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1. 发明授权

US07465435B2 Delivery of beta-blockers through an inhalation route 失效
标题翻译：通过吸入途径递送β受体阻滞剂
公开(公告)号：US07465435B2
公开(公告)日：2008-12-16
申请号：US11439475
申请日：2006-05-23
申请人： Joshua D Rabinowitz , Alejandro C Zaffaroni
发明人： Joshua D Rabinowitz , Alejandro C Zaffaroni
IPC分类号： A61K9/12 , A61K9/14 , A61M15/00
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to aerosols containing of atenolol, pindolol, esmolol, propranolol, or metoprolol that are used in inhalation therapy. In a method aspect of the present invention, of atenolol, pindolol, esmolol, propranolol, or metoprolol is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of atenolol, pindolol, esmolol, propranolol, or metoprolol, on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering of atenolol, pindolol, esmolol, propranolol, or metoprolol through an inhalation route is provided which comprises: a) a thin coating of an atenolol, pindolol, esmolol, propranolol, or metoprolol composition and b) a device for dispensing said thin coating as a condensation aerosol.
摘要翻译：本发明涉及含有用于吸入治疗的阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔的气溶胶。在本发明的方法方面，将阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔通过吸入途径施用于患者。该方法包括：a）在固体支持物上加热阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔的薄层以形成蒸气; 和b）使空气通过加热的蒸气以产生具有小于5％药物降解产物的气溶胶颗粒。在本发明的试剂盒方面，提供了用于通过吸入途径递送阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔的试剂盒，其包括：a）将阿替洛尔，吲哚洛尔，艾司洛尔，普萘洛尔或美托洛尔组合物和b）用于将所述薄涂层分配为冷凝气溶胶的装置。

2. 发明授权

US07445768B2 Delivery of sedative-hypnotics through an inhalation route 有权
标题翻译：通过吸入路线输送镇静催眠药
公开(公告)号：US07445768B2
公开(公告)日：2008-11-04
申请号：US11500735
申请日：2006-08-07
申请人： Joshua D Rabinowitz , Alejandro C Zaffaroni
发明人： Joshua D Rabinowitz , Alejandro C Zaffaroni
IPC分类号： A61K9/12 , A61K9/14 , A61M15/00
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of sedative-hypnotics through an inhalation route. Specifically, it relates to aerosols containing sedative-hypnotics that are used in inhalation therapy. In a method aspect of the present invention, a sedative-hypnotic drug is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of a sedative-hypnotic, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% sedative-hypnotic drug degradation products. In a kit aspect of the present invention, a kit for delivering a sedative-hypnotic through an inhalation route is provided which comprises: a) a thin layer of a sedative-hypnotic drug and b) a device for dispensing said thin layer a sedative-hypnotic drug as a condensation aerosol.
摘要翻译：本发明涉及通过吸入途径递送镇静催眠药。具体地说，它涉及用于吸入治疗的含有镇静催眠药的气溶胶。在本发明的方法方面，通过吸入途径向患者施用镇静催眠药物。该方法包括：a）在固体支持物上加热镇静催眠剂的薄层以形成蒸气; 并且b）使空气通过加热的蒸气以产生具有小于5％镇静催眠药物降解产物的气溶胶颗粒。在本发明的试剂盒方面，提供了一种用于通过吸入途径递送镇静催眠药物的试剂盒，其包括：a）镇静催眠药物的薄层，和b）用于分配所述薄层的镇静剂 - 催眠药物作为冷凝气溶胶。

3. 发明授权

US07485285B2 Delivery of antidepressants through an inhalation route 有权
标题翻译：通过吸入途径递送抗抑郁药
公开(公告)号：US07485285B2
公开(公告)日：2009-02-03
申请号：US11451853
申请日：2006-06-13
申请人： Joshua D Rabinowitz , Alejandro C Zaffaroni
发明人： Joshua D Rabinowitz , Alejandro C Zaffaroni
IPC分类号： A61K9/12 , A61K9/14 , A61M15/00
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of antidepressants through an inhalation route. Specifically, it relates to aerosols containing an antidepressant that are used in inhalation therapy. In a method aspect of the present invention, an antidepressant is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of an antidepressant, on a solid support, form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% antidepressant degradation products. In a kit aspect of the present invention, a kit for delivering an antidepressant through an inhalation route to a mammal is provided which comprises: a) a thin coating of an antidepressant composition and b) a device for dispensing said thin coating as a condensation aerosol.
摘要翻译：本发明涉及通过吸入途径递送抗抑郁剂。具体地说，它涉及含有用于吸入治疗的抗抑郁药的气溶胶。在本发明的方法方面，抗抑郁药通过吸入途径给予患者。该方法包括：a）在固体支持物上加热抗抑郁药薄层，形成蒸气; 并且b）使空气通过加热的蒸气以产生具有小于5％抗抑郁降解产物的气溶胶颗粒。在本发明的试剂盒方面，提供了一种用于通过吸入途径将抗抑郁药递送至哺乳动物的试剂盒，其包括：a）抗抑郁组合物的薄涂层，以及b）用于将所述薄涂层分配为凝结气溶胶的装置。

4. 发明授权

US07442368B2 Delivery of stimulants through an inhalation route 失效
标题翻译：通过吸入路线输送兴奋剂
公开(公告)号：US07442368B2
公开(公告)日：2008-10-28
申请号：US11370628
申请日：2006-03-07
申请人： Joshua D Rabinowitz , Alejandro C Zaffaroni
发明人： Joshua D Rabinowitz , Alejandro C Zaffaroni
IPC分类号： A61K9/12 , A61K9/14 , A61M15/00
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of stimulants through an inhalation route. Specifically, it relates to aerosols containing stimulants that are used in inhalation therapy. In a method aspect of the present invention, a stimulant is delivered to a patient through an inhalation route. The method comprises: a) heating a coating of a stimulant, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% stimulant degradation products. In a kit aspect of the present invention, a kit for delivering a stimulant through an inhalation route is provided which comprises: a) a coating of a stimulant drug and b) a device for dispensing said coating a stimulant as a condensation aerosol.
摘要翻译：本发明涉及通过吸入途径递送兴奋剂。具体地说，它涉及用于吸入治疗的含有兴奋剂的气溶胶。在本发明的方法方面，兴奋剂通过吸入途径输送给患者。该方法包括：a）在固体支持物上加热兴奋剂的涂层以形成蒸气; 并且b）使空气通过加热的蒸气以产生具有小于5％刺激性降解产物的气溶胶颗粒。在本发明的试剂盒方面，提供了一种用于通过吸入途径递送兴奋剂的试剂盒，其包括：a）刺激性药物的涂层和b）用于将所述涂层分配为兴奋剂作为凝结气溶胶的装置。

5. 发明授权

US07601337B2 Delivery of antipsychotics through an inhalation route 有权
标题翻译：通过吸入途径递送抗精神病药
公开(公告)号：US07601337B2
公开(公告)日：2009-10-13
申请号：US11488932
申请日：2006-07-18
申请人： Joshua D Rabinowitz , Alejandro C Zaffaroni
发明人： Joshua D Rabinowitz , Alejandro C Zaffaroni
IPC分类号： A61K9/12 , A61K9/14 , A61M15/00
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of antipsychotics through an inhalation route. Specifically, it relates to aerosols containing antipsychotics that are used in inhalation therapy. In a method aspect of the present invention, an antipsychotic is delivered to a patient through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises an antipsychotic, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% antipsychotic drug degradation products. In a kit aspect of the present invention, a kit for delivering an antipsychotic through an inhalation route is provided which comprises: a) a thin coating of an antipsychotic composition and b) a device for dispensing said thin coating as a condensation aerosol.
摘要翻译：本发明涉及通过吸入途径递送抗精神病药。具体地说，它涉及用于吸入治疗的含有抗精神病药的气溶胶。在本发明的方法方面，通过吸入途径将抗精神病药物递送至患者。该方法包括：a）加热组合物，其中组合物包含抗精神病药，形成蒸气; 和b）允许蒸汽冷却，从而形成包含具有小于5％抗精神病药物降解产物的颗粒的凝结气溶胶。在本发明的试剂盒方面，提供了一种用于通过吸入途径递送抗精神病药的试剂盒，其包括：a）抗精神病药组合物的薄涂层，和b）用于将所述薄涂层分配为冷凝气溶胶的装置。

6. 发明授权

US07449174B2 Delivery of analgesics through an inhalation route 失效
标题翻译：通过吸入路线输送镇痛药
公开(公告)号：US07449174B2
公开(公告)日：2008-11-11
申请号：US11479892
申请日：2006-06-30
申请人： Joshua D Rabinowitz , Alejandro C Zaffaroni
发明人： Joshua D Rabinowitz , Alejandro C Zaffaroni
IPC分类号： A61K9/12 , A61K9/14 , A61M15/00
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of analgesics through an inhalation route. Specifically, it relates to aerosols containing acetaminophen, orphenadrine or tramadol that are used in inhalation therapy. In a method aspect of the present invention, an analgesic is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of acetaminophen, orphenadrine or tramadol, on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% acetaminophen, orphenadrine or tramadol degradation products. In a kit aspect of the present invention, a kit for delivering acetaminophen, orphenadrine or tramadol through an inhalation is provided which comprises: a) a thin coating of an acetaminophen, orphenadrine or tramadol composition and b) a device for dispensing said thin coating as a condensation aerosol.
摘要翻译：本发明涉及通过吸入途径递送镇痛药。具体地说，它涉及用于吸入治疗的含有对乙酰氨基酚，奥芬那普或曲马多的气溶胶。在本发明的方法方面，通过吸入途径向患者施用止痛剂。该方法包括：a）在固体支持物上加热薄层的对乙酰氨基酚，或苯丙胺或曲马多，形成蒸气; 并且b）使空气通过加热的蒸气以产生具有小于5％的对乙酰氨基酚，或苯丙胺或曲马多降解产物的气溶胶颗粒。在本发明的试剂盒方面，提供了一种用于通过吸入递送对乙酰氨基酚，或苯丙胺或曲马多的试剂盒，其包括：a）对乙酰氨基酚，吩芬他定或曲马多组合物的薄涂层，和b）用于将所述薄涂层分配冷凝气溶胶。

7. 发明授权

US07510702B2 Delivery of nonsteroidal antiinflammatory drugs through an inhalation route 有权
标题翻译：通过吸入路线递送非甾体抗炎药物
公开(公告)号：US07510702B2
公开(公告)日：2009-03-31
申请号：US11501246
申请日：2006-08-07
申请人： Joshua D Rabinowitz , Alejandro C Zaffaroni
发明人： Joshua D Rabinowitz , Alejandro C Zaffaroni
IPC分类号： A61K9/12 , A61K9/14 , A61M15/00
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of nonsteroidal antiinflammatory drugs (NSAIDs) through an inhalation route. Specifically, it relates to aerosols containing NSAIDs that are used in inhalation therapy. In a method aspect of the present invention, an NSAID is delivered to a patient through an inhalation route. The method comprises: a) heating a coating of an NSAID, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particle having less than 5% NSAID degradation products. In a kit aspect of the present invention, a kit for delivering an NSAID through an inhalation route is provided which comprises: a) a coating of an NSAID composition and b) a device for dispensing said coating as a condensation aerosol.
摘要翻译：本发明涉及通过吸入途径递送非甾体抗炎药（NSAID）。具体地说，它涉及用于吸入治疗的含有NSAID的气溶胶。在本发明的方法方面，通过吸入途径将NSAID递送给患者。该方法包括：a）在固体支持物上加热NSAID的涂层以形成蒸汽; 并且b）使空气通过加热的蒸气以产生具有小于5％NSAID降解产物的气溶胶颗粒。在本发明的试剂盒方面，提供了用于通过吸入途径输送NSAID的试剂盒，其包括：a）NSAID组合物的涂层和b）用于将所述涂层分配为凝结气溶胶的装置。

8. 发明授权

US07470421B2 Delivery of diazepam through an inhalation route 失效
标题翻译：通过吸入路线递送地西泮
公开(公告)号：US07470421B2
公开(公告)日：2008-12-30
申请号：US11500736
申请日：2006-08-07
申请人： Joshua D Rabinowitz , Alejandro C Zaffaroni
发明人： Joshua D Rabinowitz , Alejandro C Zaffaroni
IPC分类号： A61K9/12 , A61K9/14 , A61M15/00
CPC分类号： A61K9/0073 , A61K9/007 , A61K31/5513 , Y10S514/958
摘要： The present invention relates to the delivery of compounds for the treatment of anxiety disorders and symptoms of such disorders through an inhalation route. Specifically, it relates to aerosols containing diazepam that are used in inhalation therapy. In a method aspect of the present invention, diazepam is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of diazepam on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering diazepam through an inhalation route is provided which comprises: a) a thin coating of a diazepam composition; and, b) a device for dispending said thin coating as a condensation aerosol.
摘要翻译：本发明涉及通过吸入途径递送用于治疗焦虑症和这种病症症状的化合物。具体来说，它涉及用于吸入治疗的含有地西泮的气溶胶。在本发明的方法方面，通过吸入途径向患者施用地西泮。该方法包括：a）在固体支持物上加热薄层的地西泮以形成蒸气; 和b）使空气通过加热的蒸气以产生具有小于5％药物降解产物的气溶胶颗粒。在本发明的试剂盒方面，提供了用于通过吸入途径递送地西泮的试剂盒，其包括：a）地西泮组合物的薄涂层; 和b）用于将所述薄涂层作为冷凝气溶胶进行排放的装置。

9. 发明授权

US07465436B2 Delivery of compounds for the treatment of Parkinson's through an inhalation route 有权
标题翻译：通过吸入路线输送用于治疗帕金森病的化合物
公开(公告)号：US07465436B2
公开(公告)日：2008-12-16
申请号：US11442917
申请日：2006-05-30
申请人： Joshua D Rabinowitz , Alejandro C Zaffaroni
发明人： Joshua D Rabinowitz , Alejandro C Zaffaroni
IPC分类号： A61K9/12 , A61K9/14 , A61M15/00
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of antiparkinsons drugs through an inhalation route. In a method aspect of the present invention, an antiparkinsons drug is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of an antiparkinsons drug on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering an antiparkinsons drug through an inhalation route is provided which comprises: a) a thin coating of a an antiparkinsons drug composition; and, b) a device for dispending said thin coating as a condensation aerosol.
摘要翻译：本发明涉及通过吸入途径递送抗帕金森药物。在本发明的方法方面，通过吸入途径向患者施用抗帕金森药物。该方法包括：a）在固体支持物上加热抗反注射药物的薄层以形成蒸气; 和b）使空气通过加热的蒸气以产生具有小于5％药物降解产物的气溶胶颗粒。在本发明的试剂盒方面，提供了一种用于通过吸入途径递送反注射药物的试剂盒，其包括：a）抗反注射药物组合物的薄涂层; 和b）用于将所述薄涂层作为冷凝气溶胶进行排放的装置。

10. 发明授权

US07449172B2 Delivery of antiemetics through an inhalation route 有权
标题翻译：通过吸入路线输送止吐药
公开(公告)号：US07449172B2
公开(公告)日：2008-11-11
申请号：US11398383
申请日：2006-04-04
申请人： Joshua D Rabinowitz , Alejandro C Zaffaroni
发明人： Joshua D Rabinowitz , Alejandro C Zaffaroni
IPC分类号： A61K9/12 , A61K9/14 , A61M15/00
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of antiemetics through an inhalation route. Specifically, it relates to aerosols containing antiemetics that are used in inhalation therapy. In a method aspect of the present invention, an antiemetic is delivered to a patient through an inhalation route. The method comprises: a) heating a thin layer of an antiemetic, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% antiemetic degradation products. In a kit aspect of the present invention, a kit for delivering an antiemetic through an inhalation route is provided which comprises: a) a thin layer of an antiemetic drug and b) a device for dispensing said thin layer an antiemetic as a condensation aerosol.
摘要翻译：本发明涉及通过吸入途径递送止吐剂。具体地说，它涉及用于吸入治疗的含有止吐剂的气溶胶。在本发明的方法方面，止吐剂通过吸入途径递送给患者。该方法包括：a）在固体支持物上加热止吐剂的薄层以形成蒸气; 和b）使空气通过加热的蒸气以产生具有小于5％止吐降解产物的气溶胶颗粒。在本发明的试剂盒方面，提供了一种用于通过吸入途径递送止吐剂的试剂盒，其包括：a）止吐药物的薄层;以及b）用于将所述薄层分配为止吐剂作为凝结气雾剂的装置。

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