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1. 发明申请

US20130224144A1 SEQUENTIAL ADMINISTRATION OF A REPLICATION DEFECTIVE ADENOVIRUS VECTOR IN VACCINATION PROTOCOLS 审中-公开
标题翻译：疫苗接种方案中的复发性腺病毒载体的顺序施用
公开(公告)号：US20130224144A1
公开(公告)日：2013-08-29
申请号：US13622263
申请日：2012-09-18
申请人： Joseph P. Balint , Frank R. Jones , Richard B. Gayle, III
发明人： Joseph P. Balint , Frank R. Jones , Richard B. Gayle, III
IPC分类号： A61K39/235 , A61K38/20 , A61K38/21 , A61K38/19
CPC分类号： A61K39/12 , A61K38/191 , A61K38/193 , A61K38/2013 , A61K38/2026 , A61K38/2033 , A61K38/204 , A61K38/2046 , A61K38/2066 , A61K38/208 , A61K38/217 , A61K39/00 , A61K39/0011 , A61K39/21 , A61K39/235 , A61K2039/5256 , A61K2039/54 , A61K2039/545 , A61K2039/55555 , A61K2039/57 , A61K2039/575 , A61P35/00 , C07K14/005 , C07K14/70503 , C07K14/71 , C12N15/86 , C12N2710/10034 , C12N2710/10321 , C12N2710/10334 , C12N2710/10343 , C12N2710/10371 , C12N2710/20034 , C12N2740/15034 , C12N2740/16234 , C12N2800/24
摘要： Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.
摘要翻译：提供了使用允许使用相同腺病毒载体进行多次疫苗接种的腺病毒载体产生免疫反应的方法，并且在具有预先存在的腺病毒免疫的个体中接种疫苗。

2. 发明申请

US20100183673A1 METHODS AND COMPOSITIONS FOR PRODUCING AN ADENOVIRUS VECTOR FOR USE WITH MULTIPLE VACCINATIONS 有权
标题翻译：用于生产用于多种疫苗的腺病毒载体的方法和组合物
公开(公告)号：US20100183673A1
公开(公告)日：2010-07-22
申请号：US12651836
申请日：2010-01-04
申请人： Joseph P. Balint , Frank R. Jones , Richard B. Gayle, III
发明人： Joseph P. Balint , Frank R. Jones , Richard B. Gayle, III
IPC分类号： A61K39/235 , C12N15/861
CPC分类号： A61K39/12 , A61K38/191 , A61K38/193 , A61K38/2013 , A61K38/2026 , A61K38/2033 , A61K38/204 , A61K38/2046 , A61K38/2066 , A61K38/208 , A61K38/217 , A61K39/00 , A61K39/0011 , A61K39/21 , A61K39/235 , A61K2039/5256 , A61K2039/54 , A61K2039/545 , A61K2039/55555 , A61K2039/57 , A61K2039/575 , C07K14/005 , C07K14/70503 , C07K14/71 , C12N15/86 , C12N2710/10034 , C12N2710/10321 , C12N2710/10334 , C12N2710/10343 , C12N2710/10371 , C12N2710/20034 , C12N2740/15034 , C12N2740/16234 , C12N2800/24
摘要： Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.
摘要翻译：提供了使用允许使用相同腺病毒载体进行多次疫苗接种的腺病毒载体产生免疫反应的方法，并且在具有预先存在的腺病毒免疫的个体中接种疫苗。

3. 发明授权

US08298549B2 Sequential administration of a replication defective adenovirus vector in vaccination protocols 有权
标题翻译：在疫苗接种方案中顺序施用复制缺陷型腺病毒载体
公开(公告)号：US08298549B2
公开(公告)日：2012-10-30
申请号：US12651836
申请日：2010-01-04
申请人： Joseph P. Balint , Frank R. Jones , Richard B. Gayle, III
发明人： Joseph P. Balint , Frank R. Jones , Richard B. Gayle, III
IPC分类号： A61K39/235 , C12N15/861
CPC分类号： A61K39/12 , A61K38/191 , A61K38/193 , A61K38/2013 , A61K38/2026 , A61K38/2033 , A61K38/204 , A61K38/2046 , A61K38/2066 , A61K38/208 , A61K38/217 , A61K39/00 , A61K39/0011 , A61K39/21 , A61K39/235 , A61K2039/5256 , A61K2039/54 , A61K2039/545 , A61K2039/55555 , A61K2039/57 , A61K2039/575 , C07K14/005 , C07K14/70503 , C07K14/71 , C12N15/86 , C12N2710/10034 , C12N2710/10321 , C12N2710/10334 , C12N2710/10343 , C12N2710/10371 , C12N2710/20034 , C12N2740/15034 , C12N2740/16234 , C12N2800/24
摘要： Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.
摘要翻译：提供了使用允许使用相同腺病毒载体进行多次疫苗接种的腺病毒载体产生免疫反应的方法，并且在具有预先存在的腺病毒免疫的个体中接种疫苗。

4. 发明授权

US5733254A Method for treating patients suffering from immune thrombocytopenic purpura 失效
标题翻译：治疗患有免疫性血小板减少性紫癜的患者的方法
公开(公告)号：US5733254A
公开(公告)日：1998-03-31
申请号：US432036
申请日：1995-05-01
申请人： Frank R. Jones , Joseph P. Balint, Jr. , Harry W. Snyder
发明人： Frank R. Jones , Joseph P. Balint, Jr. , Harry W. Snyder
IPC分类号： A61M1/34 , A61M37/00
CPC分类号： A61M1/3472 , A61M1/3486
摘要： Immune thrombocytopenic purpura is treated by removal of IgG and circulating immune complexes from the patient's blood. Removal is accomplished by exposing the blood or blood plasma to an immunoadsorbent capable of removing IgG and its complexes. The immunoadsorbent comprises a suitable solid phase coupled to a receptor capable of binding IgG and its complexes, such as protein A. The IgG and its complexes are then removed by the extracorporeal exposure of the patient's blood to the immunoadsorbent, either in a continuous or discontinuous process. In the continuous process, the blood is removed in a steady flow from the patient, separated into its plasma and cellular components, the plasma treated, and the combined cellular components and treated plasma reinfused to the patient. In the discontinuous method, a small volume of blood is removed from the patient, the entire volume separated into plasma and cellular components, the plasma treated, and the entire volume of treated plasma returned to the patient, usually after the cellular components have been returned.
摘要翻译：免疫血小板减少性紫癜通过从患者血液中除去IgG和循环免疫复合物来治疗。通过将血液或血浆暴露于能够除去IgG及其复合物的免疫吸附剂来实现去除。免疫吸附剂包含与能够结合IgG及其复合物（例如蛋白A）的受体偶联的合适的固相。然后通过体外暴露患者的血液免疫IgG或其复合物，以免疫吸附剂将其连续或不连续处理。在连续过程中，以来自患者的稳定流动除去血液，分离成其等离子体和细胞组分，将血浆处理，并将组合的细胞组分和治疗的血浆重新灌注给患者。在不连续的方法中，从患者体内除去少量的血液，整个体积分离成等离子体和细胞组分，血浆处理，经处理的血浆的总体积返回到病人，通常在细胞组分被返回后。

5. 发明授权

US4865841A Methods and compositions for transient elimination of humoral immune antibodies 失效
标题翻译：用于瞬时消除体液免疫抗体的方法和组合物
公开(公告)号：US4865841A
公开(公告)日：1989-09-12
申请号：US112853
申请日：1987-10-23
申请人： Joseph P. Balint, Jr. , Sharon Cochran , Frank R. Jones , Harry W. Snyder
发明人： Joseph P. Balint, Jr. , Sharon Cochran , Frank R. Jones , Harry W. Snyder
IPC分类号： A61M1/36
CPC分类号： A61M1/3679
摘要： Antibody is removed from the blood of patients who are being treated or diagnosed with exogenous macromolecules, such as immunotoxins. As the immunotoxins are foreign antigens, the patient will develop an immune response. The antibodies produced by the immune response upon subsequent immunization with the immunotoxins will interfere with the desired function of the immunotoxins by preventing them from binding with their specific target site. By extracorporeally removing the antibodies, the activity of the immunotoxins can be enhanced.

6. 发明授权

US4801449A Method for treatment of Kaposi's sarcoma 失效
标题翻译：卡波西肉瘤治疗方法
公开(公告)号：US4801449A
公开(公告)日：1989-01-31
申请号：US948268
申请日：1986-12-31
申请人： Joseph P. Balint, Jr. , Frank R. Jones
发明人： Joseph P. Balint, Jr. , Frank R. Jones
IPC分类号： A61M1/36 , B01J20/32 , G01N33/552 , B01D15/08 , G01N33/543
CPC分类号： B01J20/3204 , B01J20/103 , B01J20/28004 , B01J20/3071 , B01J20/3078 , B01J20/3085 , B01J20/3092 , B01J20/3217 , B01J20/3219 , B01J20/3257 , B01J20/3263 , B01J20/3274 , G01N33/552 , A61M1/3679 , B01J2220/58 , B01J2220/62
摘要： An immunoadsorbent material for removing IgG and IgG-complexes from biological fluids is prepared by covalently binding protein A to a solid-phase silica matrix. It has been found that particularly stable, high-capacity immunoadsorbents are obtained by derivatizing the silica with amino and/or carboxyl groups, and reacting the protein A with a carbodiimide at a pH in the range from 3.5 to 4.5. Binding through free hydroxyl groups may be achieved with cyanogen halides at a pH in the range from 11.0 to 11.5. After acid washing (pH 2.0-2.5) to remove non-covalently bound protein A, the immunoadsorbent may be employed in a column for therapeutic treatment of various cancers and autoimmune disorders where IgG-complexes are implicated as suppressing factors in inhibiting a normal immune response. The column has been successfully employed in treating patients suffering from Kaposi's sarcoma.
摘要翻译：通过将蛋白A与固相二氧化硅基质共价结合来制备用于从生物流体中除去IgG和IgG-复合物的免疫吸附材料。已经发现，特别稳定的高容量免疫吸附剂通过用氨基和/或羧基衍生二氧化硅获得，并且使蛋白A与碳二亚胺在3.5至4.5的pH范围内反应。通过游离羟基的结合可以在pH为11.0至11.5范围内的氰卤化物达到。在酸洗（pH2.0-2.5）以除去非共价结合的蛋白A后，免疫吸附剂可用于治疗各种癌症和自身免疫疾病的柱，其中IgG-复合物被认为是抑制正常免疫应答的抑制因子。该柱已成功用于治疗患有卡波西氏肉瘤的患者。

7. 发明授权

US5782792A Method for treatment of rheumatoid arthritis 失效
标题翻译：治疗类风湿关节炎的方法
公开(公告)号：US5782792A
公开(公告)日：1998-07-21
申请号：US353946
申请日：1994-12-12
申请人： Frank R. Jones , Harry W. Snyder, Jr. , Joseph P. Balint, Jr.
发明人： Frank R. Jones , Harry W. Snyder, Jr. , Joseph P. Balint, Jr.
IPC分类号： A61M1/34 , A61M1/36 , A61M37/00
CPC分类号： A61M1/3679 , A61M1/3472 , A61M1/3486 , A61M1/3496 , A61M2202/0419
摘要： Rheumatoid arthritis is treated by the extra corporeal removal of IgG and IgG-containing circulating immune complexes from the patient's blood. Removal is preferably accomplished by exposing the blood or blood plasma to a protein A immunoadsorbent which binds to IgG-containing immune complexes with high affinity.
摘要翻译：类风湿关节炎是通过从患者血液中去除IgG和IgG的循环免疫复合物进行额外的体外处理。优选通过将血液或血浆暴露于以高亲和力结合含IgG免疫复合物的蛋白A免疫吸附剂来完成去除。

8. 发明授权

US5037649A Method for treatment of HIV-infected patients 失效
标题翻译：治疗艾滋病毒感染患者的方法
公开(公告)号：US5037649A
公开(公告)日：1991-08-06
申请号：US301214
申请日：1989-01-24
申请人： Joseph P. Balint, Jr. , Frank R. Jones
发明人： Joseph P. Balint, Jr. , Frank R. Jones
IPC分类号： A61M1/36 , B01J20/32 , G01N33/552
CPC分类号： B01J20/3217 , B01J20/3204 , B01J20/3219 , B01J20/3274 , G01N33/552 , A61M1/3679 , Y10S424/81
摘要： Patients suffering from HIV-1 infection, including both those who have and those who have not developed acquired immunodeficiency syndrome, are treated by extracorporeal removal of IgG and immune complexes. An immunoadsorbent material for removing IgG and IgG-complexes from biological fluids is prepared by covalently binding protein A to a solid-phase silica matrix. It has been found that particularly stable, high-capacity immunoadsorbents are obtained by derivatizing the silica with amino and/or carboxyl groups, and reacting the protein A with a carbodiimide at a pH in a range from 3.5 to 4.5. Binding through free hydroxyl groups may be achieved with cyanogen halides at a pH in the range from 11.0 to 11.5. After acid washing (pH 2.0-2.5) to remove non-covalently bound protein A, the immunoadsorbent may be employed in a column for therapeutic treatment of various cancers and autoimmune disorders where IgG-complexes are implicated as suppressing factors in inhibiting a normal immune response.
摘要翻译：患有HIV-1感染的患者，包括那些患有和未发展成熟的免疫缺陷综合征的患者，通过体外去除IgG和免疫复合物进行治疗。通过将蛋白A与固相二氧化硅基质共价结合来制备用于从生物流体中除去IgG和IgG-复合物的免疫吸附材料。已经发现，特别稳定的高容量免疫吸附剂通过用氨基和/或羧基衍生二氧化硅获得，并且使蛋白A与碳二亚胺在3.5至4.5的pH范围内反应。通过游离羟基的结合可以在pH为11.0至11.5范围内的氰卤化物达到。在酸洗（pH2.0-2.5）以除去非共价结合的蛋白A后，免疫吸附剂可用于治疗各种癌症和自身免疫疾病的柱，其中IgG-复合物被认为是抑制正常免疫应答的抑制因子。

9. 发明授权

US5955516A Methods of making dispersible additives for polymeric materials 失效
标题翻译：制造聚合材料分散性添加剂的方法
公开(公告)号：US5955516A
公开(公告)日：1999-09-21
申请号：US810198
申请日：1997-03-03
申请人： Donald Caswell , Frank R. Jones , Stanley A. McIntosh , Gary W. Shore , G. Daniel Gasperson
发明人： Donald Caswell , Frank R. Jones , Stanley A. McIntosh , Gary W. Shore , G. Daniel Gasperson
IPC分类号： C08J3/22 , C08K9/08 , C08K9/10 , D01D1/06 , D01F1/04 , D01F1/10 , D01F6/60 , D01F8/04 , D01F8/12 , D06N7/00 , C08K9/00
CPC分类号： B29C47/0877 , B29C47/0014 , C08J3/226 , C08K9/08 , C08K9/10 , D01D1/065 , D01F1/04 , D01F1/10 , D01F6/60 , D01F8/04 , D01F8/12 , D06N7/0065 , C08J2467/00 , C08J2477/00 , Y10T428/23993 , Y10T428/29 , Y10T428/2927
摘要： Additives for polymeric compositions are prepared by coating pigment with a dispersant, and thereafter dispersing the dispersant-coated pigment in a liquid nonaqeous polymeric carrier. Preferably, the dispersant-coated pigment is spray-dried. That is, most preferably, an aqueous dispersion of the pigment and dispersant is subjected to a spray-drying operation so as to obtain pigment coated with the dispersant. The dispersant-coated pigment will have an average particle size of about 5 .mu.m or greater, but is capable of breaking apart to average particle sizes of about 1 .mu.m or less when dispersed in a polymeric host material.
摘要翻译：通过用分散剂涂覆颜料，然后将分散剂涂覆的颜料分散在液体非聚合物载体中来制备聚合物组合物的添加剂。优选地，分散剂涂覆的颜料被喷雾干燥。也就是说，最优选地，将颜料和分散剂的水分散体进行喷雾干燥操作，以获得涂覆有分散剂的颜料。分散剂涂覆的颜料的平均粒度为约5μm或更大，但当分散在聚合物主体材料中时能够分裂成约1μm或更小的平均粒度。

10. 发明授权

US07019050B2 Alternate dispersants for spray-dried concentrate components 失效
标题翻译：用于喷雾干燥浓缩成分的替代分散剂
公开(公告)号：US07019050B2
公开(公告)日：2006-03-28
申请号：US10613677
申请日：2003-07-03
申请人： Frank R. Jones , Stanley A. McIntosh , Gary W. Shore
发明人： Frank R. Jones , Stanley A. McIntosh , Gary W. Shore
IPC分类号： C08K9/04 , C09B67/08
CPC分类号： C08L33/02 , Y10T428/2998 , C08L2666/04
摘要： Concentrates and method of making concentrates are disclosed. The concentrates may be incorporated into thermoformable articles as a concentrate powder or as a paste. Thermoformable articles, such as fibers, containing the concentrates and methods of making the thermoformable articles are also disclosed.
摘要翻译：公开了浓缩物和浓缩物的制备方法。浓缩物可以作为浓缩粉末或作为糊剂掺入可热成型制品中。还公开了含有浓缩物的热成型制品，例如纤维，以及制造可热成形制品的方法。

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