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1. 发明申请

US20130141098A1 Alignment Phantom for MR/PET System 有权
标题翻译： MR / PET系统对准体模
公开(公告)号：US20130141098A1
公开(公告)日：2013-06-06
申请号：US13753894
申请日：2013-01-30
申请人： Jun Bao , David Faul , Ralf Ladebeck , John Thomas Pawlak , Elmar Rummert , Charles C. Watson
发明人： Jun Bao , David Faul , Ralf Ladebeck , John Thomas Pawlak , Elmar Rummert , Charles C. Watson
IPC分类号： G01R33/48
CPC分类号： G01R33/58 , G01R33/48 , G01R33/481 , G01R33/4812 , G01T1/1603 , G01T7/005
摘要： A phantom for co-registering a magnetic resonance image and a nuclear medical image is disclosed. The phantom includes a longitudinal member having a first end cap and a second end cap and a chamber contained within the longitudinal member. The chamber contains a fluid for producing a first image using a first imaging modality. The phantom further includes a first rod disposed within the chamber of the longitudinal member. The first rod contains a radioactive substance for producing a second image using a second imaging modality.
摘要翻译：公开了用于共同配准磁共振图像和核医学图像的体模。该体模包括具有第一端盖和第二端盖以及容纳在纵向构件内的室的纵向构件。该腔室包含用于使用第一成像模态产生第一图像的流体。体模还包括设置在纵向构件的腔室内的第一杆。第一杆包含用于使用第二成像模态产生第二图像的放射性物质。

2. 发明授权

US09459333B2 Alignment phantom for MR/PET system 有权
标题翻译： MR / PET系统对准体模
公开(公告)号：US09459333B2
公开(公告)日：2016-10-04
申请号：US13753894
申请日：2013-01-30
申请人： Jun Bao , David Faul , Ralf Ladebeck , John Thomas Pawlak , Elmar Rummert , Charles C. Watson
发明人： Jun Bao , David Faul , Ralf Ladebeck , John Thomas Pawlak , Elmar Rummert , Charles C. Watson
IPC分类号： G01R33/58 , G01T1/16 , G01R33/48
CPC分类号： G01R33/58 , G01R33/48 , G01R33/481 , G01R33/4812 , G01T1/1603 , G01T7/005
摘要： A phantom for co-registering a magnetic resonance image and a nuclear medical image is disclosed. The phantom includes a longitudinal member having a first end cap and a second end cap and a chamber contained within the longitudinal member. The chamber contains a fluid for producing a first image using a first imaging modality. The phantom further includes a first rod disposed within the chamber of the longitudinal member. The first rod contains a radioactive substance for producing a second image using a second imaging modality.
摘要翻译：公开了用于共同配准磁共振图像和核医学图像的体模。该体模包括具有第一端盖和第二端盖以及容纳在纵向构件内的室的纵向构件。该腔室包含用于使用第一成像模态产生第一图像的流体。体模还包括设置在纵向构件的腔室内的第一杆。第一杆包含用于使用第二成像模态产生第二图像的放射性物质。

3. 发明授权

US08299438B2 Model based estimation of a complete or partial positron emission tomography attenuation map using maximum likelihood expectation maximization 有权
标题翻译：使用最大似然预期最大化的基于全面或部分正电子发射断层扫描衰减图的模型估计
公开(公告)号：US08299438B2
公开(公告)日：2012-10-30
申请号：US12458575
申请日：2009-07-16
申请人： Matthias Fenchel , Ralf Ladebeck , Christian J. Michel , Charles C. Watson
发明人： Matthias Fenchel , Ralf Ladebeck , Christian J. Michel , Charles C. Watson
IPC分类号： G06F17/10
CPC分类号： G01R33/481 , A61B6/037 , A61B6/5235 , A61B6/5247 , G01R33/5608 , G06T11/005
摘要： Example embodiments are directed to a method of correcting attenuation in a magnetic resonance (MR) scanner and a positron emission tomography (PET) unit. The method includes acquiring PET sinogram data of an object within a field of view of the PET unit. The method further includes producing an attenuation map based on a maximum likelihood expectation maximization (MLEM) of a parameterized model instance and the PET sinogram data.
摘要翻译：示例性实施例涉及一种校正磁共振（MR）扫描仪和正电子发射断层摄影（PET）单元中的衰减的方法。该方法包括在PET单元的视野范围内获取物体的PET正弦图数据。该方法还包括基于参数化模型实例的最大似然期望最大化（MLEM）和PET正弦图数据产生衰减图。

4. 发明授权

US07888632B2 Co-registering attenuation data and emission data in combined magnetic resonance/positron emission tomography (MR/PET) imaging apparatus 有权
标题翻译：联合磁共振/正电子发射断层扫描（MR / PET）成像装置共同配准衰减数据和发射数据
公开(公告)号：US07888632B2
公开(公告)日：2011-02-15
申请号：US12564685
申请日：2009-09-22
申请人： Ralf Ladebeck , Christian J. Michel , Charles C. Watson
发明人： Ralf Ladebeck , Christian J. Michel , Charles C. Watson
IPC分类号： G01T1/161
CPC分类号： G01R33/481
摘要： A method for co-registering attenuation data of MR coils in a MR/PET imaging system with PET emission data includes computing a likelihood of PET emission data on a grid in a parameter space based on an algorithm, wherein the algorithm defines L(λ, μbody, μcoils{p}) as a log-likelihood of measured PET data, where λ is an emitter distribution (image), μbody is a known linear attenuation coefficient (LAC) distribution of the body from MRI, μcoils is a linear attenuation coefficient map of MRI coils, and {p} is a set of parameters governing the position of each coil, wherein if μcoils is assumed, then λ can be reconstructed and forward projected and L can be computed. The method includes adjusting the estimated position of the MR coils to maximize the likelihood of emission data based on the computed L.
摘要翻译：在具有PET发射数据的MR / PET成像系统中共同记录MR线圈的衰减数据的方法包括基于算法计算参数空间中的网格上的PET发射数据的可能性，其中所述算法定义L（λ， μbody，μcoils{p}）作为测量PET数据的对数似然度，其中λ是发射体分布（图像），μbody是来自MRI的身体的已知线性衰减系数（LAC）分布，μ线圈是线性衰减系数 MRI线圈图，{p}是控制每个线圈位置的一组参数，其中如果假设为μcoils，则可以重建λ并且向前投影，并且可以计算L。该方法包括调整MR线圈的估计位置，以使基于计算出的L的发射数据的可能性最大化。

5. 发明申请

US20110015904A1 Model based estimation of a complete or partial positron emission tomography attenuation map using maximum likelihood expectation maximization 有权
标题翻译：使用最大似然预期最大化的基于全面或部分正电子发射断层扫描衰减图的模型估计
公开(公告)号：US20110015904A1
公开(公告)日：2011-01-20
申请号：US12458575
申请日：2009-07-16
申请人： Matthias Fenchel , Ralf Ladebeck , Christian J. Michel , Charles C. Watson
发明人： Matthias Fenchel , Ralf Ladebeck , Christian J. Michel , Charles C. Watson
IPC分类号： G06F17/10
CPC分类号： G01R33/481 , A61B6/037 , A61B6/5235 , A61B6/5247 , G01R33/5608 , G06T11/005
摘要： Example embodiments are directed to a method of correcting attenuation in a magnetic resonance (MR) scanner and a positron emission tomography (PET) unit. The method includes acquiring PET sinogram data of an object within a field of view of the PET unit. The method further includes producing an attenuation map based on a maximum likelihood expectation maximization (MLEM) of a parameterized model instance and the PET sinogram data.
摘要翻译：示例性实施例涉及一种校正磁共振（MR）扫描仪和正电子发射断层摄影（PET）单元中的衰减的方法。该方法包括在PET单元的视野范围内获取物体的PET正弦图数据。该方法还包括基于参数化模型实例的最大似然期望最大化（MLEM）和PET正弦图数据产生衰减图。

6. 发明授权

US08242777B2 Calibration of an emission tomography subsystem 有权
标题翻译：发射断层扫描子系统的校准
公开(公告)号：US08242777B2
公开(公告)日：2012-08-14
申请号：US12585871
申请日：2009-09-28
申请人： Ralf Ladebeck , Johannes Pauli , Charles C. Watson
发明人： Ralf Ladebeck , Johannes Pauli , Charles C. Watson
IPC分类号： G01V3/00
CPC分类号： G01R33/481 , G01R33/58 , G01T1/1603 , G01T1/1648
摘要： A method and a system are disclosed for calibrating an emission tomography subsystem in a combined MR (magnetic resonance) and emission tomography imaging system. In at least one embodiment, the method includes providing a phantom that is configured such that the phantom is visible on a MR image, providing an attenuation map of the phantom, wherein the attenuation map includes an attenuation of the phantom, obtaining the MR image of the phantom, obtaining a position of the phantom from the MR image, mapping the attenuation map with the position of the phantom, and calibrating the emission tomography subsystem using the attenuation map mapped with the position of the phantom.
摘要翻译：公开了用于校准组合MR（磁共振）和发射断层摄影成像系统中的发射断层扫描子系统的方法和系统。在至少一个实施例中，该方法包括提供被配置为使得该幻像在MR图像上可见的假体，提供该体模的衰减图，其中该衰减图包括该体模的衰减，获得该虚像的MR图像幻影，从MR图像获得体模的位置，将衰减图与幻影的位置对准，并使用映射与体模位置的衰减图校准发射断层摄影子系统。

7. 发明申请

US20110074410A1 Calibration of an emission tomography subsystem 有权
标题翻译：发射断层扫描子系统的校准
公开(公告)号：US20110074410A1
公开(公告)日：2011-03-31
申请号：US12585871
申请日：2009-09-28
申请人： Ralf Ladebeck , Johannes Pauli , Charles C. Watson
发明人： Ralf Ladebeck , Johannes Pauli , Charles C. Watson
IPC分类号： G01V3/00
CPC分类号： G01R33/481 , G01R33/58 , G01T1/1603 , G01T1/1648
摘要： A method and a system are disclosed for calibrating an emission tomography subsystem in a combined MR (magnetic resonance) and emission tomography imaging system. In at least one embodiment, the method includes providing a phantom that is configured such that the phantom is visible on a MR image, providing an attenuation map of the phantom, wherein the attenuation map includes an attenuation of the phantom, obtaining the MR image of the phantom, obtaining a position of the phantom from the MR image, mapping the attenuation map with the position of the phantom, and calibrating the emission tomography subsystem using the attenuation map mapped with the position of the phantom.
摘要翻译：公开了用于校准组合MR（磁共振）和发射断层摄影成像系统中的发射断层扫描子系统的方法和系统。在至少一个实施例中，该方法包括提供被配置为使得该幻像在MR图像上可见的假体，提供该体模的衰减图，其中该衰减图包括该体模的衰减，获得该虚像的MR图像幻影，从MR图像获得体模的位置，将衰减图与幻影的位置对准，并使用映射与体模位置的衰减图校准发射断层摄影子系统。

8. 发明申请

US20100074501A1 Co-Registering Attenuation Data and Emission Data in Combined Magnetic Resonance/Positron Emission Tomography (MR/PET) Imaging Apparatus 有权
标题翻译：联合磁共振/正电子发射断层扫描（MR / PET）成像仪共同记录衰减数据和排放数据
公开(公告)号：US20100074501A1
公开(公告)日：2010-03-25
申请号：US12564685
申请日：2009-09-22
申请人： Ralf Ladebeck , Christian J. Michel , Charles C. Watson
发明人： Ralf Ladebeck , Christian J. Michel , Charles C. Watson
IPC分类号： G06K9/00 , G06F7/60
CPC分类号： G01R33/481
摘要： A method for co-registering attenuation data of MR coils in a MR/PET imaging system with PET emission data includes computing a likelihood of PET emission data on a grid in a parameter space based on an algorithm, wherein the algorithm defines L(λ, μbody, μcoils{p}) as a log-likelihood of measured PET data, where λ is an emitter distribution (image), μbody is a known linear attenuation coefficient (LAC) distribution of the body from MRI, μcoils is a linear attenuation coefficient map of MRI coils, and {p} is a set of parameters governing the position of each coil, wherein if μcoils is assumed, then λ can be reconstructed and forward projected and L can be computed. The method includes adjusting the estimated position of the MR coils to maximize the likelihood of emission data based on the computed L.
摘要翻译：在具有PET发射数据的MR / PET成像系统中共同记录MR线圈的衰减数据的方法包括基于算法计算参数空间中的网格上的PET发射数据的可能性，其中所述算法定义L（λ， μbody，μcoils{p}）作为测量PET数据的对数似然度，其中λ是发射体分布（图像），μbody是来自MRI的身体的已知线性衰减系数（LAC）分布，μ线圈是线性衰减系数 MRI线圈图，{p}是控制每个线圈位置的一组参数，其中如果假设为μcoils，则可以重建λ并且向前投影，并且可以计算L。该方法包括调整MR线圈的估计位置，以使基于计算出的L的发射数据的可能性最大化。

9. 发明申请

US20140228673A1 Supplemental Transmission Information for Attenuation Correction in Positron Emission Tomography Imaging 有权
标题翻译：补充传输信息用于正电子发射断层成像中的衰减校正
公开(公告)号：US20140228673A1
公开(公告)日：2014-08-14
申请号：US13763948
申请日：2013-02-11
申请人： Charles C. Watson
发明人： Charles C. Watson
IPC分类号： A61B6/00 , A61B5/055 , A61B6/03 , A61B5/00
CPC分类号： A61B6/5247 , A61B5/0035 , A61B5/055 , A61B5/742 , A61B6/037 , A61B6/4258 , A61B6/4417 , A61B6/461 , A61B6/5258 , A61B6/582
摘要： Supplemental transmission information is used in PET imaging with a hybrid PET/MR system. The magnetic field of the MR portion is used to direct positrons from one or more sources outside or inside the PET field of view to within the PET field of view. An oblique target or targets create an annihilation source within the PET field of view from the positron beam or beams. The resulting radiation may be detected. In combination with measurements made with the sources shielded (e.g., no positron beam-target annihilation sources), the attenuation or other characteristics outside the uniform region of the MR field of view is determined, such as calculating attenuation of arms of a patient for attenuation correction in PET imaging.
摘要翻译：补充传输信息用于具有混合PET / MR系统的PET成像。 MR部分的磁场用于将来自PET视野外部或内部的一个或多个源的正电子引导到PET视场内。倾斜目标或目标在正电子束或光束的PET视野内产生湮灭源。可以检测所得到的辐射。结合使用屏蔽源（例如，没有正电子束靶湮灭源）进行的测量，确定MR视场的均匀区域之外的衰减或其它特性，例如计算患者的臂的衰减以衰减 PET成像校正。

10. 发明授权

US07894652B2 Prompt gamma correction for non-standard isotopes in a PET scanner 有权
标题翻译： PET扫描仪中非标准同位素的伽马校正
公开(公告)号：US07894652B2
公开(公告)日：2011-02-22
申请号：US12110474
申请日：2008-04-28
申请人： Charles H. Hayden, Jr. , Michael E. Casey , Charles C. Watson
发明人： Charles H. Hayden, Jr. , Michael E. Casey , Charles C. Watson
IPC分类号： G06K9/00 , G01R23/02 , G01N23/00
CPC分类号： G01T1/2985 , A61B6/037
摘要： A method for correcting PET emission data for prompt gamma emission background components present in non-pure positron-emitting isotopes uses a two component fit of modeled scatter and modeled prompt gamma emission in the area of scatter tails in a normalized emission sinogram. The method allows a PET scan using non-standard PET isotopes to be quantitative and thus more clinically useful.
摘要翻译：用于校正存在于非纯正电子发射同位素中的迅速γ发射背景分量的PET发射数据的方法使用归一化发射正弦图中散射尾部区域中的建模散射和建模的提示γ发射的双分量拟合。该方法允许使用非标准PET同位素的PET扫描是定量的，因此在临床上更有用。

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