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1. 发明申请

US20090232740A1 Methods of detecting cancer cells and use of same for diagnosing and monitoring treatment of the disease 失效
标题翻译：检测癌细胞的方法及其用途，用于诊断和监测疾病的治疗
公开(公告)号：US20090232740A1
公开(公告)日：2009-09-17
申请号：US12379974
申请日：2009-03-05
申请人： Judith Rishpon , Rachela Popovtzer , Yosi Shacham-Diamand , Tova Neufeld , Sefi Vernick
发明人： Judith Rishpon , Rachela Popovtzer , Yosi Shacham-Diamand , Tova Neufeld , Sefi Vernick
IPC分类号： A61K49/00 , G01N33/574 , A61P35/00
CPC分类号： G01N33/5011 , C12Q1/42
摘要： A method of detecting cancer cells is disclosed. The method comprises (a) contacting the cell with a substrate for an enzyme under conditions wherein the enzyme catalyzes a reaction of the cell with said substrate, so as to generate a product capable of producing an electrical signal; and (b) measuring a level of the electrical signal, wherein a difference in a level of said electrical signal compared to a predetermined threshold is indicative of a cancer cell. The method may be adapted for diagnosis, monitoring a cancer therapy, identifying agents capable of treating cancer and individually optimizing a cancer therapy.
摘要翻译：公开了一种检测癌细胞的方法。该方法包括（a）在酶催化细胞与所述底物的反应的条件下，使细胞与酶底物接触，从而产生能产生电信号的产物; 和（b）测量电信号的电平，其中所述电信号的电平差与预定阈值相比指示癌细胞。该方法可适用于诊断，监测癌症治疗，鉴定能够治疗癌症并单独优化癌症治疗的药剂。

2. 发明授权

US08268577B2 Electrochemical methods of detecting colon cancer cells and use of same for diagnosing and monitoring treatment of the disease 失效
标题翻译：检测结肠癌细胞的电化学方法及其用于诊断和监测疾病的治疗
公开(公告)号：US08268577B2
公开(公告)日：2012-09-18
申请号：US12379974
申请日：2009-03-05
申请人： Judith Rishpon , Rachela Popovtzer , Yosi Shacham-Diamand , Tova Neufeld , Sefi Vernick
发明人： Judith Rishpon , Rachela Popovtzer , Yosi Shacham-Diamand , Tova Neufeld , Sefi Vernick
IPC分类号： C12Q1/42
CPC分类号： G01N33/5011 , C12Q1/42
摘要： A method of detecting cancer cells is disclosed. The method comprises (a) contacting the cell with a substrate for an enzyme under conditions wherein the enzyme catalyzes a reaction of the cell with the substrate, so as to generate a product capable of producing an electrical signal; and (b) measuring a level of the electrical signal, wherein a difference in a level of the electrical signal compared to a predetermined threshold is indicative of a cancer cell. The method may be adapted for diagnosis, monitoring a cancer therapy, identifying agents capable of treating cancer and individually optimizing a cancer therapy.
摘要翻译：公开了一种检测癌细胞的方法。该方法包括：（a）在酶催化细胞与底物的反应的条件下使细胞与酶底物接触，从而产生能产生电信号的产物; 和（b）测量电信号的电平，其中与预定阈值相比较的电信号电平的差异指示癌细胞。该方法可适用于诊断，监测癌症治疗，鉴定能够治疗癌症并单独优化癌症治疗的药剂。

3. 发明授权

US08530179B2 Electrochemical methods of detecting cancer with 4-aminophenyl phosphate 失效
标题翻译：用4-氨基苯基磷酸酯检测癌症的电化学方法
公开(公告)号：US08530179B2
公开(公告)日：2013-09-10
申请号：US13551642
申请日：2012-07-18
申请人： Judith Rishpon , Rachela Popovtzer , Yosi Shacham-Diamand , Tova Neufeld , Sefi Vernick
发明人： Judith Rishpon , Rachela Popovtzer , Yosi Shacham-Diamand , Tova Neufeld , Sefi Vernick
IPC分类号： C12Q1/42
CPC分类号： G01N33/5011 , C12Q1/42
摘要： A method of detecting cancer cells is disclosed. The method comprises (a) contacting the cell which is suspicious of a cancerous or undifferentiated phenotype with 4-aminophenyl phosphate (p-APP) under conditions wherein alkaline phosphatase of the cell catalyzes a reaction of the cell with the p-APP, so as to generate a product capable of producing an electrical signal; and (b) measuring a level of the electrical signal, wherein a difference in a level of the electrical signal compared to a predetermined threshold is indicative of a cancer cell.
摘要翻译：公开了一种检测癌细胞的方法。该方法包括（a）在细胞的碱性磷酸酶催化细胞与p-APP的反应的条件下，将可疑癌症或未分化表型的细胞与4-氨基苯基磷酸（p-APP）接触，以便以产生能够产生电信号的产品; 和（b）测量电信号的电平，其中与预定阈值相比较的电信号电平的差异指示癌细胞。

4. 发明申请

US20090061524A1 Enzyme-Channeling Based Electrochemical Biosensors 审中-公开
标题翻译：基于酶通道的电化学生物传感器
公开(公告)号：US20090061524A1
公开(公告)日：2009-03-05
申请号：US11918477
申请日：2006-04-11
申请人： Judith Rishpon , Tova Neufeld
发明人： Judith Rishpon , Tova Neufeld
IPC分类号： G01N33/48 , C12M1/34
CPC分类号： G01N33/5438 , C12Q1/003
摘要： Low-cost, non-toxic and fast immunoassay systems (immunosensors) and uses thereof as analytical and diagnostic tools for detecting an immune response in a subject are disclosed. The systems and methods disclosed are based on recording an electrochemical signal which is generated proportionally to an enzymatic cascade reaction (enzyme-channeling) upon detecting an analyte, and therefore can be used to determine the titer level of an antibody analyte in a liquid sample such as artificial media, serum or blood both qualitatively and quantitatively, in a one-step and separation free immunoassay. Systems and methods based on recording an electrochemical signal which is generated proportionally to an enzymatic cascade reaction (enzyme-channeling) upon detecting an analyte, which utilize a non-toxic secondary substrate such as acetaminophen are also disclosed.
摘要翻译：公开了低成本，无毒和快速免疫测定系统（免疫传感器）及其用作检测受试者中的免疫应答的分析和诊断工具。所公开的系统和方法基于记录在检测到分析物时与酶级联反应（酶 - 引导）成比例地产生的电化学信号，因此可用于确定液体样品中抗体分析物的滴度水平，例如作为人造介质，血清或血液在定性和定量上，在一步和无分离免疫测定中。还公开了基于在检测利用无毒二级底物如对乙酰氨基酚的分析物时与酶级联反应（酶 - 引导）成比例地产生的电化学信号的系统和方法。

5. 发明申请

US20100047311A1 PROTECTING ALGAE FROM BODY FLUIDS 审中-公开
标题翻译：保护身体液体
公开(公告)号：US20100047311A1
公开(公告)日：2010-02-25
申请号：US12515818
申请日：2007-11-22
申请人： Avi Rotem , Chanan Schneider , Tova Neufeld , Yoav Evron
发明人： Avi Rotem , Chanan Schneider , Tova Neufeld , Yoav Evron
IPC分类号： A61F2/00 , A61K36/02
CPC分类号： A61F2/022 , A61K35/39 , A61L27/38
摘要： Apparatus (20) is provided for implantation into a body of a subject, including isolated functional cells (28). At least one first barrier (22) having a first molecular weight cutoff is disposed with respect to the functional cells so as to protect the functional cells from components disposed within body fluid of the subject having molecular weights higher than the first cutoff. Photosynthetic elements (26) are disposed with respect to the functional cells so as to provide oxygen thereto. At least one second barrier (24) has a second molecular weight cutoff that is lower than the first cutoff. The second barrier is disposed with respect to the photosynthetic elements so as to protect the photosynthetic elements from components disposed within the body fluid of the subject having molecular weights higher than the second cutoff. Other embodiments are also described.
摘要翻译：提供装置（20）用于植入受试者的身体，包括分离的功能细胞（28）。相对于功能性细胞设置具有第一分子量截留值的至少一个第一屏障（22），以便保护功能细胞免受配对在具有高于第一截止值的分子量的受检者体液内的组分。相对于功能单元设置光合元件（26），以向其提供氧气。至少一个第二屏障（24）具有低于第一截止值的第二分子量截止值。第二屏障相对于光合元件设置，以便保护光合元件免受被配置在受试者体液中的分子量高于第二截止值的组分。还描述了其它实施例。

6. 发明授权

US09446168B2 Multiple-layer immune barrier for donor cells 有权
标题翻译：供体细胞的多层免疫屏障
公开(公告)号：US09446168B2
公开(公告)日：2016-09-20
申请号：US13153721
申请日：2011-06-06
申请人： Uriel Barkai , Avi Rotem , Yehezkel Bremer , Tova Neufeld
发明人： Uriel Barkai , Avi Rotem , Yehezkel Bremer , Tova Neufeld
IPC分类号： A61K9/00 , A61J3/06 , A61P1/18 , A61K35/12 , A61K35/39 , A61L27/20 , A01N1/02 , A61L27/36 , A61L27/34 , A61K9/50 , C12N5/00 , C12N5/071 , A61K9/16
CPC分类号： A61L27/00 , A01N1/0231 , A61K9/0024 , A61K9/1652 , A61K9/5073 , A61K35/39 , A61L27/20 , A61L27/34 , A61L27/36 , A61L27/505 , A61L27/56 , A61L2400/18 , A61L2420/02 , A61L2420/08 , A61L2430/40 , C12N5/0012 , C12N5/0676 , Y10S623/915
摘要： A system is provided, including a plurality of donor cells and a first alginate structure that encapsulates the plurality of donor cells. The first alginate structure has a guluronic acid concentration of between 64% and 74%. The system additionally includes a second alginate structure that surrounds the first alginate structure, the second alginate structure having a mannuronic acid concentration of between 52% and 60%. A selectively-permeable membrane is coupled at least in part to the second alginate structure. Other embodiments are also described.
摘要翻译：提供了一种系统，包括多个供体细胞和封装多个供体细胞的第一藻酸盐结构。第一藻酸盐结构的古洛糖醛酸浓度为64％至74％。该系统还包括围绕第一藻酸盐结构的第二藻酸盐结构，第二藻酸盐结构具有52％至60％之间的甘露糖醛酸浓度。至少部分地将选择性渗透膜耦合到第二藻酸盐结构。还描述了其它实施例。

7. 发明申请

US20110251471A1 IMPLANTABLE POWER SOURCES AND SENSORS 审中-公开
标题翻译：可植入电源和传感器
公开(公告)号：US20110251471A1
公开(公告)日：2011-10-13
申请号：US13089096
申请日：2011-04-18
申请人： Yossi Gross , Ben-Tsion Williger , Tehila Hyman , Tova Neufeld
发明人： Yossi Gross , Ben-Tsion Williger , Tehila Hyman , Tova Neufeld
IPC分类号： A61B5/1473 , H01M8/16
CPC分类号： C07K14/43595 , A61B5/14532 , A61K49/0045 , A61K49/0047 , A61K49/0056 , C07K2319/60 , G01N33/54373
摘要： A protein is provided, including a glucose binding site, cyan fluorescent protein (CFP), and yellow fluorescent protein (YFP). The protein is configured such that binding of glucose to the glucose binding site causes a reduction in a distance between the CFP and the YFP. Substance monitoring apparatus (210) is also provided, including a semi-permeable barrier (212), adapted to be implanted in a body of a subject and to allow passage therethrough of a substance, while inhibiting passage therethrough of immune cells; and microorganisms (214), disposed within the semi-permeable barrier (212) so as to produce a measurable response to a level of the substance. A sensor (220) is adapted to measure the measurable response and not to measure a response of any mammalian cells that may be disposed within the semi-permeable barrier (212).
摘要翻译：提供蛋白质，包括葡萄糖结合位点，青色荧光蛋白（CFP）和黄色荧光蛋白（YFP）。配置蛋白质使得葡萄糖与葡萄糖结合位点的结合导致CFP和YFP之间的距离减小。还提供了物质监测设备（210），其包括半渗透屏障（212），其适于植入受试者体内并允许物质通过，同时抑制免疫细胞通过; 和微生物（214），其设置在半渗透屏障（212）内，以便产生对物质水平的可测量响应。传感器（220）适于测量可测量的响应并且不测量可以设置在半渗透屏障（212）内的任何哺乳动物细胞的响应。

8. 发明申请

US20110165219A1 OPTIMIZATION OF ALGINATE ENCAPSULATION OF ISLETS FOR TRANSPLANTATION 有权
标题翻译：用于运输的离心机的铝酸盐包封的优化
公开(公告)号：US20110165219A1
公开(公告)日：2011-07-07
申请号：US12996592
申请日：2009-09-16
申请人： Uriel Barkai , Avi Rotem , Dimitry Azarov , Tova Neufeld , Zohar Gendler
发明人： Uriel Barkai , Avi Rotem , Dimitry Azarov , Tova Neufeld , Zohar Gendler
IPC分类号： A61K9/00 , A61K35/12 , A61P13/12
CPC分类号： A61L27/52 , A61L27/20 , A61L27/26 , A61L27/3604 , A61L27/3633 , A61L27/3641 , A61L27/3834 , A61L27/50 , A61L2300/64 , A61L2400/18 , C12N5/0677 , C12N11/04 , C12N11/10
摘要： Apparatus is provided, including a plurality of islets, and a hydrogel configured to macroencapsulate the plurality of islets. The hydrogel is implantable in a subcapsular space (21) of a kidney (22) of a subject and is shaped to define a planar configuration. Other applications are also described.
摘要翻译：提供了包括多个胰岛的设备，以及被配置为将所述多个胰岛大包封的水凝胶。水凝胶可植入在受试者的肾脏（22）的囊下空间（21）中并且被成形为限定平面构型。还描述了其它应用。

9. 发明授权

US09540630B2 Optimization of alginate encapsulation of islets for transplantation 有权
标题翻译：藻酸盐包封优化用于移植胰岛
公开(公告)号：US09540630B2
公开(公告)日：2017-01-10
申请号：US12996592
申请日：2009-09-16
申请人： Uriel Barkai , Avi Rotem , Dimitry Azarov , Tova Neufeld , Zohar Gendler
发明人： Uriel Barkai , Avi Rotem , Dimitry Azarov , Tova Neufeld , Zohar Gendler
IPC分类号： C12N5/071 , C12N11/04 , C12N11/10
CPC分类号： A61L27/52 , A61L27/20 , A61L27/26 , A61L27/3604 , A61L27/3633 , A61L27/3641 , A61L27/3834 , A61L27/50 , A61L2300/64 , A61L2400/18 , C12N5/0677 , C12N11/04 , C12N11/10
摘要： Apparatus is provided, including a plurality of islets, and a hydrogel configured to macroencapsulate the plurality of islets. The hydrogel is implantable in a subcapsular space (21) of a kidney (22) of a subject and is shaped to define a planar configuration. Other applications are also described.
摘要翻译：提供了包括多个胰岛的设备，以及被配置为将所述多个胰岛大包封的水凝胶。水凝胶可植入在受试者的肾脏（22）的囊下空间（21）中并且被成形为限定平面构型。还描述了其它应用。

10. 发明授权

US07951357B2 Implantable power sources and sensors 有权
标题翻译：可植入电源和传感器
公开(公告)号：US07951357B2
公开(公告)日：2011-05-31
申请号：US11632587
申请日：2005-07-13
申请人： Yossi Gross , Ben-Tsion Williger , Tehila Hyman , Tova Neufeld
发明人： Yossi Gross , Ben-Tsion Williger , Tehila Hyman , Tova Neufeld
IPC分类号： A61B5/00 , C07H21/04 , C07K14/00 , C12N15/85
CPC分类号： C07K14/43595 , A61B5/14532 , A61K49/0045 , A61K49/0047 , A61K49/0056 , C07K2319/60 , G01N33/54373
摘要： A protein is provided, including a glucose binding site, cyan fluorescent protein (CFP), and yellow fluorescent protein (YFP). The protein is configured such that binding of glucose to the glucose binding site causes a reduction in a distance between the CFP and the YFP. Substance monitoring apparatus (210) is also provided, including a semi-permeable barrier (212), adapted to be implanted in a body of a subject and to allow passage therethrough of a substance, while inhibiting passage therethrough of immune cells; and microorganisms (214), disposed within the semi-permeable barrier (212) so as to produce a measurable response to a level of the substance. A sensor (220) is adapted to measure the measurable response and not to measure a response of any mammalian cells that may be disposed within the semi-permeable barrier (212).
摘要翻译：提供蛋白质，包括葡萄糖结合位点，青色荧光蛋白（CFP）和黄色荧光蛋白（YFP）。配置蛋白质使得葡萄糖与葡萄糖结合位点的结合导致CFP和YFP之间的距离减小。还提供了物质监测设备（210），其包括半渗透屏障（212），其适于植入受试者体内并允许物质通过，同时抑制免疫细胞通过; 和微生物（214），其设置在半渗透屏障（212）内，以便产生对物质水平的可测量响应。传感器（220）适于测量可测量的响应并且不测量可以设置在半渗透屏障（212）内的任何哺乳动物细胞的响应。

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