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1. 发明授权

US08143022B2 High production system for infectious hepatitis C virus particle 失效
标题翻译：传染性丙型肝炎病毒颗粒高生产系统
公开(公告)号：US08143022B2
公开(公告)日：2012-03-27
申请号：US11992837
申请日：2006-09-29
申请人： Jun-ichi Tanabe , Saburo Sone , Takaji Wakita , Koji Ishii , Ryosuke Suzuki , Tetsuro Suzuki , Tatsuo Miyamura
发明人： Jun-ichi Tanabe , Saburo Sone , Takaji Wakita , Koji Ishii , Ryosuke Suzuki , Tetsuro Suzuki , Tatsuo Miyamura
IPC分类号： C12P21/00 , C12N7/00 , C12N5/22
CPC分类号： C12N7/00 , C12N15/86 , C12N2770/24243 , C12N2770/24252
摘要： The present invention relates to a method for producing infectious hepatitis C virus (HCV) particles, comprising a step of introducing an expression vector into a cell that allows HCV proliferation, such expression vector comprising: DNA sequences encoding the 5′ untranslated region, structural proteins, and, if necessary, non-structural proteins of HCV and DNA sequences encoding non-structural proteins and the 3′ untranslated region derived from the HCV JFH1 strain, which are located downstream of a polymerase I promoter; and a DNA fragment containing an RNA polymerase I terminator, which is located further downstream thereof.
摘要翻译：本发明涉及一种生产感染性丙型肝炎病毒（HCV）颗粒的方法，包括将表达载体导入允许HCV增殖的细胞中的步骤，所述表达载体包含：编码5'非翻译区的DNA序列，结构蛋白，如果需要，HCV的非结构蛋白和编码非结构蛋白的DNA序列和源自HCV JFH1株的3'非翻译区，位于聚合酶I启动子的下游; 和包含位于其下游的RNA聚合酶I终止子的DNA片段。

2. 发明授权

US08183044B2 Recombinant human hepatitis C virus-like particle and method for producing the same 有权
标题翻译：重组人类丙型肝炎病毒样颗粒及其制备方法
公开(公告)号：US08183044B2
公开(公告)日：2012-05-22
申请号：US11992646
申请日：2006-09-29
申请人： Jun-ichi Tanabe , Saburo Sone , Takaji Wakita , Koji Ishii , Ryosuke Suzuki , Tetsuro Suzuki , Tatsuo Miyamura
发明人： Jun-ichi Tanabe , Saburo Sone , Takaji Wakita , Koji Ishii , Ryosuke Suzuki , Tetsuro Suzuki , Tatsuo Miyamura
IPC分类号： C12N15/63
CPC分类号： C12N7/00 , C12N15/86 , C12N2770/24223 , C12N2770/24243 , C12N2770/24252
摘要： The present invention relates to a method for producing a recombinant hepatitis C virus-like particle comprising the steps of introducing into (i) a cell in which an RNA replicon comprising a nucleotide sequence comprising the 5′ untranslated region, the nucleotide sequence coding for the NS3, NS4A, NS4B, NS5A, and NS5B proteins, and the 3′ untranslated region of a genome RNA derived from a hepatitis C virus strain autonomously replicates, (ii) a vector expressing the Core, E1, E2, and p7 proteins derived from a hepatitis C virus strain that is the same as or different from that as defined in the above (i), culturing the cell, and recovering the produced virus-like particle, and a recombinant hepatitis C virus particle produced by this method.
摘要翻译：本发明涉及一种重组丙型肝炎病毒样颗粒的制备方法，包括以下步骤：（i）将包含5'非翻译区的核苷酸序列的RNA复制子，编码 NS3，NS4A，NS4B，NS5A和NS5B蛋白，并且来源于丙型肝炎病毒株的基因组RNA的3'非翻译区自主复制，（ii）表达来源于核苷酸的核心，E1，E2和p7蛋白的载体与上述（i）所定义的相同或不同的丙型肝炎病毒株，培养细胞，回收所产生的病毒样颗粒，以及通过该方法生产的重组丙型肝炎病毒颗粒。

3. 发明申请

US20100035345A1 High Production System for Infectious Hepatitis C Virus Particle 失效
标题翻译：传染性丙型肝炎病毒颗粒高生产系统
公开(公告)号：US20100035345A1
公开(公告)日：2010-02-11
申请号：US11992837
申请日：2006-09-29
申请人： Jun-ichi Tanabe , Saburo Sone , Takaji Wakita , Koji Ishii , Ryosuke Suzuki , Tetsuro Suzuki , Tatsuo Miyamura
发明人： Jun-ichi Tanabe , Saburo Sone , Takaji Wakita , Koji Ishii , Ryosuke Suzuki , Tetsuro Suzuki , Tatsuo Miyamura
IPC分类号： C12N15/63
CPC分类号： C12N7/00 , C12N15/86 , C12N2770/24243 , C12N2770/24252
摘要： The present invention relates to a method for producing infectious hepatitis C virus (HCV) particles, comprising a step of introducing an expression vector into a cell that allows HCV proliferation, such expression vector comprising: DNA sequences encoding the 5′ untranslated region, structural proteins, and, if necessary, non-structural proteins of HCV and DNA sequences encoding non-structural proteins and the 3′ untranslated region derived from the HCV JFH1 strain, which are located downstream of a polymerase I promoter; and a DNA fragment containing an RNA polymerase I terminator, which is located further downstream thereof.
摘要翻译：本发明涉及一种生产感染性丙型肝炎病毒（HCV）颗粒的方法，包括将表达载体导入允许HCV增殖的细胞中的步骤，所述表达载体包含：编码5'非翻译区的DNA序列，结构蛋白，如果需要，HCV的非结构蛋白和编码非结构蛋白的DNA序列以及来源于HCV JFH1株的3'非翻译区，位于聚合酶I启动子的下游; 和包含位于其下游的RNA聚合酶I终止子的DNA片段。

4. 发明申请

US20090221028A1 Novel Recombinant Human Hepatitis C Virus-Like Particle and Method for Producing the Same 有权
标题翻译：新型重组人类丙型肝炎病毒样颗粒及其生产方法
公开(公告)号：US20090221028A1
公开(公告)日：2009-09-03
申请号：US11992646
申请日：2006-09-29
申请人： Jun-ichi Tanabe , Saburo Sone , Takaji Wakita , Koji Ishii , Ryosuke Suzuki , Tetsuro Suzuki , Tatsuo Miyamura
发明人： Jun-ichi Tanabe , Saburo Sone , Takaji Wakita , Koji Ishii , Ryosuke Suzuki , Tetsuro Suzuki , Tatsuo Miyamura
IPC分类号： C12P21/00 , C07K14/00
CPC分类号： C12N7/00 , C12N15/86 , C12N2770/24223 , C12N2770/24243 , C12N2770/24252
摘要： The present invention relates to a method for producing a recombinant hepatitis C virus-like particle comprising the steps of introducing into (i) a cell in which an RNA replicon comprising a nucleotide sequence comprising the 5′ untranslated region, the nucleotide sequence coding for the NS3, NS4A, NS4B, NS5A, and NS5B proteins, and the 3′ untranslated region of a genome RNA derived from a hepatitis C virus strain autonomously replicates, (ii) a vector expressing the Core, E1, E2, and p7 proteins derived from a hepatitis C virus strain that is the same as or different from that as defined in the above (i), culturing the cell, and recovering the produced virus-like particle, and a recombinant hepatitis C virus particle produced by this method.
摘要翻译：本发明涉及一种重组丙型肝炎病毒样颗粒的制备方法，包括以下步骤：（i）将包含5'非翻译区的核苷酸序列的RNA复制子，编码 NS3，NS4A，NS4B，NS5A和NS5B蛋白，并且来源于丙型肝炎病毒株的基因组RNA的3'非翻译区自主复制，（ii）表达来源于核苷酸的核心，E1，E2和p7蛋白的载体与上述（i）所定义的相同或不同的丙型肝炎病毒株，培养细胞，回收所产生的病毒样颗粒，以及通过该方法生产的重组丙型肝炎病毒颗粒。

5. 发明申请

US20100291545A1 ANTIBODY HAVING INHIBITORY ACTIVITY ON INFECTION WITH HEPATITIS C VIRUS (HCV) AND USE THEREOF 审中-公开
标题翻译：具有丙型肝炎病毒（HCV）感染的感染活动的抗体及其用途
公开(公告)号：US20100291545A1
公开(公告)日：2010-11-18
申请号：US12670383
申请日：2008-07-25
申请人： Takaji Wakita , Tetsuro Suzuki , Kenichi Morikawa , Noriaki Omi , Noriko Nakamura , Daisuke Akazawa
发明人： Takaji Wakita , Tetsuro Suzuki , Kenichi Morikawa , Noriaki Omi , Noriko Nakamura , Daisuke Akazawa
IPC分类号： C12Q1/70 , C07K16/10
CPC分类号： C07K16/109 , C07K14/005 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C12N2770/24222 , G01N2333/186
摘要： The objection of the invention is to provide an antibody that inhibits infection with hepatitis C virus (HCV). To this end, this invention provides an antibody that recognizes the hepatitis C virus (HCV) particle obtained from the hepatitis C virus (HCV) genome comprising the following (i) and (ii) ligated to each other as an antigen and has an inhibitory activity on infection with hepatitis C virus (HCV): (i) (a) the 5′-untranslated region, the core protein-encoding sequence, the E1 protein-encoding sequence, the E2 protein-encoding sequence, and the p7 protein-encoding sequence of the JFH-1 strain of the hepatitis C virus (HCV) or (b) the 5′-untranslated region, the core protein-encoding sequence, the E1 protein-encoding sequence, the E2 protein-encoding sequence, and the p7 protein-encoding sequence of the J6CF strain the hepatitis C virus (HCV); and (ii) the NS2 protein-encoding sequence, the NS3 protein-encoding sequence, the NS4A protein-encoding sequence, the NS4B protein-encoding sequence, the NS5A protein-encoding sequence, the NS5B protein-encoding sequence, and the 3′-untranslated region of the JFH-1 strain.
摘要翻译：本发明的反对是提供抑制丙型肝炎病毒（HCV）感染的抗体。为此，本发明提供一种抗体，其识别从丙型肝炎病毒（HCV）基因组获得的丙型肝炎病毒（HCV）颗粒，其包含以下（i）和（ii）作为抗原彼此连接并具有抑制性丙型肝炎病毒（HCV）感染活动：（i）（a）5'非翻译区，核心蛋白编码序列，编码E1蛋白的序列，E2蛋白编码序列和p7蛋白 - 丙型肝炎病毒（HCV）的JFH-1株的编码序列或（b）5'-非翻译区，核心蛋白编码序列，E1蛋白编码序列，E2蛋白编码序列和 J6CF株丙型肝炎病毒（HCV）的p7蛋白编码序列; 和（ii）NS2蛋白编码序列，编码NS3蛋白的序列，NS4A蛋白编码序列，NS4B蛋白编码序列，NS5A蛋白编码序列，NS5B蛋白编码序列和3' JFH-1株的非翻译区。

6. 发明申请

US20100278865A1 PRODUCTION AND USE OF EPITOPE-TAGGED HEPATITIS C VIRUS PARTICLE 审中-公开
标题翻译： EPITOPE-TAGGED HEPATITIS C病毒颗粒的生产和使用
公开(公告)号：US20100278865A1
公开(公告)日：2010-11-04
申请号：US12668861
申请日：2008-07-11
申请人： Takaji Wakita , Tetsuro Suzuki , Hitoshi Takahashi
发明人： Takaji Wakita , Tetsuro Suzuki , Hitoshi Takahashi
IPC分类号： A61K39/29 , C07H21/04 , C12N15/79 , C12N7/00 , C12N5/071 , C12N7/02 , C07K16/08 , A61P31/14
CPC分类号： A61K39/29 , A61K39/12 , C07K14/005 , C07K2319/43 , C12N7/00 , C12N2770/24222 , C12N2770/24234 , C12N2770/24251
摘要： This invention relates to a nucleic acid comprising a nucleic acid sequence encoding an epitope tag peptide in the hypervariable region 1 of the E2 protein of naturally occurring or chimeric hepatitis C virus (HCV) genome, an epitope-tagged HCV particle encoded by such nucleic acid, and a method for purifying the HCV particles at a high purity in a simple manner with the use of an anti-epitope tag antibody-immobilized support.
摘要翻译：本发明涉及包含编码天然存在或嵌合丙型肝炎病毒（HCV）基因组的E2蛋白的高变区1中的表位标签肽的核酸序列的核酸，由该核酸编码的表位标记的HCV颗粒以及通过使用抗抗原标记抗体固定化载体以简单的方式纯化高纯度的HCV颗粒的方法。

7. 发明授权

US10114302B2 Photoconductor, image forming apparatus, and process cartridge 有权
公开(公告)号：US10114302B2
公开(公告)日：2018-10-30
申请号：US15590047
申请日：2017-05-09
申请人： Ryohta Takahashi , Akihiro Sugino , Eiji Kurimoto , Hidetoshi Kami , Keisuke Shimoyama , Tetsuro Suzuki , Tomoharu Asano , Toshihiro Ishida
发明人： Ryohta Takahashi , Akihiro Sugino , Eiji Kurimoto , Hidetoshi Kami , Keisuke Shimoyama , Tetsuro Suzuki , Tomoharu Asano , Toshihiro Ishida
IPC分类号： G03G5/00 , G03G5/05 , G03G5/147 , G03G15/01 , G03G15/20
摘要： A photoconductor is provided. The photoconductor includes a support, an undercoat layer overlying the support, and a photosensitive layer overlying the undercoat layer. The undercoat layer includes a binder resin and a zinc oxide particle. The photosensitive layer includes a compound represented by the following formula (1): where each of R1 and R2 independently represents an alkyl group or an aromatic hydrocarbon group.

8. 发明授权

US09753384B2 Photoconductor, electrophotographic method, electrophotographic apparatus, and electrophotographic process cartridge 有权
公开(公告)号：US09753384B2
公开(公告)日：2017-09-05
申请号：US15133915
申请日：2016-04-20
申请人： Eiji Kurimoto , Tetsuro Suzuki , Tomoharu Asano , Daisuke Nii , Toshihiro Ishida
发明人： Eiji Kurimoto , Tetsuro Suzuki , Tomoharu Asano , Daisuke Nii , Toshihiro Ishida
IPC分类号： G03G5/00 , G03G5/05 , G03G5/14 , G03G15/00 , G03G21/18
CPC分类号： G03G5/0517 , G03G5/0507 , G03G5/144 , G03G15/75 , G03G21/18
摘要： Provided is a photoconductor including a conductive support, an intermediate layer containing metal oxide particles, and a photoconductive layer. The intermediate layer and the photoconductive layer are provided over the conductive support in the order of reciting. An elastic power (We/Wt value) of the intermediate layer is greater than or equal to 20.0% but less than 35.0%. A Martens hardness (HM) of the intermediate layer is greater than or equal to 350 [N/mm2] but less than 450 [N/mm2].

9. 发明申请

US20160334720A1 PHOTOCONDUCTOR, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE 有权
标题翻译：光电子器件，图像形成装置和工艺盒
公开(公告)号：US20160334720A1
公开(公告)日：2016-11-17
申请号：US15144199
申请日：2016-05-02
申请人： Toshihiro Ishida , Eiji Kurimoto , Tetsuro Suzuki , Tomoharu Asano , Daisuke Nii
发明人： Toshihiro Ishida , Eiji Kurimoto , Tetsuro Suzuki , Tomoharu Asano , Daisuke Nii
IPC分类号： G03G15/00
CPC分类号： G03G5/144 , G03G5/142 , G03G5/1476 , G03G5/14765 , G03G21/18
摘要： A photoconductor including: a conductive support; an undercoat layer; and a photoconductive layer, the undercoat layer being disposed over the conductive support, the photoconductive layer being disposed over the undercoat layer, wherein the undercoat layer includes zinc oxide particles, wherein when a film thickness of the undercoat layer is 20 μm, the undercoat layer has transmittance of 50% or more to light having a wavelength in a range of 500 nm or more but 800 nm or less, wherein a lowest transmittance of light is 85% or less in the range, and wherein when an electric field of 5 V/μm is applied to the undercoat layer, volume resistivity of the undercoat layer is 1.0×107 Ω·cm or more but 5.0×108 Ω·cm or less at an environment of 23° C. and 55% RH.
摘要翻译：一种光电导体，包括：导电支撑体; 底漆层; 以及光导电层，所述底涂层设置在所述导电支撑体上方，所述光电导层设置在所述底涂层上，其中所述底涂层包括氧化锌颗粒，其中当所述底涂层的膜厚度为20μm时，所述底涂层对波长在500nm以上且800nm以下的波长的光具有50％以上的透射率，其中光的最低透射率在该范围内为85％以下，并且其中当电场为5V /μm施加到底涂层，在23℃和55％RH的环境下，底涂层的体积电阻率为1.0×10 7Ω·cm以上，5.0×10 8Ω·cm以下。

10. 发明申请

US20160139517A1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE 有权
标题翻译：电子照相机，图像形成装置和工艺盒
公开(公告)号：US20160139517A1
公开(公告)日：2016-05-19
申请号：US14945498
申请日：2015-11-19
申请人： Toshihiro ISHIDA , Eiji Kurimoto , Tetsuro Suzuki , Tomoharu Asano , Daisuke Nii
发明人： Toshihiro ISHIDA , Eiji Kurimoto , Tetsuro Suzuki , Tomoharu Asano , Daisuke Nii
IPC分类号： G03G15/00
CPC分类号： G03G5/144
摘要： A electrophotographic photoconductor is provided. The electrophotographic photoconductor includes a conductive support, an undercoat layer overlying the conductive support, and a photosensitive layer overlying the undercoat layer. The undercoat layer includes a metal oxide particle, binder resin, and a compound having a urea group.
摘要翻译：提供电子照相感光体。电子照相感光体包括导电载体，覆盖导电载体的底涂层和覆盖底涂层的感光层。底涂层包括金属氧化物颗粒，粘合剂树脂和具有脲基的化合物。

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