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    • 1. 发明授权
    • Cell based signal generation
    • US07022513B2
    • 2006-04-04
    • US10200013
    • 2002-07-18
    • Jun XuJoshua Trueheart
    • Jun XuJoshua Trueheart
    • C12N1/16
    • C07K14/39C07K2319/00
    • The present invention makes available a rapid, reproducible, robust assay system for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular protein, e.g., a receptor or ion channel. The subject assay enables rapid screening of large numbers of compounds to identify those which act as an agonist or antagonist to the bioactivity of the cellular protein. In particular, the assay of the invention makes use of a cell that harbors a protein that is responsive to a cellular signal transduction pathway. The protein is operatively linked to a polypeptide which causes a detectable signal to be generated upon stimulation of the pathway, e.g., when a compound interacts with and modulates the activity of a cellular receptor or ion channel of the cell. Thus, the cell provides a signal generation means comprising a novel fusion protein the expression of which is independent of stimulation/activation of the signal transduction pathway, but the activity of which is responsive to the signal transduction pathway.
    • 2. 发明授权
    • Cell based signal generation
    • 基于单元的信号生成
    • US06504008B1
    • 2003-01-07
    • US09241888
    • 1999-02-01
    • Jun XuJoshua Trueheart
    • Jun XuJoshua Trueheart
    • C07K1400
    • C07K14/39C07K2319/00
    • The present invention makes available a rapid, reproducible, robust assay system for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular protein, e.g., a receptor or ion channel. The subject assay enables rapid screening of large numbers of compounds to identify those which act as an agonist or antagonist to the bioactivity of the cellular protein. In particular, the assay of the invention makes use of a cell that harbors a protein that is responsive to a cellular signal transduction pathway. The protein is operatively linked to a polypeptide which causes a detectable signal to be generated upon stimulation of the pathway, e.g., when a compound interacts with and modulates the activity of a cellular receptor or ion channel of the cell. Thus, the cell provides a signal generation means comprising a novel fusion protein the expression of which is independent of stimulation/activation of the signal transduction pathway, but the activity of which is responsive to the signal transduction pathway.
    • 本发明提供了用于筛选和鉴定与细胞蛋白例如受体或离子通道特异性相互作用并调节细胞蛋白质的活性的药学有效化合物的快速,可重复,稳定的测定系统。 本发明分析使得能够快速筛选大量的化合物以鉴定那些充当细胞蛋白的生物活性的激动剂或拮抗剂的化合物。 特别地,本发明的测定方法利用了含有对细胞信号转导途径有响应的蛋白质的细胞。 蛋白质可操作地连接到多肽,其在刺激途径时引起可检测信号的产生,例如当化合物与细胞的细胞受体或离子通道的活性相互作用并调节其活性时。 因此,细胞提供了包含新型融合蛋白的信号产生装置,其表达与信号转导途径的刺激/激活无关,但其活性对信号转导途径有反应。
    • 5. 发明授权
    • Method and terminal for feeding back channel state information
    • 用于反馈信道状态信息的方法和终端
    • US09258048B2
    • 2016-02-09
    • US13695431
    • 2011-03-10
    • Ruyue LiJun XuYijian ChenBo DaiJunfeng Zhang
    • Ruyue LiJun XuYijian ChenBo DaiJunfeng Zhang
    • H04L12/26H04B7/06H04L1/00H04B7/04
    • H04B7/065H04B7/0452H04B7/0478H04B7/0639H04L1/0026H04L1/0029
    • The present invention discloses method and terminal for feeding back channel state information. The method comprises: UE determining channel state information comprising first-type PMI and/or second-type PMI according to indication information, wherein first-type PMI is used for indicating index of one first precoding matrix in first precoding codebook, each first precoding matrix is used for mapping channel information of one wideband and/or long-term channel; second-type PMI is used for indicating index of one second precoding matrix in second precoding codebook, each second precoding matrix is used for mapping channel information of one subband and/or short-term channel; UE feeding back first-type PMI in PUCCH periodically and feeding back second-type PMI in PUSCH periodically or non-periodically, or, feeding back first-type PMI and second-type PMI in PUCCH. Through the present invention, precision of feeding back channel state information by UE is increased, and base station can dynamically select SU-MIMO or MU-MIMO transmission.
    • 本发明公开了用于反馈信道状态信息的方法和终端。 该方法包括:UE根据指示信息确定包括第一类型PMI和/或第二类型PMI的信道状态信息,其中第一类型PMI用于指示第一预编码码本中的一个第一预编码矩阵的索引,每个第一预编码矩阵 用于映射一个宽带和/或长期信道的信道信息; 第二类型PMI用于指示第二预编码码本中的一秒预编码矩阵的索引,每个第二预编码矩阵用于映射一个子带和/或短期信道的信道信息; UE周期性地在PUCCH中反馈第一类型PMI,并在PUSCH周期性或非周期性地反馈第二类型PMI,或者在PUCCH中反馈第一类型PMI和第二类型PMI。 通过本发明,UE的反馈信道状态信息的精度提高,基站能动态选择SU-MIMO或MU-MIMO传输。
    • 7. 发明申请
    • AD EXTENSIONS ON CONTENT NETWORK
    • AD扩展内容网络
    • US20150254733A1
    • 2015-09-10
    • US13669036
    • 2012-11-05
    • Amy WUBrandon Murdock PearcyNathan Peter LucashJun XuYi ZhangZhen Yu
    • Amy WUBrandon Murdock PearcyNathan Peter LucashJun XuYi ZhangZhen Yu
    • G06Q30/02G06F17/21G06F3/0481
    • G06Q30/0277G06F3/0482G06F3/04842G06F17/211G06T3/40
    • A method of providing an ad extension includes selecting an advertisement for display. The method also includes selecting additional information related to the advertisement. The method also includes transmitting data representing the advertisement to a browser. The browser interacts with an expandable API to render an inline frame having an advertisement slot. The browser renders and displays the advertisement in the frame. The method also includes transmitting display data representing the additional information related to the advertisement to the browser. The browser receives an input to activate the ad extension. In response to the input, the browser interacts with the expandable API system to expand and render the frame. The browser renders, in the frame, the advertisement slot containing the advertisement. The browser also renders, in the frame, the additional information. The browser displays the expanded inline frame, such that the displayed frame covers a portion of the content.
    • 提供广告扩展的方法包括选择要显示的广告。 该方法还包括选择与该广告相关的附加信息。 该方法还包括将表示广告的数据发送到浏览器。 浏览器与可扩展API交互,以呈现具有广告位的内联框架。 浏览器在框架中呈现和显示广告。 该方法还包括将表示与广告相关的附加信息的显示数据发送到浏览器。 浏览器接收到一个输入以激活广告扩展。 响应于输入,浏览器与可扩展API系统交互以展开和渲染框架。 浏览器在框架中呈现包含广告的广告位。 浏览器还在框架中呈现附加信息。 浏览器显示扩展的内联框架,使得所显示的框架覆盖内容的一部分。