专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20110081674A1 CONTINUOUS-FLOW DEFORMABILITY-BASED CELL SEPARATION 有权
标题翻译：基于连续流动可变性的细胞分离
公开(公告)号：US20110081674A1
公开(公告)日：2011-04-07
申请号：US12899197
申请日：2010-10-06
申请人： Jongyoon HAN , Hansen Bow , Patrick Abgrall
发明人： Jongyoon HAN , Hansen Bow , Patrick Abgrall
IPC分类号： C12N5/071 , C12Q1/02 , C12N13/00 , C12N5/09
CPC分类号： C12N13/00 , C12M47/04 , C12Q1/025 , G01N33/5008 , G01N33/5091
摘要： This invention provides methods utilizing a microfluidic device that can quickly and accurately discern differences in deformability between individual cells and sets of cells and continuously fractionate populations of cells based on their deformability. This information may be important in disease diagnosis and treatment efficacy monitoring. For example such a device may be able to determine the stage of malarial infection by using red blood cell deformability. Additionally, methods of the invention may be used as a tool to screen drugs that can make cells more flexible in diseases such as sickle cell anemia that causes sickle cell crises. The relatively low manufacturing and operation costs of methods of the invention enable this device to be used in resource-limited settings to diagnose and monitor disease.
摘要翻译：本发明提供了利用微流体装置的方法，其可以快速且准确地辨别各个细胞和细胞组之间的变形能力的差异，并且基于它们的可变形性连续分离细胞群体。该信息在疾病诊断和治疗功效监测中可能是重要的。例如，这种装置可以通过使用红细胞变形能力来确定疟疾感染的阶段。此外，本发明的方法可以用作筛选药物的工具，所述药物可使细胞在诸如引起镰状细胞危机的镰状细胞性贫血等疾病中更加灵活。本发明方法的相对低的制造和操作成本使得该装置能够在资源有限的设置中用于诊断和监测疾病。

2. 发明授权

US08771933B2 Continuous-flow deformability-based cell separation 有权
标题翻译：连续流变形性细胞分离
公开(公告)号：US08771933B2
公开(公告)日：2014-07-08
申请号：US12899197
申请日：2010-10-06
申请人： Jongyoon Han , Hansen Bow , Patrick Abgrall
发明人： Jongyoon Han , Hansen Bow , Patrick Abgrall
IPC分类号： A01N1/02
CPC分类号： C12N13/00 , C12M47/04 , C12Q1/025 , G01N33/5008 , G01N33/5091
摘要： This invention provides methods utilizing a microfluidic device that can quickly and accurately discern differences in deformability between individual cells and sets of cells and continuously fractionate populations of cells based on their deformability. This information may be important in disease diagnosis and treatment efficacy monitoring. For example such a device may be able to determine the stage of malarial infection by using red blood cell deformability. Additionally, methods of the invention may be used as a tool to screen drugs that can make cells more flexible in diseases such as sickle cell anemia that causes sickle cell crises. The relatively low manufacturing and operation costs of methods of the invention enable this device to be used in resource-limited settings to diagnose and monitor disease.
摘要翻译：本发明提供了利用微流体装置的方法，其可以快速且准确地辨别各个细胞和细胞组之间的变形能力的差异，并且基于它们的可变形性连续分离细胞群体。该信息在疾病诊断和治疗功效监测中可能是重要的。例如，这种装置可以通过使用红细胞变形能力来确定疟疾感染的阶段。此外，本发明的方法可以用作筛选药物的工具，所述药物可使细胞在诸如引起镰状细胞危机的镰状细胞性贫血等疾病中更加灵活。本发明方法的相对低的制造和操作成本使得该装置能够在资源有限的设置中用于诊断和监测疾病。

3. 发明申请

US20120064505A1 MEASUREMENT OF MATERIAL PROPERTIES AND RELATED METHODS AND COMPOSITIONS 审中-公开
标题翻译：材料性质的测量及相关方法和组合物
公开(公告)号：US20120064505A1
公开(公告)日：2012-03-15
申请号：US13053118
申请日：2011-03-21
申请人： Subra Suresh , Jongyoon Han , Hansen Bow , Sha Huang , Monica Diez Silva , Igor V. Pivkin , Michal (Michelle) Berris , Ming Dao
发明人： Subra Suresh , Jongyoon Han , Hansen Bow , Sha Huang , Monica Diez Silva , Igor V. Pivkin , Michal (Michelle) Berris , Ming Dao
IPC分类号： C12Q1/02 , C12N5/071 , C12N5/078 , F03B11/02 , F17D3/00
CPC分类号： G01N33/5029 , B01L3/502746 , B01L2300/0816 , B01L2300/0822 , B01L2400/086 , G01N11/04 , G01N2500/10 , Y10T137/0318 , Y10T137/8593
摘要： The invention in some aspects relates to methods, devices and compositions for evaluating material properties, such as mechanical and rheological properties of substances, particularly biological substances, such as cells, tissues, and biological fluids. In some aspects, the invention relates to methods, devices and compositions for evaluating material properties of deformable objects, such as cells. In further aspects, the invention relates to methods, devices and compositions for diagnosing and/or characterizing disease based on material properties of biological cells.
摘要翻译：本发明在一些方面涉及用于评估材料性质的方法，装置和组合物，例如物质的机械和流变性质，特别是生物物质，例如细胞，组织和生物流体。在一些方面，本发明涉及用于评估诸如电池的可变形物体的材料特性的方法，装置和组合物。在其它方面，本发明涉及用于基于生物细胞的材料性质来诊断和/或表征疾病的方法，装置和组合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式