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1. 发明申请

US20100189772A1 Compositions of TLR ligands and antivirals 审中-公开
标题翻译： TLR配体和抗病毒药物的组成
公开(公告)号：US20100189772A1
公开(公告)日：2010-07-29
申请号：US12443224
申请日：2007-09-27
申请人： Jorg Vollmer , Marion Jurk , Eugen Uhlmann , Harald Debelak , Robert L. Bratzler , Alain Vicari
发明人： Jorg Vollmer , Marion Jurk , Eugen Uhlmann , Harald Debelak , Robert L. Bratzler , Alain Vicari
IPC分类号： A61K9/127 , C07H21/02 , C07H21/04 , A61K39/12 , A61P31/04 , A61P31/12
CPC分类号： A61K31/7088 , A61K45/06 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/336 , C12N2310/351 , C12N2320/31 , A61K2300/00
摘要： The invention relates to methods and products for the treatment of viral infection using a combination of anti-viral agents and TLR ligands. The invention also relates to screening assays, associated products, kits, and in vitro methods.
摘要翻译：本发明涉及使用抗病毒剂和TLR配体的组合治疗病毒感染的方法和产品。本发明还涉及筛选测定，相关产品，试剂盒和体外方法。

2. 发明申请

US20050059619A1 Immunostimulatory nucleic acids 有权
标题翻译：免疫刺激核酸
公开(公告)号：US20050059619A1
公开(公告)日：2005-03-17
申请号：US10644052
申请日：2003-08-19
申请人： Arthur Krieg , Ulrike Samulowitz , Jorg Vollmer , Eugen Uhlmann , Marion Jurk , Grayson Lipford , Robert Rankin
发明人： Arthur Krieg , Ulrike Samulowitz , Jorg Vollmer , Eugen Uhlmann , Marion Jurk , Grayson Lipford , Robert Rankin
IPC分类号： A61K31/70 , A61K48/00 , C07H19/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/117 , C12Q1/00 , C12Q1/68
CPC分类号： C12N15/117 , A61K31/70 , A61K2039/55561 , C07H19/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N2310/312 , C12N2310/3125 , C12N2310/313 , C12N2310/315 , C12N2310/336 , C12N2310/345
摘要： The invention relates to a class of soft or semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response.
摘要翻译：本发明涉及一类可用于刺激免疫应答的软或半软CpG免疫刺激性寡核苷酸。

3. 发明申请

US20070224210A1 Immunostimulatory nucleic acids 有权
标题翻译：免疫刺激核酸
公开(公告)号：US20070224210A1
公开(公告)日：2007-09-27
申请号：US11542845
申请日：2006-10-04
申请人： Arthur Krieg , Grayson Lipford , Ulrike Samulowitz , Jorg Vollmer , Eugen Uhlmann , Marion Jurk , Robert Rankin
发明人： Arthur Krieg , Grayson Lipford , Ulrike Samulowitz , Jorg Vollmer , Eugen Uhlmann , Marion Jurk , Robert Rankin
IPC分类号： A61K39/00
CPC分类号： C12N15/117 , A61K31/70 , A61K2039/55561 , C07H19/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N2310/312 , C12N2310/3125 , C12N2310/313 , C12N2310/315 , C12N2310/336 , C12N2310/345
摘要： The invention relates to a class of soft or semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response.
摘要翻译：本发明涉及一类可用于刺激免疫应答的软或半软CpG免疫刺激性寡核苷酸。

4. 发明申请

US20100144846A1 Oligoribonucleotides and uses thereof 审中-公开
标题翻译：寡核糖核苷酸及其用途
公开(公告)号：US20100144846A1
公开(公告)日：2010-06-10
申请号：US12447107
申请日：2007-10-26
申请人： Marion Jurk , Jorg Vollmer , Eugen Uhlmann
发明人： Marion Jurk , Jorg Vollmer , Eugen Uhlmann
IPC分类号： A61K31/7088 , C07H21/02 , C07K2/00 , C07K14/00 , A61P35/00 , A61P37/08 , A61P31/12 , A61P11/00 , A61P37/02
CPC分类号： C12N15/117 , A61K2039/55561 , C12N2310/17 , C12N2310/315 , C12N2310/317 , C12N2310/336 , C12N2310/3511 , C12N2310/3515 , C12N2310/3517
摘要： The invention relates to immunostimulatory RNA oligonucleotides (ORN). In particular the ORN have an immunostimulatory ORN motif directly or indirectly flanked by a 3′ poly G motif and optionally a 5′ poly-G motif. The invention also relates to methods including therapeutic methods and screening methods and related kits for use of the ORN.
摘要翻译：本发明涉及免疫刺激RNA寡核苷酸（ORN）。特别地，ORN具有直接或间接侧接于3'poly G基序和任选的5'poly-G基序的免疫刺激性ORN基序。本发明还涉及包括用于ORN的治疗方法和筛选方法以及相关试剂盒的方法。

5. 发明授权

US07956043B2 5′ CpG nucleic acids and methods of use 失效
标题翻译： 5'CpG核酸和使用方法
公开(公告)号：US07956043B2
公开(公告)日：2011-06-07
申请号：US10735592
申请日：2003-12-11
申请人： Arthur M. Krieg , Marion Jurk , Jorg Vollmer , Eugen Uhlmann
发明人： Arthur M. Krieg , Marion Jurk , Jorg Vollmer , Eugen Uhlmann
IPC分类号： A61K45/00 , A61K47/00 , A61K31/70 , A01N43/04
CPC分类号： C12N15/117 , A61K2039/55561 , C07H21/04 , C12N2310/315
摘要： The invention relates to a class of CpG immunostimulatory oligonucleotides containing a 5′TCG motif or a CG at or near the 5′ end that are useful for stimulating an immune response.
摘要翻译：本发明涉及一类含有5'5GG基序或在5'端或附近的可用于刺激免疫应答的CpG免疫刺激性寡核苷酸。

6. 发明申请

US20050239733A1 Sequence requirements for inhibitory oligonucleotides 审中-公开
标题翻译：抑制性寡核苷酸的序列要求
公开(公告)号：US20050239733A1
公开(公告)日：2005-10-27
申请号：US10977560
申请日：2004-10-29
申请人： Marion Jurk , Jorg Vollmer , Arthur Krieg , Eugen Uhlmann
发明人： Marion Jurk , Jorg Vollmer , Arthur Krieg , Eugen Uhlmann
IPC分类号： A61K48/00 , C07H21/04 , C12N15/117
CPC分类号： C12N15/117 , C12N2310/17 , C12N2310/321 , C12N2310/334 , C12N2310/3341 , C12N2310/336 , C12N2310/3521
摘要： Novel oligonucleotides having immune inhibitory effects, and methods for their use, are provided. The inhibitory oligonucleotides include those that specifically inhibit certain Toll-like receptors, including TLR7, TLR8, and TLR9. Certain of the immunoinhibitory oligonucleotides inhibit a combination of TLRs selected from TLR7, TLR8, and TLR9. Inhibitors of TLR9 are characterized by a 5′ CC dinucleotide appropriately spaced upstream of a G-rich oligomer. Inhibitors of TLR8 include specific simple dinucleotides and oligonucleotides ending at their 3′ termini with the specific dinucleotides. TLR7 inhibitors include oligonucleotides having a phosphorothioate backbone. Also provided are combinations and conjugates involving the inhibitory oligonucleotides of the invention and other agents, where the other agents include TLR agonists and antigens. Compositions of the invention can be used to shape an immune response, reduce unwanted specific TLR-mediated immunostimulation, and to treat conditions including allergy, asthma, infection, and cancer.
摘要翻译：提供了具有免疫抑制作用的新型寡核苷酸及其使用方法。抑制性寡核苷酸包括特异性抑制某些Toll样受体的那些，包括TLR7，TLR8和TLR9。某些免疫抑制性寡核苷酸抑制了选自TLR7，TLR8和TLR9的TLR的组合。 TLR9的抑制剂的特征在于在富G寡聚体上游适当间隔5'CC二核苷酸。 TLR8的抑制剂包括特异性简单二核苷酸和寡核苷酸终止于其3'末端与特异性二核苷酸。 TLR7抑制剂包括具有硫代磷酸酯骨架的寡核苷酸。还提供了涉及本发明的抑制性寡核苷酸和其它试剂的组合和缀合物，其中其它试剂包括TLR激动剂和抗原。可以使用本发明的组合物来形成免疫应答，减少不需要的特异性TLR介导的免疫刺激，并且治疗包括变态反应，哮喘，感染和癌症的病症。

7. 发明授权

US08466124B2 RNA sequence motifs in the context of defined internucleotide linkages inducing specific immune modulatory profiles 有权
标题翻译： RNA序列基序在定义的核苷酸间键的背景下诱导特异性免疫调节谱
公开(公告)号：US08466124B2
公开(公告)日：2013-06-18
申请号：US13494216
申请日：2012-06-12
申请人： Marion Jurk , Jorg Vollmer
发明人： Marion Jurk , Jorg Vollmer
IPC分类号： A61K48/00 , C12Q1/68 , C07H21/02 , C12N5/02 , C12N5/00 , C07H21/04
CPC分类号： A61K31/7105 , A61K39/39 , A61K2039/55561 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/33
摘要： Immunostimulatory polymers that contain certain sequence-dependent immunostimulatory RNA motifs and methods for the use of such immunostimulatory polymers and compositions containing such polymers are provided according to the invention. The sequence-dependent immunostimulatory RNA motifs and the polymers incorporating such motifs are potent and selective inducers of TLR7 and the TLR7-associated cytokine IFN-α.
摘要翻译：根据本发明提供了含有某些顺序依赖性免疫刺激RNA基序的免疫刺激性聚合物和使用这种免疫刺激性聚合物的方法和含有这些聚合物的组合物。序列依赖性免疫刺激RNA基序和掺入这种基序的聚合物是TLR7和TLR7相关细胞因子IFN-α的有效和选择性诱导物。

8. 发明授权

US08227447B2 RNA sequence motifs in the context of defined internucleotide linkages inducing specific immune modulatory profiles 有权
公开(公告)号：US08227447B2
公开(公告)日：2012-07-24
申请号：US13360894
申请日：2012-01-30
申请人： Marion Jurk , Jorg Vollmer
发明人： Marion Jurk , Jorg Vollmer
IPC分类号： A61K48/00 , C12Q1/68 , C07H21/02 , C12N5/02 , C12N5/00 , C07H21/04
CPC分类号： A61K31/7105 , A61K39/39 , A61K2039/55561 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/33
摘要： Immunostimulatory polymers that contain certain sequence-dependent immunostimulatory RNA motifs and methods for the use of such immunostimulatory polymers and compositions containing such polymers are provided according to the invention. The sequence-dependent immunostimulatory RNA motifs and the polymers incorporating such motifs are potent and selective inducers of TLR7 and the TLR7-associated cytokine IFN-α.

9. 发明授权

US08128944B2 RNA sequence motifs in the context of defined internucleotide linkages inducing specific immune modulatory profiles 有权
标题翻译： RNA序列基序在定义的核苷酸间键的背景下诱导特异性免疫调节谱
公开(公告)号：US08128944B2
公开(公告)日：2012-03-06
申请号：US12670697
申请日：2008-08-08
申请人： Marion Jurk , Jorg Vollmer
发明人： Marion Jurk , Jorg Vollmer
IPC分类号： A61K47/00 , A61K31/00 , C07H21/04
CPC分类号： A61K31/7105 , A61K39/39 , A61K2039/55561 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/33
摘要： Immunostimulatory polymers that contain certain sequence-dependent immunostimulatory RNA motifs and methods for the use of such immunostimulatory polymers and compositions containing such polymers are provided according to the invention. The sequence-dependent immunostimulatory RNA motifs and the polymers incorporating such motifs are potent and selective inducers of TLR7 and the TLR7-associated cytokine IFN-α.
摘要翻译：根据本发明提供了含有某些顺序依赖性免疫刺激RNA基序的免疫刺激性聚合物和使用这种免疫刺激性聚合物的方法和含有这些聚合物的组合物。序列依赖性免疫刺激RNA基序和掺入这种基序的聚合物是TLR7和TLR7相关细胞因子IFN-α的有效和选择性诱导物。

10. 发明申请

US20100272785A1 RNA SEQUENCE MOTIFS IN THE CONTEXT OF DEFINED INTERNUCLEOTIDE LINKAGES INDUCING SPECIFIC IMMUNE MODULATORY PROFILES 有权
标题翻译：诱导特异性免疫调节剂分析的定义的核苷酸连接物的RNA序列运动
公开(公告)号：US20100272785A1
公开(公告)日：2010-10-28
申请号：US12670697
申请日：2008-08-08
申请人： Marion Jurk , Jorg Vollmer
发明人： Marion Jurk , Jorg Vollmer
IPC分类号： A61K39/35 , A61K9/127 , A61K39/00 , A61P35/00 , A61P31/00 , A61P37/08
CPC分类号： A61K31/7105 , A61K39/39 , A61K2039/55561 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/33
摘要： Immunostimulatory polymers that contain certain sequence-dependent immunostimulatory RNA motifs and methods for the use of such immunostimulatory polymers and compositions containing such polymers are provided according to the invention. The sequence-dependent immunostimulatory RNA motifs and the polymers incorporating such motifs are potent and selective inducers of TLR7 and the TLR7-associated cytokine IFN-α.
摘要翻译：根据本发明提供了含有某些顺序依赖性免疫刺激RNA基序的免疫刺激性聚合物和使用这种免疫刺激性聚合物的方法和含有这些聚合物的组合物。序列依赖性免疫刺激RNA基序和掺入这种基序的聚合物是TLR7和TLR7相关细胞因子IFN-α的有效和选择性诱导物。

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