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1. 发明授权

US06518259B1 Compositions for treating autoimmune disease 失效
标题翻译：用于治疗自身免疫性疾病的组合物
公开(公告)号：US06518259B1
公开(公告)日：2003-02-11
申请号：US09575612
申请日：2000-05-22
申请人： Joseph Holoshitz , James A. Shayman , Shi-Yu Tan
发明人： Joseph Holoshitz , James A. Shayman , Shi-Yu Tan
IPC分类号： A61K3166
CPC分类号： A61K31/13 , A61K31/131 , A61K31/14 , A61K31/352
摘要： Methods and compositions are described for treating and diagnosing autoimmune diseases, and in particular for treating and detecting rheumatoid arthritis. Treatment is described with a new class of anti-RA drug, namely compounds that inhibit proliferation and induce apoptosis.
摘要翻译：描述了用于治疗和诊断自身免疫性疾病，特别是用于治疗和检测类风湿性关节炎的方法和组合物。用新型抗RA药物即抑制增殖和诱导凋亡的化合物来描述治疗。

2. 发明授权

US06098631A Compositions and methods for treating autoimmune disease 失效
公开(公告)号：US06098631A
公开(公告)日：2000-08-08
申请号：US9906
申请日：1998-01-21
申请人： Joseph Holoshitz , James A. Shayman , Shi-Yu Tan
发明人： Joseph Holoshitz , James A. Shayman , Shi-Yu Tan
IPC分类号： A61K31/13 , A61K31/131 , A61K31/14 , A61K31/352 , A61B19/00
CPC分类号： A61K31/13 , A61K31/131 , A61K31/14 , A61K31/352
摘要： Methods and compositions are described for treating and diagnosing autoimmune diseases, and in particular for treating and detecting rheumatoid arthritis. Treatment is described with a new class of anti-RA drug, namely compounds that inhibit proliferation and induce apoptosis.

3. 发明申请

US20120034252A1 COMPOSITIONS AND METHODS FOR INDUCING AN IMMUNE RESPONSE 审中-公开
标题翻译：用于诱导免疫应答的组合物和方法
公开(公告)号：US20120034252A1
公开(公告)日：2012-02-09
申请号：US13162382
申请日：2011-06-16
申请人： Joseph Holoshitz , Song Ling , Xiujun Pi , Denise de Almeida
发明人： Joseph Holoshitz , Song Ling , Xiujun Pi , Denise de Almeida
IPC分类号： A61K39/00 , A61P37/04 , C07K7/06
CPC分类号： A61K39/39 , A61K38/08 , A61K2039/55516 , C07K14/005
摘要： The present invention provides compositions and methods for inducing an immune response in a subject. In particular, the present invention provides compositions comprising immunostimulatory ligands (ISL) and methods of inducing an immune response in a subject therewith. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.
摘要翻译：本发明提供了用于在受试者中诱导免疫应答的组合物和方法。特别地，本发明提供包含免疫刺激配体（ISL）的组合物以及在其受试者中诱导免疫应答的方法。本发明的组合物和方法尤其可用于临床（例如治疗和预防性药物（例如疫苗接种））和研究应用。

4. 发明授权

US07074893B2 Methods and compositions for the treatment of diseases associated with signal transduction aberrations 失效
公开(公告)号：US07074893B2
公开(公告)日：2006-07-11
申请号：US10786774
申请日：2004-02-25
申请人： Joseph Holoshitz , Song Ling
发明人： Joseph Holoshitz , Song Ling
IPC分类号： A61K38/04
CPC分类号： A61K38/08 , A61K38/10
摘要： The present invention relates generally to therapeutic methods and compositions. More particularly, methods and compositions to counteract and reverse disease-causing signaling defects in diseases with underlying signal transduction aberrations, including but not limited to Alzheimer's Disease.

5. 发明申请

US20050013820A1 Methods and compositions for the treatment of MHC-associated conditions 有权
标题翻译：用于治疗MHC相关病症的方法和组合物
公开(公告)号：US20050013820A1
公开(公告)日：2005-01-20
申请号：US10845407
申请日：2004-05-13
申请人： Joseph Holoshitz , Song Ling
发明人： Joseph Holoshitz , Song Ling
IPC分类号： A61K38/08 , A61K38/10 , A61K39/395 , A61K39/00
CPC分类号： A61K38/08 , A61K38/10
摘要： The present invention relates to methods and compositions for counteracting and reversing disease-causing signaling defects in disorders with underlying signal transduction aberrations, including but not limited to rheumatoid arthritis.
摘要翻译：本发明涉及用于抵消和逆转疾病引起的信号缺陷的方法和组合物，其具有潜在的信号转导异常（包括但不限于类风湿性关节炎）。

6. 发明申请

US20120141516A1 COMPOSITIONS AND METHODS FOR INDUCING AN IMMUNE RESPONSE 有权
公开(公告)号：US20120141516A1
公开(公告)日：2012-06-07
申请号：US13331354
申请日：2011-12-20
申请人： Joseph Holoshitz , Song Ling , Xiujun Pi , Denise de Almeida
发明人： Joseph Holoshitz , Song Ling , Xiujun Pi , Denise de Almeida
IPC分类号： A61K39/00 , C07K19/00 , A61P31/04 , A61P37/04 , A61P35/00 , C07K7/06 , A61K39/02
CPC分类号： A61K39/00 , A61K39/0011 , A61K39/02 , A61K39/04 , A61K39/39 , A61K2039/55566 , A61K2039/57 , C07K7/06 , C07K14/70539
摘要： The present invention provides compositions and methods for inducing an immune response in a subject. In particular, the present invention provides compositions comprising immunostimulatory ligands (ISL) and methods of inducing an immune response in a subject therewith. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.

7. 发明申请

US20050215529A1 Method of treating oxidative stress-associated conditions with isopentenyl diphosphate 审中-公开
标题翻译：用异戊烯基二磷酸处理氧化应激相关病症的方法
公开(公告)号：US20050215529A1
公开(公告)日：2005-09-29
申请号：US11085298
申请日：2005-03-21
申请人： Joseph Holoshitz , Jie Zheng
发明人： Joseph Holoshitz , Jie Zheng
IPC分类号： A61K31/66
CPC分类号： A61K31/66
摘要： It has been found that isopentenyl diphosphate possesses antioxidant effects 1000 to 10,000 times more potent than classical antioxidants, such as ascorbic acid, β-carotene, and α-tocopherol, and 100 times more potent than 2-chloroadenosine. With such high potency, as disclosed herein, isopentenyl diphosphate can be used to treat or prevent one or more oxidative stress-associated conditions by administering to a host, and preferably a human being, in need thereof a therapeutically effective amount of a pharmaceutical composition containing isopentenyl diphosphate or a pharmaceutically acceptable salt thereof. Additionally, isopentenyl diphosphate can be used to treat or prevent oxidative stress-associated damage to a biomolecule by administering isopentenyl diphosphate or a pharmaceutically acceptable salt thereof to the biomolecule.
摘要翻译：已经发现，异戊烯基二磷酸酯具有抗氧化效果比经典抗氧化剂如抗坏血酸，β-胡萝卜素和α-生育酚强效1000至10,000倍，比2-氯腺苷高100倍。如本文所公开的，具有如此高的效力，异戊烯基二磷酸可用于治疗或预防一种或多种氧化应激相关病症，其通过向有需要的宿主，优选人类施用治疗有效量的含有异戊烯基二磷酸酯或其药学上可接受的盐。另外，异戊烯二磷酸可用于通过向生物分子施用异戊烯基二磷酸或其药学上可接受的盐来治疗或预防与生物分子的氧化应激相关的损伤。

8. 发明授权

US08658603B2 Compositions and methods for inducing an immune response 有权
标题翻译：用于诱导免疫应答的组合物和方法
公开(公告)号：US08658603B2
公开(公告)日：2014-02-25
申请号：US13331354
申请日：2011-12-20
申请人： Joseph Holoshitz , Song Ling , Xiujun Pi , Denise de Almeida , Chaim Gilon , Amnon Hoffman
发明人： Joseph Holoshitz , Song Ling , Xiujun Pi , Denise de Almeida , Chaim Gilon , Amnon Hoffman
IPC分类号： A61K38/12
CPC分类号： A61K39/00 , A61K39/0011 , A61K39/02 , A61K39/04 , A61K39/39 , A61K2039/55566 , A61K2039/57 , C07K7/06 , C07K14/70539
摘要： The present invention provides compositions and methods for inducing an immune response in a subject. In particular, the present invention provides compositions comprising immunostimulatory ligands (ISL) and methods of inducing an immune response in a subject therewith. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.
摘要翻译：本发明提供了用于在受试者中诱导免疫应答的组合物和方法。特别地，本发明提供包含免疫刺激配体（ISL）的组合物以及在其受试者中诱导免疫应答的方法。本发明的组合物和方法尤其可用于临床（例如治疗和预防性药物（例如疫苗接种））和研究应用。

9. 发明授权

US07208154B2 Methods and compositions for the treatment of MHC-associated conditions 有权
标题翻译：用于治疗MHC相关病症的方法和组合物
公开(公告)号：US07208154B2
公开(公告)日：2007-04-24
申请号：US10845407
申请日：2004-05-13
申请人： Joseph Holoshitz , Song Ling
发明人： Joseph Holoshitz , Song Ling
IPC分类号： A61K38/04
CPC分类号： A61K38/08 , A61K38/10
摘要： The present invention relates to methods and compositions for counteracting and reversing disease-causing signaling defects in disorders with underlying signal transduction aberrations, including but not limited to rheumatoid arthritis.
摘要翻译：本发明涉及用于抵消和逆转疾病引起的信号缺陷的方法和组合物，其具有潜在的信号转导异常（包括但不限于类风湿性关节炎）。

10. 发明授权

US4716038A Methods for the alleviation or treatment of arthritic disease 失效
标题翻译：减轻或治疗关节炎疾病的方法
公开(公告)号：US4716038A
公开(公告)日：1987-12-29
申请号：US817742
申请日：1986-02-25
申请人： John L. Stanford , Irun R. Cohen , Ayala Frenkel , Joseph Holoshitz , Willem van Eden , Graham A. W. Rook
发明人： John L. Stanford , Irun R. Cohen , Ayala Frenkel , Joseph Holoshitz , Willem van Eden , Graham A. W. Rook
IPC分类号： G01N33/564 , A61K35/74 , A61K39/04 , A61P29/00 , A61P37/04 , G01N33/569 , A61K39/02
CPC分类号： A61K35/74 , A61K39/04
摘要： The invention provides pharmaceutical compositions for the alleviation of arthritic diseases. These contain as active ingredient mycobacteria or fractions of these, e.g. obtained by fractionation in certain solvents. The compositions can also be used for vaccinations. There is also provided an assay for the diagnosis of arthritic diseases, and a kit for carrying such an assay.
摘要翻译： PCT No.PCT / GB85 / 00183 Sec。 371日期2986年2月25日 102（e）日期1986年2月25日PCT提交1985年4月29日PCT公布。第WO85 / 05034号公报 1985年11月21日，本发明提供了用于缓解关节炎疾病的药物组合物。它们含有作为活性成分的分枝杆菌或它们的分数，例如。通过在某些溶剂中分馏得到。组合物也可用于疫苗接种。还提供了关于关节炎疾病的诊断的测定法，以及用于携带这种测定的试剂盒。

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