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1. 发明授权

US07075658B2 Method for optical coherence tomography imaging with molecular contrast 有权
标题翻译：光学相干层析成像与分子对比的方法
公开(公告)号：US07075658B2
公开(公告)日：2006-07-11
申请号：US10765010
申请日：2004-01-26
申请人： Joseph A. Izatt , Divakar K. Rao , Changhuei Yang , Michael A. Choma , Siavash Yazdanfar , Andrew M. Rollins , Brian E. Applegate
发明人： Joseph A. Izatt , Divakar K. Rao , Changhuei Yang , Michael A. Choma , Siavash Yazdanfar , Andrew M. Rollins , Brian E. Applegate
IPC分类号： G01B9/02
CPC分类号： G01B9/02004 , G01B9/02002 , G01B9/02007 , G01B9/02014 , G01B9/02044 , G01B9/02069 , G01B9/02091 , G01B2290/70
摘要： Spatial information, such as concentration and displacement, about a specific molecular contrast agent, may be determined by stimulating a sample containing the agent, thereby altering an optical property of the agent. A plurality of optical coherence tomography (OCT) images may be acquired, at least some of which are acquired at different stimulus intensities. The acquired images are used to profile the molecular contrast agent concentration distribution of the sample.
摘要翻译：关于特定分子造影剂的空间信息，例如浓度和位移可以通过刺激含有试剂的样品来确定，从而改变试剂的光学性质。可以获取多个光学相干断层摄影（OCT）图像，其中至少一些在不同的刺激强度下被获取。采集的图像用于分析样品的分子造影剂浓度分布。

2. 发明授权

US07903256B2 Methods, systems, and computer program products for performing real-time quadrature projection based Fourier domain optical coherence tomography 有权
标题翻译：用于执行基于傅里叶域光学相干断层扫描的实时正交投影的方法，系统和计算机程序产品
公开(公告)号：US07903256B2
公开(公告)日：2011-03-08
申请号：US11725167
申请日：2007-03-16
申请人： Marinko V. Sarunic , Brian E. Applegate , Joseph A. Izatt
发明人： Marinko V. Sarunic , Brian E. Applegate , Joseph A. Izatt
IPC分类号： G01B11/02
CPC分类号： G01B9/02081 , A61B3/102 , A61B3/12 , G01B9/02004 , G01B9/02091 , G01B2290/45
摘要： Methods, systems, and computer program products for performing real-time quadrature projection based FDOCT are disclosed. According to one method, a plurality of interferogram signals is phase shifted. A Fourier transform is applied to each of the plurality of interferogram signals. Depth dependence of the plurality of transformed interferogram signals is then removed. A real quadrature component and an imaginary quadrature component for each of the plurality of transformed interferogram signals are subsequently calculated. The real quadrature components of the transformed interferogram signals are combined to obtain a derived real component and the imaginary quadrature components of the transformed interferogram signals are combined to obtain a derived imaginary component. A full-range depth profile of the object is constructed by adding the derived real component to the product of the derived imaginary component and a scaling factor. A full-range depth image of the object is then generated using the full-range depth profile.
摘要翻译：公开了用于执行基于实时正交投影的FDOCT的方法，系统和计算机程序产品。根据一种方法，多个干涉图信号被相移。对多个干涉图信号中的每一个进行傅立叶变换。然后去除多个变换干涉图信号的深度依赖性。随后计算多个变换干涉图信号中的每一个的真正正交分量和虚数正交分量。将变换的干涉图信号的真正正交分量组合以获得导出的实分量，并且将经变换的干涉图信号的虚数正交分量组合以获得衍生的虚分量。通过将派生的实数分量与派生的虚分量和缩放因子的乘积相加来构建对象的全范围深度分布。然后使用全范围深度轮廓生成对象的全范围深度图像。

3. 发明申请

US20080170219A1 Methods, systems, and computer program products for performing real-time quadrature projection based Fourier domain optical coherence tomography 有权
标题翻译：用于执行基于傅里叶域光学相干断层扫描的实时正交投影的方法，系统和计算机程序产品
公开(公告)号：US20080170219A1
公开(公告)日：2008-07-17
申请号：US11725167
申请日：2007-03-16
申请人： Marinko V. Sarunic , Brian E. Applegate , Joseph A. Izatt
发明人： Marinko V. Sarunic , Brian E. Applegate , Joseph A. Izatt
IPC分类号： G01N21/00 , G06F17/14 , G01B11/02
CPC分类号： G01B9/02081 , A61B3/102 , A61B3/12 , G01B9/02004 , G01B9/02091 , G01B2290/45
摘要： Methods, systems, and computer program products for performing real-time quadrature projection based FDOCT are disclosed. According to one method, a plurality of interferogram signals is phase shifted. A Fourier transform is applied to each of the plurality of interferogram signals. Depth dependence of the plurality of transformed interferogram signals is then removed. A real quadrature component and an imaginary quadrature component for each of the plurality of transformed interferogram signals are subsequently calculated. The real quadrature components of the transformed interferogram signals are combined to obtain a derived real component and the imaginary quadrature components of the transformed interferogram signals are combined to obtain a derived imaginary component. A full-range depth profile of the object is constructed by adding the derived real component to the product of the derived imaginary component and a scaling factor. A full-range depth image of the object is then generated using the full-range depth profile.
摘要翻译：公开了用于执行基于实时正交投影的FDOCT的方法，系统和计算机程序产品。根据一种方法，多个干涉图信号被相移。对多个干涉图信号中的每一个进行傅立叶变换。然后去除多个变换干涉图信号的深度依赖性。随后计算多个变换干涉图信号中的每一个的真正正交分量和虚数正交分量。将变换的干涉图信号的真正正交分量组合以获得导出的实分量，并且将经变换的干涉图信号的虚数正交分量组合以获得衍生的虚分量。通过将派生的实数分量与派生的虚分量和缩放因子的乘积相加来构建对象的全范围深度分布。然后使用全范围深度轮廓生成对象的全范围深度图像。

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