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2. 发明授权

US5962318A Cytotoxic T lymphocyte-mediated immunotherapy 失效
标题翻译：细胞毒性T淋巴细胞介导的免疫治疗
公开(公告)号：US5962318A
公开(公告)日：1999-10-05
申请号：US746726
申请日：1996-11-15
申请人： Cliona Rooney , Marie Roskrow , Geoffrey Kitchingman , Colton Smith
发明人： Cliona Rooney , Marie Roskrow , Geoffrey Kitchingman , Colton Smith
IPC分类号： A61K39/00 , A61K48/00 , C12N5/0783 , A01N63/00 , C12N5/00
CPC分类号： A61K39/0011 , C12N5/0636 , A61K2039/5156 , A61K2039/5158 , A61K48/00 , C12N2502/11
摘要： The present invention is directed to methods for stimulating primary and secondary effector cell responses for cellular immunotherapy. Cellular immunotherapy can successfully prevent or treat various viral infections and tumors, such as posttransplant EBV lymphoma. The present invention offers a general method for effecting cellular immunotherapy by providing for presentation, by the most effective antigen presenting cells, viral particles or specific antigens, without the need to develop an active viral infection in the antigen presenting cells. Furthermore, the present invention provides for generating effector cells against more than one opportunistic pathogen, e.g., Epstein-Barr virus and adenovirus. The effector cells generated according to the invention, which include CD4 and CD8 cells, are extremely long lived in vivo after adoptive transfer. In specific embodiments, dendritic cells present whole adenovirus particles via class I MHC molecules, transduced dendritic cells present a weak EBV antigen to effector cells, and EBV-transformed lymphoblastoid cells present whole adenoviral particles to effector cells, generating a population of effector cells active against EBV and adenovirus. Moreover, the adenovirus-specific effector cells of the present invention, generated against one adenovirus subgroup, recognize different adenovirus subgroups.
摘要翻译：本发明涉及用于刺激细胞免疫治疗的初级和次级效应细胞应答的方法。细胞免疫治疗可以成功地预防或治疗各种病毒感染和肿瘤，如移植后EBV淋巴瘤。本发明提供通过提供最有效的抗原呈递细胞，病毒颗粒或特异性抗原的呈递来实现细胞免疫治疗的一般方法，而不需要在抗原呈递细胞中形成活性病毒感染。此外，本发明提供针对多于一种机会性病原体（例如爱泼斯坦 - 巴尔病毒和腺病毒）产生效应细胞。根据本发明产生的包括CD4和CD8细胞的效应细胞在过继转移后在体内非常长寿命。在具体实施方案中，树突细胞通过I类MHC分子存在整个腺病毒颗粒，转导的树突状细胞对效应细胞呈现弱EBV抗原，并且EBV转化的淋巴母细胞细胞将全部腺病毒颗粒存在于效应细胞，产生一群效应细胞， EBV和腺病毒。此外，针对一个腺病毒亚组产生的本发明的腺病毒特异性效应细胞识别不同的腺病毒亚组。

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