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1. 发明申请

US20090054355A1 Proliferation Inhibitor Of Helicobacter Pylori Including Alpha-N-Acetyl-Glucosaminyl Bond-Containing Monosaccharide Derivatives 审中-公开
标题翻译：幽门螺杆菌增生抑制剂包括含有α-乙酰基 - 葡糖胺基键的单糖衍生物
公开(公告)号：US20090054355A1
公开(公告)日：2009-02-26
申请号：US11664437
申请日：2007-01-12
申请人： Jun Nakayama , Takashi Yamanoi , Masaya Fujita , Takashi Shirai
发明人： Jun Nakayama , Takashi Yamanoi , Masaya Fujita , Takashi Shirai
IPC分类号： A61K31/7004 , C07G3/00 , A61P31/00
CPC分类号： A61K31/7028 , A23L33/10 , C07H5/04
摘要： The present invention herein provides a proliferation inhibitor of Helicobacter pylori comprising a compound that can simply be mass-produced, can specifically inhibit the proliferation of H. pylori, which has high safety and never generates any resistant bacteria, as well as a diet of a food or beverage, and a pharmaceutical preparation containing the proliferation inhibitor of Helicobacter pylori. The proliferation inhibitor of Helicobacter pylori comprises an alpha-N-acetyl-glucosaminyl bond-containing monosaccharide derivative represented by the following chemical formula (1) GlcNAc1-alpha-O-Y (1) (in the formula (1), Y is a straight-, branched- or cyclic-aliphatic hydrocarbon group having 1 to 27 carbon atoms or a straight-, branched- or cyclic-acyl group having 1 to 27 carbon atoms). The diet of the food, the beverage or the pharmaceutical preparation comprises the proliferation inhibitor of Helicobacter pylori.
摘要翻译：本发明提供幽门螺杆菌增殖抑制剂，其包含可以简单地批量生产的化合物，可以特异性抑制幽门螺杆菌的增殖，其具有高安全性并且不产生任何抗性细菌，以及食品或饮料，以及包含幽门螺杆菌增殖抑制剂的药物制剂。幽门螺旋杆菌的增殖抑制剂包含由以下化学式（1）表示的含有α-N-乙酰基 - 氨基葡糖键的单糖衍生物<？in-line-formula description =“In-line Formulas”end =“lead”？ > GlcNAc1-α-OY（1）<？in-line-formula description =“In-line Formulas”end =“tail”？>（在公式（1）中，Y是直链，支链或环状，具有1至27个碳原子的脂族烃基或具有1至27个碳原子的直链，支链或环状酰基）。食物，饮料或药物制剂的饮食包括幽门螺杆菌增殖抑制剂。

2. 发明授权

US08575117B2 Proliferation inhibitor of helicobacter pylori including alpha-n-acetyl-glucosaminyl bond-containing monosaccharide derivatives 有权
标题翻译：幽门螺杆菌的增殖抑制剂包括含α-正乙酰基 - 葡糖胺键的单糖衍生物
公开(公告)号：US08575117B2
公开(公告)日：2013-11-05
申请号：US12662309
申请日：2010-04-09
申请人： Jun Nakayama , Takashi Yamanoi , Masaya Fujita , Takashi Shirai
发明人： Jun Nakayama , Takashi Yamanoi , Masaya Fujita , Takashi Shirai
IPC分类号： A61K31/7008 , A61K31/7034
CPC分类号： A61K31/7028 , A23L33/10 , C07H5/04
摘要： A method for inhibiting proliferation of Helicobacter pylori including a compound that can simply be mass-produced, can specifically inhibit the proliferation of H. pylori, which has high safety and never generates any resistant bacteria, as well as a diet of a food or beverage, and a pharmaceutical preparation containing the proliferation inhibitor of Helicobacter pylori. The proliferation inhibitor of Helicobacter pylori comprises an alpha-N-acetyl-glucosaminyl bond-containing monosaccharide derivative represented by the following chemical formula (1) GlcNAc1-alpha-O—Y (1) (in the formula (1), Y is a straight-, branched- or cyclic-aliphatic hydrocarbon group having 1 to 27 carbon atoms or a straight-, branched- or cyclic-acyl group having 1 to 27 carbon atoms). The diet of the food, the beverage or the pharmaceutical preparation comprises the proliferation inhibitor of Helicobacter pylori.
摘要翻译：抑制幽门螺杆菌增殖的方法，其包括可以简单地批量生产的化合物，可以特异性地抑制幽门螺杆菌的增殖，其具有高安全性并且不产生任何抗性细菌，以及食物或饮料的饮食，以及含有幽门螺杆菌增殖抑制剂的药物制剂。幽门螺旋杆菌增殖抑制剂包含由以下化学式（1）表示的含有α-N-乙酰基 - 葡糖胺键的单糖衍生物GlcNAc1-α-OY（1）（式（1）中，Y为直链 - 具有1至27个碳原子的支链或环状脂族烃基或具有1至27个碳原子的直链，支链或环状酰基）。食物，饮料或药物制剂的饮食包括幽门螺杆菌增殖抑制剂。

3. 发明申请

US20110237788A1 HELICOBACTER PYLORI BACTERIUM PROLIFERATION INHIBITOR 审中-公开
标题翻译： HELICOBACTER PYLORI BACTERIUM增殖抑制剂
公开(公告)号：US20110237788A1
公开(公告)日：2011-09-29
申请号：US13063876
申请日：2009-10-09
申请人： Jun Nakayama , Takashi Shirai , Takashi Yamanoi , Masaya Fujita , Masako Mori
发明人： Jun Nakayama , Takashi Shirai , Takashi Yamanoi , Masaya Fujita , Masako Mori
IPC分类号： C07H5/06
CPC分类号： A61K31/7028 , A23L5/00 , A23L29/30 , A23L33/10 , A23L33/125 , A23L33/145 , A23V2002/00 , C07H15/04 , A23V2200/32
摘要： A proliferation inhibitor of H. pylori bacteria comprising a compound that can specifically inhibit the proliferation of H. pylori bacteria, which does not generate bacterium resistant, can be eaten, drunken or administrated safely for a long period of time, can be simply mass-manufactured and can be used for foods and beverages or pharmaceutical preparation. The proliferation inhibitor of H. pylori bacteria comprises an N-acetylglucosaminyl beta-linked monosaccharide derivative represented by the following chemical formula (1): GlcNAc1-beta-O—Y (1) wherein Y is an alkyl group, an alkoxyl group, an alkenyl group, an alkynyl group, an aralkyl group, an aryl group, a heteroaryl group, a carboxyl group or an alkoxycarbonyl group.
摘要翻译：幽门螺杆菌的增殖抑制剂包括可以特异性抑制幽门螺杆菌细菌增殖的化合物，其不产生抗细菌剂，可以长时间安全地食用，饮酒或施用，制造，可用于食品和饮料或药物制剂。幽门螺旋杆菌的增殖抑制剂包含由以下化学式（1）表示的N-乙酰葡糖胺基β-连接的单糖衍生物：GlcNAc1-β-O-Y（1）其中Y为烷基，烷氧基，烯基，炔基，芳烷基，芳基，杂芳基，羧基或烷氧基羰基。

4. 发明申请

US20100197616A1 Proliferation inhibitor of helicobacter pylori including alpha-n-acetyl-glucosaminyl bond-containing monosaccharide derivatives 有权
标题翻译：幽门螺杆菌的增殖抑制剂包括含α-正乙酰基 - 葡糖胺键的单糖衍生物
公开(公告)号：US20100197616A1
公开(公告)日：2010-08-05
申请号：US12662309
申请日：2010-04-09
申请人： Jun Nakayama , Takashi Yamanoi , Masaya Fujita , Takashi Shirai
发明人： Jun Nakayama , Takashi Yamanoi , Masaya Fujita , Takashi Shirai
IPC分类号： A61K31/704 , A61P31/04
CPC分类号： A61K31/7028 , A23L33/10 , C07H5/04
摘要： A method for inhibiting proliferation of Helicobacter pylori including a compound that can simply be mass-produced, can specifically inhibit the proliferation of H. pylori, which has high safety and never generates any resistant bacteria, as well as a diet of a food or beverage, and a pharmaceutical preparation containing the proliferation inhibitor of Helicobacter pylori. The proliferation inhibitor of Helicobacter pylori comprises an alpha-N-acetyl-glucosaminyl bond-containing monosaccharide derivative represented by the following chemical formula (1) GlcNAc1-alpha-O—Y (1) (in the formula (1), Y is a straight-, branched- or cyclic-aliphatic hydrocarbon group having 1 to 27 carbon atoms or a straight-, branched- or cyclic-acyl group having 1 to 27 carbon atoms). The diet of the food, the beverage or the pharmaceutical preparation comprises the proliferation inhibitor of Helicobacter pylori.
摘要翻译：抑制幽门螺杆菌增殖的方法，其包括可以简单地大规模生产的化合物，可以特异性地抑制幽门螺杆菌的增殖，其幽门螺杆菌的安全性高，并且不会产生任何抗性细菌，以及食物或饮料的饮食，以及含有幽门螺杆菌增殖抑制剂的药物制剂。幽门螺杆菌增殖抑制剂包含由以下化学式（1）表示的含有α-N-乙酰基 - 葡糖胺键的单糖衍生物GlcNAc1-α-O-Y（1）（式（1）中，Y为具有1至27个碳原子的直链，支链或环状脂族烃基或具有1至27个碳原子的直链，支链或环状酰基）。食物，饮料或药物制剂的饮食包括幽门螺杆菌增殖抑制剂。

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