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1. 发明申请

US20100021480A1 BIOACTIVE SUBSTANCE-BLOOD PROTEIN CONJUGATE AND STABILIZATION OF A BIOACTIVE SUBSTANCE USING THE SAME 审中-公开
标题翻译：生物物质 - 血液蛋白质结合和使用相同物质的生物活性物质的稳定化
公开(公告)号：US20100021480A1
公开(公告)日：2010-01-28
申请号：US12090969
申请日：2006-10-27
申请人： Jong-Il Park , Min-Gyu Soung , Heung-Jae Kim , Chae-Jin Lim , Jong-Phil Kang , Ho-Il Choi
发明人： Jong-Il Park , Min-Gyu Soung , Heung-Jae Kim , Chae-Jin Lim , Jong-Phil Kang , Ho-Il Choi
IPC分类号： A61K39/395 , C07K14/435 , C07K14/76 , C07K16/00 , A61K38/16 , A61P35/00
CPC分类号： A61K38/26 , A61K38/09 , A61K38/2278 , A61K38/38 , A61K47/643 , C07K1/1075 , A61K2300/00
摘要： This invention relates to a technology of modifying low-molecular-weight bioactive substances with short in vivo half-life and low stability in order to achieve a stable and efficient in vivo delivery thereof. More specifically, the present invention relates to a stable bioactive substance-blood protein conjugate, wherein a low-molecular-weight bioactive substance is ex vivo conjugated with a specific functional group on a blood protein through a reactive group, the low-molecular-weight bioactive substance is available as a drug for treatment and prevention in mammals including human and selected from the group consisting of a natural substance; and a method of a stable and efficient in vivo delivery of the low-molecular-weight bioactive substance based on the use of the bioactive substance-blood protein conjugate.
摘要翻译：本发明涉及一种修改体内半衰期短，稳定性低的低分子量生物活性物质的技术，以实现其体内稳定的递送。更具体地说，本发明涉及一种稳定的生物活性物质 - 血液蛋白质结合物，其中低分子量生物活性物质通过反应性基团与血液蛋白质上的特定官能团离子结合，低分子量生物活性物质可用作包括人在内的哺乳动物的治疗和预防药物，并且选自天然物质; 以及基于使用生物活性物质 - 血液蛋白质缀合物的低分子量生物活性物质的稳定且有效的体内递送的方法。

2. 发明授权

US08829044B2 Stabilized vitamin C derivatives having a peptide molecule, preparation method thereof, and composition containing the same 有权
标题翻译：具有肽分子的稳定化维生素C衍生物及其制备方法和含有其的组合物
公开(公告)号：US08829044B2
公开(公告)日：2014-09-09
申请号：US12308604
申请日：2006-09-05
申请人： Jong-Il Park , Heung-Jae Kim , Dong-Won Kim , Chae-Jin Lim , Jong-Phil Kang , Kyeong-Yong Park , Seok-Jeong Yoon , Seon-Deok Kwon , Ho-Il Choi
发明人： Jong-Il Park , Heung-Jae Kim , Dong-Won Kim , Chae-Jin Lim , Jong-Phil Kang , Kyeong-Yong Park , Seok-Jeong Yoon , Seon-Deok Kwon , Ho-Il Choi
IPC分类号： A61K31/375 , C07K5/08 , C07K5/10 , G01N33/82
CPC分类号： C07K5/0827 , A61K8/676 , A61Q19/08 , C07D307/62 , C07K7/06 , Y10T436/142222
摘要： The present invention relates to a stabilized vitamin C derivative with a peptide molecule linked to vitamin C or a pharmaceutically acceptable salt thereof, a method of preparing the same, and a composition containing the same.
摘要翻译：本发明涉及具有与维生素C连接的肽分子的稳定的维生素C衍生物或其药学上可接受的盐，其制备方法以及含有它们的组合物。

3. 发明申请

US20100331260A1 Stabilized bitamin c derivatives having a peptide molecule, preparation method thereof, and composition containing the same 有权
标题翻译：具有肽分子的稳定的苦参素c衍生物，其制备方法和含有其的组合物
公开(公告)号：US20100331260A1
公开(公告)日：2010-12-30
申请号：US12308604
申请日：2006-09-05
申请人： Jong-II Park , Heung-Jae Kim , Dong-Won Kim , Chae-Jin Lim , Jong-Phil Kang , Kyeong-Yong Park , Seok-Jeong Yoon , Seon-Deok Kwon , Ho-Il Choi
发明人： Jong-II Park , Heung-Jae Kim , Dong-Won Kim , Chae-Jin Lim , Jong-Phil Kang , Kyeong-Yong Park , Seok-Jeong Yoon , Seon-Deok Kwon , Ho-Il Choi
IPC分类号： A61K8/64 , C07F9/24 , C07K5/083 , C07K7/06 , A61Q19/08 , A61Q19/02
CPC分类号： C07K5/0827 , A61K8/676 , A61Q19/08 , C07D307/62 , C07K7/06 , Y10T436/142222
摘要： The present invention relates to a stabilized vitamin C derivative with a peptide molecule linked to vitamin C or a pharmaceutically acceptable salt thereof, a method of preparing the same, and a composition containing the same.
摘要翻译：本发明涉及具有与维生素C连接的肽分子的稳定的维生素C衍生物或其药学上可接受的盐，其制备方法以及含有它们的组合物。

4. 发明申请

US20050175693A1 Substained release formulation of protein and preparation method thereof 审中-公开
标题翻译：蛋白质的大量释放制剂及其制备方法
公开(公告)号：US20050175693A1
公开(公告)日：2005-08-11
申请号：US10512090
申请日：2003-05-09
申请人： Hee-Yong Lee , Jung-Soo Kim , Ji-Suk Lee , Jung-In Kim , Yun-Mi Seo , Chae-Jin Lim , Sung-Kyu Kim , Young-Hwan Jung , Seung-Gu Chang , Ho-Il Choi
发明人： Hee-Yong Lee , Jung-Soo Kim , Ji-Suk Lee , Jung-In Kim , Yun-Mi Seo , Chae-Jin Lim , Sung-Kyu Kim , Young-Hwan Jung , Seung-Gu Chang , Ho-Il Choi
IPC分类号： A61K9/00 , A61K9/16 , A61K38/17 , A61K9/22 , A61K31/737
CPC分类号： A61K9/1617 , A61K9/1652
摘要： The present invention relates to a sustained release formulation comprising protein as an active ingredient, and a preparation method thereof. According to the present invention, the sustained release formulation contains protein drugs that are encapsulated in biodegradable hydrophobic matrices as pharmaceutically active forms by forming complexes with sulfated polysaccharides. The sustained release formulation prepared by the present invention can be used to effectively treat a disease without frequent injections by keeping the protein concentration at a sufficiently high level for a long period when injected in vivo once.
摘要翻译：本发明涉及包含蛋白质作为活性成分的缓释制剂及其制备方法。根据本发明，持续释放制剂含有通过与硫酸化多糖形成复合物而包封在可生物降解的疏水基质中作为药物活性形式的蛋白质药物。通过本发明制备的持续释放制剂可以用于通过在体内注射一次时将蛋白质浓度保持在足够高的水平长时间来有效地治疗疾病而不经常注射。

5. 发明授权

US09155702B2 Composition and microsphere for controlled-release of exendin, and method preparing the same 有权
标题翻译：用于控制exendin的组合物和微球及其制备方法
公开(公告)号：US09155702B2
公开(公告)日：2015-10-13
申请号：US12532311
申请日：2008-01-22
申请人： Hee-Yong Lee , Eun-Young Seol , Joon-Sik Kim , Mi-Jin Baek , Jung-Soo Kim , Ju-Han Lee , Yeon-Jin Chae , Chae-Jin Lim , Mi-Young Baek , Ho-Il Choi
发明人： Hee-Yong Lee , Eun-Young Seol , Joon-Sik Kim , Mi-Jin Baek , Jung-Soo Kim , Ju-Han Lee , Yeon-Jin Chae , Chae-Jin Lim , Mi-Young Baek , Ho-Il Choi
IPC分类号： A61K9/16 , A61K9/00 , A61K9/19 , A61K38/22 , A61K9/50 , A61K47/26 , A61K47/38
CPC分类号： A61K9/1647 , A61K9/0024 , A61K9/19 , A61K9/5015 , A61K9/5026 , A61K38/2278 , A61K47/26 , A61K47/38
摘要： A controlled-release composition and controlled-release microspheres containing an exendin as an active ingredient, and a method of preparing the same are provided. More specifically, a controlled-release composition containing an exendin as an active ingredient, a biodegradable polymer with a specific viscosity, and coating materials, having high bioavailability and showing sustained release of the active ingredient in an effective concentration for a certain period without an excessive initial burst of the active ingredient; controlled-release microspheres containing a core including an exendin as an active ingredient and a biodegradable polymer, and a coating layer coating the core; and a method of preparing controlled-release microspheres including the steps of mixing an exendin, a biodegradable polymer, and a solvent, removing the solvent from the mixture to prepare hardened microspheres, and coating the hardened microspheres to form a coating layer on the surface of each microsphere, are provided.
摘要翻译：提供含有毒蜥外泌肽作为活性成分的控释组合物和控释微球及其制备方法。更具体地说，含有毒蜥外泌肽作为活性成分的控释组合物，具有特定粘度的可生物降解的聚合物和具有高生物利用度的涂层材料，并显示有效浓度的有效成分在一定时间内持续释放而不会过度初步爆发的活性成分; 含有包含毒蜥外泌肽作为活性成分的核心和可生物降解的聚合物的控释微球，以及涂覆该芯的涂层; 以及制备控释微球的方法，包括以下步骤：混合毒蜥外泌素，可生物降解的聚合物和溶剂，从混合物中除去溶剂以制备硬化的微球，并涂覆硬化的微球，以在提供每个微球。

6. 发明申请

US20100136126A1 COMPOSITION AND MICROSPHERE FOR CONTROLLED-RELEASE OF EXENDIN, AND METHOD OF PREPARING THE SAME 有权
标题翻译：用于控制释放exendin的组合物和微球及其制备方法
公开(公告)号：US20100136126A1
公开(公告)日：2010-06-03
申请号：US12532311
申请日：2008-01-22
申请人： Hee-Yong Lee , Eun-Young Seol , Joon-Sik Kim , Mi-Jin Baek , Jung-Soo Kim , Ju-Han Lee , Yeon-Jin Chae , Chae-Jin Lim , Mi-Young Baek , Ho-Il Choi
发明人： Hee-Yong Lee , Eun-Young Seol , Joon-Sik Kim , Mi-Jin Baek , Jung-Soo Kim , Ju-Han Lee , Yeon-Jin Chae , Chae-Jin Lim , Mi-Young Baek , Ho-Il Choi
IPC分类号： A61K38/16 , A61K9/14 , A61P3/10
CPC分类号： A61K9/1647 , A61K9/0024 , A61K9/19 , A61K9/5015 , A61K9/5026 , A61K38/2278 , A61K47/26 , A61K47/38
摘要： A controlled-release composition and controlled-release microspheres containing an exendin as an active ingredient, and a method of preparing the same are provided. More specifically, a controlled-release composition containing an exendin as an active ingredient, a biodegradable polymer with a specific viscosity, and coating materials, having high bioavailability and showing sustained release of the active ingredient in an effective concentration for a certain period without an excessive initial burst of the active ingredient; controlled-release microspheres containing a core including an exendin as an active ingredient and a biodegradable polymer, and a coating layer coating the core; and a method of preparing controlled-release microspheres including the steps of mixing an exendin, a biodegradable polymer, and a solvent, removing the solvent from the mixture to prepare hardened microspheres, and coating the hardened microspheres to form a coating layer on the surface of each microsphere, are provided.
摘要翻译：提供含有毒蜥外泌肽作为活性成分的控释组合物和控释微球及其制备方法。更具体地说，含有毒蜥外泌肽作为活性成分的控释组合物，具有特定粘度的可生物降解的聚合物和具有高生物利用度的涂层材料，并显示有效浓度的有效成分在一定时间内持续释放而不会过度初步爆发的活性成分; 含有包含毒蜥外泌肽作为活性成分的核心和可生物降解的聚合物的控释微球，以及涂覆该芯的涂层; 以及制备控释微球的方法，包括以下步骤：混合毒蜥外泌素，可生物降解的聚合物和溶剂，从混合物中除去溶剂以制备硬化的微球，并涂覆硬化的微球，以在提供每个微球。

7. 发明授权

US07706783B2 Channel switching in a mobile station 有权
标题翻译：移动台中的频道切换
公开(公告)号：US07706783B2
公开(公告)日：2010-04-27
申请号：US11245503
申请日：2005-10-07
申请人： Chae-Jin Lim
发明人： Chae-Jin Lim
IPC分类号： H04M3/42
CPC分类号： H04L65/4084 , H04L29/06027 , H04L67/04 , H04L69/28 , H04W4/00 , H04W36/06 , H04W76/10 , H04W88/02
摘要： A mobile station adapted for channel switching comprises an input unit adapted to receive user input associated with selection of content. The mobile station also comprises a timer generating unit operatively coupled to the input unit, adapted to generate a timer related to transmission of a command derived from the user input to a content server in response to the user input. The mobile station also comprises a transmitting unit operatively coupled to the input unit, adapted to transmit the command derived from the user input to the content server in response to expiration of the timer. The mobile station also comprises a receiving unit operatively coupled to the transmitting unit, adapted to receive the content from the content server in response to receipt of the command derived from the user input by the content server.
摘要翻译：适于频道切换的移动台包括适于接收与选择内容相关联的用户输入的输入单元。移动台还包括可操作地耦合到输入单元的计时器产生单元，适于响应于用户输入，产生与从内容服务器导出的命令的传输有关的定时器。移动台还包括可操作地耦合到输入单元的发送单元，用于响应定时器的到期将从用户输入得到的命令发送到内容服务器。移动台还包括可操作地耦合到发射单元的接收单元，适于响应于接收到由内容服务器输入的用户的命令，从内容服务器接收内容。

8. 发明申请

US20060089132A1 Channel switching in a mobile station 有权
标题翻译：移动台中的频道切换
公开(公告)号：US20060089132A1
公开(公告)日：2006-04-27
申请号：US11245503
申请日：2005-10-07
申请人： Chae-Jin Lim
发明人： Chae-Jin Lim
IPC分类号： H04Q7/22
CPC分类号： H04L65/4084 , H04L29/06027 , H04L67/04 , H04L69/28 , H04W4/00 , H04W36/06 , H04W76/10 , H04W88/02
摘要： A mobile station adapted for channel switching comprises an input unit adapted to receive user input associated with selection of content. The mobile station also comprises a timer generating unit operatively coupled to the input unit, adapted to generate a timer related to transmission of a command derived from the user input to a content server in response to the user input. The mobile station also comprises a transmitting unit operatively coupled to the input unit, adapted to transmit the command derived from the user input to the content server in response to expiration of the timer. The mobile station also comprises a receiving unit operatively coupled to the transmitting unit, adapted to receive the content from the content server in response to receipt of the command derived from the user input by the content server.
摘要翻译：适于频道切换的移动台包括适于接收与选择内容相关联的用户输入的输入单元。移动台还包括可操作地耦合到输入单元的计时器产生单元，适于响应于用户输入，产生与从内容服务器导出的命令的传输有关的定时器。移动台还包括可操作地耦合到输入单元的发送单元，用于响应定时器的到期将从用户输入得到的命令发送到内容服务器。移动台还包括可操作地耦合到发射单元的接收单元，适于响应于接收到由内容服务器输入的用户的命令，从内容服务器接收内容。

9. 发明授权

US09359401B2 Peptide analogues with an excellent moisturizing effect and use thereof 有权
标题翻译：具有优异保湿作用的肽类似物及其用途
公开(公告)号：US09359401B2
公开(公告)日：2016-06-07
申请号：US14119854
申请日：2012-05-22
申请人： Kee-Don Park , Chae-Jin Lim , Seok-Jeong Yoon , Seon-Deok Kwon
发明人： Kee-Don Park , Chae-Jin Lim , Seok-Jeong Yoon , Seon-Deok Kwon
IPC分类号： A61K8/64 , A61K38/05 , A61K38/06 , A61K38/07 , C07K5/072 , C07K5/093 , C07K5/113 , C07K5/11 , C07K14/00 , A61Q19/00 , A61Q5/00 , A61Q19/08 , C07K5/068
CPC分类号： C07K5/1019 , A61K8/64 , A61K38/05 , A61K38/06 , A61K38/07 , A61Q5/00 , A61Q19/00 , A61Q19/007 , A61Q19/08 , C07K5/0215 , C07K5/06086 , C07K5/06104 , C07K5/0819 , C07K5/1021 , C07K14/001
摘要： The present invention relates to a peptide analog or a pharmaceutically acceptable salt thereof with excellent moisturizing effect, and use thereof for moisturization. More specifically, the present invention relates to a novel peptide analog or a pharmaceutically acceptable salt thereof, a method for preparation thereof, a moisturizing cosmetic composition comprising the same as an active ingredient, and a pharmaceutical composition for prevention and treatment of xeroderma.
摘要翻译：本发明涉及具有优异保湿效果的肽类似物或其药学上可接受的盐及其用于保湿的用途。更具体地说，本发明涉及一种新的肽类似物或其药学上可接受的盐，其制备方法，包含其作为活性成分的保湿化妆品组合物和用于预防和治疗皮肤病的药物组合物。

10. 发明申请

US20140113868A1 PEPTIDE ANALOGUES WITH AN EXCELLENT MOISTURIZING EFFECT AND USE THEREOF 有权
标题翻译：具有优异滋润作用的肽类似物及其用途
公开(公告)号：US20140113868A1
公开(公告)日：2014-04-24
申请号：US14119854
申请日：2012-05-22
申请人： Kee-Don Park , Chae-Jin Lim , Seok-Jeong Yoon , Seon-Deok Kwon
发明人： Kee-Don Park , Chae-Jin Lim , Seok-Jeong Yoon , Seon-Deok Kwon
IPC分类号： C07K5/11 , A61Q19/08 , A61Q5/00 , C07K5/068 , A61K8/64
CPC分类号： C07K5/1019 , A61K8/64 , A61K38/05 , A61K38/06 , A61K38/07 , A61Q5/00 , A61Q19/00 , A61Q19/007 , A61Q19/08 , C07K5/0215 , C07K5/06086 , C07K5/06104 , C07K5/0819 , C07K5/1021 , C07K14/001
摘要： The present invention relates to a peptide analogue or a pharmaceutically acceptable salt thereof with excellent moisturizing effect, and use thereof for moisturization. More specifically, the present invention relates to a novel peptide analogue or a pharmaceutically acceptable salt thereof, a method for preparation thereof, a moisturizing cosmetic composition comprising the same as an active ingredient, and a pharmaceutical composition for prevention and treatment of xeroderma.
摘要翻译：本发明涉及具有优异保湿作用的肽类似物或其药学上可接受的盐及其用于保湿的用途。更具体地，本发明涉及一种新的肽类似物或其药学上可接受的盐，其制备方法，包含其作为活性成分的保湿化妆品组合物和用于预防和治疗皮肤病的药物组合物。

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