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1. 发明申请

US20130231303A1 5-HALOGENOPYRAZOLE(THIO)CARBOXAMIDES 审中-公开
标题翻译： 5-羟基喹唑啉（THIO）羧酰胺
公开(公告)号：US20130231303A1
公开(公告)日：2013-09-05
申请号：US13884929
申请日：2011-11-14
申请人： Juergen Benting , Pierre Cristau , Peter Dahmen , Philippe Desbordes , Stephanie Gary , Joerg Greul , Hiroyuki Hadano , Jan Peter Schmidt , Tomoki Tsuchiya , Ulrike Wachendorff-Neumann , Lars Rodefeld
发明人： Juergen Benting , Pierre Cristau , Peter Dahmen , Philippe Desbordes , Stephanie Gary , Joerg Greul , Hiroyuki Hadano , Jan Peter Schmidt , Tomoki Tsuchiya , Ulrike Wachendorff-Neumann , Lars Rodefeld
IPC分类号： C07D409/12 , C07F7/08 , A01N55/00 , A01N43/56
CPC分类号： C07D409/12 , A01N43/56 , A01N55/00 , C07F7/0812
摘要： The present invention relates to novel 5-halogenopyrazole(thio)carboxamides, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.
摘要翻译：本发明涉及新的5-卤代吡唑（硫代）甲酰胺，其制备方法，它们作为杀真菌剂活性剂的用途，特别是杀真菌剂组合物的形式，以及使用这些化合物控制植物病原真菌，特别是植物的方法或组合物。

2. 发明授权

US08507472B2 Bicyclic pyridinylpyrazoles 有权
标题翻译：双环吡啶基吡唑
公开(公告)号：US08507472B2
公开(公告)日：2013-08-13
申请号：US13080257
申请日：2011-04-05
申请人： Amos Mattes , Hendrik Helmke , Stefan Hillebrand , Gorka Peris , Alexander Sudau , Lars Rodefeld , Stefan Gauger , Jürgen Benting , Peter Dahmen , Ruth Meissner , Ulrike Wachendorff-Neumann , Hiroyuki Hadano
发明人： Amos Mattes , Hendrik Helmke , Stefan Hillebrand , Gorka Peris , Alexander Sudau , Lars Rodefeld , Stefan Gauger , Jürgen Benting , Peter Dahmen , Ruth Meissner , Ulrike Wachendorff-Neumann , Hiroyuki Hadano
IPC分类号： A01N43/84 , A01N43/40 , A01N43/46 , A01N43/42 , C07D401/14 , C07D487/14 , C07D471/04 , C07D498/04
CPC分类号： C07D487/04 , C07D471/04 , C07D498/04 , C07D513/04
摘要： Bicyclic pyridinylpyrazoles of the formula (I) in which the symbols have the meanings given in the description and agrochemically active salts thereof and their use for controlling unwanted microorganisms in crop protection and the protection of materials and for reducing mycotoxins in plants and plant parts, and also processes for preparing compounds of the formula (I).
摘要翻译：式（I）的双环吡啶基吡唑其中符号具有说明书中给出的含义及其农业化学活性盐及其在作物保护中控制不需要的微生物的用途以及保护植物和植物部分中的霉菌毒素，以及也是制备式（I）化合物的方法。

3. 发明申请

US20100217015A1 Process for the preparation of substituted heteroaromatics 有权
标题翻译：制备取代杂芳族化合物的方法
公开(公告)号：US20100217015A1
公开(公告)日：2010-08-26
申请号：US12663536
申请日：2008-05-27
申请人： Antje Hieronymi , Lars Rodefeld
发明人： Antje Hieronymi , Lars Rodefeld
IPC分类号： C07D333/10
CPC分类号： C07D333/08
摘要： A process is described for the preparation of substituted heteroaromatics of the general formula (I) where X is oxygen, sulphur or NR5 where R5 is hydrogen, C1-C20-alkyl or C5-C6-aryl and R4 is C1-C20-alkyl, C5-C6-aryl or heteroaryl, R1, R2, R3 is hydrogen, halogen, C1-C20-alkyl, C5-C6-aryl or heteroaryl, by reaction A) of a halogenated heteroaromatic of the general formula (II) where X has the meaning given for formula (I) and R6 is bromine, iodine or chlorine and R1, R2 and R3 have the meaning given for formula (I), with a Grignard reagent of the general formula (III) R4MgHal (III) where R4 has the meaning given for formula (I) and Hal is bromine, iodine or chlorine or B) reaction of the halogenated heteroaromatics of the formula (II) with magnesium firstly to give a Grignard compound of the general formula (IIIa) where Hal is bromine, iodine or chlorine and X and R1, R2 and R3 have the meaning given for formula (I), and further reaction with a halogenated compound of the general formula (IV) R4Hal (IV) where R4 has the meaning given for formula (I) and Hal is bromine, iodine or chlorine, where the reactions A) or B) are in each case carried out in the presence of an Ni or Pd catalyst, characterized in that the process is carried out in the presence of cycloalkyl alkyl ether as solvent and optionally a further solvent. Likewise described is the use of cycloalkyl alkyl ethers, in particular cyclopentyl methyl ether, in the Kumada reaction for the preparation of substituted heteroaromatics, in particular substituted thiophenes.
摘要翻译：描述了制备通式（I）的取代杂芳族化合物的方法，其中X是氧，硫或NR 5，其中R 5是氢，C 1 -C 20 - 烷基或C 5 -C 6 - 芳基，R 4是C 1 -C 20烷基， C 2 -C 6 - 芳基或杂芳基，R 1，R 2，R 3是氢，卤素，C 1 -C 20烷基，C 5 -C 6 - 芳基或杂芳基，通过反应A）通式（II）的卤代杂芳基，其中X具有对于式（I）和R6给出的含义是溴，碘或氯，并且R 1，R 2和R 3具有式（I）给出的含义，通式（III）的格利雅试剂R4MgHal（III）其中R4具有式（I）给出的含义和Hal是溴，碘或氯或B）式（II）的卤化杂芳族化合物与镁的反应首先得到通式（IIIa）的格利雅化合物，其中Hal是溴，碘或氯，X和R 1，R 2和R 3具有式（I）给出的含义，并进一步与本发明的卤代化合物反应式（IV）R4Hal（IV）其中R4具有式（I）给出的含义，Hal是溴，碘或氯，其中反应A）或B）在每种情况下在Ni或 Pd催化剂，其特征在于该方法在环烷基烷基醚作为溶剂和任选的另外的溶剂的存在下进行。同样地描述了在Kumada反应中使用环烷基烷基醚，特别是环戊基甲基醚来制备取代的杂芳族化合物，特别是取代的噻吩。

4. 发明授权

US07094923B2 Method for producing substituted nitro benzoic acids by oxidation of corresponding nitro toluenes, nitro benzyl alcohols, esters and/or ethers 失效
标题翻译：通过氧化相应的硝基甲苯，硝基苄醇，酯和/或醚来制备取代的硝基苯甲酸的方法
公开(公告)号：US07094923B2
公开(公告)日：2006-08-22
申请号：US11083746
申请日：2005-03-17
申请人： Reinhard Langer , Lars Rodefeld , Karl Heinz Neumann
发明人： Reinhard Langer , Lars Rodefeld , Karl Heinz Neumann
IPC分类号： C07C309/00 , C07C51/16 , C07C51/255 , C07C51/23 , C07C51/15
CPC分类号： C07C303/22 , C07C201/12 , C07C309/58 , C07C205/57 , C07C205/58 , C07C205/61
摘要： The present invention relates to the preparation of nitrobenzoic acids by oxidizing particular nitrotoluenes, nitrobenzyl alcohols, esters and/or ethers in the presence of nitric acid at elevated temperature and elevated pressure. It has been found that the particular nitrotoluenes, nitrobenzyl alcohols, esters and/or ethers may be oxidized particularly reliably and in high yields using nitric acid to the benzoic acid derivatives when they are metered into the nitric acid.
摘要翻译：本发明涉及通过在高温和高压下在硝酸存在下氧化特定的硝基甲苯，硝基苄醇，酯和/或醚来制备硝基苯甲酸。已经发现，当特定的硝基甲苯，硝基苄基醇，酯和/或醚可以特别可靠地被氧化并且当它们被计量到硝酸中时，使用硝酸对苯甲酸衍生物是高产率的。

5. 发明授权

US06900349B2 Method for producing substituted nitro benzoic acids by oxidation of corresponding nitro toluenes, nitrol benzyl alcohols, esters and/or ethers 失效
标题翻译：通过氧化相应的硝基甲苯，硝基苄醇，酯和/或醚来制备取代的硝基苯甲酸的方法
公开(公告)号：US06900349B2
公开(公告)日：2005-05-31
申请号：US10257062
申请日：2001-03-30
申请人： Reinhard Langer , Lars Rodefeld , Karl Heinz Neumann
发明人： Reinhard Langer , Lars Rodefeld , Karl Heinz Neumann
IPC分类号： C07C201/12 , C07C205/57 , C07C205/58 , C07C303/22 , C07C309/58 , C07C309/00 , C07C51/15 , C07C51/16 , C07C51/23 , C07C51/255
CPC分类号： C07C303/22 , C07C201/12 , C07C309/58 , C07C205/57 , C07C205/58 , C07C205/61
摘要： The present invention relates to the preparation of nitrobenzoic acids by oxidizing particular nitrotoluenes, nitrobenzyl alcohols, esters and/or ethers in the presence of nitric acid at elevated temperature and elevated pressure. It has been found that the particular nitrotoluenes, nitrobenzyl alcohols, esters and/or ethers may be oxidized particularly reliably and in high yields using nitric acid to the benzoic acid derivatives when they are metered into the nitric acid.
摘要翻译：本发明涉及通过在高温和高压下在硝酸存在下氧化特定的硝基甲苯，硝基苄醇，酯和/或醚来制备硝基苯甲酸。已经发现，当特定的硝基甲苯，硝基苄基醇，酯和/或醚可以特别可靠地被氧化并且当它们被计量到硝酸中时，使用硝酸对苯甲酸衍生物是高产率的。

6. 发明授权

US06759558B2 Process for preparing halogen-substituted dibenzyl alcohols, these halogen-substituted dibenzyl alcohols and their use 失效
标题翻译：制备卤素取代的二苄醇，这些卤素取代的二苄醇及其用途的方法
公开(公告)号：US06759558B2
公开(公告)日：2004-07-06
申请号：US10117523
申请日：2002-04-05
申请人： Lars Rodefeld
发明人： Lars Rodefeld
IPC分类号： C07C3328
CPC分类号： C07C33/46 , C07C29/147
摘要： A novel process allows a simple preparation of highly pure halogen-substituted dibenzyl alcohols by reduction of the corresponding halogen-substituted terephthalic acids and reaction with an alkylating agent, sulfuric acid, alkyl- or arylsulfonic acids. The highly pure halogen-substituted dibenzyl alcohols obtained are suitable in particular for preparing pharmaceutically or agrochemically active compounds.
摘要翻译：一种新方法可以通过还原相应的卤素取代的对苯二甲酸和与烷基化剂，硫酸，烷基 - 或芳基磺酸反应来简单地制备高纯度卤代 - 取代的二苄醇。获得的高纯度卤素取代的二苄醇特别适用于制备药学上或农业化学活性化合物。

7. 发明申请

US20090171119A1 PROCESS FOR PREPARING MENTHYLAMIDES 审中-公开
标题翻译：制备戊烯酰胺的方法
公开(公告)号：US20090171119A1
公开(公告)日：2009-07-02
申请号：US12279200
申请日：2007-02-13
申请人： Andreas Job , Uwe Westeppe , Lars Rodefeld
发明人： Andreas Job , Uwe Westeppe , Lars Rodefeld
IPC分类号： C07C231/10
CPC分类号： C07C231/10 , C07C233/58
摘要： An improved process for preparing menthylamides is provided by reacting menthyl halides with magnesium or lithium and subsequent reaction with an isocyanate, a heterocycle or a carbamoyl chloride.
摘要翻译：通过使薄荷醇卤化物与镁或锂反应并随后与异氰酸酯，杂环或氨基甲酰氯反应来提供制备薄荷酰胺的改进方法。

8. 发明授权

US06753444B2 Method for producing 2,3,5,6-tetrahalogen-xylyidene compounds 失效
标题翻译：制备2,3,5,6-四卤代 - 亚二甲基化合物的方法
公开(公告)号：US06753444B2
公开(公告)日：2004-06-22
申请号：US10181997
申请日：2002-07-24
申请人： Reinhard Langer , Lars Rodefeld
发明人： Reinhard Langer , Lars Rodefeld
IPC分类号： C07C6976
CPC分类号： C07C17/093
摘要： The invention relates to a process for preparing 2,3,5,6-tetrahaloxylylidene compounds of formula (I) where each Hal is independently fluorine or chlorine, and X is fluorine, chlorine, bromine, —O—R, or —O—C(═O)R, where R is hydrogen, a straight-chain or branched C1-C12-alkyl- or a C6-C14-aryl radical, by reacting 2,3,5,6-tetrahaloxylylidenediamines of formula (II) with an alkyl nitrite and/or nitrous acid in HX as a solvent.
摘要翻译：本发明涉及一种制备式（I）的2,3,5,6-四卤氧基亚甲基化合物的方法，其中每个Hal独立地为氟或氯，X为氟，氯，溴，-OR或-OC（= O ）R，其中R是氢，直链或支链C 1 -C 12 - 烷基 - 或C 6 -C 14 - 芳基，通过使式（II）的2,3,5,6-四烷氧基亚磺酰胺与亚硝酸烷基酯反应，以及 /或HX中的亚硝酸作为溶剂。

9. 发明授权

US06620962B2 Method for producing n-butyryl-4-amino-3-methyl-methyl benzoate and the novel compound n-(4-bromine-2-methylphenyl)-butanamide 失效
标题翻译：正丁酰基-4-氨基-3-甲基 - 甲基苯甲酸酯和新型化合物n-（4-溴-2-甲基苯基） - 丁酰胺的制备方法
公开(公告)号：US06620962B2
公开(公告)日：2003-09-16
申请号：US10239678
申请日：2002-09-24
申请人： Lars Rodefeld , Thomas Höpfner , Alexander Klausener , Horst Behre
发明人： Lars Rodefeld , Thomas Höpfner , Alexander Klausener , Horst Behre
IPC分类号： C07C22702
CPC分类号： C07C233/15 , C07C231/12 , C07C233/54
摘要： According to the invention, N-butyryl-4-amino-3-methyl-methyl benzoate is obtained in a particularly advantageous manner by, initially, reacting o-toluidine with butyric acid chloride, by brominating the reaction product and by reacting the bromide obtained therefrom with carbon monoxide and methanol in the presence of a palladium catalyst. The invention also relates to the important novel chemical compound N-(4-bromine-2-methylphenyl)-butanamide.
摘要翻译：根据本发明，以特别有利的方式，通过使邻甲苯胺与丁酰氯反应，通过溴化反应产物并使所得到的溴化物反应，得到N-丁酰基-4-氨基-3-甲基 - 甲基苯甲酸酯与一氧化碳和甲醇在钯催化剂存在下反应。本发明还涉及重要的新化合物N-（4-溴-2-甲基苯基） - 丁酰胺。

10. 发明授权

US06465678B1 Method for preparing methyl carbazate 有权
标题翻译：制备甲基肼基甲酸酯的方法
公开(公告)号：US06465678B1
公开(公告)日：2002-10-15
申请号：US09889813
申请日：2001-07-20
申请人： Lars Rodefeld , Horst Behre , Alexander Klausener , Robert Söllner
发明人： Lars Rodefeld , Horst Behre , Alexander Klausener , Robert Söllner
IPC分类号： C07C22900
CPC分类号： C07C281/02
摘要： Methyl carbazate which is particularly pure and has a particularly low tendency toward discoloration is obtained from hydrazine and dimethyl carbonate if the two reactants are metered simultaneously into an initially introduced first solvent at from −20 to +30° C., the solvent and low-boiling components are then distilled off under reduced pressure, and then either a second solvent is added to the crude methyl carbazate present and this solvent is distilled off under reduced pressure or an inert gas is passed through the crude methyl carbazate present.
摘要翻译：如果两个反应物在-20至+ 30℃下同时计量到初始引入的第一溶剂中，则可从肼和碳酸二甲酯得到特别纯的具有特别低的变色趋势的肼基甲酸甲酯，然后在减压下蒸馏沸腾的组分，然后将第二溶剂加入到存在的粗甲基肼基甲酸酯中，并在减压下蒸馏掉该溶剂，或使惰性气体通过存在的粗甲基肼基甲酸酯。

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