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1. 发明授权

US06420519B1 Modifying tissue surfaces by liquid crystal formation 有权
标题翻译：通过液晶形成改变组织表面
公开(公告)号：US06420519B1
公开(公告)日：2002-07-16
申请号：US09446966
申请日：1999-12-29
申请人： Julia Hwang , Samuel I. Stupp
发明人： Julia Hwang , Samuel I. Stupp
IPC分类号： A61B1900
CPC分类号： A61L27/50 , A61B17/00491 , A61B2017/564 , A61F2/30756 , A61F2002/30084 , A61F2002/30673 , A61F2240/008 , A61L27/26 , A61L27/34 , A61L2400/18 , C08L77/04
摘要： A method for modifying the surface properties of tissue in vivo is described. The method comprises forming a liquid crystalline matrix on the tissue surface by contacting the surface with a composition comprising a poly(hydroxy substituted amino acid). Compositions comprising a poly(hydroxy substituted amino acid) and synovial fluid are also provided.
摘要翻译：描述了一种修饰体内组织表面性质的方法。该方法包括通过使表面与包含聚（羟基取代的氨基酸）的组合物接触来在组织表面上形成液晶基质。还提供了包含聚（羟基取代的氨基酸）和滑液的组合物。

2. 发明授权

US06784282B2 Modifying tissue surfaces by liquid crystal formation 失效
标题翻译：通过液晶形成改变组织表面
公开(公告)号：US06784282B2
公开(公告)日：2004-08-31
申请号：US10188426
申请日：2002-07-02
申请人： Julia Hwang , Samuel I. Stupp
发明人： Julia Hwang , Samuel I. Stupp
IPC分类号： A61B1900
CPC分类号： A61L27/50 , A61B17/00491 , A61B2017/564 , A61F2/30756 , A61F2002/30084 , A61F2002/30673 , A61F2240/008 , A61L27/26 , A61L27/34 , A61L2400/18 , C08L77/04
摘要： A method for modifying the surface properties of tissue in vivo is described. The method comprises forming a liquid crystalline matrix on the tissue surface wherein the matrix comprises a tissue surface component. In one embodiment there is provided a method for improving the bonding of surgical glues and cements to cartilage and other synovial fluid wetted tissue surfaces. Such surfaces are contacted with a composition comprising a poly(hydroxy substituted amino acid) to form a liquid crystalline matrix on the tissue surface. The matrix is readily removed to provide a tissue surface that exhibits improved bonding with surgical glues.
摘要翻译：描述了一种修饰体内组织表面性质的方法。该方法包括在组织表面上形成液晶基质，其中基质包括组织表面组分。在一个实施方案中，提供了一种用于改善外科胶水和水泥与软骨和其它滑液润湿组织表面的结合的方法。这样的表面与包含聚（羟基取代的氨基酸）的组合物接触以在组织表面上形成液晶基质。容易移除基质以提供表现出改善的与手术胶粘结的组织表面。

3. 发明授权

US06849711B2 Modifying tissue surfaces by liquid crystal formation 失效
标题翻译：通过液晶形成改变组织表面
公开(公告)号：US06849711B2
公开(公告)日：2005-02-01
申请号：US10188422
申请日：2002-07-02
申请人： Julia Hwang , Samuel I. Stupp
发明人： Julia Hwang , Samuel I. Stupp
IPC分类号： A61B17/00 , A61B17/56 , A61F2/00 , A61F2/02 , A61F2/30 , A61L24/00 , A61L27/26 , A61L27/34 , A61L27/50 , A61L31/00 , A61B19/00 , A61K38/00 , C07K14/00
CPC分类号： A61L27/50 , A61B17/00491 , A61B2017/564 , A61F2/30756 , A61F2002/30084 , A61F2002/30673 , A61F2240/008 , A61L27/26 , A61L27/34 , A61L2400/18 , C08L77/04
摘要： A method for modifying the surface properties of tissue in vivo is described The method comprises forming a liquid crystalline matrix on the tissue surface wherein the matrix comprises a tissue surface component In one embodiment there is provided a method for improving the bonding of surgical glues and cements to cartilage and other synovial fluid wetted tissue surfaces. Such surfaces are contacted with a composition comprising a poly(hydroxy substituted amino acid) to form a liquid crystalline matrix on the tissue surface The matrix is readily removed to provide a tissue surface that exhibits improved bonding with surgical glues.
摘要翻译：描述了一种用于修饰体内组织的表面性质的方法。该方法包括在组织表面上形成液晶基质，其中基质包括组织表面组分。在一个实施方案中，提供了一种改善手术胶和水泥粘合的方法软骨和其他滑液润湿的组织表面。这样的表面与包含聚（羟基取代的氨基酸）的组合物接触以在组织表面上形成液晶基质。容易地除去基质以提供表现出改善的与手术胶粘结的组织表面。

4. 发明授权

US6051272A Method for synthesizing organoapatites on to surgical metal alloys 失效
标题翻译：将有机磷灰石合成到外科金属合金上的方法
公开(公告)号：US6051272A
公开(公告)日：2000-04-18
申请号：US247203
申请日：1999-02-09
申请人： Samuel I. Stupp , Julia Hwang
发明人： Samuel I. Stupp , Julia Hwang
IPC分类号： A61L27/32 , A61L27/46 , B05D1/36 , B05D3/10 , B05D7/14
CPC分类号： A61L27/32 , A61L27/46
摘要： The present invention provides a method for growing or depositing artificial bone materials called organoapatites on a metal surgical alloy. The method involves pretreating the alloy with at least one aqueous solution of a poly(amino acid). After this pretreatment step, the organoapatites can be synthesized onto the alloy. Because most surgical implants are made from metal alloys, this method can be used to make implants which contain organoapatites may promote the formation of natural bone when placed into a human patient in vivo.
摘要翻译：本发明提供了一种在金属手术合金上生长或沉积称为有机磷灰石的人造骨材料的方法。该方法包括用至少一种聚（氨基酸）水溶液预处理合金。在该预处理步骤之后，可以合成有机磷灰石。因为大多数外科手术植入物是由金属合金制成的，所以这种方法可以用来制造含有有机磷灰石的植入体，在体内置入人体患者时可以促进天然骨的形成。

5. 发明授权

US09650421B2 Self-assembled nanostructures 有权
公开(公告)号：US09650421B2
公开(公告)日：2017-05-16
申请号：US14342245
申请日：2012-08-31
申请人： Samuel I. Stupp , Yves Ruff
发明人： Samuel I. Stupp , Yves Ruff
IPC分类号： C07K14/00 , A61K47/48 , A61K31/713 , H01L51/00
CPC分类号： C07K14/001 , A61K31/713 , A61K47/60 , A61K47/64 , A61K47/6455 , A61K47/69 , C07K14/00 , C07K2319/20 , C07K2319/73 , H01L51/0093
摘要： The present disclosure is directed to the preparation of nanostructures by the encapsulation of a charged compound with individual self-assembled unit nano structures.

6. 发明申请

US20170053721A1 Modular Supramolecular Approach for Co-Crystallization of Donors and Acceptors into Ordered Networks 有权
标题翻译：供体和受体共同结晶的模块化超分子方法进入有序网络
公开(公告)号：US20170053721A1
公开(公告)日：2017-02-23
申请号：US15252852
申请日：2016-08-31
申请人： Samuel I. Stupp , J. Fraser Stoddart , Alexander K. Shveyd , Alok S. Tayi , Chi-Hau Sue , Ashwin Narayanan
发明人： Samuel I. Stupp , J. Fraser Stoddart , Alexander K. Shveyd , Alok S. Tayi , Chi-Hau Sue , Ashwin Narayanan
IPC分类号： H01B1/12
CPC分类号： H01B1/121 , C07D487/14
摘要： Organic charge-transfer (CT) co-crystals in a mixed stack system are disclosed, wherein a donor molecule (D) and an acceptor molecule (A) occupy alternating positions (DADADA) along the CT axis. A platform is provided which amplifies the molecular recognition of donors and acceptors and produces co-crystals at ambient conditions, wherein the platform comprises (i) a molecular design of the first constituent (α-complement), (ii) a molecular design of the second compound (β-complement), and (iii) a solvent system that promotes co-crystallization.
摘要翻译：公开了混合堆叠系统中的有机电荷转移（CT）共晶体，其中供体分子（D）和受体分子（A）沿CT轴占据交替位置（DADADA）。提供了一种平台，其放大了供体和受体的分子识别，并在环境条件下产生共晶体，其中平台包括（i）第一组分（α-互补体）的分子设计，（ii）第二化合物（β-补体），和（iii）促进共结晶的溶剂体系。

7. 发明申请

US20150031127A1 SELF-ASSEMBLED NANOSTRUCTURES 有权
标题翻译：自组装的纳米结构
公开(公告)号：US20150031127A1
公开(公告)日：2015-01-29
申请号：US14342245
申请日：2012-08-31
申请人： Samuel I. Stupp , Yves Ruff
发明人： Samuel I. Stupp , Yves Ruff
IPC分类号： C07K14/00 , A61K31/713 , H01L51/00 , A61K47/48
CPC分类号： C07K14/001 , A61K31/713 , A61K47/60 , A61K47/64 , A61K47/6455 , A61K47/69 , C07K14/00 , C07K2319/20 , C07K2319/73 , H01L51/0093
摘要： The present disclosure is directed to the preparation of nanostructures by the encapsulation of a charged compound with individual self-assembled unit nano structures.
摘要翻译：本公开涉及通过将带电化合物与单独的自组装单元纳米结构包封来制备纳米结构体。

8. 发明授权

US08512693B2 Self-assembling membranes and related methods thereof 有权
标题翻译：自组装膜及其相关方法
公开(公告)号：US08512693B2
公开(公告)日：2013-08-20
申请号：US12031421
申请日：2008-02-14
申请人： Ramille M. Capito , Helena S. Azevedo , Samuel I. Stupp
发明人： Ramille M. Capito , Helena S. Azevedo , Samuel I. Stupp
IPC分类号： C12N11/00 , A61K35/00 , A61K47/00 , A61P43/00
CPC分类号： C12N11/04 , A61K9/1274
摘要： The present invention relates to self-assembling membranes. In particular, the present invention provides self-assembling membranes configured for securing and/or delivering bioactive agents. In some embodiments, the self-assembling membranes are used in the treatment of diseases, and related methods (e.g., diagnostic methods, research methods, drug screening).
摘要翻译：本发明涉及自组装膜。特别地，本发明提供了用于固定和/或递送生物活性剂的自组装膜。在一些实施方案中，自组装膜用于治疗疾病和相关方法（例如诊断方法，研究方法，药物筛选）。

9. 发明授权

US08450271B2 Peptide-based scaffolds for cartilage regeneration and methods for their use 有权
标题翻译：用于软骨再生的基于肽的支架及其使用方法
公开(公告)号：US08450271B2
公开(公告)日：2013-05-28
申请号：US12759683
申请日：2010-04-13
申请人： Ramille N. Shah , Nirav A. Shah , Samuel I. Stupp
发明人： Ramille N. Shah , Nirav A. Shah , Samuel I. Stupp
IPC分类号： A61K38/18 , A61K38/00 , A61K38/04 , C07K14/495 , C07K5/00 , A61P19/00
CPC分类号： C07K14/00 , A61K38/1841 , C07K7/06 , A61K2300/00
摘要： Disclosed herein are novel peptide amphiphile molecules and compositions composed of a peptide sequence that non-covalently binds the growth factor TGF-β1. Also disclosed are methods of using these peptide amphiphiles to create a gel scaffold in situ that enhances articular cartilage regeneration when used in combination with microfracture. Significant improvement in tissue quality and overall O'Driscoll histological scores were observed in rabbits with full thickness articular cartilage defects treated with the TGF-binding peptide amphiphile. The gel can further serve as a delivery vehicle for recombinant TGF-β1 protein growth factor. Scaffolds that localize and retain chondrogenic growth factors may synergistically enhance cartilage repair when combined with microfracture, by inducing bone marrow mesenchymal stem cells into chondrogenic differentiation. This invention represents a promising new biomimetic approach to enhance current techniques of articular cartilage regeneration in the clinical setting.
摘要翻译：本文公开了新型肽两亲物分子和由非共价结合生长因子TGF-β1的肽序列组成的组合物。还公开了使用这些肽两亲物来制备原位凝胶支架的方法，当与微裂缝组合使用时，其可增强关节软骨再生。在用TGF-结合肽两亲物处理的全层关节软骨缺损的兔子中观察到组织质量和总体O'Driscoll组织学评分的显着改善。该凝胶可进一步用作重组TGF-β1蛋白生长因子的递送载体。定位和保留软骨形成生长因子的支架可以通过将骨髓间充质干细胞诱导成软骨形成分化来协同增强软骨修复与微裂缝结合。本发明代表了在临床环境中增强关节软骨再生的当前技术的有希望的新的仿生方法。

10. 发明申请

US20130069010A1 MODULAR SUPRAMOLECULAR APPROACH FOR CO-CRYSTALLIZATION OF DONORS AND ACCEPTORS INTO ORDERED NETWORKS 有权
标题翻译：捐赠者和接受者共同结构化到有序网络的模块化SUPRAMONAL分析方法
公开(公告)号：US20130069010A1
公开(公告)日：2013-03-21
申请号：US13476974
申请日：2012-05-21
申请人： Samuel I. Stupp , J. Fraser Stoddart , Alexander K. Shveyd , Alok S. Tayi , Andrew C.H. Sue
发明人： Samuel I. Stupp , J. Fraser Stoddart , Alexander K. Shveyd , Alok S. Tayi , Andrew C.H. Sue
IPC分类号： H01B1/12 , C07D487/14
CPC分类号： H01B1/121 , C07D487/14
摘要： Organic charge-transfer (CT) co-crystals in a mixed stack system are disclosed, wherein a donor molecule (D) and an acceptor molecule (A) occupy alternating positions (DADADA) along the CT axis. A platform is provided which amplifies the molecular recognition of donors and acceptors and produces co-crystals at ambient conditions, wherein the platform comprises (i) a molecular design of the first constituent (α-complement), (ii) a molecular design of the second compound (β-complement), and (iii) a solvent system that promotes co-crystallization.
摘要翻译：公开了混合堆叠系统中的有机电荷转移（CT）共晶体，其中供体分子（D）和受体分子（A）沿CT轴占据交替位置（DADADA）。提供了一种平台，其放大了供体和受体的分子识别，并在环境条件下产生共晶体，其中平台包括（i）第一组分（α-互补体）的分子设计，（ii）第二化合物（＆bgr; - 补体），和（iii）促进共结晶的溶剂体系。

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