专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08475798B2 Monoclonal antibodies recognizing a coagulase-negative staphylococcal protein 有权
标题翻译：识别凝固酶阴性葡萄球菌蛋白的单克隆抗体
公开(公告)号：US08475798B2
公开(公告)日：2013-07-02
申请号：US11917435
申请日：2006-06-16
申请人： Joseph M. Patti , Jeff T. Hutchins , Andrea Hall , Linda Santos , Maria Bowden , Magnus Hook
发明人： Joseph M. Patti , Jeff T. Hutchins , Andrea Hall , Linda Santos , Maria Bowden , Magnus Hook
IPC分类号： A61K39/40 , A61K39/00 , A61K39/395 , G01N33/569
CPC分类号： C07K16/1271 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/92
摘要： Monoclonal antibodies which can bind to the SdrF protein of Staphylococcus epidermidis are provided which can be useful in the treatment and protection against infection from staphylococcal bacteria such as Staphylococcus epidermidis. The monoclonal antibodies of the invention are advantageous in that they can also recognize binding domains and subdomains of the S. epidermidis SdrF protein in addition to the protein itself. Suitable compositions and passive vaccines based on the monoclonal antibodies of the invention, as well as methods for their use, are also provided.
摘要翻译：提供可以结合表皮葡萄球菌的SdrF蛋白的单克隆抗体，其可用于治疗和保护葡萄球菌如表皮葡萄球菌感染。本发明的单克隆抗体是有利的，除了蛋白质本身之外，它们还可以识别表皮葡萄球菌SdrF蛋白的结合结构域和亚结构域。还提供了基于本发明的单克隆抗体的合适的组合物和被动疫苗以及它们的使用方法。

2. 发明申请

US20100183623A1 MONOCLONAL ANTIBODIES RECOGNIZING A COAGULASE-NEGATIVE STAPHYLOCOCCAL PROTEIN 有权
标题翻译：识别凝集素阴性血清白蛋白的单克隆抗体
公开(公告)号：US20100183623A1
公开(公告)日：2010-07-22
申请号：US11917435
申请日：2006-06-16
申请人： Joseph M. Patti , Jeff T. Hutchins , Andrea Hall , Linda Santos , Maria Bowden , Magnus Hook
发明人： Joseph M. Patti , Jeff T. Hutchins , Andrea Hall , Linda Santos , Maria Bowden , Magnus Hook
IPC分类号： A61K39/40 , C07K16/12 , G01N33/569 , A61P31/04
CPC分类号： C07K16/1271 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/92
摘要： Monoclonal antibodies which can bind to the SdrF protein of Staphylococcus epidermidis are provided which can be useful in the treatment and protection against infection from staphylococcal bacteria such as Staphylococcus epidermidis. The monoclonal antibodies of the invention are advantageous in that they can also recognize binding domains and subdomains of the S. epidermidis SdrF protein in addition to the protein itself. Suitable compositions and passive vaccines based on the monoclonal antibodies of the invention, as well as methods for their use, are also provided.
摘要翻译：提供可以结合表皮葡萄球菌的SdrF蛋白的单克隆抗体，其可用于治疗和保护葡萄球菌如表皮葡萄球菌感染。本发明的单克隆抗体是有利的，除了蛋白质本身之外，它们还可以识别表皮葡萄球菌SdrF蛋白的结合结构域和亚结构域。还提供了基于本发明的单克隆抗体的合适的组合物和被动疫苗以及它们的使用方法。

3. 发明授权

US07850974B2 Bioinformatic method for identifying surface-anchored proteins from gram-positive bacteria and proteins obtained thereby 有权
标题翻译：用于从革兰氏阳性细菌和由此获得的蛋白质中鉴定表面锚定蛋白的生物信息学方法
公开(公告)号：US07850974B2
公开(公告)日：2010-12-14
申请号：US12575909
申请日：2009-10-08
申请人： Magnus Hook , Yi Xu , Jouko V. Sillanpaa , Narayana Sthanam , Karthe Ponnuraj , Joseph M. Patti , Jeff T. Hutchins , Andrea Hall , Maria G. Bowden
发明人： Magnus Hook , Yi Xu , Jouko V. Sillanpaa , Narayana Sthanam , Karthe Ponnuraj , Joseph M. Patti , Jeff T. Hutchins , Andrea Hall , Maria G. Bowden
IPC分类号： A61K39/02
CPC分类号： G01N33/56916 , A61K38/00 , C07K14/315 , C07K16/1267 , G01N33/56911 , G06F19/16 , G06F19/22 , Y02A90/26 , Y10S435/975
摘要： A bioinformatic method for identifying and isolating proteins and peptides with MSCRAMM®-like characteristics from Gram positive bacteria, such as Enterococcus, Staphylococcus, Streptococcus and Bacillus bacteria, and proteins and peptides obtained thereby are provided which can be utilized in methods to prevent and treat infections caused by Gram-positive bacteria. The method involves identifying from sequence information those proteins with a putative C-terminal LPXTG (SEQ ID NO:1) cell wall sorting signal and other structural similarities to MSCRAMM® proteins having the LPXTG-anchored cell wall proteins. The MSCRAMM® proteins and immunogenic regions therein that are identified and isolated using the present invention may be useful in the diagnosis, treatment or prevention of Gram positive bacterial infections.
摘要翻译：提供了用于从革兰氏阳性细菌如肠球菌属，葡萄球菌属，链球菌属和芽孢杆菌属细菌鉴定和分离具有MSCRAMM®样特征的蛋白质和肽的生物信息学方法，以及由此得到的蛋白质和肽，其可用于预防和治疗革兰氏阳性菌引起的感染。该方法包括从序列信息中鉴定具有推定的C末端LPXTG（SEQ ID NO：1）细胞壁分选信号的蛋白质和具有LPXTG锚定的细胞壁蛋白质的MSCRAMM®蛋白质的其他结构相似性的蛋白质。使用本发明鉴定和分离的MSCRAMM蛋白质及其免疫原性区域可用于革兰氏阳性细菌感染的诊断，治疗或预防。

4. 发明授权

US07615616B2 Bioinformatic method for identifying surface-anchored proteins from gram-positive bacteria and proteins obtained thereby 有权
标题翻译：用于从革兰氏阳性细菌和由此获得的蛋白质中鉴定表面锚定蛋白的生物信息学方法
公开(公告)号：US07615616B2
公开(公告)日：2009-11-10
申请号：US10661809
申请日：2003-09-15
申请人： Magnus Hook , Yi Xu , Jouko V. Sillanpaa , Narayana Sthanam , Karthe Ponnuraj , Joseph M. Patti , Jeff T. Hutchins , Andrea Hall , Maria G. Bowden
发明人： Magnus Hook , Yi Xu , Jouko V. Sillanpaa , Narayana Sthanam , Karthe Ponnuraj , Joseph M. Patti , Jeff T. Hutchins , Andrea Hall , Maria G. Bowden
IPC分类号： C07K16/00
CPC分类号： G01N33/56916 , A61K38/00 , C07K14/315 , C07K16/1267 , G01N33/56911 , G06F19/16 , G06F19/22 , Y02A90/26 , Y10S435/975
摘要： A bioinformatic method is provided for identifying and isolating proteins with MSCRAMM®—like characteristics from Gram positive bacteria, such as Enterococcus, Staphylococcus, Streptococcus and Bacillus bacteria, which can then be utilized in methods to prevent and treat infections caused by Gram-positive bacteria. The method involves identifying from sequence information those proteins with a putative C-terminal LPXTG (SEQ ID NO:1) cell wall sorting signal and other structural similarities to MSCRAMM® proteins having the LPXTG-anchored cell wall proteins. The MSCRAMM® proteins and immunogenic regions therein that are identified and isolated using the present invention may be used to generate antibodies useful in the diagnosis, treatment or prevention of Gram positive bacterial infections.
摘要翻译：提供了一种生物信息学方法，用于从革兰氏阳性菌（例如肠球菌属，葡萄球菌属，链球菌属和芽孢杆菌属细菌）中鉴定和分离具有类似MSCRAMM（R）样特征的蛋白质，其可用于预防和治疗由革兰氏阴性菌引起的感染的方法，阳性细菌。该方法包括从序列信息中鉴定具有推定的C末端LPXTG（SEQ ID NO：1）细胞壁分选信号的蛋白质和具有LPXTG锚定的细胞壁蛋白质的MSCRAMM蛋白质的其它结构相似性的蛋白质。使用本发明鉴定和分离的MSCRAMM蛋白质及其免疫原性区域可用于产生用于诊断，治疗或预防革兰氏阳性细菌感染的抗体。

5. 发明授权

US08017133B2 Multicomponent vaccines 有权
标题翻译：多组分疫苗
公开(公告)号：US08017133B2
公开(公告)日：2011-09-13
申请号：US12710790
申请日：2010-02-23
申请人： Joseph M. Patti , Timothy J. Foster , Magnus Hook
发明人： Joseph M. Patti , Timothy J. Foster , Magnus Hook
IPC分类号： A61K39/085
CPC分类号： C07K16/1271 , A61K39/085
摘要： Multicomponent vaccines are provided which aid in the prevention and treatment of staphylococcal infections and which include certain selected combinations of bacterial binding proteins or fragments thereof, or antibodies to those proteins or fragments. By careful selection of the proteins, fragments, or antibodies, a vaccine is provided that imparts protection against a broad spectrum of Staphylococcus and other bacterial strains and against proteins that are expressed at different stages of the logarithmic growth curve. In one embodiment of the invention, a composition is provided that includes a fibrinogen binding domain of a fibrinogen binding protein and a bacterial component such as a capsular polysaccharide, and both active and passive vaccines based on these components are also provided, along with methods of treating infection using these compositions and vaccines.
摘要翻译：提供了有助于预防和治疗葡萄球菌感染的多组分疫苗，其包括某些所选择的细菌结合蛋白或其片段的组合，或对那些蛋白质或片段的抗体。通过仔细选择蛋白质，片段或抗体，提供疫苗，其对广泛的葡萄球菌和其他细菌菌株和针对在对数生长曲线的不同阶段表达的蛋白质提供保护。在本发明的一个实施方案中，提供了包括纤维蛋白原结合蛋白的纤维蛋白原结合结构域和诸如荚膜多糖的细菌组分的组合物，以及基于这些组分的主动和被动疫苗以及方法使用这些组合物和疫苗治疗感染。

6. 发明授权

US07045131B2 Staphylococcal immunotherapeutics via donor selection and donor stimulation 有权
公开(公告)号：US07045131B2
公开(公告)日：2006-05-16
申请号：US10091494
申请日：2002-03-07
申请人： Joseph M. Patti , Timothy J. Foster , Magnus Hook
发明人： Joseph M. Patti , Timothy J. Foster , Magnus Hook
IPC分类号： A61K39/085
CPC分类号： A61K9/0019 , A61K39/00 , A61K2039/505 , C07K16/1271 , C07K2317/20 , C07K2317/76
摘要： A method and composition for the passive immunization of patients infected with or susceptible to infection from Staphylococcus bacteria such as S. aureus and S. epidermidis infection is provided that includes the selection or preparation of a donor plasma pool with high antibody titers to carefully selected Staphylococcus adhesins or MSCRAMMs, or fragments or components thereof, or sequences with substantial homology thereto. The donor plasma pool can be prepared by combining individual blood or blood component samples which have higher than normal titers of antibodies to one or more of the selected adhesins or other proteins that bind to extracellular matrix proteins, or by administering carefully selected proteins or peptides to a host to induce the expression of desired antibodies, and subsequently recovering the enhanced high titer serum or plasma pool from the treated host. In either case, the donor plasma pool is preferably purified and concentrated prior to intravenous introduction into the patient, and the present invention is advantageous in that a patient can be immunized against a wide variety of potentially dangerous staphylococcal infections. Kits for identifying potential donor with high titers of the selected adhesins are also provided. The present invention thus provides methods and compositions which can be highly effective against infections associated with Staphylococcus bacteria.

7. 发明授权

US06692739B1 Staphylococcal immunotherapeutics via donor selection and donor stimulation 有权
标题翻译：葡萄球菌免疫治疗通过供体选择和供体刺激
公开(公告)号：US06692739B1
公开(公告)日：2004-02-17
申请号：US09386960
申请日：1999-08-31
申请人： Joseph M. Patti , Timothy J. Foster , Magnus Hook
发明人： Joseph M. Patti , Timothy J. Foster , Magnus Hook
IPC分类号： A61K39395
CPC分类号： A61K9/0019 , A61K39/00 , A61K2039/505 , C07K16/1271 , C07K2317/20 , C07K2317/76
摘要： A method and composition for the passive immunization of patients infected with or susceptible to infection from Staphylococcus bacteria such as S. aureus and S. epidermidis infection is provided that includes the selection or preparation of a donor plasma pool with high antibody titers to carefully selected Staphylococcus adhesins or MSCRAMMs, or fragments or components thereof, or sequences with substantial homology thereto. The donor plasma pool can be prepared by combining individual blood or blood component samples which have higher than normal titers of antibodies to one or more of the selected adhesins or other proteins that bind to extracellular matrix proteins, or by administering carefully selected proteins or peptides to a host to induce the expression of desired antibodies, and subsequently recovering the enhanced high titer serum or plasma pool from the treated host. In either case, the donor plasma pool is preferably purified and concentrated prior to intravenous introduction into the patient, and the present invention is advantageous in that a patient can be immunized against a wide variety of potentially dangerous staphylococcal infections. Kits for identifying potential donor with high titers of the selected adhesins are also provided. The present invention thus provides methods and compositions which can be highly effective against infections associated with Staphylococcus bacteria.
摘要翻译：提供了感染或易感染葡萄球菌如金黄色葡萄球菌和表皮葡萄球菌感染的患者的被动免疫的方法和组合物，其包括选择或制备具有高抗体滴度的供体血浆池以精心选择的葡萄球菌粘附素或MSCRAMM，或其片段或组分，或与其基本上同源的序列。供体血浆池可以通过将具有高于正常滴度的抗体的单个血液或血液成分样品与一种或多种所选择的粘附素或与细胞外基质蛋白结合的其它蛋白质组合，或通过将仔细选择的蛋白质或肽给予诱导所需抗体表达的宿主，随后从被处理的宿主中回收增强的高效价血清或血浆池。在任一情况下，供体血浆池优选在静脉内引入患者体内之前进行纯化和浓缩，本发明的优点在于可以免疫多种潜在危险的葡萄球菌感染。还提供了用于鉴定具有高滴度选择的粘附素的潜在供体的试剂盒。因此，本发明提供了可以高效地抵抗与葡萄球菌细菌相关的感染的方法和组合物。

8. 发明授权

US07666438B1 Multicomponent vaccines 有权
标题翻译：多组分疫苗
公开(公告)号：US07666438B1
公开(公告)日：2010-02-23
申请号：US10795267
申请日：2004-03-09
申请人： Joseph M. Patti , Timothy J. Foster , Magnus Hook
发明人： Joseph M. Patti , Timothy J. Foster , Magnus Hook
IPC分类号： A61K39/085
CPC分类号： C07K16/1271 , A61K39/085
摘要： Multicomponent vaccines are provided which aid in the prevention and treatment of staphylococcal infections and which include certain selected combinations of bacterial binding proteins or fragments thereof, or antibodies to those proteins or fragments. By careful selection of the proteins, fragments, or antibodies, a vaccine is provided that imparts protection against a broad spectrum of Staphylococcus and other bacterial strains and against proteins that are expressed at different stages of the logarithmic growth curve. In one embodiment of the invention, a composition is provided that includes a fibrinogen binding domain of a fibrinogen binding protein and a bacterial component such as ca capsular polysaccharide, and both active and passive vaccines based on these components are also provided, along with methods of treating infection using these compositions and vaccines.
摘要翻译：提供了有助于预防和治疗葡萄球菌感染的多组分疫苗，其包括某些所选择的细菌结合蛋白或其片段的组合，或对那些蛋白质或片段的抗体。通过仔细选择蛋白质，片段或抗体，提供疫苗，其对广泛的葡萄球菌和其他细菌菌株和针对在对数生长曲线的不同阶段表达的蛋白质提供保护。在本发明的一个实施方案中，提供了包含纤维蛋白原结合蛋白的纤维蛋白原结合结构域和诸如ca荚膜多糖的细菌组分的组合物，并且还提供了基于这些组分的主动和被动疫苗以及两者的方法使用这些组合物和疫苗治疗感染。

9. 发明授权

US06703025B1 Multicomponent vaccines 有权
标题翻译：多组分疫苗
公开(公告)号：US06703025B1
公开(公告)日：2004-03-09
申请号：US09386959
申请日：1999-08-31
申请人： Joseph M. Patti , Timothy J. Foster , Magnus Hook
发明人： Joseph M. Patti , Timothy J. Foster , Magnus Hook
IPC分类号： A61K39085
CPC分类号： C07K16/1271 , A61K39/085
摘要： Multicomponent vaccines are provided which aid in the prevention and treatment of staphylococcal infections and which include certain selected combinations of bacterial binding proteins or fragments thereof, or antibodies to those proteins or fragments. By careful selection of the proteins, fragments, or antibodies, a vaccine is provided that imparts protection against a broad spectrum of Staphylococcus bacterial strains and against proteins that are expressed at different stages of the logarithmic growth curve. In one embodiment of the invention, a composition is provided that includes at least a collagen binding protein or peptide (or an appropriate site directed mutated sequence thereof) such as CNA, or a protein or fragment with sufficiently high homology thereto, in combination with a fibrinogen binding protein, preferably Clumping factor A (“ClfA”) or Clumping factor B (“ClfB”), or a useful fragment thereof or a protein or fragment with sufficiently high homology thereto. The vaccines and products of the present invention are advantageous in that they respond to the urgent need of the medical community for a substitute for small molecule antibiotics, which are rapidly losing effectiveness and provide effective combinations of the large number of known bacterial surface adhesins which can impart effective protection against a broad spectrum of bacterial infections.
摘要翻译：提供了有助于预防和治疗葡萄球菌感染的多组分疫苗，其包括某些所选择的细菌结合蛋白或其片段的组合，或对那些蛋白质或片段的抗体。通过仔细选择蛋白质，片段或抗体，提供疫苗，其对广泛的葡萄球菌细菌菌株和针对在对数生长曲线的不同阶段表达的蛋白质提供保护。在本发明的一个实施方案中，提供了一种组合物，其包含至少一种胶原结合蛋白或肽（或其适当的定点突变的序列），例如CNA或与其具有足够高同源性的蛋白质或片段，与纤维蛋白原结合蛋白，优选结合因子A（“ClfA”）或凝集因子B（“ClfB”）或其有用片段或与其同源性具有足够高同源性的蛋白质或片段。本发明的疫苗和产品是有利的，因为它们响应医学界迫切需要替代小分子抗生素，其正在快速丧失有效性并提供大量已知细菌表面粘附素的有效组合，其可以有效保护免受广泛的细菌感染。

10. 发明授权

US07241592B2 Cross-reactive displacing antibodies from collagen-binding proteins and method of identification and use 有权
标题翻译：来自胶原蛋白结合蛋白的交叉反应置换抗体及鉴定和使用方法
公开(公告)号：US07241592B2
公开(公告)日：2007-07-10
申请号：US09810428
申请日：2001-03-19
申请人： Magnus Hook , Yi Xu , Pietro Speziale , Livia Visal , Fabrizia Casolini , Joseph M. Patti , Pratiksha Patel , Paul Domanski
发明人： Magnus Hook , Yi Xu , Pietro Speziale , Livia Visal , Fabrizia Casolini , Joseph M. Patti , Pratiksha Patel , Paul Domanski
IPC分类号： C12P21/08 , C12N1/00 , A61K39/395 , A61K39/40 , C07K16/12
CPC分类号： C07K16/1271 , A61K39/085 , A61K2039/505 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/56938 , G01N2333/31 , G01N2333/78 , G01N2500/00
摘要： Antibodies to the CNA protein and to other regions from the collagen binding domain, including domain CNA19, are provided, and antibodies produced in this manner have been shown to be cross reactive to both Staphylococcus aureus and Staphylococcus epidermidis bacteria and which can thus be used in the prevention and treatment of infections caused by both of these types of bacteria. In addition, medical instruments can be treated using the antibodies of the invention in order to reduce or eliminate the possibility of their becoming infected or further spreading the infection. In particular, the proteins are advantageous because they are cross-reactive and may thus be administered to patients so as to reduce or prevent severe infection by staphylococcal bacteria of more than one species. Antibodies generated in this manner have also been shown to exhibit displacement activity and can thus be utilized advantageously in methods wherein these antibodies will be administered to patients having pre-existing staphylococcal infections because of the ability to displace bacterial proteins from binding sites on the extracellular matrix. Finally, a method of identifying, isolating and utilizing displacing antibodies is also provided.
摘要翻译：提供了对CNA蛋白和来自胶原结合结构域的其他区域（包括结构域CNA19）的抗体，并且以这种方式产生的抗体已显示与金黄色葡萄球菌和表皮葡萄球菌交叉反应，因此可以用于预防和治疗由这两种细菌引起的感染。此外，可以使用本发明的抗体治疗医疗器械，以便减少或消除它们被感染或进一步扩散感染的可能性。特别地，蛋白质是有利的，因为它们是交叉反应性的，并且因此可以施用于患者，以便减少或预防多于一种物种的葡萄球菌细菌的严重感染。以这种方式产生的抗体也已显示出显示置换活性，因此可有利地用于其中将这些抗体施用于具有预先存在的葡萄球菌感染的患者的方法，因为能够从细胞外基质上的结合位点置换细菌蛋白质。最后，还提供了鉴定，分离和利用置换抗体的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式