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1. 发明申请

US20080208328A1 Systems and Methods For Placement of Valve Prosthesis System 审中-公开
标题翻译：瓣膜假体系统的放置系统与方法
公开(公告)号：US20080208328A1
公开(公告)日：2008-08-28
申请号：US11870001
申请日：2007-10-10
申请人： Joseph D. Antocci , David G. Lamphere , Salvatore Castro , Gregorio Ramon M. Abesames , Howard C. Herrmann
发明人： Joseph D. Antocci , David G. Lamphere , Salvatore Castro , Gregorio Ramon M. Abesames , Howard C. Herrmann
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/243 , A61F2/2436 , A61F2/2439
摘要： Valve prosthesis systems and methods/systems for placement of such valve prostheses are provided that facilitate efficient, reliable and minimally invasive delivery modalities. The placement systems and methods permit remote manipulation and positioning of the valve prosthesis such that desirable placement relative to anatomical structures, e.g., the heart annulus, may be achieved. The valve prosthesis includes a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring. The delivery system includes a first elongate element that terminates at the valve prosthesis and is manipulable by an operator to remotely rotate the positioning elements relative to the flexible ring. A second elongate element terminates at the valve prosthesis and is manipulable by an operator to remotely advance the valve prosthesis downward into an anatomical annulus. The second elongate element may be manipulated to remotely advance the valve prosthesis into the anatomical annulus to assume a position for supporting post-implantation function of the valve prosthesis in situ. The first elongate element may be further manipulated to remotely rotate the positioning element relative to the flexible ring to cause the positioning element to engage tissue associated with the anatomical annulus and to thereby maintain the post-implantation position of the valve prosthesis in situ. Methods for valve prosthesis deployment are also provided.
摘要翻译：提供了用于放置这种瓣膜假体的瓣膜假体系统和方法/系统，其有助于有效，可靠和微创的递送方式。放置系统和方法允许瓣膜假体的远程操作和定位，使得可以实现相对于解剖结构（例如心脏环）的期望的放置。瓣膜假体包括弹性环，相对于弹性环安装的多个传膜，以及相对于柔性环可移动地安装的多个定位元件。递送系统包括终止于瓣膜假体处的第一细长元件，并且可由操作者操纵以相对于柔性环远程旋转定位元件。第二细长元件终止在瓣膜假体处，并且可由操作者操纵以将瓣膜假体向下远进地推进到解剖环形中。第二细长元件可以被操纵以将瓣膜假体远程地推进到解剖环空中，以呈现用于在原位支撑瓣膜假体的植入后功能的位置。可以进一步操作第一细长元件以相对于柔性环远程旋转定位元件，以使得定位元件接合与解剖学环带相关联的组织，并由此原位维持瓣膜假体的植入后位置。还提供了用于瓣膜假体部署的方法。

2. 发明授权

US5266268A Centrifugal analyzer rotors 失效
标题翻译：离心分析仪转子
公开(公告)号：US5266268A
公开(公告)日：1993-11-30
申请号：US745520
申请日：1991-08-15
申请人： Joseph D. Antocci , Richard H. Darling , Maxwell E. Lawrence, Jr. , Joseph A. Luongo
发明人： Joseph D. Antocci , Richard H. Darling , Maxwell E. Lawrence, Jr. , Joseph A. Luongo
IPC分类号： G01N21/07 , G01N35/02 , G01N21/90 , G01N1/10
CPC分类号： G01N21/07 , Y10T436/111666 , Y10T436/113332 , Y10T436/25375
摘要： A multicuvette rotor which reduces unacceptable tendencies of reagent or a sample material to spontaneously move or "wick" from one chamber compartment to the other, resulting in premature conmingling of reactants, and of sample or reagent material to flow out of one or more of the radially outer loading ports during acceleration of the rotor for transfer of the sample or reagent material from inner chambers to corresponding outer chambers.

3. 发明授权

US5682026A Multiple carousel carrier and carousel handling mechanism 失效
标题翻译：多转盘载体和转盘处理机构
公开(公告)号：US5682026A
公开(公告)日：1997-10-28
申请号：US609371
申请日：1996-03-01
申请人： John M. Auclair , Joseph D. Antocci
发明人： John M. Auclair , Joseph D. Antocci
IPC分类号： G01N30/24 , G01N35/02 , G01N35/04 , G06F17/00
CPC分类号： G01N35/04 , G01N2035/0441 , G01N2035/0451 , G01N2035/0453 , G01N35/025
摘要： A sample handling mechanism including a direct drive carrier for positioning multiple trays or carousels of sample vials and a direct drive carousel handling mechanism that eliminates pulleys and belts and the problems associated therewith. The carousels handled by the sample handling mechanism are individually identifiable, stackable and include a viewing area for identifying and viewing the individual sample vials grouped in a respective carousel. The sample handling mechanism consists of two logical drive modules. A single center line or axis of rotation is effected in each of the drive modules. The two logical drive modules include a carrier mechanism that transports a plurality of sample carousels to a sampling station, and a carousel drive mechanism which engages a single carousel and presents the appropriate vial to be sampled. The carrier mechanism includes a multi-position spoke-like carrier portion that is driven by a single drive shaft coupled to a gear reduction stepper motor by a coupling. The carousel drive mechanism includes a linear actuator portion and a rotary actuator portion on a common center line or axis. The linear actuator portion effects engagement and disengagement of the rotary actuator portion with a properly positioned carousel, and includes a linear actuator stepper motor with a motor shaft attached to a lift housing. The lift housing holds the rotary actuator portion.
摘要翻译：一种样品处理机构，包括用于定位样品瓶的多个托盘或转盘的直接驱动载体和消除皮带轮和皮带的直接驱动转盘处理机构以及与之相关的问题。由样品处理机构处理的转盘可单独识别，可堆叠，并且包括用于识别和观察分组在相应转盘中的各个样品瓶的观察区域。样品处理机构由两个逻辑驱动模块组成。在每个驱动模块中实现单个中心线或旋转轴。两个逻辑驱动器模块包括将多个样品转盘传送到采样站的载体机构，以及接合单个转盘并呈现要被采样的适当样品瓶的转盘驱动机构。载体机构包括多位置轮辐状载体部分，该部分由联接到齿轮减速步进马达的单个驱动轴驱动。转盘驱动机构包括在公共中心线或轴上的线性致动器部分和旋转致动器部分。线性致动器部分利用适当定位的转盘实现旋转致动器部分的接合和分离，并且包括线性致动器步进马达，其中电动机轴附接到升降机壳体。升降机壳体保持旋转致动器部分。

4. 发明申请

US20150082882A1 SYSTEM FOR DETERMINING THE LEVEL OF A LIQUID IN A CONTAINER 审中-公开
标题翻译：用于确定容器中液体水平的系统
公开(公告)号：US20150082882A1
公开(公告)日：2015-03-26
申请号：US14498079
申请日：2014-09-26
申请人： Joseph D. Antocci
发明人： Joseph D. Antocci
IPC分类号： G01F23/18 , G01F23/14
CPC分类号： G01F23/18 , G01F23/168
摘要： A system for determining liquid level in containers. According to one embodiment, the system is configured for use with a single container. The system includes a tube having a distal branch and two proximal branches. The distal branch is sized to extend from inside the container to a remote location. One proximal branch is coupled to a pressure transducer for emitting a signal in response to the sensed fluid pressure head in the container, and the other proximal branch is coupled through a check valve to a gas displacement device used periodically to blow debris from the distal branch. A processor coupled to the transducer uses the fluid pressure head signal to determine the liquid level. A display coupled to the processor displays the determined liquid level. In another embodiment, the system may be used to determine the liquid level in any, some, or all of a plurality of containers.
摘要翻译：用于确定容器中液位的系统。根据一个实施例，系统被配置为与单个容器一起使用。该系统包括具有远端分支和两个近端分支的管。远端分支的大小从容器内部延伸到远处。一个近端分支耦合到压力传感器，用于响应于容器中感测到的流体压力头而发出信号，而另一个近端分支通过止回阀联接到周期性地使用的气体置换装置，以从远端分支。耦合到换能器的处理器使用流体压头信号来确定液位。耦合到处理器的显示器显示所确定的液位。在另一个实施例中，该系统可用于确定多个容器中的任何一个或多个容器中的液面。

5. 外观设计

USD332835S Reagent container 失效
公开(公告)号：USD332835S
公开(公告)日：1993-01-26
申请号：US473384
申请日：1990-02-01
申请人： Joseph D. Antocci , George P. Anderson
设计人： Joseph D. Antocci , George P. Anderson

6. 发明授权

US06367847B1 Coupler for placing two or more fluid streams in communication 有权
标题翻译：用于将两个或多个流体流放置在通信中的耦合器
公开(公告)号：US06367847B1
公开(公告)日：2002-04-09
申请号：US09263453
申请日：1999-03-05
申请人： Theodore A. Dourdeville , Dennis DellaRovere , Joseph D. Antocci
发明人： Theodore A. Dourdeville , Dennis DellaRovere , Joseph D. Antocci
IPC分类号： F16L3900
CPC分类号： F16L19/02 , F16L19/025 , F16L19/07 , F16L49/06 , G01N30/10 , G01N30/20 , G01N2030/205 , G01N30/6095
摘要： One embodiment of the present coupler comprises two or more conduits for transporting fluid. Each of the two or more conduits has at least one end defining an opening in said conduit, and each of the conduits has an axis running parallel to the flow of fluid through said conduit. The coupler further comprises a housing body having a first housing planar surface. The housing body holds the two or more conduits in alignment wherein the axis of each conduit is substantially parallel, and at least one end of each conduit is aligned about said first housing planar surface. And, the coupler has a cap element having a cap planar surface. The cap planar surface is fixed to the first housing planar surface in sealed engagement. At least one of the first housing planar surface and the cap planar surface has a channel in fluid communication with the opening in the conduits. The channel allows two or more fluid streams, each fluid stream defined by one of said conduits, to be placed in communication.
摘要翻译：本耦合器的一个实施例包括两个或更多个用于输送流体的导管。两个或更多个导管中的每一个具有限定所述导管中的开口的至少一个端部，并且每个导管具有平行于通过所述导管的流体流动的轴线。联接器还包括具有第一壳体平面的壳体。壳体保持两个或更多个导管对准，其中每个导管的轴线基本上平行，并且每个导管的至少一个端部围绕所述第一壳体平面表面对准。并且，耦合器具有具有盖平面的盖元件。盖平表面以密封接合方式固定到第一壳体平面表面。第一壳体平面表面和盖平面表面中的至少一个具有与管道中的开口流体连通的通道。通道允许两个或多个流体流，由所述管道之一限定的每个流体流被放置成连通。

7. 发明授权

US6071477A Sample handling mechanism 失效
标题翻译：样品处理机制
公开(公告)号：US6071477A
公开(公告)日：2000-06-06
申请号：US932720
申请日：1997-09-18
申请人： John M. Auclair , Joseph D. Antocci
发明人： John M. Auclair , Joseph D. Antocci
IPC分类号： G01N30/24 , G01N35/02 , G01N35/04
CPC分类号： G01N35/04 , G01N2035/0441 , G01N2035/0451 , G01N2035/0453 , G01N35/025
摘要： A sample handling mechanism including a direct drive carrier for positioning multiple trays or carousels of sample vials and a direct drive carousel handling mechanism that eliminates pulleys and belts and the problems associated therewith. The carousels handled by the sample handling mechanism are individually identifiable, stackable and include a viewing area for identifying and viewing the individual sample vials grouped in a respective carousel. The sample handling mechanism consists of two logical drive modules. A single center line or axis of rotation is effected in each of the drive modules. The two logical drive modules include a carrier mechanism that transports a plurality of sample carousels to a sampling station, and a carousel drive mechanism which engages a single carousel and presents the appropriate vial to be sampled. The carrier mechanism includes a multi-position spoke-like carrier portion that is driven by a single drive shaft coupled to a gear reduction stepper motor by a coupling. The carousel drive mechanism includes a linear actuator portion and a rotary actuator portion on a common center line or axis. The linear actuator portion effects engagement and disengagement of the rotary actuator portion with a properly positioned carousel, and includes a linear actuator stepper motor with a motor shaft attached to a lift housing. The lift housing holds the rotary actuator portion.
摘要翻译：一种样品处理机构，包括用于定位样品瓶的多个托盘或转盘的直接驱动载体和消除皮带轮和皮带的直接驱动转盘处理机构以及与之相关的问题。由样品处理机构处理的转盘可单独识别，可堆叠，并且包括用于识别和观察分组在相应转盘中的各个样品瓶的观察区域。样品处理机构由两个逻辑驱动模块组成。在每个驱动模块中实现单个中心线或旋转轴。两个逻辑驱动器模块包括将多个样品转盘传送到采样站的载体机构，以及接合单个转盘并呈现要被采样的适当样品瓶的转盘驱动机构。载体机构包括多位置轮辐状载体部分，该部分由联接到齿轮减速步进马达的单个驱动轴驱动。转盘驱动机构包括在公共中心线或轴上的线性致动器部分和旋转致动器部分。线性致动器部分利用适当定位的转盘实现旋转致动器部分的接合和分离，并且包括线性致动器步进马达，其中电动机轴附接到升降机壳体。升降机壳体保持旋转致动器部分。

8. 发明授权

US08840784B2 Device for holding a column or cartridge in proximity to a detector and methods of using the same 有权
标题翻译：用于将色谱柱或墨盒固定在检测器附近的装置及其使用方法
公开(公告)号：US08840784B2
公开(公告)日：2014-09-23
申请号：US10598313
申请日：2005-03-02
申请人： David P. Prentice , Theodore C. Ciolkosz , Joseph D. Antocci
发明人： David P. Prentice , Theodore C. Ciolkosz , Joseph D. Antocci
IPC分类号： G01N30/62 , G01N30/60 , G01N30/30
CPC分类号： G01N30/6047 , G01N30/6091 , G01N30/62 , G01N2030/3007 , G01N2030/3084
摘要： Embodiments of the present invention are directed to methods and devices for minimizing band spreading of compositions separated by chromatographic processes. One embodiment of the present invention features a device (11) for holding a separation column or cartridge. The device (11) includes a housing (15) having a chamber for receiving one or more columns or cartridges. The columns and cartridges have an inlet for receiving fluid and an outlet for discharging fluid and a column axis corresponding generally with the flow of fluid from the inlet to the outlet. The columns and cartridges are suitable for performing separations in which a constant temperature is desirable. The housing (15) further includes a heating element for maintaining said chamber at a constant temperature. The device (11) further includes positioning means (17) for placing the column and cartridge outlet in proximity to a detector.
摘要翻译：本发明的实施方案涉及用于最小化通过色谱法分离的组合物的带扩展的方法和装置。本发明的一个实施例的特征在于用于保持分离柱或筒的装置（11）。设备（11）包括具有用于接收一个或多个柱或盒的室的壳体（15）。柱和筒具有用于接收流体的入口和用于排出流体的出口和与从入口到出口的流体流大致对应的柱轴。色谱柱和墨盒适用于需要恒定温度的分离。壳体（15）还包括用于将所述腔室保持在恒定温度的加热元件。装置（11）还包括定位装置（17），用于将柱和盒出口放置在检测器附近。

9. 发明申请

US20080277345A1 Device for Holding a Column or Cartridge in Proximity to a Detector and Methods of Using the Same 有权
标题翻译：用于保持靠近检测器的色谱柱或墨盒的设备及其使用方法
公开(公告)号：US20080277345A1
公开(公告)日：2008-11-13
申请号：US10598313
申请日：2005-03-02
申请人： David P. Prentice , Theodore C. Ciolkosz , Joseph D. Antocci
发明人： David P. Prentice , Theodore C. Ciolkosz , Joseph D. Antocci
IPC分类号： B01D15/08
CPC分类号： G01N30/6047 , G01N30/6091 , G01N30/62 , G01N2030/3007 , G01N2030/3084
摘要： Embodiments of the present invention are directed to methods and devices for minimizing band spreading of compositions separated by chromatographic processes. One embodiment of the present invention features a device (11) for holding a separation column or cartridge. The device (11) includes a housing (15) having a chamber for receiving one or more columns or cartridges. The columns and cartridges have an inlet for receiving fluid and an outlet for discharging fluid and a column axis corresponding generally with the flow of fluid from the inlet to the outlet. The columns and cartridges are suitable for performing separations in which a constant temperature is desirable. The housing (15) further includes a heating element for maintaining said chamber at a constant temperature. The device (11) further includes positioning means (17) for placing the column and cartridge outlet in proximity to a detector.
摘要翻译：本发明的实施方案涉及用于最小化通过色谱法分离的组合物的带扩展的方法和装置。本发明的一个实施例的特征在于用于保持分离柱或筒的装置（11）。设备（11）包括具有用于接收一个或多个柱或盒的室的壳体（15）。柱和筒具有用于接收流体的入口和用于排出流体的出口和与从入口到出口的流体流大致对应的柱轴。色谱柱和墨盒适用于需要恒定温度的分离。壳体（15）还包括用于将所述腔室保持在恒定温度的加热元件。装置（11）还包括定位装置（17），用于将柱和盒出口放置在检测器附近。

10. 发明授权

US06602413B2 Sealed centrifugal clarifier 失效
公开(公告)号：US06602413B2
公开(公告)日：2003-08-05
申请号：US09832525
申请日：2001-04-11
申请人： Glen Jorgensen , William F. Aitkenhead , Joseph D. Antocci
发明人： Glen Jorgensen , William F. Aitkenhead , Joseph D. Antocci
IPC分类号： B04B702
CPC分类号： B01D21/262 , B01D2221/06 , B04B5/0428 , B04B5/0442 , B04B7/02 , B04B13/00
摘要： A sealed centrifugal clarifier with a pre-sterilized and disposable container which lines the separation chamber is disclosed. More particularly, the centrifugal clarifier contains a feed port that allows a liquid-solid mixture to be continuously fed into the device wherein the solid is sedimented by rotation of the separation chamber and the clarified liquid is released into an outside receptacle through an effluent port. The throughput rate of the clarifier is adjustable and can be determined as a function of the fill radius of the separation chamber.

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