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1. 发明申请

US20100209468A1 IMPLANTABLE DEVICES FOR PRODUCING INSULIN 有权
标题翻译：用于生产胰岛素的可植入装置
公开(公告)号：US20100209468A1
公开(公告)日：2010-08-19
申请号：US12439057
申请日：2007-08-29
申请人： Joseph P. Kennedy , Gabor Erdodi
发明人： Joseph P. Kennedy , Gabor Erdodi
IPC分类号： A61K35/12 , A61K9/00 , A61K38/28 , A61P3/10
CPC分类号： A61L27/3804 , A61F2/022 , A61K9/0024 , A61L27/3839
摘要： The present invention generally relates to implantable devices for producing insulin in diabetic animals. Some embodiments include amphiphilic biomembranes for use in biological applications (e.g., as an alternative and/or supplemental insulin source). Some embodiments also include live insulin-producing cells contained within one or more amphiphilic membranes so as to prevent or diminish an immuno-response and/or rejection by the host.
摘要翻译：本发明一般涉及用于在糖尿病动物中产生胰岛素的可植入装置。一些实施方案包括用于生物应用的两亲生物膜（例如，作为替代和/或补充胰岛素源）。一些实施方案还包括含在一个或多个两亲膜内的活的产生胰岛素的细胞，以便防止或减少宿主的免疫应答和/或排斥。

2. 发明授权

US07569652B2 Synthesis and characterization of novel cyclosiloxanes and their self- and co-condensation with silanol-terminated polydimethylsiloxane 有权
标题翻译：新型环硅氧烷的合成和表征及其与硅烷醇封端的聚二甲基硅氧烷的自共缩合
公开(公告)号：US07569652B2
公开(公告)日：2009-08-04
申请号：US11209136
申请日：2005-08-22
申请人： Joseph P. Kennedy , Jeremy Daum , Gabor Erdodi
发明人： Joseph P. Kennedy , Jeremy Daum , Gabor Erdodi
IPC分类号： C08G77/14
CPC分类号： C08G77/045 , C08G77/06 , C08G77/14
摘要： The present invention is directed to syntheses of cyclolinear networks. Two novel cyclic siloxanes were used as starting materials. The cyclic siloxanes are self-condensed and co-condensed with silanol-terminated polydimethylsiloxane to vinyl-terminated cyclolinear polymers. Cyclolinear networks can be synthesized by hydrosilylation of vinyl-terminated cyclolinear polyorganosiloxanes with a copolymer of dimethylsiloxane and methylhydrosiloxane.
摘要翻译：本发明涉及环线性网络的合成。使用两种新的环状硅氧烷作为原料。环状硅氧烷是自缩合的，并与硅烷醇封端的聚二甲基硅氧烷共缩合成乙烯基封端的环状共聚物。可以通过乙烯基封端的环状线性聚有机硅氧烷与二甲基硅氧烷和甲基氢硅氧烷的共聚物的氢化硅烷化来合成环线性网络。

3. 发明申请

US20130281742A1 METHOD AND SYNTHESIS OF INITIATORS FOR TELECHELIC POLYISOBUTYLENES 审中-公开
标题翻译：电纺聚对苯二甲酸乙二酯的方法与合成
公开(公告)号：US20130281742A1
公开(公告)日：2013-10-24
申请号：US13977941
申请日：2011-12-30
申请人： Joseph P. Kennedy , Gabor Erdodi
发明人： Joseph P. Kennedy , Gabor Erdodi
IPC分类号： C07C41/01
CPC分类号： C07C41/01 , C07C29/159 , C07C29/78 , C07C41/09 , C07C407/00 , C07C409/08 , C07C409/22 , C07C33/26 , C07C43/162
摘要： A new methodology for the synthesis of a novel difunctional- and a known trifunctional initiator, i.e., 1,3-di(2-methoxy-2-propyl)-5-isopropyl benzene and 1,3,5-tri(2-methoxy-2-propyl)benzene, respectively, for the preparation of di- and tri-telechelic polyisobutylenes. The synthesis proceeds in three steps: 1) catalytic peroxidation of 1,3,5-triisopropylbenzene, 2) reduction of the peroxides to the corresponding alcohols, and 3) methylation of the alcohols. By controlling the conversion of the key peroxidation step the relative ratio of di- and tri-functional intermediates can be controlled. By the use of the 1,3-di(2-methoxy-2-propyl)-5-isopropyl-benzene, well-defined di-methoxy telechelic polyisobutylenes can be synthesized. Although the overall combined yield of the two initiators was only 14-20%, because of the low cost of the starting material, reagents used, and simple manipulations these compounds represent the most cost effective initiators to-date for the preparation of telechelic polyisobutylenes.
摘要翻译：用于合成新的双官能和已知三官能引发剂的新方法，即1,3-二（2-甲氧基-2-丙基）-5-异丙基苯和1,3,5-三（2-甲氧基 -2-丙基）苯，用于制备二 - 和三 - 遥爪聚异丁烯。合成分三个步骤进行：1）1,3,5-三异丙基苯的催化过氧化，2）过氧化物还原成相应的醇，3）醇的甲基化。通过控制关键过氧化步骤的转化，可以控制二官能和三官能中间体的相对比例。通过使用1,3-二（2-甲氧基-2-丙基）-5-异丙基苯，可以合成明确定义的二甲氧基遥爪聚异丁烯。尽管两种引发剂的总体组合产率仅为14-20％，但是由于原料成本低，使用的试剂和简单的操作，这些化合物代表了迄今为止制备遥爪聚异丁烯的成本最高的引发剂。

4. 发明申请

US20130041108A1 POLYMERS HAVING BOTH HARD AND SOFT SEGMENTS, AND PROCESS FOR MAKING SAME 审中-公开
标题翻译：具有两个硬和软部分的聚合物，以及制备它们的方法
公开(公告)号：US20130041108A1
公开(公告)日：2013-02-14
申请号：US13547276
申请日：2012-07-12
申请人： Joseph P. Kennedy , Gabor Erdodi , Jungrnee Kang , Suresh Jewrajka
发明人： Joseph P. Kennedy , Gabor Erdodi , Jungrnee Kang , Suresh Jewrajka
IPC分类号： C08F255/10 , C08F8/30 , C08F8/32
CPC分类号： C08G18/44 , C08G18/244 , C08G18/246 , C08G18/4854 , C08G18/5024 , C08G18/69 , C08G18/696 , C08G18/698 , C08G18/73 , C08G18/758 , C08G18/7671 , C08G18/10 , C08G18/3228 , C08G18/50 , C08G18/12 , C08G18/3206
摘要： The present invention generally relates to alcohol- and amine-terminated polyisobutylene (PIB) compounds, and to a process for making such compounds. In one embodiment, the present invention relates to primary alcohol- and amine-terminated polyisobutylene compounds, and to a process for making such compounds. In still another embodiment, the present invention relates to polyisobutylene compounds that can be used to synthesize polyurethanes and polyureas, to polyurethane and polyurea compounds made via the use of such polyisobutylene compounds, and to processes for making such compounds. In yet another embodiment, the present invention relates to polyisobutylene compounds containing urea or urethane segments therein, and to a method of producing such compounds. In still yet another embodiment, the present invention relates to a polymer having one or more different soft segments and one or more different hard segments.
摘要翻译：本发明一般涉及醇和胺封端的聚异丁烯（PIB）化合物，以及制备这些化合物的方法。在一个实施方案中，本发明涉及伯醇和胺封端的聚异丁烯化合物，以及制备这些化合物的方法。在另一个实施方案中，本发明涉及可用于合成聚氨酯和聚脲的聚异丁烯化合物，通过使用这种聚异丁烯化合物制备的聚氨酯和聚脲化合物以及制备这些化合物的方法。在另一个实施方案中，本发明涉及其中含有脲或氨基甲酸酯链段的聚异丁烯化合物及其制备方法。在又一个实施方案中，本发明涉及具有一个或多个不同软链段和一个或多个不同硬链段的聚合物。

5. 发明申请

US20100267897A1 THERMOPLASTIC AMPHIPHILIC CO-NETWORKS 有权
标题翻译：热塑性共聚物网络
公开(公告)号：US20100267897A1
公开(公告)日：2010-10-21
申请号：US12740829
申请日：2008-11-03
申请人： Joseph P. Kennedy , Gabor Erdodi , Jungmee Kang
发明人： Joseph P. Kennedy , Gabor Erdodi , Jungmee Kang
IPC分类号： C08L29/04 , C08L83/04 , C08L39/06 , C08L33/26 , C08L33/02 , C08L75/04 , C08L39/08
CPC分类号： C08F265/00 , C08G77/442 , C08G77/458 , C08L51/085 , C08L83/10 , C08L2205/02 , C08L2666/24
摘要： The present invention relates generally to thermoplastic amphiphilic networks and/or co-networks. In one embodiment, the present invention relates to thermoplastic (TP) amphiphilic co-networks (APCNs) and the preparation of membranes from such APCNs. In another embodiment, the present invention relates to an amphiphilic network comprising at least one hydrophilic polymer-derived portion, at least one hydrophobic polymer-derived portion and at least one thermoplastic polymer-derived portion. In still another embodiment, the present invention relates to thermoplastic amphiphilic co-networks prepared by combining the chemistries of APCNs and polyurethanes (PUs) and to the preparation of membranes therefrom.
摘要翻译：本发明一般涉及热塑性两亲性网络和/或共同网络。在一个实施方案中，本发明涉及热塑性（TP）两亲性共同网络（APCN）和来自这种APCN的膜的制备。在另一个实施方案中，本发明涉及包含至少一种亲水性聚合物衍生部分，至少一种疏水性聚合物衍生部分和至少一种热塑性聚合物衍生部分的两亲网络。在另一个实施方案中，本发明涉及通过将APCN和聚氨酯（PU）的化学物质组合并由其制备的膜制备的热塑性两亲性共网络。

6. 发明授权

US08889926B2 Method for the synthesis of low cost initiators for telechelic polyisobutylenes 有权
标题翻译：用于合成远程聚异丁烯的低成本引发剂的方法
公开(公告)号：US08889926B2
公开(公告)日：2014-11-18
申请号：US14130079
申请日：2012-07-02
申请人： Joseph P. Kennedy , Gabor Erdodi
发明人： Joseph P. Kennedy , Gabor Erdodi
IPC分类号： C07C17/16 , C07C17/35 , C07C29/132 , C07C2/86 , C07C407/00 , C07C15/02 , C08F110/10 , C07C22/04 , C08F110/00
CPC分类号： C07C17/16 , C07C2/861 , C07C15/02 , C07C17/35 , C07C22/04 , C07C29/132 , C07C407/00 , C07C2527/128 , C08F110/00 , C08F110/10 , C08F4/00 , C07C409/12 , C07C33/26
摘要： A method for the synthesis of 1,3-di(chloropropyl)-5-tert-butyl benzene includes the steps of conducting Friedl-Crafts alkylation of 1,3-diisopropyl benzene by tert-butyl chloride in the presence of an alkylation catalyst to obtain 1-tert-butyl-3,5-diisopropylbenzene; peroxidizing the 1-tert-butyl-3,5-diisopropyl benzene by gaseous oxygen in the presence of a peroxidation catalyst in a basic solution to obtain 1,3-di(peroxypropyl)-5-tert-butylbenzene; reducing the 1,3-di(peroxypropyl)-5-tert-butylbenzene with a reducing agent to 1,3-di(hydroxylpropyl)-5-tert-butylbenzene; and chlorinating the 1,3-di(hydroxypropyl)-5-tert-butylbenzene to obtain 1,3-di(chloropropyl)-5-tert-butyl benzene.
摘要翻译：合成1,3-二（氯丙基）-5-叔丁基苯的方法包括以下步骤：在烷基化催化剂存在下，用叔丁基氯进行1,3-二异丙基苯的Fried-Crafts烷基化，得到1-叔丁基-3,5-二异丙基苯; 在碱性溶液中，在过氧化催化剂存在下，用气态氧过氧化1-叔丁基-3,5-二异丙基苯，得到1,3-二（过氧丙基）-5-叔丁基苯; 用还原剂将1,3-二（过氧丙基）-5-叔丁基苯还原成1,3-二（羟基丙基）-5-叔丁基苯; 并将1,3-二（羟丙基）-5-叔丁基苯氯化，得到1,3-二（氯丙基）-5-叔丁基苯。

7. 发明授权

US08702810B2 Bio-artificial pancreas and a procedure for preparation of same 有权
标题翻译：生物人造胰腺及其制备方法
公开(公告)号：US08702810B2
公开(公告)日：2014-04-22
申请号：US12529732
申请日：2008-03-10
申请人： Joseph P. Kennedy , Gabor Erdodi , Mukerrem Cakmak , Baris Yalcin , Jungmee Kang
发明人： Joseph P. Kennedy , Gabor Erdodi , Mukerrem Cakmak , Baris Yalcin , Jungmee Kang
IPC分类号： A61F2/02 , A61K9/24
CPC分类号： A61K9/0024 , A61F2/022
摘要： The present invention generally relates to implantable devices for producing insulin in diabetic animals and to methods of making same. Some embodiments include amphiphilic biomembranes for use in biological applications (e.g., as an alternative and/or supplemental insulin source). Some embodiments also include live insulin-producing cells contained within one or more amphiphilic membranes so as to prevent or diminish an immuno-response and/or rejection by the host.
摘要翻译：本发明一般涉及用于在糖尿病动物中产生胰岛素的可植入装置及其制备方法。一些实施方案包括用于生物应用的两亲生物膜（例如，作为替代和/或补充胰岛素源）。一些实施方案还包括含在一个或多个两亲膜内的活的产生胰岛素的细胞，以便防止或减少宿主的免疫应答和/或排斥。

8. 发明授权

US08247515B2 Amphiphilic grafts and co-networks and process for making same 有权
标题翻译：两亲性移植物和共网络及其制备方法
公开(公告)号：US08247515B2
公开(公告)日：2012-08-21
申请号：US12376171
申请日：2007-08-03
申请人： Joseph P. Kennedy , Gabor Erdodi
发明人： Joseph P. Kennedy , Gabor Erdodi
IPC分类号： C08G77/08
CPC分类号： C08L33/26 , C08K5/549 , C08L83/04 , C08L2312/00 , C08L83/00
摘要： The present invention generally relates to amphiphilic grafts and co-networks made from at least one hydrophilic polymer and at least one hydrophobic polymer, and to processes for preparing such amphiphilic grafts and co-networks. In another embodiment, the present invention relates to amphiphilic co-networks formed from the combination of at least one polysiloxane and at least one polyacrylamide. In yet another embodiment, the present invention relates to amphiphilic co-networks formed from the combination of at least one polysiloxane, at least one polyacrylamide and at least one crosslinking agent.
摘要翻译：本发明一般涉及由至少一种亲水性聚合物和至少一种疏水性聚合物制成的两亲移植物和共网络，以及制备这种两亲移植物和共网络的方法。在另一个实施方案中，本发明涉及由至少一种聚硅氧烷和至少一种聚丙烯酰胺的组合形成的两亲性共网络。在另一个实施方案中，本发明涉及由至少一种聚硅氧烷，至少一种聚丙烯酰胺和至少一种交联剂的组合形成的两亲性共网络。

9. 发明申请

US20110213084A1 POLYMERS HAVING BOTH HARD AND SOFT SEGMENTS, AND PROCESS FOR MAKING SAME 审中-公开
标题翻译：具有两个硬和软部分的聚合物，以及制备它们的方法
公开(公告)号：US20110213084A1
公开(公告)日：2011-09-01
申请号：US13120927
申请日：2009-10-01
申请人： Joseph P. Kennedy , Gabor Erdodi , Suresh Jewrajka , Jungmee Kang
发明人： Joseph P. Kennedy , Gabor Erdodi , Suresh Jewrajka , Jungmee Kang
IPC分类号： C08F255/10 , C08G18/65 , C08G18/08
CPC分类号： C08G18/6204 , C08G18/10 , C08G18/758 , C08G18/3228
摘要： The present invention generally relates to alcohol- and amine-terminated polyisobutylene (PIB) compounds, and to a process for making such compounds. In one embodiment, the present invention relates to primary alcohol- and amine-terminated polyisobutylene compounds, and to a process for making such compounds. In still another embodiment, the present invention relates to polyisobutylene compounds that can be used to synthesize polyurethanes and polyureas, to polyurethane and polyurea compounds made via the use of such polyisobutylene compounds, and to processes for making such compounds. In yet another embodiment, the present invention relates to polyisobutylene compounds containing urea or urethane segments therein, and to a method of producing such compounds. In still yet another embodiment, the present invention relates to a polymer having one or more different soft segments and one or more different hard segments.
摘要翻译：本发明一般涉及醇和胺封端的聚异丁烯（PIB）化合物，以及制备这些化合物的方法。在一个实施方案中，本发明涉及伯醇和胺封端的聚异丁烯化合物，以及制备这些化合物的方法。在另一个实施方案中，本发明涉及可用于合成聚氨酯和聚脲的聚异丁烯化合物，通过使用这种聚异丁烯化合物制备的聚氨酯和聚脲化合物以及制备这些化合物的方法。在另一个实施方案中，本发明涉及其中含有脲或氨基甲酸酯链段的聚异丁烯化合物及其制备方法。在又一个实施方案中，本发明涉及具有一个或多个不同软链段和一个或多个不同硬链段的聚合物。

10. 发明申请

US20140235905A1 METHOD FOR THE SYNTHESIS OF LOW COST INITIATORS FOR TELECHELIC POLYISOBUTYLENES 有权
标题翻译：合成低成本发射体电纺聚异丁烯的方法
公开(公告)号：US20140235905A1
公开(公告)日：2014-08-21
申请号：US14130079
申请日：2012-07-02
申请人： Joseph P. Kennedy , Gabor Erdodi
发明人： Joseph P. Kennedy , Gabor Erdodi
IPC分类号： C07C17/16 , C07C22/04
CPC分类号： C07C17/16 , C07C2/861 , C07C15/02 , C07C17/35 , C07C22/04 , C07C29/132 , C07C407/00 , C07C2527/128 , C08F110/00 , C08F110/10 , C08F4/00 , C07C409/12 , C07C33/26
摘要： A method for the synthesis of 1,3-di(chloropropyl)-5-tert-butyl benzene includes the steps of conducting Friedl-Crafts alkylation of 1,3-diisopropyl benzene by tert-butyl chloride in the presence of an alkylation catalyst to obtain 1-tert-butyl-3,5-diisopropylbenzene; peroxidizing the 1-tert-butyl-3,5-diisopropyl benzene by gaseous oxygen in the presence of a peroxidation catalyst in a basic solution to obtain 1,3-di(peroxypropyl)-5-tert-butylbenzene; reducing the 1,3-di(peroxypropyl)-5-tert-butylbenzene with a reducing agent to 1,3-di(hydroxyl propyl)-5-tert-butylbenzene; and chlorinating the 1,3-di(hydroxypropyl)-5-tert-butylbenzene to obtain 1,3-di(chloropropyl)-5-tert-butyl benzene.
摘要翻译：合成1,3-二（氯丙基）-5-叔丁基苯的方法包括以下步骤：在烷基化催化剂存在下，用叔丁基氯进行1,3-二异丙基苯的Fried-Crafts烷基化，得到1-叔丁基-3,5-二异丙基苯; 在碱性溶液中，在过氧化催化剂存在下，用气态氧过氧化1-叔丁基-3,5-二异丙基苯，得到1,3-二（过氧丙基）-5-叔丁基苯; 用还原剂将1,3-二（过氧丙基）-5-叔丁基苯还原成1,3-二（羟基丙基）-5-叔丁基苯; 并将1,3-二（羟丙基）-5-叔丁基苯氯化，得到1,3-二（氯丙基）-5-叔丁基苯。

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