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1. 发明申请

US20100184833A1 METHODS AND MEANS FOR TREATING DNA REPEAT INSTABILITY ASSOCIATED GENETIC DISORDERS 审中-公开
标题翻译：用于治疗DNA重复不稳定相关遗传病的方法和手段
公开(公告)号：US20100184833A1
公开(公告)日：2010-07-22
申请号：US12377160
申请日：2007-08-10
申请人： Josephus Johannes De Kimpe , Gerard Johannes Platenburg , Derick Gert Wansink
发明人： Josephus Johannes De Kimpe , Gerard Johannes Platenburg , Derick Gert Wansink
IPC分类号： A61K31/7052 , A61K48/00 , C07H21/00 , C12N15/63 , C12N15/00 , C12Q1/68 , A61P43/00
CPC分类号： C12N15/11 , A61K48/00 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/346 , C12Q1/6883 , C12Q2600/156 , C12N2310/3521
摘要： The current invention provides for methods and medicaments that apply oligonucleotide molecules complementary only to a repetitive sequence in a human gene transcript, for the manufacture of a medicament for the diagnosis, treatment or prevention of a cis-element repeat instability associated genetic disorders in humans. The invention hence provides a method of treatment for cis-element repeat instability associated genetic disorders. The invention also pertains to modified oligonucleotides which can be applied in method of the invention to prevent the accumulation and/or translation of repeat expanded transcripts in cells.
摘要翻译：本发明提供了应用寡核苷酸分子与人基因转录物中的重复序列互补的方法和药物，用于制备用于诊断，治疗或预防人类中与顺式元件重复不稳定相关的遗传疾病的药物。因此，本发明提供了一种治疗与顺式元件重复不稳定相关的遗传疾病的方法。本发明还涉及修饰的寡核苷酸，其可以在本发明的方法中应用，以防止细胞中重复扩增的转录物的积累和/或翻译。

2. 发明授权

US09243245B2 Means and methods for counteracting muscle disorders 有权
标题翻译：抵消肌肉疾病的手段和方法
公开(公告)号：US09243245B2
公开(公告)日：2016-01-26
申请号：US12767702
申请日：2010-04-26
申请人： Josephus Johannes De Kimpe , Gerard Johannes Platenburg , Judith Christina Theodora Van Deutekom , Annemieke Aartsma-Rus , Garrit-Jan Boudewijn Van Ommen
发明人： Josephus Johannes De Kimpe , Gerard Johannes Platenburg , Judith Christina Theodora Van Deutekom , Annemieke Aartsma-Rus , Garrit-Jan Boudewijn Van Ommen
IPC分类号： A61K48/00 , C07H21/02 , C07H21/04 , A01N45/00 , C12N15/113 , A61K31/56 , A61K31/57 , A61K38/17 , A61K31/7088 , A61K45/06
CPC分类号： C12N15/113 , A61K31/56 , A61K31/57 , A61K31/573 , A61K31/58 , A61K31/7088 , A61K38/1719 , A61K45/06 , A61K48/00 , C12N2310/11 , C12N2310/111 , C12N2310/31 , C12N2310/313 , C12N2310/314 , C12N2310/315 , C12N2310/3181 , C12N2310/321 , C12N2310/3231 , C12N2310/3233 , C12N2310/346 , C12N2320/31 , C12N2320/33 , A61K2300/00
摘要： The invention provides means and methods for alleviating one or more symptom(s) of Duchenne Muscular Dystrophy and/or Becker Muscular Dystrophy. Therapies using compounds for providing patients with functional muscle proteins are combined with at least one adjunct compound for reducing inflammation, preferably for reducing muscle tissue inflammation, and/or at least one adjunct compound for improving muscle fiber function, integrity and/or survival.
摘要翻译：本发明提供了减轻Duchenne肌营养不良症和/或Becker肌营养不良症的一种或多种症状的方法和方法。使用化合物提供功能性肌肉蛋白的患者的治疗与至少一种辅助化合物合并，用于减少炎症，优选减少肌肉组织炎症，和/或至少一种辅助化合物，用于改善肌肉纤维功能，完整性和/或存活。

3. 发明授权

US09139828B2 Method for efficient exon (44) skipping in duchenne muscular dystrophy and associated means 有权
标题翻译：用于高效外显子（44）跳过杜氏肌营养不良症和相关手段的方法
公开(公告)号：US09139828B2
公开(公告)日：2015-09-22
申请号：US12992218
申请日：2010-11-11
申请人： Gerard Johannes Platenburg , Josephus Johannes de Kimpe , Judith Christina Theodora van Deutekom , Garrit-Jan Boudewijn van Ommen , Annemieke Aartsma-Rus
发明人： Gerard Johannes Platenburg , Josephus Johannes de Kimpe , Judith Christina Theodora van Deutekom , Garrit-Jan Boudewijn van Ommen , Annemieke Aartsma-Rus
IPC分类号： C12N15/11 , C07H21/04 , C12N15/113 , A61K48/00
CPC分类号： C12N15/113 , A61K48/00 , C12N2310/11 , C12N2310/111 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/3233 , C12N2310/346 , C12N2310/3513 , C12N2310/3517 , C12N2320/33 , C12N2310/3521
摘要： The invention relates to oligonucleotides that bind to and induce skipping of exon 44 in the human dystrophin pre-mRNA, and methods of use.
摘要翻译：本发明涉及结合并诱导人肌营养不良蛋白前mRNA中外显子44的跳跃的寡核苷酸，以及使用方法。

4. 发明申请

US20120059042A1 METHOD FOR EFFICIENT EXON (44) SKIPPING IN DUCHENNE MUSCULAR DYSTROPHY AND ASSOCIATED MEANS 有权
标题翻译：有效的方法（44）穿梭在杜氏肌肉和相关的手段
公开(公告)号：US20120059042A1
公开(公告)日：2012-03-08
申请号：US12992218
申请日：2010-11-11
申请人： Gerard Johannes Platenburg , Josephus Johannes de Kimpe , Judith Christina Theodora van Deutekom , Garrit-Jan Boudewijn van Ommen , Annemieke Aartsma-Rus
发明人： Gerard Johannes Platenburg , Josephus Johannes de Kimpe , Judith Christina Theodora van Deutekom , Garrit-Jan Boudewijn van Ommen , Annemieke Aartsma-Rus
IPC分类号： A61K31/7105 , A61P21/00 , C12N5/10 , C07H21/02 , C12N15/63
CPC分类号： C12N15/113 , A61K48/00 , C12N2310/11 , C12N2310/111 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/3233 , C12N2310/346 , C12N2310/3513 , C12N2310/3517 , C12N2320/33 , C12N2310/3521
摘要： The invention relates to a nucleic acid molecule that binds and/or is complementary to the nucleotide molecule having sequence 5′-GUGGCUAACAGAAGCU (SEQ ID NO 1) and to its use in a method for inducing skipping of exon 44 of the DMD gene in a DMD patient.
摘要翻译：本发明涉及与具有序列5'-GUGGCUAACAGAAGCU（SEQ ID NO 1）的核苷酸分子结合和/或互补的核酸分子，并且其用于诱导在DMD基因的外显子44中跳跃的方法 DMD患者。

5. 发明申请

US20110294753A1 Means and methods for counteracting muscle disorders 有权
标题翻译：抵消肌肉疾病的手段和方法
公开(公告)号：US20110294753A1
公开(公告)日：2011-12-01
申请号：US12767702
申请日：2010-04-26
申请人： Josephus Johannes De Kimpe , Gerard Johannes Platenburg , Judith Christina Theodora Van Deutekom , Annemieke Aartsma-Rus , Garrit-Jan Boudewijn Van Ommen
发明人： Josephus Johannes De Kimpe , Gerard Johannes Platenburg , Judith Christina Theodora Van Deutekom , Annemieke Aartsma-Rus , Garrit-Jan Boudewijn Van Ommen
IPC分类号： A61K31/7105 , C12N5/071 , A61P29/00 , A61K31/4245 , A61P21/00 , A61K31/7036 , A61K31/712
CPC分类号： C12N15/113 , A61K31/56 , A61K31/57 , A61K31/573 , A61K31/58 , A61K31/7088 , A61K38/1719 , A61K45/06 , A61K48/00 , C12N2310/11 , C12N2310/111 , C12N2310/31 , C12N2310/313 , C12N2310/314 , C12N2310/315 , C12N2310/3181 , C12N2310/321 , C12N2310/3231 , C12N2310/3233 , C12N2310/346 , C12N2320/31 , C12N2320/33 , A61K2300/00
摘要： The invention provides means and methods for alleviating one or more symptom(s) of Duchenne Muscular Dystrophy and/or Becker Muscular Dystrophy. Therapies using compounds for providing patients with functional muscle proteins are combined with at least one adjunct compound for reducing inflammation, preferably for reducing muscle tissue inflammation, and/or at least one adjunct compound for improving muscle fiber function, integrity and/or survival.
摘要翻译：本发明提供了减轻Duchenne肌营养不良症和/或Becker肌营养不良症的一种或多种症状的方法和方法。使用化合物提供功能性肌肉蛋白的患者的治疗与至少一种辅助化合物合并，用于减少炎症，优选减少肌肉组织炎症，和/或至少一种辅助化合物，用于改善肌肉纤维功能，完整性和/或存活。

6. 发明授权

US08609065B2 Molecules for targeting compounds to various selected organs, tissues or tumor cells 有权
标题翻译：用于将化合物靶向各种选择的器官，组织或肿瘤细胞的分子
公开(公告)号：US08609065B2
公开(公告)日：2013-12-17
申请号：US12684534
申请日：2010-01-08
申请人： Petra Van Kuik-Romeijn , Gerard Johannes Platenburg
发明人： Petra Van Kuik-Romeijn , Gerard Johannes Platenburg
IPC分类号： A61K38/10 , C07K5/12
CPC分类号： A61K47/62
摘要： The invention provides conjugates, comprising an organ, tissue or tumor cell homing molecule linked to a moiety. Such a moiety can be, for example, an oligonucleotide, small interfering RNA, gene, virus, protein, pharmaceutical or detectable agent. In addition the invention provides methods to diagnose or treat neuronal or neuromuscular disease, or a pathology of the brain, or a tumor of neuronal or neuroectodermal origin, by administrating to a subject having or suspected of having a pathology a molecule or conjugate that homes to, binds to and is taken up by the brain cells or neuronal cells, or by the tumor cells of neuronal or neuroectodermal origin. The invention also provides a method of identifying and measuring neurite growth in neuronal cells.
摘要翻译：本发明提供了缀合物，其包含与部分连接的器官，组织或肿瘤细胞归巢分子。这样的部分可以是例如寡核苷酸，小干扰RNA，基因，病毒，蛋白质，药物或可检测的试剂。此外，本发明提供了通过施用给患有或怀疑具有病理学的分子或结合物的受试者来诊断或治疗神经元或神经肌肉疾病，或脑的病理学或神经元或神经外胚层起源的肿瘤的方法，，结合并被脑细胞或神经元细胞或由神经元或神经外胚层起源的肿瘤细胞所吸收。本发明还提供了一种识别和测量神经元细胞中神经突生长的方法。

7. 发明申请

US20110229552A1 NOVEL mRNA SPLICE VARIANT OF THE DOUBLECORTIN-LIKE KINASE GENE AND ITS USE IN DIAGNOSIS AND THERAPY OF CANCERS OF NEUROECTODERMAL ORIGIN 审中-公开
标题翻译：单链RNA激酶基因的新型mRNA片段变异及其在神经胚胎原体癌的诊断和治疗中的应用
公开(公告)号：US20110229552A1
公开(公告)日：2011-09-22
申请号：US12161951
申请日：2007-01-23
申请人： Erno Vreugdenhil , Petru Van Kuik-Romeijn , Gerard Johannes Platenburg
发明人： Erno Vreugdenhil , Petru Van Kuik-Romeijn , Gerard Johannes Platenburg
IPC分类号： A61K9/127 , A61P35/00 , A61K31/713 , C12N5/00 , A61K39/395 , C12N9/12 , C12Q1/48 , C07H21/04 , G01N33/50
CPC分类号： G01N33/57488 , C07K14/47 , C12N9/1205 , Y10T436/143333
摘要： The present invention relates to novel nucleic acid and protein molecules and their use in cancer therapy and diagnosis.
摘要翻译：本发明涉及新型核酸和蛋白质分子及其在癌症治疗和诊断中的应用。

8. 发明申请

US20090318403A1 ANTIBIOTIC COMPOSITION 审中-公开
标题翻译：抗生素组合物
公开(公告)号：US20090318403A1
公开(公告)日：2009-12-24
申请号：US12376221
申请日：2007-08-02
申请人： Peter Christian De Visser , Gerard Johannes Platenburg , Jaap Tamino Van Dissel
发明人： Peter Christian De Visser , Gerard Johannes Platenburg , Jaap Tamino Van Dissel
IPC分类号： A61K31/43 , A61K31/5377 , A61K31/4365 , A61P31/00 , A61K31/133 , A61P31/04 , A61K31/131 , A01N43/76 , A01N43/90
CPC分类号： A61K9/0019 , A61K9/08 , A61K31/131 , A61K45/06 , Y02A50/475 , Y02A50/478 , Y02A50/481 , A61K2300/00
摘要： The present invention provides antimicrobial compositions comprising an antibiotic and a sensitizer that enhances the effectiveness or activity of the antibiotic, wherein the sensitizer is preferably a primary amine containing a long alkyl chain. Such compositions are particularly useful for the treatment of infections by drug resistant bacteria.
摘要翻译：本发明提供包含增强抗生素的有效性或活性的抗生素和敏化剂的抗微生物组合物，其中敏化剂优选为含有长烷基链的伯胺。这样的组合物特别可用于治疗耐药菌的感染。

9. 发明授权

US08268962B2 Molecules for targeting compounds to various selected organs or tissues 有权
标题翻译：用于将化合物靶向各种选择的器官或组织的分子
公开(公告)号：US08268962B2
公开(公告)日：2012-09-18
申请号：US12685369
申请日：2010-01-11
申请人： Johannes Antonius Heemskerk , Judith Christina Theodora Van Deutekom , Petra Van Kuik-Romeijn , Gerard Johannes Platenburg
发明人： Johannes Antonius Heemskerk , Judith Christina Theodora Van Deutekom , Petra Van Kuik-Romeijn , Gerard Johannes Platenburg
IPC分类号： C07K17/02
CPC分类号： A61K49/0056 , A61K47/62 , A61K49/0032 , A61K49/0047
摘要： The invention provides conjugates, comprising an organ, tissue or tumor cell homing molecule linked to a moiety. Such a moiety can be, for example, an oligonucleotide, small interfering RNA, gene, virus, protein, pharmaceutical or detectable agent. In addition the invention provides methods to diagnose or treat a pathology of the muscle or heart, by administrating to a subject having or suspected of having a pathology a molecule or conjugate that homes to, binds to and is taken up by the muscle cells or heart cells.
摘要翻译：本发明提供了缀合物，其包含与部分连接的器官，组织或肿瘤细胞归巢分子。这样的部分可以是例如寡核苷酸，小干扰RNA，基因，病毒，蛋白质，药物或可检测的试剂。此外，本发明提供了诊断或治疗肌肉或心脏的病理学的方法，通过施用于具有或怀疑具有病理学的受试者的家族，结合和被肌肉细胞或心脏摄取的分子或结合物细胞。

10. 发明申请

US20090233981A1 Compounds for Hydrolyzing Ribonucleic Acids (RNA's) 审中-公开
标题翻译：水解核糖核酸（RNA）的化合物
公开(公告)号：US20090233981A1
公开(公告)日：2009-09-17
申请号：US10592175
申请日：2005-03-09
申请人： Brigitte Wanner , Gerard Johannes Platenburg
发明人： Brigitte Wanner , Gerard Johannes Platenburg
IPC分类号： A61K31/7125 , A61K31/7105 , C07H21/00 , C07H21/02
CPC分类号： C07H21/00 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/3181 , C12N2310/3511 , C12N2330/30
摘要： The present invention relates to a method and compounds for hydrolysing nucleic acids. In particular it relates to compounds that can be used for the preferential cleavage of a phosphodiester bond at a specific position in RNA.
摘要翻译：本发明涉及一种用于水解核酸的方法和化合物。特别地，它涉及可用于在RNA中特定位置上优先切割磷酸二酯键的化合物。

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