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1. 发明申请

US20150157597A1 NEURODEGENERATIVE DISEASE TREATMENT USING JAK/STAT INHIBITION 审中-公开
标题翻译：使用JAK / STAT抑制剂治疗神经病毒性疾病
公开(公告)号：US20150157597A1
公开(公告)日：2015-06-11
申请号：US14570625
申请日：2014-12-15
申请人： Jun Tan , Frank Fernandez , Nan Sun , Roland D. Shytle , Jared Ehrhart
发明人： Jun Tan , Frank Fernandez , Nan Sun , Roland D. Shytle , Jared Ehrhart
IPC分类号： A61K31/353 , A61K31/4745
CPC分类号： A61K31/353 , A01K2267/0318 , A61K31/4745 , A61K36/82 , C12N2740/16111 , C12N2740/16311
摘要： The invention relates to treatment of neurodegenerative diseases with JAK/STAT pathway inhibitors to eliminate extracellular cell signaling events leading to cell cycle abrogation and/or apoptosis. Primary neurons were administered neurotoxic proteins, such as gp120, Tat, or gp120 and Tat, with or without IFN-γ added, resulting in neuronal death, and simulated neurodegenerative diseases. The neurodegenerative disease is treated using a JAK/STAT pathway inhibitor, including (-)-epigallocatechin-3-gallate (EGCG), to modulate JAK1 or STAT1 phosphorylation, resulting in resistance to gp120 or Tat neurotoxicity. The invention may be used to treat neurons afflicted with HIV-associated Dementia, multiple sclerosis, Alzheimer's Disease, Parkinson's Disease, amyotrophic lateral sclerosis, or Pick's Disease, and may act in conjunction with antiviral treatment, like HAART.
摘要翻译：本发明涉及用JAK / STAT途径抑制剂治疗神经变性疾病，以消除导致细胞周期消除和/或凋亡的细胞外细胞信号传导事件。主要神经元被施用神经毒性蛋白质，例如gp120，Tat或gp120和Tat，加入或不加入IFN-γ，导致神经元死亡和模拟的神经变性疾病。神经变性疾病使用JAK / STAT途径抑制剂（包括（ - ） - 表没食子儿茶素-3-没食子酸酯（EGCG））来调节JAK1或STAT1磷酸化，导致抗gp120或Tat神经毒性。本发明可用于治疗患有HIV相关性痴呆，多发性硬化，阿尔茨海默氏病，帕金森病，肌萎缩性侧索硬化或皮克病的神经元，并且可以与抗病毒治疗一起起作用，如HAART。

2. 发明申请

US20100069479A1 NEURODEGENERATIVE DISEASE TREATMENT USING JAK/STAT INHIBITION 审中-公开
标题翻译：使用JAK / STAT抑制剂治疗神经病毒性疾病
公开(公告)号：US20100069479A1
公开(公告)日：2010-03-18
申请号：US12552715
申请日：2009-09-02
申请人： Jun Tan , Frank Fernandez , Nan Sun , Roland D. Shytle , Jared Ehrhart
发明人： Jun Tan , Frank Fernandez , Nan Sun , Roland D. Shytle , Jared Ehrhart
IPC分类号： A61K31/352 , C12N5/00 , A61P25/00
CPC分类号： A61K31/353 , A01K2267/0318 , A61K31/4745 , A61K36/82 , C12N2740/16111 , C12N2740/16311
摘要： The invention relates to treatment of neurodegenerative diseases with JAK/STAT pathway inhibitors to eliminate extracellular cell signaling events leading to cell cycle abrogation and/or apoptosis. Primary neurons were administered neurotoxic proteins, such as gp120, Tat, or gp120 and Tat, with or without IFN-γ added, resulting in neuronal death, and simulated neurodegenerative diseases. The neurodegenerative disease is treated using a JAK/STAT pathway inhibitor, including (—)-epigallocatechin-3-gallate (EGCG), to modulate JAK1 or STAT1 phosphorylation, resulting in resistance to gp120 or Tat neurotoxicity. The invention may be used to treat neurons afflicted with HIV-associated Dementia, multiple sclerosis, Alzheimer's Disease, Parkinson's Disease, amyotrophic lateral sclerosis, or Pick's Disease, and may act in conjunction with antiviral treatment, like HAART.
摘要翻译：本发明涉及用JAK / STAT途径抑制剂治疗神经变性疾病，以消除导致细胞周期消除和/或凋亡的细胞外细胞信号传导事件。主要神经元被施用神经毒性蛋白质，例如gp120，Tat或gp120和Tat，加入或不加入IFN-γ，导致神经元死亡和模拟的神经变性疾病。神经变性疾病使用JAK / STAT途径抑制剂（包括（ - ） - 表没食子儿茶素-3-没食子酸酯（EGCG））来调节JAK1或STAT1磷酸化，导致抗gp120或Tat神经毒性。本发明可用于治疗患有HIV相关性痴呆，多发性硬化，阿尔茨海默氏病，帕金森病，肌萎缩性侧索硬化或皮克病的神经元，并且可以与抗病毒治疗一起起作用，如HAART。

3. 发明授权

US5241568A Method and apparatus for synchronizing a receiver to a transmitted signal while conserving power 失效
标题翻译：同时保持功率同步接收机与发送信号的方法和装置
公开(公告)号：US5241568A
公开(公告)日：1993-08-31
申请号：US801329
申请日：1991-12-02
申请人： Frank Fernandez , Richard A. Erhart
发明人： Frank Fernandez , Richard A. Erhart
IPC分类号： H04L7/04 , H04L7/10 , H04W52/02 , H04W88/02
CPC分类号： H04L7/10 , H04W52/0229 , H04L7/042 , H04W88/022
摘要： A receiver (200) receives (203) a transmitted signal having a first predetermined signal for indicating a start of a new transmission to the receiver and having a second predetermined signal inserted at periodic sampling time intervals for synchronizing the receiver to the transmitted signal. The receiver (200) synchronizes to the transmitted signal by detecting the first predetermined signal (208) followed by the second predetermined signal (210), and establishing subsequent periodic sampling time intervals therefrom. The receiver (200) conserves power (228) during a second portion of a periodic sampling time interval following a detection of a first portion of the second predetermined signal (210) during a first portion of the periodic sampling time interval. If the receiver (200) does not detect the first portion of the second predetermined signal (210) then the receiver (200) searches for a portion of the first predetermined signal (208) during the second portion of the periodic sampling time interval to determine a possible start of a new transmission.
摘要翻译：接收机（200）接收（203）具有第一预定信号的发射信号，用于指示接收机的新传输的开始，并具有以周期性采样时间间隔插入的第二预定信号，以使接收机与发射信号同步。接收机（200）通过检测第一预定信号（208）跟随第二预定信号（210）同步到所发送的信号，并从其建立后续周期性采样时间间隔。在周期性采样时间间隔的第一部分中检测到第二预定信号（210）的第一部分之后，接收器（200）在周期性采样时间间隔的第二部分期间节省功率（228）。如果接收机（200）没有检测到第二预定信号（210）的第一部分，则接收机（200）在周期性采样时间间隔的第二部分期间搜索第一预定信号（208）的一部分，以确定可能开始新的传输。

4. 发明授权

US5726639A Method and device for off hour over the air software programming of selective call receivers 失效
标题翻译：选择呼叫接收机的空中软件编程方法和装置
公开(公告)号：US5726639A
公开(公告)日：1998-03-10
申请号：US521405
申请日：1995-08-30
申请人： Osvaldo Romero , Frank Fernandez
发明人： Osvaldo Romero , Frank Fernandez
IPC分类号： G08B5/22 , H04W8/24 , H04W88/02 , G08B3/10 , H04B7/00 , H04L7/00
CPC分类号： H04W8/245 , G08B5/229 , H04W88/022
摘要： A selective call receiver (10) utilizes a method for performing over-the-air software programming when the selective call receiver (10) is on or switched off by a user. A first selective call signal is received and programming related information including an anticipated time of transmission of a second selective call signal is received. The selective call receiver (10) is prepared to receive the second selective call signal in response to the programming related information received, whereby the receiver circuitry (30) is energized at the anticipated time of transmission to receive the second selective call signal. The selective call receiver (10) is further switched on at the anticipated time of transmission of the second selective call signal, and the receiver circuitry (30) is energized to receive the second selective call signal when the user has switched off the selective call receiver (10) prior to the anticipated time.
摘要翻译：选呼接收机（10）利用一种用于当选呼接收机（10）由用户接通或切断时执行空中软件编程的方法。接收第一选呼信号，并接收包括第二选呼信号的预期发送时间的编程相关信息。选择呼叫接收机（10）准备响应于所接收的编程相关信息而接收第二选呼信号，由此接收机电路（30）在传输的预期时间被激励以接收第二选呼信号。选择呼叫接收机（10）在传输第二选呼信号的预期时间进一步接通，并且当用户已经关闭选呼接收机时，接收机电路（30）被激励以接收第二选呼信号（10）。

5. 发明授权

US5376975A Method and apparatus for preamble battery saving in selective call receivers 失效
标题翻译：在选择性呼叫接收机中节省前置码电池的方法和装置
公开(公告)号：US5376975A
公开(公告)日：1994-12-27
申请号：US982523
申请日：1992-11-27
申请人： Osvaldo D. Romero , Frank Fernandez , Timothy C. Laflin , Pamela A. Rakolta
发明人： Osvaldo D. Romero , Frank Fernandez , Timothy C. Laflin , Pamela A. Rakolta
IPC分类号： H04W52/02 , H04W88/02 , H04Q7/00
CPC分类号： H04W52/0232 , H04W88/022
摘要： A selective call receiver receives a selective call signal (400) comprising a preamble signal (410). The selective call receiver comprises receiver circuitry (102) for receiving and demodulating the selective call signal (400). A preamble detector (105) is coupled to the receiver circuitry (102) for detecting the preamble signal (410), and a battery saver circuit (126) selectively activates and deactivates the receiver circuitry (102) in response to a signal from a processor (114). The processor (114) provides the signal to the battery saver circuit (126) to deactivate and activate the receiver circuitry (102) during reception of the preamble signal (410) in response to and subsequent to the preamble detector (105) detecting a portion of the preamble signal (410).
摘要翻译：选呼接收机接收包括前同步信号（410）的选呼信号（400）。选呼接收机包括用于接收和解调选呼信号（400）的接收机电路（102）。前导码检测器（105）耦合到接收器电路（102），用于检测前置信号（410），并且电池保护电路（126）响应于来自处理器的信号有选择地激活和停用接收机电路（102）（114）。处理器（114）响应于前导码检测器（105）检测到部分的前后部分（105）并且之后，在接收前导码信号（410）期间向电池节约电路（126）提供信号以去激活和激活接收机电路（102）的前导码信号（410）。

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