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1. 发明授权

US5595711A Isolated biological and medical waste processor and lid liner carrying a chemically sensitive decontaminant 失效
标题翻译：隔离的生物和医疗废物处理器和盖衬里携带化学敏感的去污剂
公开(公告)号：US5595711A
公开(公告)日：1997-01-21
申请号：US504920
申请日：1995-07-20
申请人： Joseph H. Wilson , David C. Haeberle , Raymond C. Kralovic , Kenneth R. Lamaster , David B. Mennel , Jeffrey C. Rapp , Lewis I. Schwartz , Kathleen M. Antloga
发明人： Joseph H. Wilson , David C. Haeberle , Raymond C. Kralovic , Kenneth R. Lamaster , David B. Mennel , Jeffrey C. Rapp , Lewis I. Schwartz , Kathleen M. Antloga
IPC分类号： A61L11/00 , G01N31/22
CPC分类号： A61L11/00 , Y10S241/606 , Y10S588/90
摘要： A processing chamber for the treatment and decontamination of biological or medical waste includes a rotating waste treatment system carried within an open-top processing chamber, a cap for closing the chamber opening, a gas-pervious liner carried within the chamber for preventing waste from adhering to the underside of the cap as a result of waste-treatment operations, a sealing member disposed at and for sealing the interface of the cap and the processing chamber, and a chemical indicator carried within the interior of the processing chamber for confirming the presence of decontaminant during a waste treatment cycle.
摘要翻译：用于生物或医疗废物的处理和去污的处理室包括承载在开顶处理室内的旋转废物处理系统，用于关闭室开口的盖，在室内承载的可透气衬里，用于防止废物粘附通过废物处理操作到盖的下侧，设置在密封盖和处理室的界面处并用于密封盖和处理室的界面的密封构件以及在处理室内部承载的化学指示器，用于确认存在废物处理循环期间的净化剂。

2. 发明授权

US07803315B2 Decontamination of surfaces contaminated with prion-infected material with gaseous oxidizing agents 有权
标题翻译：用气态氧化剂对被朊病毒感染物质污染的表面进行去污染
公开(公告)号：US07803315B2
公开(公告)日：2010-09-28
申请号：US10116090
申请日：2002-04-03
申请人： Gerald E. McDonnell , Kathleen M. Antloga , Herbert J. Kaiser
发明人： Gerald E. McDonnell , Kathleen M. Antloga , Herbert J. Kaiser
IPC分类号： A61L9/00 , A61L2/00 , B08B9/00 , B08B3/00
CPC分类号： A61L2/186 , A61K31/327 , A61L2/0082 , A61L2/0088 , A61L2/14 , A61L2/208 , A61L2202/122 , A61L2202/24 , C11D3/3947 , C11D11/0023
摘要： A surface which carries a material which is infected with prions is cleaned with an alkaline cleaning solution to remove as much proteinaceous material as possible from the surface. The solution contains an alkaline cleaning agent which attacks prions remaining on the surface and which attacks prions removed from the surface during the cleaning step. After the cleaning step, the surface is exposed to a strong gaseous oxidant, preferably hydrogen peroxide vapor. The hydrogen peroxide or other strong oxidant attacks the prions, particularly the unclumped prion strands, deactivating the prions.
摘要翻译：携带被朊病毒感染的材料的表面用碱性清洁溶液清洗，以从表面去除尽可能多的蛋白质材料。该溶液含有一种碱性清洁剂，其在清洁步骤中侵蚀残留在表面上的朊病毒，并且会从表面去除朊病毒。在清洁步骤之后，表面暴露于强气体氧化剂，优选过氧化氢蒸气。过氧化氢或其他强氧化剂会攻击朊病毒，特别是未切开的朊病毒链，使朊病毒失活。

3. 发明授权

US07001873B2 Decontamination of surfaces contaminated with prion-infected material with oxidizing agent-based formulations 有权
公开(公告)号：US07001873B2
公开(公告)日：2006-02-21
申请号：US10098767
申请日：2002-03-14
申请人： Gerald E. McDonnell , Herbert J. Kaiser , Kathleen M. Antloga , Jennifer A. Scocos
发明人： Gerald E. McDonnell , Herbert J. Kaiser , Kathleen M. Antloga , Jennifer A. Scocos
IPC分类号： C11D1/00 , C02F5/08
CPC分类号： A61L2/186 , A61K31/327 , A61L2/0082 , A61L2/0088 , A61L2/14 , A61L2/208 , A61L2/22 , A61L2202/24 , C11D3/3947 , C11D11/0023
摘要： A surface which carries a material which is infected with prions is cleaned with an alkaline cleaning solution to remove as much proteinaceous material as possible from the surface. The cleaning agent is an alkaline cleaning agent which attacks prions remaining on the surface and which attacks prions removed from the surface during the cleaning step. After the cleaning solution is drained, a solution of surfactants, buffers, and heavy metal free corrosion inhibitors is circulated over the surface at 50°–60° C. The surfactants disperse and unclump the prion-contaminated material. A strong oxidant, preferably peracetic acid, is added to the solution to bring the peracetic acid concentration to 1,000–2,500 ppm. The peracetic acid or other strong oxidant attacks the prions, particularly the unclumped prion strands, deactivating the prions. After rinsing and drying, the surface may be wrapped in a microbe impermeable barrier and subjected to terminal sterilization, such as steam autoclaving.

4. 发明申请

US20100248287A1 DECONTAMINATION OF PRION-CONTAMINATED SURFACES WITH PHENOLS 有权
标题翻译：用酚醛去除污染的表面
公开(公告)号：US20100248287A1
公开(公告)日：2010-09-30
申请号：US12711446
申请日：2010-02-24
申请人： Gerald E. McDonnell , Herbert J. Kaiser , Kathleen M. Antloga , Shahin Kellor
发明人： Gerald E. McDonnell , Herbert J. Kaiser , Kathleen M. Antloga , Shahin Kellor
IPC分类号： C12Q1/02 , G01N33/53
CPC分类号： A61L2/18 , A61L2/22 , A61L2/23
摘要： A method of decontaminating a surface or liquid which is contaminated with prions includes treating the surface with a composition which includes one or more phenol. Phenols which are particularly effective include p-chloro-m-xylanol, thymol, triclosan, 4-chloro, 3-methylphenol, pentachlorophenol, hexachlorophene, 2,2-methyl-bis(4-chlorophenol), and p-phenylphenol.
摘要翻译：用朊病毒污染的表面或液体去污的方法包括用包含一种或多种苯酚的组合物处理表面。特别有效的酚包括对氯 - 间 - 木聚糖，百里酚，三氯生，4-氯，3-甲基苯酚，五氯苯酚，六氯酚，2,2-甲基 - 双（4-氯苯酚）和对苯基苯酚。

5. 发明授权

US07071152B2 Cleaning and decontamination formula for surfaces contaminated with prion-infected material 有权
标题翻译：用朊病毒感染材料污染的表面的清洁和去污配方
公开(公告)号：US07071152B2
公开(公告)日：2006-07-04
申请号：US10448910
申请日：2003-05-30
申请人： Gerald E. McDonnell , Herbert J. Kaiser , Kathleen M. Antloga , Mildred R. Bernardo
发明人： Gerald E. McDonnell , Herbert J. Kaiser , Kathleen M. Antloga , Mildred R. Bernardo
IPC分类号： C11D3/395 , C11D7/18
CPC分类号： A61L2/186 , A01N59/00 , A61L2/16 , A61L2202/17 , A61L2202/24 , C11D3/0073 , C11D3/222 , C11D3/3765 , C11D3/3947 , C11D3/43 , C11D11/0041 , C11D17/003 , A01N25/04 , A01N2300/00
摘要： A method of treating the surfaces of medical instruments which are contaminated with prions includes contacting the surface with a composition containing a source of peroxide ions, such as hydrogen peroxide, at a molar concentration of at least 1.5M peroxide (equivalent to approximately 5% hydrogen peroxide) and preferably, about 2M peroxide (approximately 7% hydrogen peroxide). The composition is optionally in the form of a gel. The composition is retained in contact with the surfaces for about 1–2 hours until all or substantially all prion contamination is removed.
摘要翻译：治疗被朊病毒污染的医疗器械的表面的方法包括使表面与含有过氧化物离子源（例如过氧化氢）的组合物接触，摩尔浓度为至少1.5M过氧化物（相当于约5％氢过氧化物），优选约2M过氧化物（约7％过氧化氢）。组合物任选呈凝胶形式。将组合物保持与表面接触约1-2小时，直至除去所有或基本上所有的朊病毒污染物。

6. 发明授权

US07129080B2 Vitro model of priocidal activity 有权
标题翻译：体育活动的体外模型
公开(公告)号：US07129080B2
公开(公告)日：2006-10-31
申请号：US10264606
申请日：2002-10-04
申请人： Kathleen M. Antloga , Gerald E. McDonnell
发明人： Kathleen M. Antloga , Gerald E. McDonnell
IPC分类号： A01N25/00 , A01L2/00 , A61L2/16 , A61L101/00
CPC分类号： A61L2/186 , A61K31/327 , A61L2/0082 , A61L2/0088 , A61L2/14 , A61L2/208 , A61L2/28 , A61L2202/17 , A61L2202/24 , C11D3/3947 , C11D11/0023
摘要： A proteinaceous material has been found to show similar activity and treatment response to that of disease causing prions, such as CJD. A prion model which incorporates the proteinaceous material has a variety of applications. The model has an ability to be cultured either in vivo or in vitro, allowing rapid screening of potential drugs for treating animals or humans, or methods of treating food products or items which may come into contact with prions, such as medical or dental devices. Several treatment methods and materials have been developed using the model.
摘要翻译：已经发现蛋白质材料显示与引起朊病毒的疾病相似的活性和治疗反应，例如CJD。结合蛋白质材料的朊病毒模型具有多种应用。该模型具有在体内或体外培养的能力，允许对用于治疗动物或人的潜在药物的快速筛选，或处理可能与朊病毒例如医疗或牙科装置接触的食品或物品的方法。已经使用该模型开发了几种处理方法和材料。

7. 发明授权

US08236492B2 Decontamination of prion-contaminated surfaces with phenols 有权
标题翻译：用酚类污染朊蛋白污染的表面
公开(公告)号：US08236492B2
公开(公告)日：2012-08-07
申请号：US12711446
申请日：2010-02-24
申请人： Gerald E. McDonnell , Herbert J. Kaiser , Kathleen M. Antloga , Shahin Kellor
发明人： Gerald E. McDonnell , Herbert J. Kaiser , Kathleen M. Antloga , Shahin Kellor
IPC分类号： C12Q1/70
CPC分类号： A61L2/18 , A61L2/22 , A61L2/23
摘要： A method of decontaminating a surface or liquid which is contaminated with prions includes treating the surface with a composition which includes one or more phenol. Phenols which are particularly effective include p-chloro-m-xylanol, thymol, triclosan, 4-chloro, 3-methylphenol, pentachlorophenol, hexachlorophene, 2,2-methyl-bis(4-chlorophenol), and p-phenylphenol.
摘要翻译：用朊病毒污染的表面或液体去污的方法包括用包含一种或多种苯酚的组合物处理表面。特别有效的酚包括对氯 - 间 - 木聚糖，百里酚，三氯生，4-氯，3-甲基苯酚，五氯苯酚，六氯酚，2,2-甲基 - 双（4-氯苯酚）和对苯基苯酚。

8. 发明授权

US4653584A Maleimide-modified bioresistant polymers and enhanced oil recovery method employing same 失效
标题翻译：马来酰亚胺改性的生物抗性聚合物和采用其的增强的油回收方法
公开(公告)号：US4653584A
公开(公告)日：1987-03-31
申请号：US739480
申请日：1985-05-30
申请人： Lawrence E. Ball , William M. Griffin , Kathleen M. Antloga , Amy L. Nemecek
发明人： Lawrence E. Ball , William M. Griffin , Kathleen M. Antloga , Amy L. Nemecek
IPC分类号： C08F220/56 , C09K8/588 , E21B43/22
CPC分类号： C09K8/588 , C08F220/56 , Y10S507/936
摘要： A polymer is disclosed which is represented by the formula ##STR1## wherein: Y is hydrogen, ammonium, an alkali metal or an alkaline earth metal; R.sup.1 and R.sup.2 are independently hydrogen, hydroxyl, amino, nitro, sulfo, phospho, carboxy, carboxyamido groups or hydrocarbon groups of 1 to about 20 carbon atoms; R.sup.3 is hydrogen or a hydrocarbon group of from 1 to about 12 carbon atoms; R.sup.4 and R.sup.5 are independently hydrogen or alkyl groups of 1 to about 3 carbon atoms; m is a number sufficient to provide the acid or salt portion of said polymer at a level of from zero to about 90% by weight of the total weight of said polymer; n is a number sufficient to provide the amide portion of said polymer at a level of from about 10% to about 99.5% by weight of the total weight of said polymer; p is a number sufficient to provide the maleimide portion of said polymer at a level of at least about 0.2% by weight of the total weight of said polymer; and x is a number sufficient to provide said polymer with a molecular weight of at least about 100,000. A method for recovering oil from a subterranean formation comprising injecting into said formation an aqueous composition comprising a thickening amount of the foregoing polymer is also disclosed.
摘要翻译：公开了由下式表示的聚合物：其中：Y是氢，铵，碱金属或碱土金属; R 1和R 2独立地是氢，羟基，氨基，硝基，磺基，磷酸基，羧基，羧基酰胺基或具有1至约20个碳原子的烃基; R3是氢或1至约12个碳原子的烃基; R 4和R 5独立地是氢或1至约3个碳原子的烷基; m是足以提供所述聚合物的酸或盐部分的量为所述聚合物总重量的0至约90重量％的数量; n是足以使所述聚合物的酰胺部分以所述聚合物总重量的约10重量％至约99.5重量％的水平提供的数字; p是足以提供所述聚合物的马来酰亚胺部分至少为所述聚合物总重量的约0.2重量％的数量; 并且x是足以提供所述聚合物具有至少约100,000的分子量的数字。还公开了一种从地层中回收油的方法，包括向所述地层注入包含增稠量的上述聚合物的含水组合物。

9. 发明授权

US07393818B2 Cleaning and decontamination formula for surfaces contaminated with prion-infected material 有权
标题翻译：用朊病毒感染材料污染的表面的清洁和去污配方
公开(公告)号：US07393818B2
公开(公告)日：2008-07-01
申请号：US11732443
申请日：2007-04-03
申请人： Gerald E. McDonnell , Herbert J. Kaiser , Kathleen M. Antloga , Mildred R. Bernardo
发明人： Gerald E. McDonnell , Herbert J. Kaiser , Kathleen M. Antloga , Mildred R. Bernardo
IPC分类号： C11D3/395 , C11D3/43
CPC分类号： A61L2/186 , A01N59/00 , A61L2/16 , A61L2202/17 , A61L2202/24 , C11D3/0073 , C11D3/222 , C11D3/3765 , C11D3/3947 , C11D3/43 , C11D11/0041 , C11D17/003 , A01N25/04 , A01N2300/00
摘要： A method of treating the surfaces of medical instruments which are contaminated with prions includes contacting the surface with a composition containing a source of peroxide ions, such as hydrogen peroxide, at a molar concentration of at least 1.5M peroxide (equivalent to approximately 5% hydrogen peroxide) and preferably, about 2M peroxide (approximately 7% hydrogen peroxide). The composition is optionally in the form of a gel. The composition is retained in contact with the surfaces for about 1-2 hours until all or substantially all prion contamination is removed.
摘要翻译：治疗被朊病毒污染的医疗器械的表面的方法包括使表面与含有过氧化物离子源（例如过氧化氢）的组合物接触，摩尔浓度为至少1.5M过氧化物（相当于约5％氢过氧化物），优选约2M过氧化物（约7％过氧化氢）。组合物任选呈凝胶形式。将组合物保持与表面接触约1-2小时，直至除去所有或基本上所有的朊病毒污染物。

10. 发明授权

US07217685B2 Cleaning and decontamination formula for surfaces contaminated with prion-infected material 有权
公开(公告)号：US07217685B2
公开(公告)日：2007-05-15
申请号：US11430699
申请日：2006-05-09
申请人： Gerald E. McDonnell , Herbert J. Kaiser , Kathleen M. Antloga , Mildred R. Bernardo
发明人： Gerald E. McDonnell , Herbert J. Kaiser , Kathleen M. Antloga , Mildred R. Bernardo
IPC分类号： C11D3/395 , C11D3/43
CPC分类号： A61L2/186 , A01N59/00 , A61L2/16 , A61L2202/17 , A61L2202/24 , C11D3/0073 , C11D3/222 , C11D3/3765 , C11D3/3947 , C11D3/43 , C11D11/0041 , C11D17/003 , A01N25/04 , A01N2300/00
摘要： A method of treating the surfaces of medical instruments which are contaminated with prions includes contacting the surface with a composition containing a source of peroxide ions, such as hydrogen peroxide, at a molar concentration of at least 1.5M peroxide (equivalent to approximately 5% hydrogen peroxide) and preferably, about 2M peroxide (approximately 7% hydrogen peroxide). The composition is optionally in the form of a gel. The composition is retained in contact with the surfaces for about 1–2 hours until all or substantially all prion contamination is removed.

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