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1. 发明授权

US5331073A Polymeric compositions and intraocular lenses made from same 失效
标题翻译：聚合物组合物和由其制成的人工晶状体
公开(公告)号：US5331073A
公开(公告)日：1994-07-19
申请号：US973470
申请日：1992-11-09
申请人： Joseph I. Weinschenk, III , F. Richard Christ
发明人： Joseph I. Weinschenk, III , F. Richard Christ
IPC分类号： G02C7/04 , A61F2/16 , A61L27/00 , A61L27/16 , C08L33/04 , C08L101/00 , G02B1/04 , C08F226/10 , C08F212/08 , C08F220/10 , C08F220/54
CPC分类号： G02B1/043 , A61L27/16 , A61F2/16 , A61L2430/16
摘要： New high refractive index polymeric compositions and foldable intraocular lenses made from such compositions are disclosed. In one embodiment, the present compositions comprise a copolymer including a major amount of a first constituent derived from a first monomeric component the homopolymers of which have a refractive index of at least about 1.50, a minor amount of a second constituent derived from a second monomeric component other than the first monomeric component the homopolymers of which have a glass transition temperature of less than about 300.degree. C., preferably less than about 220.degree. C., and a third constituent derived from a crosslinking monomeric component in an amount effective to facilitate returning a deformed intraocular lens made of the composition to its original shape.
摘要翻译：公开了由这样的组合物制成的新的高折射率聚合物组合物和可折叠眼内透镜。在一个实施方案中，本发明组合物包含共聚物，其包含主要量的第一组分，其衍生自具有至少约1.50的折射率的均聚物的第一单体组分，少量衍生自第二单体的第二组分其组分不是第一单体组分，其均聚物具有小于约300℃，优选小于约220℃的玻璃化转变温度，以及衍生自交联单体组分的第三组分，其量有效促进将由所述组合物制成的变形的人工晶状体返回到其原始形状。

2. 发明授权

US5359021A Polymeric compositions and intraocular lenses made from same 失效
标题翻译：聚合物组合物和由其制成的人工晶状体
公开(公告)号：US5359021A
公开(公告)日：1994-10-25
申请号：US123016
申请日：1993-09-16
申请人： Joseph I. Weinschenk, III , F. Richard Christ
发明人： Joseph I. Weinschenk, III , F. Richard Christ
IPC分类号： G02C7/04 , A61F2/16 , A61L27/00 , A61L27/16 , C08L33/04 , C08L101/00 , G02B1/04 , C08F226/10 , C08F212/08 , C08F220/10 , C08F220/54
CPC分类号： G02B1/043 , A61L27/16 , A61F2/16 , A61L2430/16
摘要： New high refractive index polymeric compositions and foldable intraocular lenses made from such compositions are disclosed. In one embodiment, the present compositions comprise a copolymer including a major amount of a first constituent derived from a first monomeric component the homopolymers of which have a refractive index of at least about 1.50, a minor amount of a second constituent derived from a second monomeric component other than the first monomeric component the homopolymers of which have a glass transition temperature of less than about 30.degree. C., preferably less than about 22.degree. C., and a third constituent derived from a crosslinking monomeric component in an amount effective to facilitate returning a deformed intraocular lens made of the composition to its original shape.
摘要翻译：公开了由这样的组合物制成的新的高折射率聚合物组合物和可折叠眼内透镜。在一个实施方案中，本发明组合物包含共聚物，其包含主要量的第一组分，其衍生自具有至少约1.50的折射率的均聚物的第一单体组分，少量衍生自第二单体的第二组分其组分不是第一单体组分，其均聚物的玻璃化转变温度低于约30℃，优选小于约22℃，第三组分衍生自交联单体组分，其量有效促进将由所述组合物制成的变形的人工晶状体返回到其原始形状。

3. 发明授权

US5984889A Apparatus and method for delivering viscoelastic material to an eye 失效
标题翻译：将粘弹性材料输送到眼睛的装置和方法
公开(公告)号：US5984889A
公开(公告)日：1999-11-16
申请号：US832460
申请日：1997-04-02
申请人： F. Richard Christ , Edward R. Zaleski
发明人： F. Richard Christ , Edward R. Zaleski
IPC分类号： A61F9/00 , A61F9/007 , A61B17/20
CPC分类号： A61F9/00745 , A61F9/0008
摘要： A phacoemulsification handpiece for ophthalmic surgical procedures includes a needle having a tip and connected to a source of ultrasonic energy, for cutting and/or fragmenting eye tissue along with a conduit for introducing irrigation fluid proximate the needle tip. The handpiece also includes separate structure for introducing a viscous fluid, such as a viscoelastic material, proximate the needle tip as well as bore through the needle and handpiece for aspirating irrigation fluid, viscoelastic material end cut and/or fragmented eye tissue. An accumulator, connected to the housing is provided for containing a supply of viscous fluid. A diaphragm assembly and a manual valve are provided for delivering viscous material to the needle tip.
摘要翻译：用于眼科外科手术的晶状体乳化手术包括具有尖端并连接到超声能量源的针，用于将眼组织连同用于在针尖附近引入冲洗流体的导管切割和/或碎裂。手持件还包括用于在针尖附近引入诸如粘弹性材料的粘性流体以及穿过针头和手持件以吸入冲洗流体，粘弹性材料端部切割和/或碎裂眼组织的单独结构。连接到壳体的蓄能器被提供用于容纳粘性流体供应。提供隔膜组件和手动阀，用于将粘性材料输送到针尖。

4. 发明授权

US5647409A On-site syringe filling apparatus for viscoelastic materials, and corresponding method for on-site syringe filling 失效
标题翻译：用于粘弹性材料的现场注射器灌装装置及相应的现场注射器灌装方法
公开(公告)号：US5647409A
公开(公告)日：1997-07-15
申请号：US416101
申请日：1995-04-04
申请人： F. Richard Christ , Erick F. Fischer , Kenneth E. Kadziauskas
发明人： F. Richard Christ , Erick F. Fischer , Kenneth E. Kadziauskas
IPC分类号： B65B3/00 , B65B1/04
CPC分类号： B65B3/003
摘要： An automated, syringe filling apparatus is disclosed for the on-site filling of syringes with a viscoelastic fluid material from a supply reservoir. A housing has a port for receiving the outlet end region of the viscoelastic supply reservoir and a retainer is provided for releasably retaining a conventional syringe to be filled from the viscoelastic supply reservoir. A flexible plastic tube, preferably formed as part of the viscoelastic supply reservoir, is used to interconnect the supply reservoir with a filling end of a syringe retained in the syringe retainer. A peristaltic pump mounted in the housing has a rotating head with a plurality of rollers which force the viscoelastic material through the tube from the supply reservoir into a retained syringe when the tube is locked between the pump head and a back-up member. Electric pump controls include a timer calibrated for causing the automatic filling of the syringe with predetermined amounts of viscoelastic material from the supply reservoir. The controls include a sensor that automatically shuts off the pump when a syringe being filled is filled to a preestablished maximum level. An air pump is provided for pressurizing the viscoelastic supply reservoir to aid in the viscoelastic pumping operation and insure against air voids being formed in a syringe being filled. A corresponding method is disclosed for the on-site filling of a syringe with a viscoelastic fluid form a supply reservoir.
摘要翻译：公开了一种自动注射器填充装置，用于从供应储存器用粘弹性流体材料现场填充注射器。壳体具有用于接收粘弹性供应储存器的出口端区域的端口，并且设置有用于可释放地保持要从粘弹性供应储存器填充的常规注射器的保持器。优选地形成为粘弹性供应储存器的一部分的柔性塑料管用于将供应储存器与保持在注射器保持器中的注射器的填充端相互连接。安装在壳体中的蠕动泵具有带有多个辊的旋转头，当管被锁定在泵头和支撑构件之间时，多个辊将粘弹性材料通过管从供给储器插入保持的注射器。电动泵控制器包括定时器，该定时器被校准为使来自供应储存器的预定量的粘弹性材料自动填充注射器。控制器包括一个传感器，当填充的注射器填充到预先建立的最大水平时，该传感器会自动关闭泵。提供一个空气泵用于对粘弹性供应容器进行加压以帮助进行粘弹性泵送操作，并确保在填充的注射器中形成的空气空隙。公开了一种相应的方法用于现场填充具有形成供应储器的粘弹性流体的注射器。

5. 发明授权

US4880426A Haptic to optic attachment for a soft IOL 失效
标题翻译：触觉为软IOL的光学附件
公开(公告)号：US4880426A
公开(公告)日：1989-11-14
申请号：US228709
申请日：1988-08-04
申请人： Albert C. Ting , Timothy R. Willis , F. Richard Christ , Steven R. Bacich , Dean K. Pettit , Stanley L. Van Gent , Jeffrey C. Day
发明人： Albert C. Ting , Timothy R. Willis , F. Richard Christ , Steven R. Bacich , Dean K. Pettit , Stanley L. Van Gent , Jeffrey C. Day
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61F2/1608
摘要： A method of making an intraocular lens including providing a fixation member having a proximal end portion with the proximal end portion including an elongated filament, converting a region of said filament at said proximal end portion from a first configuration into a second configuration which is adapted to provide a mechanical interlock and molding an optic about the proximal end portion of the fixation member to form a mechanical interlock between the second configuration and the optic and to attach the fixation member to the optic.
摘要翻译：一种制造眼内透镜的方法，包括提供具有近端部分的固定构件，其基端部分包括细长细丝，将所述近端部分处的所述细丝的区域从第一构型转换成适于提供机械互锁并围绕固定构件的近端部分模制光学器件，以在第二构造和光学元件之间形成机械互锁并将固定构件附接到光学元件。

6. 发明授权

US4834751A Staking ring for soft IOL 失效
标题翻译：松软戒指为IOL
公开(公告)号：US4834751A
公开(公告)日：1989-05-30
申请号：US804674
申请日：1985-12-04
申请人： Patricia M. Knight , Vladimir Portnoy , F. Richard Christ , Alan E. Alosio , Stanley L. Van Gent , Lyle E. Paul
发明人： Patricia M. Knight , Vladimir Portnoy , F. Richard Christ , Alan E. Alosio , Stanley L. Van Gent , Lyle E. Paul
IPC分类号： A61F2/16 , A61L2/16
CPC分类号： A61F2/1613 , A61F2002/1686
摘要： An intraocular lens comprising a deformable optic and first and second fixation members. Each of the fixation members has a proximal end portion. First and second elongated anchors are coupled to the proximal end portions of the fixation members, respectively, and the anchors and the proximal end portions are within peripheral regions of the optic so that the anchors can assist in attaching the fixation members to the optic. The anchors are spaced apart so that the deformable optic can be folded to facilitate insertion of the optic through a relatively small incision into the eye.
摘要翻译：一种眼内透镜，包括可变形光学元件和第一和第二固定构件。每个固定构件具有近端部分。第一和第二细长锚固件分别联接到固定构件的近端部分，并且锚固件和近端部分在光学元件的周边区域内，使得锚固件可以帮助将固定构件附接到光学元件。锚定件间隔开，使得可变形的光学元件可被折叠以便于光学元件通过相对较小的切口插入到眼睛中。

7. 发明授权

US06254587B1 Method for delivering viscoelastic material to an eye 失效
标题翻译：将粘弹性材料输送到眼睛的方法
公开(公告)号：US06254587B1
公开(公告)日：2001-07-03
申请号：US09395546
申请日：1999-09-11
申请人： F. Richard Christ , Edward R. Zaleski
发明人： F. Richard Christ , Edward R. Zaleski
IPC分类号： A61M3100
CPC分类号： A61F9/00745 , A61F9/0008
摘要： A phacoemulsification handpiece for ophthalmic surgical procedures includes a needle having a tip and connected to a source of ultrasonic energy, for cutting and/or fragmenting eye tissue along with a conduit for introducing irrigation fluid proximate the needle tip. The handpiece also includes separate structure for introducing a viscous fluid, such as a viscoelastic material, proximate the needle tip as well as bore through the needle and handpiece for aspirating irrigation fluid, viscoelastic material end cut and/or fragmented eye tissue. An accumulator, connected to the housing is provided for containing a supply of viscous fluid. A diaphragm assembly and a manual valve are provided for delivering viscous material to the needle tip.
摘要翻译：用于眼科外科手术的晶状体乳化手术包括具有尖端并连接到超声能量源的针，用于将眼组织连同用于在针尖附近引入冲洗流体的导管切割和/或碎裂。手持件还包括用于在针尖附近引入诸如粘弹性材料的粘性流体以及穿过针头和手持件以吸入冲洗流体，粘弹性材料端部切割和/或碎裂眼组织的单独结构。连接到壳体的蓄能器被提供用于容纳粘性流体供应。提供隔膜组件和手动阀，用于将粘性材料输送到针尖。

8. 发明授权

US6162393A Contact lens and ophthalmic solutions 有权
标题翻译：隐形眼镜和眼科解决方案
公开(公告)号：US6162393A
公开(公告)日：2000-12-19
申请号：US130542
申请日：1998-08-06
申请人： Chris De Bruiju , F. Richard Christ , Anthony J. Dziabo , Joseph Vigh
发明人： Chris De Bruiju , F. Richard Christ , Anthony J. Dziabo , Joseph Vigh
IPC分类号： G02C13/00 , A61K36/28 , A61K36/45 , A61L2/18 , A61L12/08 , A61L12/14 , C11D3/00 , C11D3/06 , C11D3/10 , C11D3/20 , C11D3/22 , C11D3/33 , C11D3/36 , C11D3/37 , C11D3/382 , C11D3/48 , C11D7/44
CPC分类号： A61L12/08 , A61L12/14 , A61L12/143 , C11D3/0078 , C11D3/382 , C11D7/44 , Y10S514/839 , Y10S514/84
摘要： Benzyldimethyl {2-[2-(p-1,1,3,3-tetramethylbutylphenoxy)ethoxy]ethyl} ammonium chloride (BDT) forms the basis of contact lens solutions that are unusually effective at reducing the number and wide variety of pathogenic microorganisms that may infect rigid gas permeable or soft contact lenses. Furthermore, it has been discovered that natural occurring compounds alone and in combination with chemical agents can be used in ophthalmic solutions such as contact lens solution to enhance and complement their anti-microbial, cleaning and wetting activity or to reduce irritation to the eye. The basic contact lens solution comprises an effective concentration of BDT (preferably 1 to 100 parts per million), with naturally occurring plant products possessing activities complementary to BDT, in an isotonic diluent buffered with a physiologically acceptable buffer to a physiologically natural range.
摘要翻译：苄基二甲基{2- [2-（对1,1,3,3-四甲基丁基苯氧基）乙氧基]乙基}氯化铵（BDT）形成隐形眼镜溶液的基础，其在减少病原微生物数量和多样性方面异常有效这可能会感染刚性透气或软性隐形眼镜。此外，已经发现天然存在的化合物单独和与化学剂组合可以用于眼用溶液如隐形眼镜溶液中，以增强和补充其抗微生物，清洁和润湿活性或减少对眼睛的刺激。基本隐形眼镜溶液包含有效浓度的BDT（优选1至100份/百万份），天然存在的植物产品具有与BDT互补的活性，在用生理学上可接受的缓冲液缓冲至生理天然范围内的等渗稀释剂中。

9. 发明授权

US5344449A Intraocular lenses, fixation member assemblies and methods for making same 失效
标题翻译：人工晶状体，固定构件组件及其制造方法
公开(公告)号：US5344449A
公开(公告)日：1994-09-06
申请号：US88066
申请日：1993-07-06
申请人： F. Richard Christ , James E. Francese , Bernard F. Grisoni
发明人： F. Richard Christ , James E. Francese , Bernard F. Grisoni
IPC分类号： A61F2/16 , A61L27/14 , B29C59/14 , B29D11/02
CPC分类号： B29D11/023 , A61L27/14 , A61F2002/1686 , B29C59/14
摘要： New intraocular lenses, fixation member assemblies for use in such lenses and methods for making the same are disclosed. In one embodiment, the present invention involves a method for producing a fixation member assembly which comprises exposing a fixation member component to a first plasma at conditions effective to enhance, relative to a substantially identical fixation member component which is not subjected to the exposing step, the bondability between the fixation member component and a polymeric coating to be located on the fixation member component; and exposing the fixation member to a second plasma in the presence of at least one material selected from polymeric components, polymerizable components and mixtures thereof at conditions effective to form the polymeric coating located on the fixation member component. Enhanced bondability between the polymeric coating-containing fixation member component and the optic of the intraocular lens and/or enhanced biocompatibility are preferably provided.
摘要翻译：公开了新的眼内透镜，用于这种透镜的固定构件组件及其制造方法。在一个实施例中，本发明涉及一种用于制造固定构件组件的方法，该方法包括：将固定构件组件暴露于第一等离子体，其条件是有效地相对于基本上相同的不经过曝光步骤的固定构件部件，固定构件部件和位于固定构件部件上的聚合物涂层之间的粘合性; 以及在有效地形成位于固定构件部件上的聚合物涂层的条件下，在选自聚合物组分，可聚合组分及其混合物中的至少一种材料的存在下将固定构件暴露于第二等离子体。优选提供增强的含聚合物涂层的固定构件组件和眼内透镜的光学元件之间的粘合性和/或增强的生物相容性。

10. 发明授权

US5262097A Methods for attaching fixation members to optics of intraocular lenses 失效
标题翻译：将固定部件固定在眼内透镜的光学部件上的方法
公开(公告)号：US5262097A
公开(公告)日：1993-11-16
申请号：US824556
申请日：1992-01-23
申请人： F. Richard Christ , James E. Francese , Bernard F. Grisoni
发明人： F. Richard Christ , James E. Francese , Bernard F. Grisoni
IPC分类号： A61F2/16 , A61L27/14 , A61L27/34 , B29C59/14 , B29D11/02 , B29D11/00
CPC分类号： B29D11/023 , A61L27/14 , A61L27/34 , A61F2002/1686 , A61L2400/18 , B29C59/14
摘要： New intraocular lenses, fixation member assemblies for use in such lenses and methods for making the same. In one embodiment, the present invention involves a method for producing a fixation member assembly which includes exposing a fixation member component to a first plasma at conditions effective to enhance, relative to a substantially identical fixation member component which is not subjected to the exposing step, the bondability between the fixation member component and a polymeric coating to be located on the fixation member component; and exposing the fixation member to a second plasma in the presence of at least one material selected from polymeric components, polymerizable components and mixtures thereof at conditions effective to form the polymeric coating located on the fixation member component. Enhanced bondability between the polymeric coating-containing fixation member component and the optic of the intraocular lens and/or enhanced biocompatibility are preferably provided.
摘要翻译：新的眼内透镜，用于这种透镜的固定构件组件及其制造方法。在一个实施例中，本发明涉及一种用于生产固定构件组件的方法，该方法包括：将固定构件部件暴露于第一等离子体，其条件是有效地相对于不经受曝光步骤的基本上相同的固定构件部件，固定构件部件和位于固定构件部件上的聚合物涂层之间的粘合性; 以及在有效地形成位于固定构件部件上的聚合物涂层的条件下，在选自聚合物组分，可聚合组分及其混合物中的至少一种材料的存在下将固定构件暴露于第二等离子体。优选提供增强的含聚合物涂层的固定构件组件和眼内透镜的光学元件之间的粘合性和/或增强的生物相容性。

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