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1. 发明授权

US08685440B2 Nanoliposome using esterified lecithin and method for preparing the same, and composition for preventing or treating skin diseases comprising the same 有权
标题翻译：使用酯化卵磷脂的纳米脂质体及其制备方法，以及用于预防或治疗包含其的皮肤病的组合物
公开(公告)号：US08685440B2
公开(公告)日：2014-04-01
申请号：US12375739
申请日：2007-08-01
申请人： Joon Pio Hong , Sang Kil Lee , Won Chul Kim , Chae Ha Yoon , Sang Wook Lee , Kyeong Sun Shin , Seung Kook Park
发明人： Joon Pio Hong , Sang Kil Lee , Won Chul Kim , Chae Ha Yoon , Sang Wook Lee , Kyeong Sun Shin , Seung Kook Park
IPC分类号： A61K36/00 , A61K9/127 , A61K8/14 , A61K8/55
CPC分类号： A61K9/1271 , A61K8/14 , A61K8/553 , A61K9/1277 , A61K2800/413 , A61Q19/00 , B82Y5/00
摘要： The present invention relates to a nanoliposome comprising a liposome membrane containing esterified lecithin, and one or more physiologically active ingredients included in inner space of the liposome membrane; a method for preparing the same; and a composition for preventing or treating skin diseases, comprising the same. The nanoliposome according to the present invention has long-term stability and uniformity, and so can be used to prepare a composition for skin having excellent moisturizing and penetrating properties, such as cosmetics, medicament for treating skin diseases, or the like. In particular, the present composition for preventing or treating skin diseases comprises epidermal growth factor included in the nanoliposome, thereby showing an excellent effect of stimulating skin-penetration and good pharmaceutical stability. Also, the esterified lecithin used in preparing liposome can provide effects of softening skin and stimulating skin-penetration, thereby enhancing the penetration of epidermal growth factor and natural extract into skin, as well as additional moisturizing effect which is advantageous in treating skin diseases. Further, since the present composition comprises nanoliposome prepared by containing esterified lecithin in liposome membrane, the conventional problems of heating and dispersing active ingredients at high temperature (70° C. or more), low stability and uniformity, or the like can be solved.
摘要翻译：本发明涉及包含含有酯化卵磷脂的脂质体膜和包含在脂质体膜的内部空间中的一种或多种生理活性成分的纳米脂质体，其制备方法; 以及用于预防或治疗皮肤病的组合物。根据本发明的纳米脂质体具有长期的稳定性和均匀性，因此可以用于制备具有优异的保湿和渗透性的皮肤组合物，例如化妆品，用于治疗皮肤病的药物等。特别地，本发明的皮肤病预防或治疗组合物包括纳米脂质体中所含的表皮生长因子，因此显示刺激皮肤渗透和良好药物稳定性的优异效果。此外，用于制备脂质体的酯化卵磷脂可以提供软化皮肤和刺激皮肤渗透的作用，从而增强表皮生长因子和天然提取物对皮肤的渗透性，以及有利于治疗皮肤疾病的额外的保湿效果。此外，由于本发明的组合物包含通过在脂质体膜中含有酯化的卵磷脂而制备的纳米脂质体，因此可以解决在高温（70℃以上）下加热分散有效成分的常规问题，稳定性和均匀性低等。

2. 发明申请

US20090263473A1 Nanoliposome Using Esterified Lecithin And Method For Preparing The Same, And Composition For Preventing Or Treating Skin Diseases Comprising The Same 有权
标题翻译：使用酯化卵磷脂的纳米脂质体及其制备方法，以及用于预防或治疗包含其的皮肤疾病的组合物
公开(公告)号：US20090263473A1
公开(公告)日：2009-10-22
申请号：US12375739
申请日：2007-08-01
申请人： Joon Pio Hong , Sang Kil Lee , Won Chul Kim , Chae Ha Yoon , Sang Wook Lee , Kyeong Sun Shin , Seung Kook Park
发明人： Joon Pio Hong , Sang Kil Lee , Won Chul Kim , Chae Ha Yoon , Sang Wook Lee , Kyeong Sun Shin , Seung Kook Park
IPC分类号： A61K9/127 , A61K38/43 , A61K36/00
CPC分类号： A61K9/1271 , A61K8/14 , A61K8/553 , A61K9/1277 , A61K2800/413 , A61Q19/00 , B82Y5/00
摘要： The present invention relates to a nanoliposome comprising a liposome membrane containing esterified lecithin, and one or more physiologically active ingredients included in inner space of the liposome membrane; a method for preparing the same; and a composition for preventing or treating skin diseases, comprising the same. The nanoliposome according to the present invention has long-term stability and uniformity, and so can be used to prepare a composition for skin having excellent moisturizing and penetrating properties, such as cosmetics, medicament for treating skin diseases, or the like. In particular, the present composition for preventing or treating skin diseases comprises epidermal growth factor included in the nanoliposome, thereby showing an excellent effect of stimulating skin-penetration and good pharmaceutical stability. Also, the esterified lecithin used in preparing liposome can provide effects of softening skin and stimulating skin-penetration, thereby enhancing the penetration of epidermal growth factor and natural extract into skin, as well as additional moisturizing effect which is advantageous in treating skin diseases. Further, since the present composition comprises nanoliposome prepared by containing esterified lecithin in liposome membrane, the conventional problems of heating and dispersing active ingredients at high temperature (70° C. or more), low stability and uniformity, or the like can be solved.
摘要翻译：本发明涉及包含含有酯化卵磷脂的脂质体膜和包含在脂质体膜的内部空间中的一种或多种生理活性成分的纳米脂质体，其制备方法; 以及用于预防或治疗皮肤病的组合物。根据本发明的纳米脂质体具有长期的稳定性和均匀性，因此可以用于制备具有优异的保湿和渗透性的皮肤组合物，例如化妆品，用于治疗皮肤病的药物等。特别地，本发明的皮肤病预防或治疗组合物包括纳米脂质体中所含的表皮生长因子，因此显示刺激皮肤渗透和良好药物稳定性的优异效果。此外，用于制备脂质体的酯化卵磷脂可以提供软化皮肤和刺激皮肤渗透的作用，从而增强表皮生长因子和天然提取物对皮肤的渗透性，以及有利于治疗皮肤疾病的额外的保湿作用。此外，由于本发明的组合物包含通过在脂质体膜中含有酯化的卵磷脂而制备的纳米脂质体，因此可以解决在高温（70℃以上）下加热分散有效成分的常规问题，稳定性和均匀性低等。

3. 发明授权

US07811786B1 Preparation method for the production of active and soluble proteins in prokaryotes and polycistronic vectors therefor 有权
标题翻译：用于在原核生物和多顺反子载体中生产活性和可溶性蛋白质的制备方法
公开(公告)号：US07811786B1
公开(公告)日：2010-10-12
申请号：US11579753
申请日：2004-06-11
申请人： Bong Yong Lee , Seung Kook Park , Shin Hye Park , Oh Byung Kwon , Chae Ha Yoon , Young Ju Kim , Song Young Kim , Kyung Hyun Min , Yoon Seok Lee , Tae Hee Lee , Tai Young Koo
发明人： Bong Yong Lee , Seung Kook Park , Shin Hye Park , Oh Byung Kwon , Chae Ha Yoon , Young Ju Kim , Song Young Kim , Kyung Hyun Min , Yoon Seok Lee , Tae Hee Lee , Tai Young Koo
IPC分类号： C12N15/00 , C12N1/20 , C12P21/06
CPC分类号： C12P21/02 , C12N15/70
摘要： Disclosed are a method of producing a target protein in a biologically-active, soluble form in prokaryotic cells and polycistronic vectors therefor.
摘要翻译：公开了在原核细胞和多顺反子载体中生产生物活性的可溶形式的靶蛋白的方法。

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