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1. 发明申请

US20080317747A1 RECOMBINANT ANTI-CD30 ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：重组抗CD30抗体及其用途
公开(公告)号：US20080317747A1
公开(公告)日：2008-12-25
申请号：US12116660
申请日：2008-05-07
申请人： Joseph A. Francisco , Grant Risdon , Alan F. Wahl , Clay Siegall , Peter D. Senter , Sveltana Doronina , Brian E. Toki
发明人： Joseph A. Francisco , Grant Risdon , Alan F. Wahl , Clay Siegall , Peter D. Senter , Sveltana Doronina , Brian E. Toki
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2878 , A61K39/39558 , A61K45/06 , A61K47/64 , A61K47/642 , A61K47/6849 , A61K2039/505 , C07K2317/24 , C07K2317/73
摘要： The present invention relates to methods and compositions for the treatment of Hodgkin's Disease, comprising administering proteins characterized by their ability to bind to CD30, or compete with monoclonal antibodies AC10 or HeFi-1 for binding to CD30, and exert a cytostatic or cytotoxic effect on Hodgkin's disease cells in the absence of effector cells or complement. Such proteins include derivatives of monoclonal antibodies AC10 and HeFi-1. The proteins of the invention can be human, humanized, or chimeric antibodies; further, they can be conjugated to cytotoxic agents such as chemotherapeutic drugs. The invention further relates to nucleic acids encoding the proteins of the invention. The invention yet further relates to a method for identifying an anti-CD30 antibody useful for the treatment or prevention of Hodgkin's Disease.
摘要翻译：本发明涉及用于治疗霍奇金病的方法和组合物，其包括给予特征为结合CD30的能力的蛋白质，或与单克隆抗体AC10或HeFi-1竞争结合CD30，并对细胞生长抑制或细胞毒性作用霍奇金病细胞在没有效应细胞或补体的情况下。这些蛋白质包括单克隆抗体AC10和HeFi-1的衍生物。本发明的蛋白质可以是人，人源化或嵌合抗体; 此外，它们可以与细胞毒性剂如化学治疗药物缀合。本发明还涉及编码本发明蛋白质的核酸。本发明还涉及用于鉴定可用于治疗或预防霍奇金病的抗CD30抗体的方法。

2. 发明申请

US20080213289A1 RECOMBINANT ANTI-CD30 ANTIBODIES AND USES THEREOF 审中-公开
公开(公告)号：US20080213289A1
公开(公告)日：2008-09-04
申请号：US12016978
申请日：2008-01-18
申请人： Joseph A. Francisco , Grant Risdon , Alan F. Wahl , Clay Siegall , Peter D. Senter , Svetlana Doronina , Brian E. Toki
发明人： Joseph A. Francisco , Grant Risdon , Alan F. Wahl , Clay Siegall , Peter D. Senter , Svetlana Doronina , Brian E. Toki
IPC分类号： A61K39/395 , C07K17/00
CPC分类号： A61K47/642 , A61K47/64 , A61K47/6817 , A61K47/6851 , A61K47/6867 , C07K5/0205
摘要： The present invention relates to methods and compositions for the treatment of Hodgkin's Disease, comprising administering proteins characterized by their ability to bind to CD30, or compete with monoclonal antibodies AC10 or HeFi-1 for binding to CD30, and exert a cytostatic or cytotoxic effect on Hodgkin's disease cells in the absence of effector cells or complement. Such proteins include derivatives of monoclonal antibodies AC10 and HeFi-1. The proteins of the invention can be human, humanized, or chimeric antibodies; further, they can be conjugated to cytotoxic agents such as chemotherapeutic drugs. The invention further relates to nucleic acids encoding the proteins of the invention. The invention yet further relates to a method for identifying an anti-CD30 antibody useful for the treatment or prevention of Hodgkin's Disease.

3. 发明授权

US07090843B1 Recombinant anti-CD30 antibodies and uses thereof 有权
标题翻译：重组抗CD30抗体及其用途
公开(公告)号：US07090843B1
公开(公告)日：2006-08-15
申请号：US09724406
申请日：2000-11-28
申请人： Joseph A. Francisco , Grant Risdon , Alan F. Wahl , Clay Siegall
发明人： Joseph A. Francisco , Grant Risdon , Alan F. Wahl , Clay Siegall
IPC分类号： A61K39/395
CPC分类号： C07K16/2878 , A61K45/06 , A61K47/6849 , A61K2039/505 , C07K2317/24
摘要： The present invention relates to methods and compositions for the treatment of Hodgkin's Disease, comprising administering proteins characterized by their ability to bind to CD30, or compete with monoclonal antibodies AC10 or HeFi-1 for binding to CD30, and exert a cytostatic or cytotoxic effect on Hodgkin's Disease cells. Such proteins include derivatives of monoclonal antibodies AC10 and HeFi-1. The proteins of the invention can be human, humanized, or chimeric antibodies; further, they can be conjugated to cytotoxic agents such as chemotherapeutic drugs. The invention further relates to nucleic acids encoding the proteins of the invention. The invention yet further relates to a method for identifying an anti-CD30 antibody useful for the treatment or prevention of Hodgkin's Disease.
摘要翻译：本发明涉及用于治疗霍奇金病的方法和组合物，其包括给予特征为结合CD30的能力的蛋白质，或与单克隆抗体AC10或HeFi-1竞争结合CD30，并对细胞生长抑制或细胞毒性作用霍奇金病细胞。这些蛋白质包括单克隆抗体AC10和HeFi-1的衍生物。本发明的蛋白质可以是人，人源化或嵌合抗体; 此外，它们可以与细胞毒性剂如化学治疗药物缀合。本发明还涉及编码本发明蛋白质的核酸。本发明还涉及用于鉴定可用于治疗或预防霍奇金病的抗CD30抗体的方法。

4. 发明授权

US07510711B2 Methods for the treatment of cancer using anti-CD40 antibodies 有权
标题翻译：使用抗CD40抗体治疗癌症的方法
公开(公告)号：US07510711B2
公开(公告)日：2009-03-31
申请号：US11102743
申请日：2005-04-08
申请人： Clay B. Siegall , Alan F. Wahl , Joseph A. Francisco , Henry Perry Fell, Jr.
发明人： Clay B. Siegall , Alan F. Wahl , Joseph A. Francisco , Henry Perry Fell, Jr.
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2878 , A61K38/00 , A61K2039/505 , C07K5/1021 , C07K2317/622
摘要： The present invention relates to methods and compositions for the prevention and treatment of cancer, inflammatory diseases and disorders or deficiencies of the immune system. The methods of the invention comprise administering a CD40 binding protein that potentiates the binding of CD40 to CD40 ligand.
摘要翻译：本发明涉及用于预防和治疗癌症，炎性疾病和紊乱或免疫系统缺陷的方法和组合物。本发明的方法包括施用增强CD40与CD40配体结合的CD40结合蛋白。

5. 发明授权

US06843989B1 Methods for the treatment and prevention of cancer using anti-CD40 antibodies 有权
标题翻译：使用抗CD40抗体治疗和预防癌症的方法
公开(公告)号：US06843989B1
公开(公告)日：2005-01-18
申请号：US09724530
申请日：2000-11-28
申请人： Clay B. Siegall , Alan F. Wahl , Joseph A. Francisco , Henry Perry Fell, Jr.
发明人： Clay B. Siegall , Alan F. Wahl , Joseph A. Francisco , Henry Perry Fell, Jr.
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61P1/04 , A61P1/16 , A61P7/00 , A61P11/00 , A61P11/06 , A61P17/00 , A61P19/02 , A61P19/10 , A61P21/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/04 , A61P37/08 , C07K5/113 , C07K16/18 , C07K16/28 , C07K16/46 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02
CPC分类号： C07K16/2878 , A61K38/00 , A61K2039/505 , C07K5/1021 , C07K2317/622
摘要： The present invention relates to methods and compositions for the prevention and treatment of cancer, inflammatory diseases and disorders or deficiencies of the immune system. The methods of the invention comprise administering a CD40 binding protein that potentiates the binding of CD40 to CD40 ligand.
摘要翻译：本发明涉及用于预防和治疗癌症，炎性疾病和紊乱或免疫系统缺陷的方法和组合物。本发明的方法包括施用增强CD40与CD40配体结合的CD40结合蛋白。

6. 发明申请

US20100158906A1 METHODS FOR AUGMENTING AN IMMUNE RESPONSE USING ANTI-CD40 ANTIBODIES 有权
标题翻译：使用抗CD40抗体来增强免疫反应的方法
公开(公告)号：US20100158906A1
公开(公告)日：2010-06-24
申请号：US12648108
申请日：2009-12-28
申请人： Clay B. Siegall , Alan F. Wahl , Joseph A. Francisco , Henry Perry Fell, JR.
发明人： Clay B. Siegall , Alan F. Wahl , Joseph A. Francisco , Henry Perry Fell, JR.
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/2878 , A61K38/00 , A61K2039/505 , C07K5/1021 , C07K2317/622
摘要： The present invention relates to methods and compositions for the prevention and treatment of cancer, inflammatory diseases and disorders or deficiencies of the immune system. The methods of the invention comprise administering a CD40 binding protein that potentiates the binding of CD40 to CD40 ligand.
摘要翻译：本发明涉及用于预防和治疗癌症，炎性疾病和紊乱或免疫系统缺陷的方法和组合物。本发明的方法包括施用增强CD40与CD40配体结合的CD40结合蛋白。

7. 发明申请

US20090280117A1 METHODS FOR THE TREATMENT OR PREVENTION OF IMMUNE DISORDERS USING ANTI-CD40 ANTIBODIES 有权
标题翻译：使用抗CD40抗体治疗或预防免疫缺陷病毒的方法
公开(公告)号：US20090280117A1
公开(公告)日：2009-11-12
申请号：US12356511
申请日：2009-01-20
申请人： Clay B. Siegall , Alan F. Wahl , Joseph A. Francisco , Henry Perry Fell, JR.
发明人： Clay B. Siegall , Alan F. Wahl , Joseph A. Francisco , Henry Perry Fell, JR.
IPC分类号： A61K39/395 , A61P37/02
CPC分类号： C07K16/2878 , A61K38/00 , A61K2039/505 , C07K5/1021 , C07K2317/622
摘要： The present invention relates to methods and compositions for the prevention and treatment of cancer, inflammatory diseases and disorders or deficiencies of the immune system. The methods of the invention comprise administering a CD40 binding protein that potentiates the binding of CD40 to CD40 ligand.
摘要翻译：本发明涉及用于预防和治疗癌症，炎性疾病和紊乱或免疫系统缺陷的方法和组合物。本发明的方法包括施用增强CD40与CD40配体结合的CD40结合蛋白。

8. 发明授权

US06946129B1 Recombinant anti-CD40 antibody and uses thereof 有权
标题翻译：重组抗CD40抗体及其用途
公开(公告)号：US06946129B1
公开(公告)日：2005-09-20
申请号：US09328296
申请日：1999-06-08
申请人： Clay B. Siegall , Alan F. Wahl , Joseph A. Francisco , Henry Perry Fell, Jr.
发明人： Clay B. Siegall , Alan F. Wahl , Joseph A. Francisco , Henry Perry Fell, Jr.
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61P1/04 , A61P1/16 , A61P7/00 , A61P11/00 , A61P11/06 , A61P17/00 , A61P19/02 , A61P19/10 , A61P21/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/04 , A61P37/08 , C07K5/113 , C07K16/18 , C07K16/28 , C07K16/46 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02
CPC分类号： C07K16/2878 , A61K38/00 , A61K2039/505 , C07K5/1021 , C07K2317/622
摘要： The present invention relates to methods and compositions for the prevention and treatment of cancer, inflammatory diseases and disorders or deficiencies of the immune system. The methods of the invention comprise administering a CD40 binding protein that potentiates the binding of CD40 to CD40 ligand.
摘要翻译：本发明涉及用于预防和治疗癌症，炎性疾病和紊乱或免疫系统缺陷的方法和组合物。本发明的方法包括施用增强CD40与CD40配体结合的CD40结合蛋白。

9. 发明授权

US06838261B1 Nucleic acids encoding anti-CD40 proteins and methods of producing recombinant anti-CD40 proteins 有权
标题翻译：编码抗CD40蛋白的核酸和产生重组抗CD40蛋白的方法
公开(公告)号：US06838261B1
公开(公告)日：2005-01-04
申请号：US09724409
申请日：2000-11-28
申请人： Clay B. Siegall , Alan F. Wahl , Joseph A. Francisco , Henry Perry Fell, Jr.
发明人： Clay B. Siegall , Alan F. Wahl , Joseph A. Francisco , Henry Perry Fell, Jr.
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61P1/04 , A61P1/16 , A61P7/00 , A61P11/00 , A61P11/06 , A61P17/00 , A61P19/02 , A61P19/10 , A61P21/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/04 , A61P37/08 , C07K5/113 , C07K16/18 , C07K16/28 , C07K16/46 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C07H21/04 , C12N5/16 , C12N15/00
CPC分类号： C07K16/2878 , A61K38/00 , A61K2039/505 , C07K5/1021 , C07K2317/622
摘要： The present invention relates to methods and compositions for the prevention and treatment of cancer, inflammatory diseases and disorders or deficiencies of the immune system. The methods of the invention comprise administering a CD40 binding protein that potentiates the binding of CD40 to CD40 ligand.

10. 发明授权

US07824683B2 Methods for augmenting an immune response using anti-CD40 antibodies 有权
标题翻译：使用抗CD40抗体增强免疫应答的方法
公开(公告)号：US07824683B2
公开(公告)日：2010-11-02
申请号：US12648108
申请日：2009-12-28
申请人： Clay B. Siegall , Alan F. Wahl , Joseph A. Francisco , Henry Perry Fell, Jr.
发明人： Clay B. Siegall , Alan F. Wahl , Joseph A. Francisco , Henry Perry Fell, Jr.
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2878 , A61K38/00 , A61K2039/505 , C07K5/1021 , C07K2317/622
摘要： The present invention relates to methods and compositions for the prevention and treatment of cancer, inflammatory diseases and disorders or deficiencies of the immune system. The methods of the invention comprise administering a CD40 binding protein that potentiates the binding of CD40 to CD40 ligand.
摘要翻译：本发明涉及用于预防和治疗癌症，炎性疾病和紊乱或免疫系统缺陷的方法和组合物。本发明的方法包括施用增强CD40与CD40配体结合的CD40结合蛋白。

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