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1. 发明授权

US5719045A Process for preparing nicotinamide 失效
标题翻译：制备烟酰胺的方法
公开(公告)号：US5719045A
公开(公告)日：1998-02-17
申请号：US741806
申请日：1996-10-31
申请人： Josef Heveling , Erich Armbruster , Lukas Utiger , Markus Rohner , Hans-Rudolf Dettwiler , Roderick J. Chuck
发明人： Josef Heveling , Erich Armbruster , Lukas Utiger , Markus Rohner , Hans-Rudolf Dettwiler , Roderick J. Chuck
IPC分类号： C07D213/82 , B01J23/28 , C12P13/02 , C12P17/12 , C12R1/01
CPC分类号： C12P17/12
摘要： A process for preparing nicotinamide, wherein, in the first stage, 2-methyl-1,5-diaminopentane is catalytically converted into 3-picoline, then the 3-picoline is converted via an ammonoxidation into 3-cyanopyridine and, finally, the 3-cyanopyridine is converted microbiologically into the nicotinamide.
摘要翻译：制备烟酰胺的方法，其中在第一阶段将2-甲基-1,5-二氨基戊烷催化转化为3-甲基吡啶，然后将3-甲基吡啶通过氨氧化转化为3-氰基吡啶，最后，将3 - 氰基吡啶被微生物转化成烟酰胺。

2. 发明授权

US5516661A Microbiological process for the production of aromatic hydroxy-heterocyclic carboxylic acids 失效
标题翻译：用于生产芳香族羟基 - 杂环羧酸的微生物过程
公开(公告)号：US5516661A
公开(公告)日：1996-05-14
申请号：US384695
申请日：1995-02-03
申请人： Andreas Kiener , Markus Rohner , Klaus Heinzmann
发明人： Andreas Kiener , Markus Rohner , Klaus Heinzmann
IPC分类号： C12N1/21 , C12P17/12 , C12P17/14 , C12R1/05 , C12R1/38 , C12N1/20
CPC分类号： C12R1/05 , C12P17/12 , C12R1/38 , Y10S435/822 , Y10S435/829 , Y10S435/874
摘要： The microbiological process for the production of hydroxy-heterocyclic carboxylic acid of formula ##STR1## wherein R.sub.1 means a hydrogen or a halogen atom and X means a nitrogen atom or a CR.sub.2 function, wherein R.sub.2 means a hydrogen or halogen atom, starting from the corresponding heterocyclic carboxylic acid. The process is performed so that an aerobic biomass which utilizes nicotinic acid, is cultivated in a molar ratio of nicotinic acid to mineral acid of 1 to 8. The ratio is assured over the entire cultivation phase. The the hydroxylation of the corresponding heterocyclic carboxylic acid of the general formula ##STR2## wherein R.sub.1 and X have the above-mentioned meanings, is performed with the biomass. Under these conditions, strain Pseudomonas acidovorans DSM 7205, strain Pseudomonas acidovorans DSM 7203, strain Alcaligenes faecalis DSM 7204 and strain Arthrobacter crystallopoietes DSM 7202 are concentrated in the cultivation phase.
摘要翻译：用于制备式基因原子的羟基 - 杂环羧酸的微生物方法，X表示氮原子或CR 2官能团，其中R2表示氢或卤素原子，从相应的杂环羧酸开始。以烟碱酸与无机酸的摩尔比为1〜8培养利用烟酸的好氧生物质的方法进行。在整个培养阶段确保比例。通过生物质进行其中R1和X具有上述含义的通式“IMAGE”II的相应杂环羧酸的羟基化。在这些条件下，将菌株Pseudomonas acidovorans DSM 7205，耐酸假单胞菌DSM 7203，粪肠杆菌粪肠球菌DSM 7204和菌株节杆菌结晶洗脱液DSM2202浓缩在培养阶段。

3. 发明授权

US5167371A Fan jet nozzle 失效
标题翻译：风扇喷嘴
公开(公告)号：US5167371A
公开(公告)日：1992-12-01
申请号：US705319
申请日：1991-05-24
申请人： Markus Rohner
发明人： Markus Rohner
IPC分类号： B05B1/04
CPC分类号： B05B1/042
摘要： A fan jet nozzle for surface coating, particularly for high-pressure spraying, is created whose inside dome is not fashioned rotationally-symmetrical. The dome interior is semicircular in the one plane of section in which the nozzle slot extends, but is ogive in the plane perpendicular thereto, the plane which is perpendicular to the lengthwise plane of the fan jet nozzle slot. The two sections, semicircular and ogive, steadily verge into one another around the center axis of the nozzle. The dome configuration results in less wear from abrasion of spraying fluid through the nozzle slot, in particular, onto the wall edge between the dome and the nozzle slot.
摘要翻译：产生用于表面涂层的风扇喷嘴，特别是用于高压喷涂，其内部圆顶不是旋转对称的。圆顶内部在喷嘴槽延伸的一个平面中是半圆形的，但是在与其垂直的平面中垂直于与风扇喷嘴狭槽的纵向平面垂直的平面。半圆形和ogive的两个部分围绕喷嘴的中心轴稳定地彼此相邻。圆顶结构导致较少的喷涂流体穿过喷嘴槽的磨损，特别是在圆顶和喷嘴槽之间的壁边缘上的磨损。

4. 发明申请

US20120148685A1 METHODS AND COMPOSITIONS FOR TREATING INSULIN RESISTANCE, DIABETES MELLITUS TYPE 2, METABOLIC SYNDROME AND RELATED DISORDERS 审中-公开
标题翻译：治疗胰岛素抵抗的方法和组合物，2型糖尿病，代谢综合征和相关疾病
公开(公告)号：US20120148685A1
公开(公告)日：2012-06-14
申请号：US13376438
申请日：2010-06-10
申请人： Markus Rohner
发明人： Markus Rohner
IPC分类号： A61K31/205 , A61K35/74 , A61K31/455 , A61K36/889 , A61K36/82 , A61K31/202 , A61P3/04 , A61P3/10 , A61P3/00 , A61P9/00 , A61P3/06 , A61K36/185 , A61K36/48 , A61K31/366 , A61K36/53 , A61K31/353 , A61K36/42 , A61K36/258 , A61K36/481
CPC分类号： A61K31/205 , A61K31/202 , A61K31/455 , A61K31/7004 , A61K36/02 , A61K36/48 , A61K36/481 , A61K36/55 , A61K36/82 , A61K36/889 , A61K45/06 , A61K2300/00
摘要： The present invention relates to compositions comprising (i) an activator of transport of fatty acids into the mitochondria; (ii) an activator of fatty acid oxidation; and (iii) an inhibitor of fatty acid biosynthesis, and methods for treating insulin resistance, diabetes mellitus type 2, metabolic syndrome, dyslipidemias, obesity, and/or cardiovascular disorders in a subject.
摘要翻译：本发明涉及包含（i）脂肪酸转运到线粒体中的活化剂的组合物; （ii）脂肪酸氧化活化剂; 和（iii）脂肪酸生物合成的抑制剂，以及治疗受试者的胰岛素抵抗，2型糖尿病，代谢综合征，血脂异常，肥胖症和/或心血管疾病的方法。

5. 发明申请

US20090081320A1 Method for Weight Reduction 审中-公开
标题翻译：减肥方法
公开(公告)号：US20090081320A1
公开(公告)日：2009-03-26
申请号：US12086083
申请日：2006-12-04
申请人： Markus Rohner
发明人： Markus Rohner
IPC分类号： A61K36/82 , A61K36/00
CPC分类号： A61K31/205 , A23L33/105 , A23L33/30 , A23V2002/00 , A61K31/353 , A61K36/185 , G06F19/3475 , A61K2300/00 , A23V2200/332 , A23V2250/0612 , A23V2250/21
摘要： The present invention relates to a method for weight reduction in a mammal, comprising a diet that either reduces or lifts the fat metabolism by glucose, combined with an intake of a composition that contains one or several active agents that promote fat burning.
摘要翻译：本发明涉及哺乳动物体重减轻的方法，其包括通过葡萄糖降低或升高脂肪代谢的饮食，以及含有一种或几种促进脂肪燃烧的活性剂的组合物的摄入。

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