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    • 5. 发明授权
    • Graft-versus-host disease predicting marker and use thereof
    • 移植物抗宿主病预测标记及其用途
    • US08603754B2
    • 2013-12-10
    • US13204799
    • 2011-08-08
    • Akira ShibuyaHiroshi Kojima
    • Akira ShibuyaHiroshi Kojima
    • G01N33/53
    • G01N33/573A61K39/3955A61K2039/505C07K16/2803G01N2333/91245G01N2800/245
    • A test method that provides data useful in predicting the probability of onset of acute graft-versus-host disease (GVHD) is described along with a kit for performing the method, and a pharmaceutical preparation and a molecular targeted therapy for treating or preventing GVHD. The test method includes measuring the blood DNAM-1 concentration of a patient of hematopoietic stem cell transplantation from bone marrow or the like over a period after the transplantation to provide data concerning the transition of the concentration to an abnormally high level deviating from the normal range, whereby the probability of the development of acute graft-versus-host disease is predicted, the risk of the development is estimated, or therapeutic effects after the development are evaluated. Concerning the molecular targeted therapy and pharmaceutical preparation used therefor wherein blood DNAM-1 of a GVHD patient or a graft recipient that is a possible patient is used as a target molecule, GVHD is treated or prevented by administering an anti-DNAM-1 antibody that is a neutralizing antibody.
    • 描述了提供用于预测急性移植物抗宿主病(GVHD)发病概率的数据的测试方法以及用于进行该方法的试剂盒以及用于治疗或预防GVHD的药物制剂和分子靶向治疗。 测试方法包括在移植后的一段时间内测量来自骨髓等的造血干细胞移植患者的血液DNAM-1浓度,以提供关于浓度向偏离正常范围的异常高水平转变的数据 预测急性移植物抗宿主病发展的可能性,估计发展的风险,或发展后的治疗效果。 关于其中使用的分子靶向治疗和药物制剂,其中GVHD患者的血液DNAM-1或作为可能患者的移植物接受体用作靶分子,通过施用抗-DNAM-1抗体来治疗或预防GVHD, 是中和抗体。
    • 8. 发明授权
    • Vibration proofing apparatus
    • 防振装置
    • US08302946B2
    • 2012-11-06
    • US11664066
    • 2005-09-29
    • Hiroshi KojimaYoshitaka Otsubo
    • Hiroshi KojimaYoshitaka Otsubo
    • F16F5/00
    • F16F13/16
    • In a vibration proofing apparatus, two second pressure receiving liquid chambers are arranged between an outer tube and a mounting attachment, and are configured to communicate with an auxiliary liquid chamber through two second orifices when an auxiliary vibration along an auxiliary amplitude direction orthogonal to an axial direction is input to the mounting attachment, a rubber elastic body is elastically deformed along an auxiliary amplitude direction, and expands and contracts an internal volume of the second pressure receiving liquid chambers. At this time, since a resonance phenomenon is generated in the liquid circulating between the second pressure receiving liquid chambers and the auxiliary liquid chamber through the second orifices in synchronization with the input auxiliary vibration, a low-frequency vibration input along the auxiliary amplitude direction due to a pressure change, and a viscous resistance generated together with the resonance phenomenon of the liquid is effectively absorbed.
    • 在防振装置中,在外管和安装附件之间设置两个第二压力接收液室,并且构造成当沿辅助振动方向的辅助振动与轴向正交时通过两个第二孔连通辅助液室 方向输入到安装附件,橡胶弹性体沿着辅助振幅方向弹性变形,并使第二受压液体室的内部容积膨胀和收缩。 此时,由于与输入的辅助振动同步地通过第二孔与在第二受压液室和辅助液室之间循环的液体产生共振现象,因此沿着辅助振幅方向输入的低频振动 并且与液体的共振现象一起产生的粘性电阻被有效地吸收。
    • 10. 发明授权
    • Processing method of glass substrate, and highly flat and highly smooth glass substrate
    • 玻璃基板的加工方法,以及高度平坦且高度平滑的玻璃基板
    • US08137574B2
    • 2012-03-20
    • US12233884
    • 2008-09-19
    • Koji OtsukaHiroshi KojimaMasabumi Ito
    • Koji OtsukaHiroshi KojimaMasabumi Ito
    • B44C1/22C03C15/00
    • C03C15/02B24B7/242B24B37/08C03C3/06C03C19/00C03C23/005C03C23/006C03C2201/42C03C2204/08Y10T428/24355
    • The present invention is to provide a processing method for manufacturing a highly flat and highly smooth glass substrate with good productivity. A highly flat and highly smooth glass substrate is obtained with good productivity by processing of a glass substrate, which comprises a step of measuring the surface shape of the glass substrate prior to processing, a step of processing the surface of the substrate by changing a processing condition for each site (first processing step), and a step of finish-polishing the surface of the glass substrate that has been subjected to the first processing step (second processing step). At that time, the processing condition for each site within the surface of the substrate in the first processing step is determined from a processing amount that is determined from the concave-convex shape of the surface of the glass substrate prior to processing and the in-plane distribution of a processing amount by the second processing step separately measured by using a similar substrate.
    • 本发明提供一种以高生产率制造高度平坦且高度光滑的玻璃基板的加工方法。 通过处理玻璃基板,通过加工玻璃基板,以高生产率获得高度平坦且高度平滑的玻璃基板,其包括在处理之前测量玻璃基板的表面形状的步骤,通过改变处理来处理基板的表面的步骤 (第一处理步骤),以及对经过第一处理步骤(第二处理步骤)的玻璃基板的表面进行精抛光的步骤。 此时,根据从处理前的玻璃基板的表面的凹凸形状确定的处理量来确定第一处理工序中的基板的表面内的每个部位的处理条件, 通过使用相似的基板分别测量的第二处理步骤的处理量的平面分布。