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1. 发明申请

US20080124247A1 Chip element for micro chemical system and micro chemical system using the chip element 审中-公开
标题翻译：用于微化学系统的芯片元件和使用芯片元件的微量化学系统
公开(公告)号：US20080124247A1
公开(公告)日：2008-05-29
申请号：US11983917
申请日：2007-11-13
申请人： Yoshinori Matsuoka , Jun Yamaguchi , Takashi Fukuzawa , Akihiko Hattori , Takehiko Kitamori
发明人： Yoshinori Matsuoka , Jun Yamaguchi , Takashi Fukuzawa , Akihiko Hattori , Takehiko Kitamori
IPC分类号： G01N21/64 , G01N21/00
CPC分类号： G01N21/0303 , B01L3/5027 , G01N21/171 , G01N21/645
摘要： There are provided a chip for micro chemical systems which can obviate the need of alignment at every measurement and can improve the measurement sensitivity and reduce the variation of measurement, and a micro chemical system using the chip. A thermal lens spectrometry system 10 comprises: a micro chemical chip 2 having a groove 1 into which a sample solution is injected; a rod lens 3 disposed on the micro chemical chip 2 at a predetermined spacing above the groove 1; a lens holder 9 disposed above the micro chemical chip 2; a securing section 4; an optical fiber 5; a ferrule 6 secured by the securing section 4 above the rod lens 3; a light source unit 7 connected to the optical fiber 5, and a detection device 8 disposed below the micro chemical chip 2. The securing section 4 comprises a seating 32 laid on the micro chemical chip 2, and a metal split sleeve 33 for fitting the ferrule 6 and the lens holder 9 at the outside thereof.
摘要翻译：提供了一种用于微量化学系统的芯片，可以消除每次测量时对准的需要，并且可以提高测量灵敏度并减少测量的变化，以及使用该芯片的微型化学系统。热透镜分光系统10包括：微化学芯片2，其具有注入样品溶液的槽1; 棒状透镜3，以规定的间隔配置在微细化学品片2上，设置在微化学芯片2上方的透镜架9; 固定部分4; 光纤5; 由杆状透镜3上方的固定部4固定的套圈6; 连接到光纤5的光源单元7和设置在微化学芯片2下方的检测装置8。固定部分4包括放置在微化学芯片2上的座32和用于将套圈6和透镜保持器9装配在其外侧的金属分开套筒33。

2. 发明授权

US07304734B2 Fluorescence analysis optical multiplexer/demultiplexer, fluorescence analysis optical module, fluorescence analyzer, fluorescence/photothermal conversion spectroscopic analyzer, and fluorescence analysis chip 有权
公开(公告)号：US07304734B2
公开(公告)日：2007-12-04
申请号：US11329456
申请日：2006-01-09
申请人： Takashi Fukuzawa , Jun Yamaguchi , Akihiko Hattori , Takao Miwa
发明人： Takashi Fukuzawa , Jun Yamaguchi , Akihiko Hattori , Takao Miwa
IPC分类号： G01J3/30
CPC分类号： G01N21/645 , G01N2021/6482 , G01N2021/6484
摘要： A fluorescence analysis optical multiplexer/demultiplexer, a fluorescence analysis optical module, a fluorescence analyzer, a fluorescence/photothermal conversion spectroscopic analyzer, and a fluorescence analysis chip, according to which LIF analysis can be carried out easily and with high sensitivity, and moreover photothermal conversion spectroscopic analysis can be carried out easily and simultaneously with the LIF analysis. A microchemical system 100 as the fluorescence analyzer is comprised of a fluorescence analysis optical module 100a, a probe 50 that condenses exciting light onto a sample solution in a channel 204 inside a fluorescence analysis chip 20, and a sample stage 21 on which the fluorescence analysis chip 20 is mounted. The fluorescence analysis optical module 100a is comprised of an exciting light source 53 that outputs exciting light of dominant wavelength λ1, a fluorescence analysis optical multiplexer/demultiplexer 56 for use in the fluorescence analyzer which analyzes fluorescence of dominant wavelength λ2 (λ2>λ1) emitted from the sample upon the sample being irradiated with the exciting light via the probe 50, a detector 54 that receives the fluorescence, an optical fiber 106 that connects the fluorescence analysis optical multiplexer/demultiplexer 56 to the exciting light source 53, an optical fiber 107 that connects the fluorescence analysis optical multiplexer/demultiplexer 56 to the probe 50, and an optical fiber 108 that connects the fluorescence analysis optical multiplexer/demultiplexer 56 to the detector 54. The channel 204 through which the sample solution is passed is coated with a reflective metal film 205.

3. 发明授权

US06930778B2 Microchemical system 失效
标题翻译：微化学系统
公开(公告)号：US06930778B2
公开(公告)日：2005-08-16
申请号：US10733491
申请日：2003-12-10
申请人： Jun Yamaguchi , Akihiko Hattori , Takehiko Kitamori , Manabu Tokeshi
发明人： Jun Yamaguchi , Akihiko Hattori , Takehiko Kitamori , Manabu Tokeshi
IPC分类号： G01N25/16 , G01N21/17 , G02B6/42 , G01N21/00
CPC分类号： G01N21/171
摘要： A microchemical system is provided, which can improve the working efficiency of the user and can be designed compact in size. The microchemical system is provided with an optical fiber 10 with a gradient index rod lens 102 mounted on an end thereof. The lens-possessing optical fiber 10 is comprised of an optical fiber 101 that transmits exciting light and detecting light in the single mode, and a ferrule 103 for expanding the outer diameter of the optical fiber 101 to the same value as that of the gradient index rod lens 102. The gradient index rod lens 102 and the optical fiber 101 are rigidly joined together by means of a sleeve 104.
摘要翻译：提供了一种微化学系统，可以提高用户的工作效率，设计尺寸紧凑。微化学系统设置有光纤10，其具有安装在其一端的梯度折射率棒透镜102。具有透镜的光纤10包括以单模发射激发光并检测光的光纤101，以及用于将光纤101的外径扩大到与梯度指数相同的值的套圈103 棒状透镜102。梯度分度杆透镜102和光纤101通过套筒104刚性地接合在一起。

4. 发明申请

US20080123088A1 Microchemical system and method for calculating TLM output thereof 审中-公开
标题翻译：用于计算TLM输出的微化学系统和方法
公开(公告)号：US20080123088A1
公开(公告)日：2008-05-29
申请号：US11985823
申请日：2007-11-16
申请人： Masatoshi Nara , Ryo Anraku , Takahiro Asai , Jun Yamaguchi , Akihiko Hattori , Takehiko Kitamori , Manabu Tokeshi , Akihide Hibara , Kazuma Mawatari
发明人： Masatoshi Nara , Ryo Anraku , Takahiro Asai , Jun Yamaguchi , Akihiko Hattori , Takehiko Kitamori , Manabu Tokeshi , Akihide Hibara , Kazuma Mawatari
IPC分类号： G01N21/41
CPC分类号： G01N21/171 , G01N35/08
摘要： There are provided a microchemical system capable of acquiring a highly accurate TLM output value and a method for calculating TLM output thereof. A microchemical system 1 comprises: a microchemical chip having a channel with a depth t in which a sample flows; an exciting light source 13 adapted to irradiate the sample with an exciting light through an objective lens 10 with a numerical aperture NA; a detecting light source 14 adapted to irradiate the sample with a detecting light coaxially with the exciting light through the objective lens 10; and a PD adapted to receive a transmitted light when the detecting light transmits the sample before and after formation of a thermal lens 12. When a TLM output is calculated in the microchemical system 1 on the basis of a received light amount of the PD, the depth t (μm) is set to the range of 75≦t≦300, the numerical aperture NA is set to the range of 0.04≦NA≦0.1 and chromatic aberrations df (nm) for the exciting light and the detecting light of the objective lens 10 is set to the range of 100≦df≦250.
摘要翻译：提供了能够获得高度精确的TLM输出值的微化学系统和用于计算TLM输出的方法。微化学系统1包括：具有样品流过深度t的通道的微化学芯片; 激光光源13，其适于通过具有数值孔径NA的物镜10照射具有激发光的样品; 检测光源14，适于通过物镜10与激发光同轴地检测具有检测光的样品; 以及适于在检测光在形成热透镜12之前和之后透射样品时接收透射光的PD。当在微量化学系统1中基于PD的接收光量计算TLM输出时，深度t（母体）设定为75 <= t <= 300的范围，数值孔径NA设定为0.04 <= NA <= 0.1的范围，激发光的色差df（nm）物镜10的光被设定在100 <= df <= 250的范围内。

5. 发明授权

US07339677B2 Microchemical system, and photothermal conversion spectroscopic analysis method 失效
标题翻译：微化学系统和光热转化光谱分析方法
公开(公告)号：US07339677B2
公开(公告)日：2008-03-04
申请号：US10830284
申请日：2004-04-21
申请人： Jun Yamaguchi , Akihiko Hattori
发明人： Jun Yamaguchi , Akihiko Hattori
IPC分类号： G01N21/00
CPC分类号： G01N21/171
摘要： A microchemical system according to which measurement can be carried out with high sensitivity. The microchemical system 1 has a two-wavelength multiplexing device in which gradient index rod lenses 501 and 502 are connected together at an end face of each thereof and a dielectric multi-layer film filter 503 is formed between these end faces. Exciting light and detecting light is multiplexed by the two-wavelength multiplexing device, and then the exciting light and the detecting light are guided to an optical fiber unit 10 through an optical fiber 101 with a single mode. The optical fiber unit 10 has built therein a gradient index rod lens 102 at a leading end thereof, and the exciting light and the detecting light are irradiated onto a sample from the gradient index rod lens 102.
摘要翻译：一种可以高灵敏度进行测量的微观化学系统。微化学系统1具有双波长多路复用装置，其中梯度折射率棒状透镜501和502在其端面处连接在一起，并且在这些端面之间形成电介质多层膜滤光器503。激发光和检测光被双波长多路复用装置复用，然后激发光和检测光通过单一模式的光纤101被引导到光纤单元10。光纤单元10内置有在其前端的梯度折射率棒状透镜102，激发光和检测光从梯度分度杆透镜102照射到样品上。

6. 发明授权

US07092099B2 Microchemical system and photothermal conversion spectroscopic analysis method implemented by the system 失效
标题翻译：系统实现的微化学系统和光热转换光谱分析方法
公开(公告)号：US07092099B2
公开(公告)日：2006-08-15
申请号：US10766582
申请日：2004-01-27
申请人： Jun Yamaguchi , Akihiko Hattori , Takehiko Kitamori , Manabu Tokeshi
发明人： Jun Yamaguchi , Akihiko Hattori , Takehiko Kitamori , Manabu Tokeshi
IPC分类号： G01N21/00
CPC分类号： G01N21/17 , G01N21/05 , G01N21/171 , G01N2021/0346
摘要： A microchemical system is provided, which can improve the working efficiency of the user. In the microchemical system 1, a plate-shaped element 10 that constitutes an optical unit 1a has an optical wave guide path 20, which acts as an optical path for exciting light and detecting light. An irradiation lens 30 is disposed at an end of the optical wave guide path 20 downstream in the direction of travel of the exciting light and the detecting light, and a channel 40 is located downstream of the irradiation lens 30, through which a liquid containing a sample flows. A detector 50 is disposed at an end of the plate-shaped element 10 downstream of the channel 40 and detects the detecting light for analysis of the sample.
摘要翻译：提供了微化学系统，可以提高用户的工作效率。在微化学系统1中，构成光学单元1a的板状元件10具有作为用于激发光并检测光的光路的光波导路径20。照射透镜30设置在光波导路径20的沿着激发光和检测光的行进方向的下游的端部，并且通道40位于照射透镜30的下游，通过该照射透镜30，样品流。检测器50设置在通道40下游的板状元件10的端部，并检测用于样品分析的检测光。

7. 发明授权

US07057729B2 Photothermal conversion spectroscopic analysis method, and photothermal conversion spectroscopic analysis apparatus for carrying out the method 失效
公开(公告)号：US07057729B2
公开(公告)日：2006-06-06
申请号：US10445629
申请日：2003-05-27
申请人： Jun Yamaguchi , Akihiko Hattori
发明人： Jun Yamaguchi , Akihiko Hattori
IPC分类号： G01N21/00
CPC分类号： G01N21/171
摘要： There is provided that enables high-sensitivity analysis to be carried out, and a photothermal conversion spectroscopic analysis apparatus that is compact in size and is able to implement the photothermal conversion spectroscopic analysis method. Exciting light and detecting light are convergently irradiated onto the sample by a converging lens. The sample is analyzed using a change in intensity of the detecting light due to refraction upon passing through the thermal lens produced through the convergent irradiation of the exciting light. A molar absorption coefficient of the sample at a wavelength of the exciting light is a predetermined number of times greater than a molar absorption coefficient of the sample at a wavelength of the detecting light.

8. 发明授权

US07012692B2 Photothermal conversion spectroscopic analysis method, and photothermal conversion spectroscopic analysis apparatus for carrying out the method 失效
标题翻译：光热转化光谱分析方法和光热转化光谱分析装置的实施方法
公开(公告)号：US07012692B2
公开(公告)日：2006-03-14
申请号：US10734980
申请日：2003-12-12
申请人： Jun Yamaguchi , Akihiko Hattori , Takehiko Kitamori , Manabu Tokeshi
发明人： Jun Yamaguchi , Akihiko Hattori , Takehiko Kitamori , Manabu Tokeshi
IPC分类号： G01N21/01
CPC分类号： G01N21/171 , G01N2021/1712
摘要： It is an object to provide a photothermal conversion spectroscopic analysis method that enables measurement to be carried out with high sensitivity, and a photothermal conversion spectroscopic analysis apparatus that carries out the method. The photothermal conversion spectroscopic analysis apparatus is comprised of an exciting light source 111, a chopper 112 that is disposed close to the exciting light source 111 in the optical path of exciting light emitted from the exciting light source 111, a mirror 114 that changes the direction of travel of the exciting light, a detecting light source 120, a dichroic mirror 113 that has detecting light from the detecting light source 120 incident thereon and makes the exciting light and the detecting light coaxial, a lens 10 that has a suitable amount of chromatic aberration, and a holder 15 that holds the lens 10 such as to enable adjustment along three axes.
摘要翻译：本发明的目的是提供能够以高灵敏度进行测量的光热转换光谱分析方法，以及实施该方法的光热转换光谱分析装置。光热转换光谱分析装置包括激发光源111，在从激发光源111发射的激发光的光路中靠近激发光源111设置的斩波器112，改变方向激发光的行进，检测光源120，具有入射在其上的检测光源120的检测光并使激发光和检测光同轴的分色镜113，具有适当量的色度的透镜10 像差，以及保持透镜10的保持器15，以能够沿三个轴进行调节。

9. 发明授权

US06941041B2 Gradient index rod lens unit and microchemical system having the same 失效
标题翻译：渐变折射杆镜片单元和微化学系统具有相同的特性
公开(公告)号：US06941041B2
公开(公告)日：2005-09-06
申请号：US10754761
申请日：2004-01-09
申请人： Jun Yamaguchi , Akihiko Hattori , Takehiko Kitamori
发明人： Jun Yamaguchi , Akihiko Hattori , Takehiko Kitamori
IPC分类号： G01N25/16 , G01N21/41 , G01N27/447 , G01N37/00 , G02B3/00 , G02B6/028 , G02B6/32 , G02B6/00
CPC分类号： G02B3/0087
摘要： There is provided a gradient index rod lens unit having a desired chromatic aberration. The gradient index rod lens unit is comprised of two gradient index rod lenses 11 and 12 with different chromatic aberrations and the entire lengths thereof adjusted, which are disposed in series with the optical axes thereof in alignment. The chromatic aberration of the gradient index rod lens unit can be set to a value falling within chromatic aberration ranges inherently possessed by the respective gradient index rod lenses 11 and 12.
摘要翻译：提供了具有期望的色差的梯度折射率棒状透镜单元。梯度分度杆透镜单元由具有不同色差的两个梯度折射率棒透镜11和12组成，并且其整个长度被调整，其与其光轴对准地排列成一列。梯度折射率棒状透镜单元的色差可以被设定为落在各个梯度折射率棒状透镜11和12固有地具有的色像差范围内的值。

10. 发明申请

US20050140971A1 Microchemical system chip and microchemical system 审中-公开
标题翻译：微化学系统芯片和微化学系统
公开(公告)号：US20050140971A1
公开(公告)日：2005-06-30
申请号：US10944653
申请日：2004-09-17
申请人： Jun Yamaguchi , Akihiko Hattori , Takehiko Kitamori , Manabu Tokeshi
发明人： Jun Yamaguchi , Akihiko Hattori , Takehiko Kitamori , Manabu Tokeshi
IPC分类号： B01L3/00 , G01N21/03 , G01N21/05 , G01N21/25 , G01N21/64
CPC分类号： G01N21/05 , B01L3/502715 , B01L2300/0654 , B01L2300/0816 , G01N2021/0346
摘要： A microchemical system chip and a microchemical system that can be reduced in size while improving measurement sensitivity. The microchemical system chip 1 is comprised of a plate-shaped glass substrate 10, and the glass substrate 10 has a U-shaped channel 11 therein. The U-shaped channel 11 is comprised of a longitudinal channel 11a, and a pair of transverse channels 11b and 11c that are connected to the two ends of the longitudinal channel 11a. The glass substrate 10 has therein two voids provided coaxially with the longitudinal channel 11a near the two ends of the longitudinal channel 11a, and gradient index rod lenses 14 and 15 are housed respectively in the two voids. An optical fiber 16 that propagates detecting light emitted from a light source is connected to the gradient index rod lens 14, and an optical fiber 17 that leads detecting light received by the gradient index rod lens 15 to a detector is connected to the gradient index rod lens 15.
摘要翻译：微化学系统芯片和微化学系统，可以减小尺寸，同时提高测量灵敏度。微化学系统芯片1由板状的玻璃基板10构成，玻璃基板10具有U形的通道11。 U形通道11包括纵向通道11a和连接到纵向通道11a的两端的一对横向通道11b和11c。玻璃基板10具有在纵向通道11a的两端附近与纵向通道11a同轴设置的两个空隙，梯度分度杆透镜14和15分别容纳在两个空隙中。将从光源发出的检测光传播的光纤16连接到梯度折射率棒状透镜14，将由梯度折射率棒状透镜15接收的检测光引导到检测器的光纤17连接到梯度折射率棒镜头15。

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