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    • 9. 发明授权
    • High specific gravity intragastric device
    • 高比重胃内装置
    • US08758385B2
    • 2014-06-24
    • US12645466
    • 2009-12-22
    • John Hancock
    • John Hancock
    • A61M29/00
    • A61F5/0036A61F5/003
    • The teachings are directed to an intragastric device comprising a flexible and expandable bladder having a predetermined shape upon expansion for contacting the antrum of the stomach of a subject. The device is designed to avoid passage of any part of the device beyond the pylorus and lower esophageal sphincter while the bladder is expanded during use. In these embodiments, the bladder can contain a high specific gravity material when expanded; wherein, the high specific gravity material contributes to an in vivo specific gravity of the device that ranges from about 1.2 g/ml to about 2.1 g/ml and functions to direct the device to the pyloric antrum of the subject during use of the device. Moreover, these embodiments can include a filling material comprising a biocompatible fluid component and a hydrogel component to make the device substantially leakproof and contribute to the in vivo specific gravity of the device.
    • 该教导涉及一种胃内装置,其包括在膨胀时具有预定形状的柔性和可膨胀囊,用于接触受试者胃的胃窦。 该装置被设计成在使用过程中膀胱膨胀时避免设备的任何部分超过幽门和食管下括约肌。 在这些实施例中,当膨胀时,气囊可以包含高比重材料; 其中,所述高比重物质有助于所述装置的体内比重为约1.2g / ml至约2.1g / ml,并且用于在使用所述装置期间将所述装置引导至所述受试者的幽门窦。 此外,这些实施方案可以包括包含生物相容性流体组分和水凝胶组分的填充材料,以使得该装置基本上防漏并有助于该装置的体内比重。