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1. 发明授权

US08875748B2 Device for filling a filter, and method therefor 有权
标题翻译：用于填充过滤器的装置及其方法
公开(公告)号：US08875748B2
公开(公告)日：2014-11-04
申请号：US13061782
申请日：2009-09-02
申请人： Josef Beden , Itka Bado , Georg Verch
发明人： Josef Beden , Itka Bado , Georg Verch
IPC分类号： A61M1/16 , B01D61/30 , A61M1/36 , B01D65/00
CPC分类号： A61M1/3643 , A61M1/1607 , A61M1/1658 , A61M1/3644 , A61M1/365 , A61M2205/3393 , B01D61/30 , B01D65/00 , B01D2313/16
摘要： An apparatus for the filling of a medical filter has at least one first space and one second space which are semipermeably separated by one or more membranes, with the spaces each having at least one inflow and outflow. The apparatus includes a detection unit having a first element and a second element, with a liquid discharge from at least one of the first and second spaces being detectable by the first element, and the state of the filling of the filter being determinable by the second element with reference to the detected liquid discharge. A method of filling a medical filter employs the apparatus.
摘要翻译：用于填充医疗过滤器的装置具有至少一个第一空间和一个第二空间，该第一空间和第二空间被一个或多个膜半透明地分开，空间各自具有至少一个流入和流出。该装置包括具有第一元件和第二元件的检测单元，其中第一和第二空间中的至少一个的液体排放可由第一元件检测，并且过滤器的填充状态可由第二元件确定参考检测到的液体排出。填充医疗过滤器的方法采用该装置。

2. 发明申请

US20110237997A1 METHOD AND DEVICE FOR MONITORING THE INTRODUCTION OF SUBSTITUTION FLUIDS UPSTREAM OF DOWNSTREAM OF A DIALYZER OF FILTER 有权
标题翻译：用于监测过滤器的DIALYZER下游水替代液的上游的介绍的方法和装置
公开(公告)号：US20110237997A1
公开(公告)日：2011-09-29
申请号：US13124353
申请日：2009-10-08
申请人： Josef Beden , Itka Bado , Georg Verch
发明人： Josef Beden , Itka Bado , Georg Verch
IPC分类号： A61M1/34
CPC分类号： A61M1/342 , A61M1/16 , A61M1/3434 , A61M1/3437 , A61M1/3627 , A61M2205/3386
摘要： A method is provided for monitoring the introduction of substitution fluids for an extra-corporeal blood processing device with an extra-corporeal blood circuit, comprising an arterial blood line, running from an arterial patient connection to a first chamber of a dialyzer or filter divided into said first chamber and a second chamber by a membrane and a venous blood line, running from the first chamber of the dialyzer or filter to a venous patient connection. A device is provided for monitoring the introduction of substitution fluids for an extra-corporeal blood processing unit with an extra-corporeal blood circuit and an extra-corporeal blood processing device with a device for monitoring the introduction of substitution fluids. The method and the device for monitoring the introduction of substitution fluids are based on monitoring the fluid level in the bubble trap, arranged in the venous blood line of the extra-corporeal blood circuit. The method and the device require that fluid is added to fill the extra-corporeal blood circuit, for example, for a rinsing procedure of the extra-corporeal blood circuit by means of the substitution fluid supply line arranged upstream or downstream of the dialyzer. A pre-dilution can be commanded when, after initiating the rinsing process the fill level in the bubble trap does not drop below a certain level. When by contrast the fill level drops below a given level a post-dilution can be commanded.
摘要翻译：提供了一种用于监测引入具有体外血液回路的体外血液处理装置的替代流体的方法，其包括动脉血液管线，从动脉患者连接到透析器或过滤器的第一腔室分为所述第一腔室和通过膜和静脉血液管线的第二腔室，其从透析器或过滤器的第一腔室延伸到静脉患者连接。提供了一种装置，用于监测引入具有体外血液回路的体外血液处理装置的替代液体和具有用于监测引入取代流体的装置的体外血液处理装置。用于监测引入替代液体的方法和装置是基于监测排列在体外血液回路的静脉血管中的气泡阱中的液位。该方法和装置要求添加流体以填充超体内血液回路，例如通过布置在透析器上游或下游的替代流体供应管线来进行体外血液回路的漂洗程序。在开始漂洗处理之后，可以命令预稀释，气泡阱中的填充水平不会下降到一定水平以下。当相反，填充水平降低到给定水平以下时，可以命令后稀释。

3. 发明申请

US20110168291A1 DEVICE FOR FILLING A FILTER, AND METHOD THEREFOR 有权
标题翻译：用于填充过滤器的装置及其方法
公开(公告)号：US20110168291A1
公开(公告)日：2011-07-14
申请号：US13061782
申请日：2009-09-02
申请人： Josef Beden , Itka Bado , Georg Verch
发明人： Josef Beden , Itka Bado , Georg Verch
IPC分类号： B65B3/04
CPC分类号： A61M1/3643 , A61M1/1607 , A61M1/1658 , A61M1/3644 , A61M1/365 , A61M2205/3393 , B01D61/30 , B01D65/00 , B01D2313/16
摘要： The present invention relates to an apparatus and a method for the filling of a medical filter, wherein the filter has at least one first space and one second space which are semipermeably separated by one or more membranes, wherein the spaces each have at least one inflow and outflow, and wherein a detection unit having first and second means is provided, with liquid discharge from at least one of the spaces being able to be detected by means of the first means and the state of the filling of the filter being able to be determined by means of the second means with reference to the detected liquid discharge.
摘要翻译：本发明涉及一种用于填充医疗过滤器的装置和方法，其中过滤器具有至少一个第一空间和一个第二空间，其通过一个或多个膜半透膜地分开，其中每个空间具有至少一个流入并且其中设置有具有第一和第二装置的检测单元，其中至少一个空间的液体排出能够通过第一装置检测，并且过滤器的填充状态能够通过参考检测到的液体排出通过第二装置确定。

4. 发明授权

US08852135B2 Method and device for monitoring the introduction of substitution fluids upstream of downstream of a dialyzer of filter 有权
标题翻译：用于监测过滤器透析器下游上游引入替代液的方法和装置
公开(公告)号：US08852135B2
公开(公告)日：2014-10-07
申请号：US13124353
申请日：2009-10-08
申请人： Josef Beden , Itka Bado , Georg Verch
发明人： Josef Beden , Itka Bado , Georg Verch
IPC分类号： A61M1/34
CPC分类号： A61M1/342 , A61M1/16 , A61M1/3434 , A61M1/3437 , A61M1/3627 , A61M2205/3386
摘要： A method is provided for monitoring the introduction of substitution fluids for an extra-corporeal blood processing device with an extra-corporeal blood circuit, comprising an arterial blood line, running from an arterial patient connection to a first chamber of a dialyzer or filter divided into said first chamber and a second chamber by a membrane and a venous blood line, running from the first chamber of the dialyzer or filter to a venous patient connection. A device is provided for monitoring the introduction of substitution fluids for an extra-corporeal blood processing unit with an extra-corporeal blood circuit and an extra-corporeal blood processing device with a device for monitoring the introduction of substitution fluids. The method and the device for monitoring the introduction of substitution fluids are based on monitoring the fluid level in the bubble trap, arranged in the venous blood line of the extra-corporeal blood circuit. The method and the device require that fluid is added to fill the extra-corporeal blood circuit, for example, for a rinsing procedure of the extra-corporeal blood circuit by means of the substitution fluid supply line arranged upstream or downstream of the dialyzer. A pre-dilution can be commanded when, after initiating the rinsing process the fill level in the bubble trap does not drop below a certain level. When by contrast the fill level drops below a given level a post-dilution can be commanded.
摘要翻译：提供了一种用于监测引入具有体外血液回路的体外血液处理装置的替代流体的方法，其包括动脉血液管线，从动脉患者连接到透析器或过滤器的第一腔室分为所述第一腔室和通过膜和静脉血液管线的第二腔室，其从透析器或过滤器的第一腔室延伸到静脉患者连接。提供了一种装置，用于监测引入具有体外血液回路的体外血液处理装置的替代液体和具有用于监测引入取代流体的装置的体外血液处理装置。用于监测引入替代液体的方法和装置是基于监测排列在体外血液回路的静脉血管中的气泡阱中的液位。该方法和装置要求添加流体以填充超体内血液回路，例如通过布置在透析器上游或下游的替代流体供应管线来进行体外血液回路的漂洗程序。在开始漂洗处理之后，可以命令预稀释，气泡阱中的填充水平不会下降到一定水平以下。当相反，填充水平降低到给定水平以下时，可以命令后稀释。

5. 发明申请

US20110120227A1 METHOD FOR OPERATING A PRESSURE MEASURING UNIT, APPARATUS HAVING AT LEAST ONE PRESSURE MEASURING UNIT, DEVICE HAVING SUCH AN APPARATUS, AND USE OF A MEASURING CHAMBER 有权
标题翻译：用于操作压力测量单元的方法，具有至少一个压力测量单元的装置，具有这种装置的装置和使用测量室
公开(公告)号：US20110120227A1
公开(公告)日：2011-05-26
申请号：US13055558
申请日：2009-07-21
申请人： Josef Beden , Itka Bado , Patrick Spalt
发明人： Josef Beden , Itka Bado , Patrick Spalt
IPC分类号： G01L9/00
CPC分类号： A61M1/3639 , A61M1/3641 , A61M2205/3331 , A61M2205/702
摘要： The present invention relates to a method for the operation of a pressure measuring device for the measurement of the pressure in a system through which fluid flows, in particular in an extracorporeal circuit of a medical unit, with the pressure measuring device having a measuring chamber which is bounded by a flexible membrane, through which fluid flows in the operation of the system or which is filled with fluid and also having a pressure sensor connected to the membrane for the purpose of pressure measurement, with the method including the following steps not requiring any intervention of the staff: a. increasing the pressure in the measuring chamber (12) to a pressure value at which the membrane (13) is at least slightly outwardly curved relative to the measuring chamber (12) in the state not connected to the pressure sensor (14) or determining such a pressure value; b: separating the membrane (13) of the measuring chamber (12) from the pressure sensor (14); c. joining together the membrane (13) of the measuring chamber (12) and of the pressure sensor (14) such that the membrane (13) of the measuring chamber (12) contacts the pressure sensor (14); and d. repeating the steps a. to c. at predetermined intervals and/or on the occurrence of an error case.
摘要翻译：本发明涉及一种压力测量装置的操作方法，该压力测量装置用于测量流体流动的系统中的压力，特别是在医疗单元的体外回路中，压力测量装置具有测量室，由柔性膜界定，流体在系统操作中流动，或者填充有流体，并且还具有连接到膜的压力传感器用于压力测量，该方法包括以下步骤，不需要任何工作人员干预：a。在不连接到压力传感器（14）的状态下，将测量室（12）中的压力增加到压力值，在该压力值膜（13）相对于测量室（12）至少稍微向外弯曲，或者确定压力值 b：将测量室（12）的膜（13）与压力传感器（14）分离; C。将测量室（12）的膜（13）和压力传感器（14）接合在一起，使得测量室（12）的膜（13）接触压力传感器（14）; 和d。重复步骤a。到c。以预定间隔和/或出现错误情况。

6. 发明授权

US08375797B2 Method for operating a pressure measuring unit, apparatus having at least one pressure measuring unit, device having such an apparatus, and use of a measuring chamber 有权
标题翻译：用于操作压力测量单元的方法，具有至少一个压力测量单元的设备，具有这种设备的设备以及测量室的使用
公开(公告)号：US08375797B2
公开(公告)日：2013-02-19
申请号：US13055558
申请日：2009-07-21
申请人： Josef Beden , Itka Bado , Patrick Spalt
发明人： Josef Beden , Itka Bado , Patrick Spalt
IPC分类号： G01L9/00 , A61B8/00
CPC分类号： A61M1/3639 , A61M1/3641 , A61M2205/3331 , A61M2205/702
摘要： The present invention relates to a method for the operation of a pressure measuring device for the measurement of the pressure in a system through which fluid flows, in particular in an extracorporeal circuit of a medical unit, with the pressure measuring device having a measuring chamber which is bounded by a flexible membrane, through which fluid flows in the operation of the system or which is filled with fluid and also having a pressure sensor connected to the membrane for the purpose of pressure measurement, with the method including the following steps not requiring any intervention of the staff: a. increasing the pressure in the measuring chamber (12) to a pressure value at which the membrane (13) is at least slightly outwardly curved relative to the measuring chamber (12) in the state not connected to the pressure sensor (14) or determining such a pressure value; b: separating the membrane (13) of the measuring chamber (12) from the pressure sensor (14); c. joining together the membrane (13) of the measuring chamber (12) and of the pressure sensor (14) such that the membrane (13) of the measuring chamber (12) contacts the pressure sensor (14); and d. repeating the steps a. to c. at predetermined intervals and/or on the occurrence of an error case.
摘要翻译：本发明涉及一种压力测量装置的操作方法，该压力测量装置用于测量流体流动的系统中的压力，特别是在医疗单元的体外回路中，压力测量装置具有测量室，由柔性膜界定，流体在系统操作中流动，或者填充有流体，并且还具有连接到膜的压力传感器用于压力测量，该方法包括以下步骤，不需要任何工作人员干预：a。在不连接到压力传感器（14）的状态下，将测量室（12）中的压力增加到压力值，在该压力值膜（13）相对于测量室（12）至少稍微向外弯曲，或者确定压力值 b：将测量室（12）的膜（13）与压力传感器（14）分离; C。将测量室（12）的膜（13）和压力传感器（14）接合在一起，使得测量室（12）的膜（13）接触压力传感器（14）; 和d。重复步骤a。到c。以预定间隔和/或出现错误情况。

7. 发明申请

US20120170020A1 DEVICE AND METHOD FOR DETECTING BLOOD OR BLOOD CONSTITUENTS IN THE LIQUID SYSTEM OF A DEVICE FOR EXTRACORPOREAL BLOOD TREATMENT 有权
标题翻译：用于检测血液中血液或血液成分的装置和方法，用于超声波血液处理装置的液体系统
公开(公告)号：US20120170020A1
公开(公告)日：2012-07-05
申请号：US13388603
申请日：2010-07-31
申请人： Itka Bado , Peter Scheunert
发明人： Itka Bado , Peter Scheunert
IPC分类号： A61M1/16 , G01N21/27 , B01D61/30 , G01N21/59
CPC分类号： G01N33/49 , A61M1/1692 , A61M2205/18 , A61M2205/3313 , G01N21/251
摘要： The present invention relates to a device and a method for detecting blood or blood constituents in the liquid system of a device for extracorporeal blood treatment, comprising a dialysis device or filter divided by a semipermeable membrane into a first chamber and a second chamber, wherein the first chamber is part of the extracorporeal blood circulation system and the second chamber part of the liquid system of the extracorporeal blood treatment device. The device according to the present invention for detecting blood or blood constituents in the liquid system of an extracorporeal blood treatment device is designed as a unit for differentiating between the entry of blood into the liquid system due to a defect of the dialysis device or filter, for example a rupture of the semipermeable membrane of the dialysis device or filter, or the entry of hemoglobin into the liquid system due to hemolysis, wherein a differentiation is made between a defect of the dialysis device or filter or hemolysis based on the change in intensity of at least the blue fraction of the light exiting from the liquid.
摘要翻译：本发明涉及用于检测用于体外血液处理的装置的液体系统中的血液或血液成分的装置和方法，包括由半透膜分成第一腔室和第二腔室的透析装置或过滤器，其中第一室是体外血液循环系统的一部分和体外血液处理装置的液体系统的第二室部分。根据本发明的用于检测体外血液处理装置的液体系统中的血液或血液成分的装置被设计为用于区分由于透析装置或过滤器的缺陷导致的血液进入液体系统的单元，例如透析装置或过滤器的半透膜的破裂或由于溶血引起的血红蛋白进入液体系统，其中在透析装置的缺陷或过滤器之间进行分化或基于强度变化进行溶血至少从液体出射的光的蓝色部分。

8. 发明申请

US20090279071A1 SPECTROSCOPIC DETECTOR AND METHOD FOR DETERMINING THE PRESENCE OF BLOOD AND BIOLOGICAL MARKER SUBSTANCES IN LIQUIDS 有权
标题翻译：光谱检测器和确定液体中血液和生物标记物质的存在的方法
公开(公告)号：US20090279071A1
公开(公告)日：2009-11-12
申请号：US12306088
申请日：2007-06-26
申请人： Itka Bado , Michael Herrenbauer , Ulrich Moissl
发明人： Itka Bado , Michael Herrenbauer , Ulrich Moissl
IPC分类号： G01N33/49 , G01N33/00
CPC分类号： G01N21/53 , A61B5/14557 , A61M1/1692 , G01N21/534 , G01N21/85
摘要： The invention relates to a detector for measuring scattered light in liquids having a housing, a transparent, flexible tube for transporting liquid through the housing, a light emitter, and a light detector. Two parallel surfaces are formed in the housing, between which the tube is arranged such that two opposing tube walls are formed in a planar parallel manner. The light emitter is arranged in such a way that the optical axis thereof is perpendicular to the parallel surfaces of the first tube wall, and the light detector is adjacent to the light emitter, the optical axes of the light emitter and light detector forming an angle smaller than 90°. The invention also relates to a method for detecting the presence of blood and for the quantitative determination of biological marker substances, especially bilirubin, in solution, and to a device for treating blood containing the detector.
摘要翻译：本发明涉及一种用于测量液体中散射光的检测器，其具有壳体，用于将液体输送通过壳体的透明柔性管，光发射器和光检测器。两个平行的表面形成在壳体中，管之间布置有两个相对的管壁以平面平行的方式形成。光发射器被布置成使得其光轴垂直于第一管壁的平行表面，并且光检测器与光发射器相邻，光发射器和光检测器的光轴形成角度小于90°。本发明还涉及一种用于检测血液存在和用于定量测定溶液中的生物标记物质，特别是胆红素的方法以及用于处理含有检测器的血液的装置的方法。

9. 发明授权

US08743353B2 Device and method for detecting blood or blood constituents in the liquid system of a device for extracorporeal blood treatment 有权
标题翻译：用于检测用于体外血液处理的装置的液体系统中的血液或血液成分的装置和方法
公开(公告)号：US08743353B2
公开(公告)日：2014-06-03
申请号：US13388603
申请日：2010-07-31
申请人： Itka Bado , Peter Scheunert
发明人： Itka Bado , Peter Scheunert
IPC分类号： G01N33/48 , G01N33/49 , G01N21/25
CPC分类号： G01N33/49 , A61M1/1692 , A61M2205/18 , A61M2205/3313 , G01N21/251
摘要： The present invention relates to a device and a method for detecting blood or blood constituents in the liquid system of a device for extracorporeal blood treatment, comprising a dialysis device or filter divided by a semipermeable membrane into a first chamber and a second chamber, wherein the first chamber is part of the extracorporeal blood circulation system and the second chamber part of the liquid system of the extracorporeal blood treatment device. The device according to the present invention for detecting blood or blood constituents in the liquid system of an extracorporeal blood treatment device is designed as a unit for differentiating between the entry of blood into the liquid system due to a defect of the dialysis device or filter, for example a rupture of the semipermeable membrane of the dialysis device or filter, or the entry of hemoglobin into the liquid system due to hemolysis, wherein a differentiation is made between a defect of the dialysis device or filter or hemolysis based on the change in intensity of at least the blue fraction of the light exiting from the liquid.
摘要翻译：本发明涉及用于检测用于体外血液处理的装置的液体系统中的血液或血液成分的装置和方法，包括由半透膜分成第一腔室和第二腔室的透析装置或过滤器，其中第一室是体外血液循环系统的一部分和体外血液处理装置的液体系统的第二室部分。根据本发明的用于检测体外血液处理装置的液体系统中的血液或血液成分的装置被设计为用于区分由于透析装置或过滤器的缺陷导致的血液进入液体系统的单元，例如透析装置或过滤器的半透膜的破裂或由于溶血引起的血红蛋白进入液体系统，其中在透析装置的缺陷或过滤器之间进行分化或基于强度变化进行溶血至少从液体出射的光的蓝色部分。

10. 发明授权

US08269953B2 Spectroscopic detector and method for determining the presence of blood and biological marker substances in liquids 有权
标题翻译：用于确定液体中血液和生物标记物质的存在的光谱检测器和方法
公开(公告)号：US08269953B2
公开(公告)日：2012-09-18
申请号：US13241428
申请日：2011-09-23
申请人： Itka Bado , Michael Herrenbauer , Ulrich Moissl
发明人： Itka Bado , Michael Herrenbauer , Ulrich Moissl
IPC分类号： G01N33/48
CPC分类号： G01N21/53 , A61B5/14557 , A61M1/1692 , G01N21/534 , G01N21/85
摘要： The invention relates to a detector for measuring scattered light in liquids having a housing, a transparent, flexible tube for transporting liquid through the housing, a light emitter, and a light detector. Two parallel surfaces are formed in the housing, between which the tube is arranged such that two opposing tube walls are formed in a planar parallel manner. The light emitter is arranged in such a way that the optical axis thereof is perpendicular to the parallel surfaces of the first tube wall, and the light detector is adjacent to the light emitter, the optical axes of the light emitter and light detector forming an angle smaller than 90°. The invention also relates to a method for detecting the presence of blood and for the quantitative determination of biological marker substances, especially bilirubin, in solution, and to a device for treating blood containing the detector.
摘要翻译：本发明涉及一种用于测量液体中散射光的检测器，其具有壳体，用于将液体输送通过壳体的透明柔性管，光发射器和光检测器。两个平行的表面形成在壳体中，管之间布置有两个相对的管壁以平面平行的方式形成。光发射器被布置成使得其光轴垂直于第一管壁的平行表面，并且光检测器与光发射器相邻，光发射器和光检测器的光轴形成角度小于90°。本发明还涉及一种用于检测血液存在和用于定量测定溶液中的生物标记物质，特别是胆红素的方法以及用于处理含有检测器的血液的装置的方法。

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