专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07300949B2 Thiazolopyrazoles and methods of their use 有权
标题翻译：噻唑并唑及其使用方法
公开(公告)号：US07300949B2
公开(公告)日：2007-11-27
申请号：US11094241
申请日：2005-03-31
申请人： Joseph Barbosa , Cynthia A. Fink , Spencer D. Kimball , Hartmuth Kolb , Zhi-Cai Shi , Ashok R. Tunoori
发明人： Joseph Barbosa , Cynthia A. Fink , Spencer D. Kimball , Hartmuth Kolb , Zhi-Cai Shi , Ashok R. Tunoori
IPC分类号： C07D513/02 , A61K31/429
CPC分类号： C07D513/04
摘要： This invention concerns novel thiazolopyrazole compounds and compositions comprising them. Methods of using these compounds for the treatment, prevention and management of various diseases and disorders are also encompassed by the invention.
摘要翻译：本发明涉及新型噻唑并吡唑化合物及其组合物。使用这些化合物治疗，预防和治疗各种疾病和病症的方法也包括在本发明中。

2. 发明申请

US20050282874A1 Novel thiazolopyrazoles and methods of their use 有权
标题翻译：新型噻唑并唑及其使用方法
公开(公告)号：US20050282874A1
公开(公告)日：2005-12-22
申请号：US11094241
申请日：2005-03-31
申请人： Joseph Barbosa , Cynthia Fink , Spencer Kimball , Hartmuth Kolb , Zhi-Cai Shi , Ashok Tunoori
发明人： Joseph Barbosa , Cynthia Fink , Spencer Kimball , Hartmuth Kolb , Zhi-Cai Shi , Ashok Tunoori
IPC分类号： A61K31/429 , C07D513/02 , C07D513/04
CPC分类号： C07D513/04
摘要： This invention concerns novel thiazolopyrazole compounds and compositions comprising them. Methods of using these compounds for the treatment, prevention and management of various diseases and disorders are also encompassed by the invention.
摘要翻译：本发明涉及新型噻唑并吡唑化合物及其组合物。使用这些化合物治疗，预防和治疗各种疾病和病症的方法也包括在本发明中。

3. 发明授权

US07179827B2 Thiazoles and methods of their use 失效
标题翻译：噻唑及其使用方法
公开(公告)号：US07179827B2
公开(公告)日：2007-02-20
申请号：US11094237
申请日：2005-03-31
申请人： Haihong Jin , Zhi-Cai Shi , Heidi Theis , Hartmuth Kolb
发明人： Haihong Jin , Zhi-Cai Shi , Heidi Theis , Hartmuth Kolb
IPC分类号： A61K31/426 , A61K31/427 , C07D277/56 , C07D417/06
CPC分类号： C07D277/56 , C07D417/06
摘要： This invention concerns novel thiazole compounds. Methods of using these compounds for the treatment, prevention and management of various diseases or disorders, as well as pharmaceutical compositions of these compounds, are also disclosed.
摘要翻译：本发明涉及新的噻唑化合物。还公开了使用这些化合物治疗，预防和治疗各种疾病或病症的方法，以及这些化合物的药物组合物。

4. 发明申请

US20050282807A1 Novel thiazoles and methods of their use 失效
标题翻译：新的噻唑及其使用方法
公开(公告)号：US20050282807A1
公开(公告)日：2005-12-22
申请号：US11094237
申请日：2005-03-31
申请人： Haihong Jin , Zhi-Cai Shi , Heidi Theis , Hartmuth Kolb
发明人： Haihong Jin , Zhi-Cai Shi , Heidi Theis , Hartmuth Kolb
IPC分类号： A61K31/426 , A61K31/427 , A61K31/454 , A61K31/5377 , C07D277/56 , C07D417/02 , C07D417/06
CPC分类号： C07D277/56 , C07D417/06
摘要： This invention concerns novel thiazole compounds. Methods of using these compounds for the treatment, prevention and management of various diseases or disorders, as well as pharmaceutical compositions of these compounds, are also disclosed.
摘要翻译：本发明涉及新的噻唑化合物。还公开了使用这些化合物治疗，预防和治疗各种疾病或病症的方法，以及这些化合物的药物组合物。

5. 发明申请

US20090036668A1 MICROFLUIDIC RADIOSYNTHESIS SYSTEM FOR POSITRON EMISSION TOMOGRAPHY BIOMARKERS 失效
标题翻译：微生物放射生物标志物放射免疫系统
公开(公告)号：US20090036668A1
公开(公告)日：2009-02-05
申请号：US12102822
申请日：2008-04-14
申请人： Arkadij M. Elizarov , Carroll Edward Ball , Jianzhong Zhang , Hartmuth Kolb , R. Michael van Dam , Lawrence Talcott Diener , Sean Ford , Reza Miraghaie
发明人： Arkadij M. Elizarov , Carroll Edward Ball , Jianzhong Zhang , Hartmuth Kolb , R. Michael van Dam , Lawrence Talcott Diener , Sean Ford , Reza Miraghaie
IPC分类号： C07H5/02 , B01J19/00
CPC分类号： C07H5/02 , B01J19/0093 , B01J2219/00783 , B01J2219/0086 , B01J2219/00873 , B01J2219/00891 , B01J2219/00907 , B01J2219/00909
摘要： Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.
摘要翻译：公开了以快速，有效和紧凑的方式全面自动合成用于成像的放射性化合物的方法和装置，例如通过正电子发射断层摄影（PET）。特别地，本发明的各种实施例提供了在具有不受限制的气流通过反应器的微流体装置上的整个放射合成循环的自动化的，独立的，免手操作的操作，从目标水开始并产生纯化的PET放射性示踪器时间比传统化学系统短。因此，本发明的一个方面涉及用于放射性标记的化合物的放射合成的微流体芯片，包括反应室，连接到反应室的一个或多个流动通道，连接到所述反应室的一个或多个通气口，以及一个或多个更一体化的阀来实现进出所述反应室的流量控制。

6. 发明申请

US20130005972A1 Application of Staudinger Ligation in PET Imaging 审中-公开
标题翻译： Staudinger连接在PET成像中的应用
公开(公告)号：US20130005972A1
公开(公告)日：2013-01-03
申请号：US13634308
申请日：2011-03-29
申请人： Dhanalakshmi Kasi , Umesh Gangadharmath , Joseph Walsh , Hartmuth Kolb
发明人： Dhanalakshmi Kasi , Umesh Gangadharmath , Joseph Walsh , Hartmuth Kolb
IPC分类号： C07C231/10 , C07C269/06 , C07D239/95 , C07D233/91 , C07D403/06
CPC分类号： C07B59/00
摘要： A method for generating a radiolabeled tracer. The method includes providing a phosphine molecule having at least one carbocyclic, aromatic, or pyrrolidinyl ring with an OH substitute. The OH of this phosphines molecule is then condensed with an acid to produce a phosphine ester. Staudinger ligation is then performed to generate the radiolabeled tracer by treating the phosphine ester with a radiolabeled azide having a PET radioisotope moiety.
摘要翻译：一种产生放射性标记示踪剂的方法。该方法包括提供具有至少一个具有OH取代基的碳环，芳族或吡咯烷基环的膦分子。然后将该膦分子的OH与酸缩合以产生膦酯。然后通过用具有PET放射性同位素部分的放射性标记的叠氮化物处理膦酯来进行施陶丁格连接以产生放射性标记的示踪剂。

7. 发明申请

US20070200081A1 Microfluidic method and structure with an elastomeric gas-permeable gasket 有权
标题翻译：具有弹性体透气垫片的微流体方法和结构
公开(公告)号：US20070200081A1
公开(公告)日：2007-08-30
申请号：US11701917
申请日：2007-02-02
申请人： Arkadij Elizarov , James Heath , Hartmuth Kolb , Michael Dam
发明人： Arkadij Elizarov , James Heath , Hartmuth Kolb , Michael Dam
IPC分类号： F16K1/00
CPC分类号： F16K7/126 , B01L3/502707 , B01L3/502738 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2400/0478 , B01L2400/0638 , F16K99/0001 , F16K99/0015 , F16K2099/008
摘要： A microfluidic structure and method, where the structure comprises a featureless gasket layer allowing for efficient and reproducible structure production and assembly. Layering methods allow for the use of a variety of device materials and easy assembly.
摘要翻译：微流体结构和方法，其中结构包括无特征的垫片层，其允许有效且可重复的结构生产和组装。分层方法允许使用各种装置材料并易于装配。

8. 发明授权

US09023316B2 Synthesis of 18F-labeled tracers in hydrous organic solvents 有权
标题翻译：在含水有机溶剂中合成18F标记的示踪剂
公开(公告)号：US09023316B2
公开(公告)日：2015-05-05
申请号：US13634708
申请日：2011-04-08
申请人： Umesh Gangadharmath , Joseph Walsh , Hartmuth Kolb
发明人： Umesh Gangadharmath , Joseph Walsh , Hartmuth Kolb
IPC分类号： C07B59/00 , B01D15/36 , A61K51/04
CPC分类号： B01D15/363 , A61K51/04 , A61K51/0448 , A61K51/0453 , A61K51/0455 , A61K51/0459 , A61K51/047 , A61K51/0491
摘要： A method for synthesizing an 18F-labeled probe. The method includes a step of eluting an amount of 18F with a first solvent which includes a predetermined amount of water and at least one organic solvent. In this step, the 18F elutes as an 18F solution. The method also includes a step of using the 18F solution to perform 18F-labeling in the presence of at least one labeling reagent and at least one phase transfer catalyst so as to generate the 18F-labeled probe. In the method, there is no step of drying the 18F starting from a time when the eluting step is performed and ending at a time when the 18F-labeling step is performed.
摘要翻译：合成18F标记的探针的方法。该方法包括用包含预定量的水和至少一种有机溶剂的第一溶剂洗脱一定量的18F的步骤。在这一步中，18F洗脱为18F溶液。该方法还包括使用18F溶液在存在至少一种标记试剂和至少一种相转移催化剂的情况下进行18F标记以产生18F标记的探针的步骤。在该方法中，从执行洗脱步骤的时间开始并且在进行18F标记步骤的时刻结束时，没有干燥18F的步骤。

9. 发明申请

US20070217963A1 Microfluidic chip capable of synthesizing radioactively labeled molecules on a scale suitable for human imaging with positron emission tomography 有权
标题翻译：能够以适合于使用正电子发射断层扫描的人成像的量表合成放射性标记分子的微流控芯片
公开(公告)号：US20070217963A1
公开(公告)日：2007-09-20
申请号：US11540344
申请日：2006-09-29
申请人： Arkadij Elizarov , Hartmuth Kolb
发明人： Arkadij Elizarov , Hartmuth Kolb
IPC分类号： B01J19/00
CPC分类号： B01F11/0042 , B01F11/0071 , B01F13/0059 , B01J19/0093 , B01J2219/00286 , B01J2219/00396 , B01J2219/00398 , B01J2219/00414 , B01J2219/00418 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/00731 , B01J2219/00759 , B01J2219/00783 , B01J2219/00788 , B01J2219/00822 , B01J2219/00824 , B01J2219/00826 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00858 , B01J2219/0086 , B01J2219/00862 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00907 , B01J2219/00916 , B01J2219/00927 , B01J2219/00986
摘要： Described herein are automated, integrated microfluidic device comprising a chemical reaction chip comprising for performing chemical reaction, a microscale column integrated with the chip and configured for liquid flow from the column to at least one flow channel, and wherein the fluid flow into the column is controlled by on-chip valves; and comprising at least two on-chip valves for controlling fluid flow in the microfluidic device.
摘要翻译：本文描述的是包括用于进行化学反应的化学反应芯片的自动化集成微流体装置，与芯片集成的微量柱，并且构造成用于从柱流到至少一个流动通道的液体流，并且其中流入塔的流体流是由片上阀控制; 并且包括用于控制微流体装置中的流体流动的至少两个片上阀。

10. 发明申请

US20060269942A1 In situ click chemistry method for screening high affinity molecular imaging probes 审中-公开
标题翻译：用于筛选高亲和力分子成像探针的原位点击化学方法
公开(公告)号：US20060269942A1
公开(公告)日：2006-11-30
申请号：US11413967
申请日：2006-04-27
申请人： Hartmuth Kolb , Vani Mocharla , Joseph Walsh
发明人： Hartmuth Kolb , Vani Mocharla , Joseph Walsh
IPC分类号： C40B40/04 , C40B40/08 , C40B40/10
CPC分类号： G01N33/532 , A61K51/0453 , A61K51/0455 , G01N33/533 , G01N33/534 , G01N2800/2821
摘要： The invention provides a method for identifying a candidate imaging probe, the method comprising: a) contacting a first library of candidate compounds with a target biomacromolecule, b) identifying a first member from the first library exhibiting affinity for the first binding site; c) contacting the first member identified from the first library affinity for the first binding site with the target biomacromolecule; d) contacting a second library of candidate compounds with the first member and the target biomacromolecule, e) reacting the complementary first functional group with the second functional group via a biomacromolecule induced click chemistry reaction to form the candidate imaging probe; f) isolating and identifying the candidate imaging probe; g) preparing the candidate imaging probe by chemical synthesis; and h) for imaging applications, converting the candidate imaging probe into an imaging probe.
摘要翻译：本发明提供了一种用于鉴定候选成像探针的方法，所述方法包括：a）使候选化合物的第一文库与靶生物大分子接触，b）鉴定第一个文库对第一结合位点表现出亲和性; c）将从第一文库鉴定的第一结合位点与第一结合位点接触的目标生物大分子; d）使候选化合物的第二文库与第一成员和靶生物大分子接触，e）通过生物大分子诱导的点击化学反应使互补的第一官能团与第二官能团反应以形成候选成像探针; f）分离和识别候选成像探针; g）通过化学合成制备候选成像探针; 和h）用于成像应用，将候选成像探针转换成成像探针。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式