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1. 发明申请

US20140193868A1 EXTRACELLULAR POLYHYDROXYALKANOATES PRODUCED BY GENETICALLY ENGINEERED MICROORGANISMS 审中-公开
标题翻译：通过遗传工程微生物生产的细菌聚羟基烷酸酯
公开(公告)号：US20140193868A1
公开(公告)日：2014-07-10
申请号：US14148820
申请日：2014-01-07
申请人： Julia Sabirova , Peter Golyshin , Manuel Ferrer , Heinrich Lünsdorf , Wolf-Rainer Abraham , Kenneth Timmis
发明人： Julia Sabirova , Peter Golyshin , Manuel Ferrer , Heinrich Lünsdorf , Wolf-Rainer Abraham , Kenneth Timmis
IPC分类号： C12P7/62
CPC分类号： C12P7/625 , C12N9/1029 , C12N9/1205 , C12N9/13 , C12N9/16 , C12N9/88
摘要： The present invention is in the field of biosynthesis of polyhydroxyalkanoates (PHA). The invention relates to a genetically engineered microorganism having at least one gene involved in the metabolism, preferably in the production, of polyhydroxyalkanoates (PHA). This microorganism is useful in commercial production of polyhydroxyalkanoates. The present invention further relates to a method for the production of polyhydroxyalkanoates (PHA).
摘要翻译：本发明涉及聚羟基链烷酸酯（PHA）的生物合成领域。本发明涉及具有至少一种涉及聚羟基链烷酸酯（PHA）代谢，优选在生产中的基因的遗传工程微生物。该微生物可用于商业生产聚羟基链烷酸酯。本发明还涉及一种生产聚羟基链烷酸酯（PHA）的方法。

2. 发明授权

US08623632B2 Extracellular polyhydroxyalkanoates produced by genetically engineered microorganisms 失效
标题翻译：由遗传工程微生物产生的细胞外聚羟基链烷酸酯
公开(公告)号：US08623632B2
公开(公告)日：2014-01-07
申请号：US11989909
申请日：2006-08-09
申请人： Julia Sabirova , Peter Golyshin , Manuel Ferrer , Heinrich Lunsdorf , Wolf-Rainer Abraham , Kenneth Timmis
发明人： Julia Sabirova , Peter Golyshin , Manuel Ferrer , Heinrich Lunsdorf , Wolf-Rainer Abraham , Kenneth Timmis
IPC分类号： C12N1/20
CPC分类号： C12P7/625 , C12N9/1029 , C12N9/1205 , C12N9/13 , C12N9/16 , C12N9/88
摘要： The present invention is in the field of biosynthesis of polyhydroxyalkanoates (PHA). The invention relates to a genetically engineered microorganism having at least one gene involved in the metabolism, preferably in the production, of polyhydroxyalkanoates (PHA). This microorganism is useful in commercial production of polyhydroxyalkanoates. The present invention further relates to a method for the production of polyhydroxyalkanoates (PHA).
摘要翻译：本发明涉及聚羟基链烷酸酯（PHA）的生物合成领域。本发明涉及具有至少一种涉及聚羟基链烷酸酯（PHA）代谢，优选在生产中的基因的遗传工程微生物。该微生物可用于商业生产聚羟基链烷酸酯。本发明还涉及一种生产聚羟基链烷酸酯（PHA）的方法。

3. 发明申请

US20110183388A1 Extracellular Polyhydroxyalkanoates Produced By Genetically Engineered Microorganisms 失效
标题翻译：由遗传工程微生物产生的细胞外聚羟基链烷酸酯
公开(公告)号：US20110183388A1
公开(公告)日：2011-07-28
申请号：US11989909
申请日：2006-08-09
申请人： Julia Sabirova , Peter Golyshin , Manuel Ferrer , Heinrich Lunsdorf , Wolf-Rainer Abraham , Kenneth Timmis
发明人： Julia Sabirova , Peter Golyshin , Manuel Ferrer , Heinrich Lunsdorf , Wolf-Rainer Abraham , Kenneth Timmis
IPC分类号： C12P7/62 , C12N1/21 , C07H21/04 , C12N9/16 , C12N15/63
CPC分类号： C12P7/625 , C12N9/1029 , C12N9/1205 , C12N9/13 , C12N9/16 , C12N9/88
摘要： The present invention is in the field of biosynthesis of polyhydroxyalkanoates (PHA). The invention relates to a genetically engineered microorganism having at least one gene involved in the metabolism, preferably in the production, of polyhydroxyalkanoates (PHA). This microorganism is useful in commercial production of polyhydroxyalkanoates. The present invention further relates to a method for the production of polyhydroxyalkanoates (PHA).
摘要翻译：本发明涉及聚羟基链烷酸酯（PHA）的生物合成领域。本发明涉及具有至少一种涉及聚羟基链烷酸酯（PHA）代谢，优选在生产中的基因的遗传工程微生物。该微生物可用于商业生产聚羟基链烷酸酯。本发明还涉及一种生产聚羟基链烷酸酯（PHA）的方法。

4. 发明申请

US20100196965A1 Acidophilic Enzymes 失效
标题翻译：嗜酸性酶
公开(公告)号：US20100196965A1
公开(公告)日：2010-08-05
申请号：US11885109
申请日：2006-03-03
申请人： Olga Golyshina , Peter Golyshin , Kenneth Timmis , Manuel Ferrer
发明人： Olga Golyshina , Peter Golyshin , Kenneth Timmis , Manuel Ferrer
IPC分类号： C12P19/34 , C12N9/00 , C12N9/16 , C12N9/24
CPC分类号： C12N9/16 , C12N9/18 , C12N9/2402 , C12N9/93
摘要： The present invention relates to enzymes having catalytic activity at a pH below 5.0. The present invention provides hydrolyzing enzymes obtainable from archaeobacteria, in detail to hydrolytic enzymes obtainable from the archaeobacterium Ferroplasma acidiphilum. In general, the present invention provides enzymes which are active and stable at acidic pH values, especially at pH values from 1 to 4, especially in the range of pH 2 to 3, obtainable from Ferroplasma acidiphilum, especially to an esterase, glycosidases and a DNA ligase. In addition to stability and activity at low pH values, the enzymes according to the present invention are all dependent on Fe2+ for their catalytic activity.
摘要翻译：本发明涉及在pH低于5.0时具有催化活性的酶。本发明提供了可从古细菌获得的水解酶，详细地可从碱性阿斯法氏球菌获得的水解酶。通常，本发明提供了在酸性pH值下，特别是在pH值为1至4，特别是在pH2至3的pH值范围内具有活性和稳定性的酶，其可从碳酸亚铁（Ferroplasma acidiphilum），特别是酯酶，糖苷酶和 DNA连接酶。除了在低pH值下的稳定性和活性之外，根据本发明的酶全部依赖于Fe 2+作为其催化活性。

5. 发明申请

US20090305339A1 Polypeptides With Laccase Activity 审中-公开
标题翻译：具有漆酶活性的多肽
公开(公告)号：US20090305339A1
公开(公告)日：2009-12-10
申请号：US12280545
申请日：2007-02-23
申请人： Carsten Strompl , Manuel Ferrer , Tatyana Chernikova , Olga Golyshina , Kenneth Timmis , Kieran Elborough , Graeme Jarvis , Peter Golyshin
发明人： Carsten Strompl , Manuel Ferrer , Tatyana Chernikova , Olga Golyshina , Kenneth Timmis , Kieran Elborough , Graeme Jarvis , Peter Golyshin
IPC分类号： C12P21/02 , C12N9/02 , C12N15/11 , C12N15/00 , C12N1/21
CPC分类号： D06M16/003 , C12N9/0061 , D06L4/40 , D06M2101/06 , D06P5/15 , D21C5/005 , D21H17/005
摘要： The invention relates to a new laccase from rumen, namely the RL5 laccase. In particular, the invention relates to a polypeptide comprising the amino acid sequence shown in FIG. 11 and comprising at least the amino acids No. 80 to No. 150 of the amino acid sequence shown in FIG. 11, respectively. The invention also relates to the use of polypeptides further comprising the amino acid sequence of a DUF152 domain with a core sequence as shown in FIG. 18 as laccases. Furthermore, the invention relates to methods for producing inventive polypeptides and their use.
摘要翻译：本发明涉及一种来自瘤胃的新漆酶，即RL5漆酶。特别地，本发明涉及包含图1所示氨基酸序列的多肽。并且至少包含图11所示的氨基酸序列的第80至150号氨基酸。 11。本发明还涉及进一步包含具有核心序列的DUF152结构域的氨基酸序列的多肽的用途，如图1所示。 18作为漆酶。此外，本发明涉及生产本发明多肽的方法及其用途。

6. 发明授权

US08003357B2 Acidophilic enzymes 失效
标题翻译：嗜酸酶
公开(公告)号：US08003357B2
公开(公告)日：2011-08-23
申请号：US11885109
申请日：2006-03-03
申请人： Olga Golyshina , Peter Golyshin , Kenneth Timmis , Manuel Ferrer
发明人： Olga Golyshina , Peter Golyshin , Kenneth Timmis , Manuel Ferrer
IPC分类号： C12N9/00 , C12P19/34 , C12Q1/68 , C07H21/04
CPC分类号： C12N9/16 , C12N9/18 , C12N9/2402 , C12N9/93
摘要： The present invention relates to enzymes having catalytic activity at a pH below 5.0. The present invention provides hydrolyzing enzymes obtainable from archaeobacteria, in detail to hydrolytic enzymes obtainable from the archaeobacterium Ferroplasma acidiphilum. In general, the present invention provides enzymes which are active and stable at acidic pH values, especially at pH values from 1 to 4, especially in the range of pH 2 to 3, obtainable from Ferroplasma acidiphilum, especially to an esterase, glycosidases and a DNA ligase. In addition to stability and activity at low pH values, the enzymes according to the present invention are all dependent on Fe2+ for their catalytic activity.
摘要翻译：本发明涉及在pH低于5.0时具有催化活性的酶。本发明提供了可从古细菌获得的水解酶，详细地可从碱性阿斯法氏球菌获得的水解酶。通常，本发明提供了在酸性pH值下，特别是在pH值为1至4，特别是在pH2至3的pH值范围内具有活性和稳定性的酶，其可从碳酸亚铁（Ferroplasma acidiphilum），特别是酯酶，糖苷酶和 DNA连接酶。除了在低pH值下的稳定性和活性之外，根据本发明的酶全部依赖于Fe 2+作为其催化活性。

7. 发明申请

US20090255014A1 Transgenic organisms with lower growth temperature 有权
标题翻译：生长温度较低的转基因生物
公开(公告)号：US20090255014A1
公开(公告)日：2009-10-08
申请号：US10575505
申请日：2004-10-11
申请人： Manuel Ferrer , Kenneth Timmis , Tatjana Chernikova , Peter Golyshin , Michail Yakimov
发明人： Manuel Ferrer , Kenneth Timmis , Tatjana Chernikova , Peter Golyshin , Michail Yakimov
IPC分类号： A01H5/00 , C12P21/00 , C12P21/02
CPC分类号： C12R1/01 , C12N1/20
摘要： The invention relates to the growth temperature of organisms, especially plants and microorganisms and the manipulation of the tolerable cultivation temperature. More specifically, the present invention relates to the expression of heterologous proteins in microorganisms, and especially to the heterologous expression of heat sensitive proteins in bacteria, either gram-negative or gram-positive. In a first aspect, the present invention provides a method for manipulation of cells and the resultant cells, wherein at least one gene from a psychrophilic micro organism coding for at least one chaperone or chaperonin is expressed. Such cells are selected among cultivated eukaryotic cells, i.e. animal and plant cells and entire plants, gram-negative and gram-positive bacteria, fungi and yeasts.
摘要翻译：本发明涉及生物体，特别是植物和微生物的生长温度以及可耐受栽培温度的操作。更具体地，本发明涉及异源蛋白在微生物中的表达，特别涉及在细菌中革兰氏阴性或革兰氏阳性的热敏蛋白的异源表达。在第一方面，本发明提供了一种用于操作细胞和所得细胞的方法，其中表达来自编码至少一个伴侣或伴侣蛋白的嗜热微生物的至少一个基因。这样的细胞选自培养的真核细胞，即动物和植物细胞以及整个植物，革兰氏阴性和革兰氏阳性细菌，真菌和酵母。

8. 发明申请

US20090078384A1 Esterases from rumen 审中-公开
标题翻译：来自瘤胃的酯酶
公开(公告)号：US20090078384A1
公开(公告)日：2009-03-26
申请号：US11631708
申请日：2005-07-06
申请人： Manuel Ferrer , Peter Golyshin , Olga Golyshina , Tatyana Chernikova , Carsten Strompl , Kenneth Timmis , Kieran Elborough , Graeme Jarvis
发明人： Manuel Ferrer , Peter Golyshin , Olga Golyshina , Tatyana Chernikova , Carsten Strompl , Kenneth Timmis , Kieran Elborough , Graeme Jarvis
IPC分类号： C12P21/04 , C12N9/16 , C12N15/11 , C07H1/00 , D21H17/22 , C11D3/386 , C12S11/00 , A23L1/48 , D21H17/24 , A23L1/00 , C12N15/00 , C12N1/21
CPC分类号： C12N9/16 , C12N9/14
摘要： The invention provides polypeptides coding for new esterases from rumen. The invention also relates to functional fragments or functional derivatives thereof as well as to nucleic acids encoding the polypeptides of the invention, vectors and host cells containing said nucleic acids, a method for producing the polypeptides and the use of the polypeptides according to the present invention for various industrial purposes and medical treatments. The invention also relate to the conversion of said esterases into lipases.
摘要翻译：本发明提供了编码来自瘤胃的新酯酶的多肽。本发明还涉及功能性片段或其功能性衍生物以及编码本发明多肽的核酸，含有所述核酸的载体和宿主细胞，产生多肽的方法以及根据本发明的多肽的用途用于各种工业用途和医疗。本发明还涉及将所述酯酶转化成脂肪酶。

9. 发明授权

US07811784B2 Transgenic organisms with lower growth temperature 有权
标题翻译：生长温度较低的转基因生物
公开(公告)号：US07811784B2
公开(公告)日：2010-10-12
申请号：US10575505
申请日：2004-10-11
申请人： Manuel Ferrer , Kenneth Timmis , Tatjana Chernikova , Peter Golyshin , Michail Yakimov
发明人： Manuel Ferrer , Kenneth Timmis , Tatjana Chernikova , Peter Golyshin , Michail Yakimov
IPC分类号： C12P21/06 , C12N9/00
CPC分类号： C12R1/01 , C12N1/20
摘要： The invention relates to the growth temperature of organisms, especially plants and microorganisms and the manipulation of the tolerable cultivation temperature. More specifically, the present invention relates to the expression of heterologous proteins in microorganisms, and especially to the heterologous expression of heat sensitive proteins in bacteria, either gram-negative or gram-positive. In a first aspect, the present invention provides a method for manipulation of cells and the resultant cells, wherein at least one gene from a psychrophilic micro organism coding for at least one chaperone or chaperonin is expressed. Such cells are selected among cultivated eukaryotic cells, i.e. animal and plant cells and entire plants, gram-negative and gram-positive bacteria, fungi and yeasts.
摘要翻译：本发明涉及生物体，特别是植物和微生物的生长温度以及可耐受栽培温度的操作。更具体地，本发明涉及异源蛋白在微生物中的表达，特别涉及在细菌中革兰氏阴性或革兰氏阳性的热敏蛋白的异源表达。在第一方面，本发明提供了一种用于操作细胞和所得细胞的方法，其中表达来自编码至少一个伴侣或伴侣蛋白的嗜热微生物的至少一个基因。这样的细胞选自培养的真核细胞，即动物和植物细胞以及整个植物，革兰氏阴性和革兰氏阳性细菌，真菌和酵母。

10. 发明申请

US20080261267A1 Cellulases from Rumen 审中-公开
标题翻译：瘤胃纤维素酶
公开(公告)号：US20080261267A1
公开(公告)日：2008-10-23
申请号：US11631243
申请日：2005-06-30
申请人： Manuel Ferrer , Peter Golyshin , Olga Golyshina , Tatyana Chernikova , Carsten Strompl , Kenneth Timmis , Kieran Elborough , Graeme Jarvis
发明人： Manuel Ferrer , Peter Golyshin , Olga Golyshina , Tatyana Chernikova , Carsten Strompl , Kenneth Timmis , Kieran Elborough , Graeme Jarvis
IPC分类号： C12P21/04 , C12N9/42 , C12N15/11 , C12N15/00 , C12N1/20
CPC分类号： C12N9/2437 , C12Y302/01004
摘要： The invention provides polypeptides coding for new cellulases from rumen, particularly from rumen ecosystem. The invention also relates to functional fragments or functional derivatives thereof as well as to nucleic acids encoding the polypeptides of the invention, vectors and host cells containing said nucleic acids, a method for producing the polypeptides and the use of the polypeptides according to the present invention for various industrial purposes and medical treatments.
摘要翻译：本发明提供了编码来自瘤胃，特别是瘤胃生态系统的新的纤维素酶的多肽。本发明还涉及功能性片段或其功能性衍生物以及编码本发明多肽的核酸，含有所述核酸的载体和宿主细胞，产生多肽的方法以及根据本发明的多肽的用途用于各种工业用途和医疗。

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