氨基基肽模拟物，其中A，D，E，J，Q1 R1，R2，R3，p和j如所公开的，或其药学上可接受的盐或酯。式（I）化合物对生长抑素受体亚型sst1和/或sst4具有高亲和力和选择性，并且可用于治疗或诊断其中sst1和/或sst4激动剂或拮抗剂被认为有用的疾病或病症。

2. 发明申请

US20100004339A1 Somatostatin Receptor 1 and/or 4 Selective Agonists and Antagonists 审中-公开
标题翻译：生长抑素受体1和/或4种选择性激动剂和拮抗剂
公开(公告)号：US20100004339A1
公开(公告)日：2010-01-07
申请号：US12559324
申请日：2009-09-14
申请人： Jussi Tomperi , Päivi Hautamäki , Harri Salo , Mia Engström , Andrei Tauber , Anna-Marja Hoffrén , Siegfried Wurster
发明人： Jussi Tomperi , Päivi Hautamäki , Harri Salo , Mia Engström , Andrei Tauber , Anna-Marja Hoffrén , Siegfried Wurster
IPC分类号： A61K31/18 , A61P25/00 , A61P35/00 , A61P27/00 , A61P7/00
CPC分类号： C07D333/62 , A61K31/18 , A61K31/445 , C07C311/19 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D209/16
摘要： The invention relates to (hetero)arylsulfonylamino based peptidomimetics of formula (I), wherein R1, R2, R3, A, B, D, Q, k and n are defined as disclosed, or a pharmaceutically acceptable salt or ester thereof. Compounds of formula (I) possess high affinity and selectivity for the somatostatin receptor subtypes SSTR1 and/or SSTR4 and can be used for the treatment or diagnosis of diseases or conditions wherein an interaction with SSTR1 and/or SSTR4 is indicated to be useful.
摘要翻译：本发明涉及式（I）的（杂）芳基磺酰氨基基肽模拟物，其中R1，R2，R3，A，B，D，Q，k和n如所公开的定义，或其药学上可接受的盐或酯。式（I）化合物对生长抑素受体亚型SSTR1和/或SSTR4具有高亲和力和选择性，并且可用于治疗或诊断与SSTR1和/或SSTR4的相互作用被认为有用的疾病或病症。

3. 发明授权

US08975254B2 Androgen receptor modulating compounds 有权
标题翻译：雄激素受体调节化合物
公开(公告)号：US08975254B2
公开(公告)日：2015-03-10
申请号：US13504511
申请日：2010-10-27
申请人： Gerd Wohlfahrt , Olli Törmäkangas , Harri Salo , Iisa Höglund , Arja Karjalainen , Pia Knuuttila , Patrik Holm , Sirpa Rasku , Anniina Vesalainen
发明人： Gerd Wohlfahrt , Olli Törmäkangas , Harri Salo , Iisa Höglund , Arja Karjalainen , Pia Knuuttila , Patrik Holm , Sirpa Rasku , Anniina Vesalainen
IPC分类号： C07D231/14 , C07D401/12 , C07D417/12 , C07D405/12 , C07D413/12 , C07D403/12
CPC分类号： C07D513/04 , C07D231/12 , C07D231/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/04
摘要： The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions and methods of treating comprising compounds of formula (I), and pharmaceutically acceptable salts thereof.
摘要翻译：本公开涉及式（I）的化合物及其药学上可接受的盐。本公开还涉及包含式（I）化合物及其药学上可接受的盐的组合物和治疗方法。

4. 发明申请

US20070129422A1 Somatostatin receptor 1 and/or 4 selective agonists and antagonists 失效
标题翻译：生长抑素受体1和/或4种选择性激动剂和拮抗剂
公开(公告)号：US20070129422A1
公开(公告)日：2007-06-07
申请号：US10574584
申请日：2004-10-05
申请人： Jussi Tomperi , Paivi Hautamaki , Harri Salo , Mia Engstrom , Andrei Tauber , Anna-Marja Hoffren , Siegfried Wurster
发明人： Jussi Tomperi , Paivi Hautamaki , Harri Salo , Mia Engstrom , Andrei Tauber , Anna-Marja Hoffren , Siegfried Wurster
IPC分类号： A61K31/404 , A61K31/381 , A61K31/18 , C07D209/36
CPC分类号： A61K31/18 , A61K31/381 , A61K31/404 , A61K31/445 , C07C311/19 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D209/14 , C07D209/16 , C07D333/62
摘要： The invention relates to (hetero)arylsulfonylamino based peptidomimetics of formula (I), wherein R1, R2, R3, A, B, D, Q, k and n are defined as disclosed, or a pharmaceutically acceptable salt or ester thereof. Compounds of formula (I) possess high affinity and selectivity for the somatostatin receptor subtypes SSTR1 and/or SSTR4 and can be used for the treatment or diagnosis of diseases or conditions wherein an interaction with SSTR1 and/or SSTR4 is indicated to be useful.
摘要翻译：本发明涉及式（I）的（杂）芳基磺酰氨基基肽模拟物，其中R1，R2，R3，A，B，D，Q，k和n如所公开的定义，或其药学上可接受的盐或酯。式（I）化合物对生长抑素受体亚型SSTR1和/或SSTR4具有高亲和力和选择性，并且可用于治疗或诊断与SSTR1和/或SSTR4的相互作用被认为有用的疾病或病症。

5. 发明授权

US07741362B2 Somatostatin receptor 1 and/or 4 selective agonists and antagonists 失效
标题翻译：生长抑素受体1和/或4种选择性激动剂和拮抗剂
公开(公告)号：US07741362B2
公开(公告)日：2010-06-22
申请号：US10574584
申请日：2004-10-05
申请人： Jussi Tomperi , Paivi Hautamaki , Harri Salo , Mia Engstrom , Andrei Tauber , Anna-Marja Hoffren , Siegfried Wurster
发明人： Jussi Tomperi , Paivi Hautamaki , Harri Salo , Mia Engstrom , Andrei Tauber , Anna-Marja Hoffren , Siegfried Wurster
IPC分类号： A61K31/40 , A61K31/38 , A01N41/06 , A61K31/18 , C07D209/36 , C07D333/00
CPC分类号： A61K31/18 , A61K31/381 , A61K31/404 , A61K31/445 , C07C311/19 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D209/14 , C07D209/16 , C07D333/62
摘要： The invention relates to (hetero)arylsulfonylamino based peptidomimetics of formula (I), wherein R1, R2, R3, A, B, D, Q, k and n are defined as disclosed, or a pharmaceutically acceptable salt or ester thereof. Compounds of formula (I) possess high affinity and selectivity for the somatostatin receptor subtypes SSTR1 and/or SSTR4 and can be used for the treatment or diagnosis of diseases or conditions wherein an interaction with SSTR1 and/or SSTR4 is indicated to be useful.
摘要翻译：本发明涉及式（I）的（杂）芳基磺酰氨基基肽模拟物，其中R1，R2，R3，A，B，D，Q，k和n如所公开的定义，或其药学上可接受的盐或酯。式（I）化合物对生长抑素受体亚型SSTR1和/或SSTR4具有高亲和力和选择性，并且可用于治疗或诊断与SSTR1和/或SSTR4的相互作用被认为有用的疾病或病症。

6. 发明申请

US20120225867A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS 有权
标题翻译：雄激素受体调节化合物
公开(公告)号：US20120225867A1
公开(公告)日：2012-09-06
申请号：US13504511
申请日：2010-10-27
申请人： Gerd Wohlfahrt , Olli Törmäkangas , Harri Salo , lisa Höglund , Arja Karjalainen , Pia Knuuttila , Patrik Holm , Sirpa Rasku , Anniina Vesalainen
发明人： Gerd Wohlfahrt , Olli Törmäkangas , Harri Salo , lisa Höglund , Arja Karjalainen , Pia Knuuttila , Patrik Holm , Sirpa Rasku , Anniina Vesalainen
IPC分类号： A61K31/4155 , A61K31/496 , C07D413/14 , A61K31/5377 , C07D405/12 , A61K31/497 , C07D403/12 , C07D487/04 , A61K31/519 , C07D403/14 , A61K31/501 , A61K31/4985 , C07D417/14 , C07D401/14 , A61K31/4439 , A61K31/427 , A61P35/00 , C07D498/04 , A61K31/5383 , A61K31/5365 , C07D405/14
CPC分类号： C07D513/04 , C07D231/12 , C07D231/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/04
摘要： The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions and methods of treating comprising compounds of formula (I), and pharmaceutically acceptable salts thereof.
摘要翻译：本公开涉及式（I）的化合物及其药学上可接受的盐。本公开还涉及包含式（I）化合物及其药学上可接受的盐的组合物和治疗方法。

7. 发明授权

US06767909B2 Compounds useful for treatment or prevention of disease mediated by alpha-2B-adrenoceptor 失效
标题翻译：可用于治疗或预防由α-2B肾上腺素受体介导的疾病的化合物
公开(公告)号：US06767909B2
公开(公告)日：2004-07-27
申请号：US10196123
申请日：2002-07-17
申请人： Topi Joutsamo , Andrei Yurievitch Tauber , Harri Salo , Anna-Maria Hoffrén , Siegfreid Wurster
发明人： Topi Joutsamo , Andrei Yurievitch Tauber , Harri Salo , Anna-Maria Hoffrén , Siegfreid Wurster
IPC分类号： C07D23942
CPC分类号： C07D239/42 , C07D401/12 , C07D403/12
摘要： A compound, suitable as an alpha-2B-adrenoceptor antagoist, having a structure of formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, R4 and R5 are independently of each other H, a straight or branched alkyl or alkoxy group with 1 to 4 carbon atoms, or a halogen; X is H, a straight or branched alkyl chain with 1 to 4 carbon atoms, phenyl, —OH or ═O; Z is H, acetyl, —CH2—Ph—O—CF3 or —CH2—Ph—CF3, Y is a ring structure optionally linked to formula (I) with an alkyl chain having one or two carbon atoms. The compound is suitable for use in a method for treatment or prevention of a disease mediated by the alpha-2B-adrenoceptor in a mammal.
摘要翻译：适合作为α-2B肾上腺素受体拮抗剂的化合物，其具有式（I）结构或其药学上可接受的盐，其中R 1，R 2，R 3，R 4和R 5彼此独立地为H，直链或支链烷基或具有1至4个碳原子的烷氧基，或卤素; X是H，具有1至4个碳原子的直链或支链烷基链，苯基，-OH或= O; Z是H，乙酰基，-CH2-Ph-O-CF3或-CH2-Ph-CF3，Y是任选与式（I）连接的具有一个或两个碳原子的烷基链的环结构。该化合物适合用于治疗或预防哺乳动物中由α-2B-肾上腺素受体介导的疾病的方法。

8. 发明申请

US20110275085A1 METHOD FOR DETECTION OF AUTOIMMUNE DISEASES 审中-公开
标题翻译：检测自身免疫性疾病的方法
公开(公告)号：US20110275085A1
公开(公告)日：2011-11-10
申请号：US13132048
申请日：2009-12-01
申请人： Harri Salo , Jarno Honkanen , Outi Vaarala
发明人： Harri Salo , Jarno Honkanen , Outi Vaarala
IPC分类号： C12Q1/68 , G06F19/24
CPC分类号： C12Q1/6883 , C12Q2600/158 , G16B25/00 , G16B40/00 , Y02A90/22 , Y02A90/24 , Y02A90/26
摘要： The present invention relates to the field of diagnostics, especially to the detection of autoimmune diseases such as rheumatoid arthritis. Particularly, the invention provides a method for detecting the presence or absence of rheumatoid arthritis, or of a predisposition therefore or for monitoring rheumatoid arthritis in a subject using expression data of target genes related to immune system and tools of bioinformatics.
摘要翻译：本发明涉及诊断领域，特别涉及自身免疫疾病如类风湿性关节炎的检测。特别地，本发明提供了一种用于检测类风湿性关节炎的存在或不存在或倾向性或用于使用与生物信息学的免疫系统和工具相关的靶基因的表达数据来监测受试者的类风湿性关节炎的方法。

9. 发明授权

US07631569B2 Arrangement for moving measuring head of measuring device into and out of process space 有权
标题翻译：将测量装置测量头移入和移出工艺空间的布置
公开(公告)号：US07631569B2
公开(公告)日：2009-12-15
申请号：US11450386
申请日：2006-06-12
申请人： Harri Salo
发明人： Harri Salo
IPC分类号： G01D11/00
CPC分类号： G01B5/0004 , G01N2001/2057
摘要： An arrangement for moving a measuring head of a measuring device into and out of a process space. The arrangement includes a valve member that is attached to a wall of the process space. A measuring device is attached to the valve member and includes a body part provided with an elongated portion which in turn has a measuring head at one end. The measurement device also includes a placement device arranged to seize the measuring device and to move it through the valve member into a first position in which the measuring head extends into the process space and, correspondingly, into a second position in which the measuring head is not in contact with the process space. The placement device includes a stop element configured to seize the measuring device and to form a sealed casing around the body part of the measuring device, and a housing part arranged to attach to the valve member and to form a sealed casing around the stop element. The placement device is equipped with features that move the stop element seizing the body part of the measuring device inside the housing part so that the measuring device moves between the first position and the second position.
摘要翻译：一种用于将测量装置的测量头移入和移出工艺空间的装置。该装置包括附接到处理空间的壁的阀构件。测量装置附接到阀构件并且包括设置有细长部分的主体部分，细长部分在一端具有测量头。测量装置还包括布置成将测量装置抓住并将其移动通过阀构件的放置装置到第一位置，在第一位置，测量头延伸到处理空间中，并且相应地进入第二位置，其中测量头不与过程空间接触。放置装置包括：止动元件，其构造成抓住测量装置并且围绕测量装置的主体部分形成密封壳体;以及壳体部分，其布置成附接到阀构件并且围绕止动元件形成密封壳体。所述放置装置配备有使所述止动元件将所述测量装置的主体部分卡在所述壳体部内部的特征，使得所述测量装置在所述第一位置与所述第二位置之间移动。

10. 发明申请

US20070051194A1 Arrangement for moving measuring head of measuring device into and out of process space 有权
标题翻译：将测量装置测量头移入和移出工艺空间的布置
公开(公告)号：US20070051194A1
公开(公告)日：2007-03-08
申请号：US11450386
申请日：2006-06-12
申请人： Harri Salo
发明人： Harri Salo
IPC分类号： G01D21/00
CPC分类号： G01B5/0004 , G01N2001/2057
摘要： An arrangement for moving a measuring head of a measuring device into and out of a process space. The arrangement comprises: a valve member to be attached to a wall of the process space; a measuring device to be attached to the valve member, the measuring device comprising a body part provided with an elongated portion which in turn has a measuring head at one end thereof; and a placement device arranged to seize the measuring device and to move it through the valve member into a first position in which the measuring head extends into the process space and, correspondingly, into a second position in which the measuring head is not in contact with the process space. The placement device comprises a stop element configured to seize the measuring device and to form a sealed casing around the body part of the measuring device, and a housing part arranged to attach to the valve member and to form a sealed casing around the stop element. The placement device is equipped with means for moving the stop element seizing the body part of the measuring device inside the housing part in such a manner that the measuring device moves between the first position and the second position.
摘要翻译：一种用于将测量装置的测量头移入和移出工艺空间的装置。该装置包括：阀构件，其附接到处理空间的壁; 测量装置，其附接到所述阀构件，所述测量装置包括主体部分，所述主体部分设置有细长部分，所述细长部分在其一端依次具有测量头; 以及放置装置，布置成抓住测量装置并将其移动通过阀构件进入第一位置，在第一位置，测量头延伸到处理空间中，并且相应地进入到测量头不与其接触的第二位置过程空间。所述放置装置包括：止动元件，其构造成抓住所述测量装置并且围绕所述测量装置的主体部分形成密封壳体;以及壳体部件，其布置成附接到所述阀构件并且围绕所述止动元件形成密封壳体。该放置装置具有用于使止动元件以使得测量装置在第一位置和第二位置之间移动的方式将止动元件移动到使壳体部分内部的测量装置的主体部分移动的装置。

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