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    • 6. 发明申请
    • ULTRASENSITIVE BIOLOGICAL AND CHEMICAL DETECTION USING SURFACE PLASMON RESONANCE
    • 使用表面等离子体共振的超声生物和化学检测
    • US20130110467A1
    • 2013-05-02
    • US13284025
    • 2011-10-28
    • Robert E. FellerAndre KnoesenRobert D. Miller
    • Robert E. FellerAndre KnoesenRobert D. Miller
    • G06F15/00
    • G01N21/05G01N21/274G01N21/553
    • A device, including sample and reference channels through which first and second solutions flow, respectively, the first solution including an analyte, the channels having a metal film in contact with the first and second solutions, the metal film configured with a linker to selectively bind the analyte; a light source whose output is modulated by an optical system, so that light is directed from the optical system alternately towards the sample and reference channels, surface plasmons within the metal film being created; a first photodetector that monitors the strength of the output from the light source; a second photodetector that collects optical signals reflected from the metal film; electronics that monitors output from the first and the second photodetectors, thereby detecting a noise-compensated difference in signals from the two channels; and a computer processor that determines, from analysis of the noise-compensated difference, presence of the analyte in the first solution.
    • 一种装置,包括第一和第二溶液分别通过其流动的样品和参考通道,第一溶液包括分析物,通道具有与第一和第二溶液接触的金属膜,金属膜配置有接头以选择性地结合 分析物; 其光输出被光学系统调制的光源,使得光从光学系统交替地朝向样品和参考通道引导,在金属膜内形成表面等离子体; 第一光电检测器,其监测来自光源的输出的强度; 第二光电检测器,其收集从金属膜反射的光信号; 监视来自第一和第二光电检测器的输出的电子装置,从而检测来自两个通道的信号的噪声补偿差分; 以及计算机处理器,其从噪声补偿差分的分析确定第一解决方案中分析物的存在。